Transcriptional profile of muscle following acute induction of symptoms in a mouse model of Kennedy's disease/spinobulbar muscular atrophy. by Katherine Halievski, Kaiguo Mo, J Timothy Westwood, Douglas A Monks

“…We previously reported a microarray study of genes differentially expressed in muscle of three genetically unique mouse models of KD/SBMA but were unable to detect those which are androgen-dependent or are associated with onset of symptoms.…”
Get full text

Adenosine Receptor 3 in Liver Cancer: Expression Variability, Epigenetic Modulation, and Enhanced Histone Deacetylase Inhibitor Effects by Louise Kaldjob-Heinrich, Sandro Nuciforo, Steffen Lemke, Aaron Stahl, Stefan Czemmel, Sepideh Babaei, Lauriane Blukacz, Marie-Anne Meier, Yizheng Zhang, Christian M. Schürch, Irene Gonzalez-Menendez, Pascal Woelffing, Nisar P. Malek, Veit Scheble, Sven Nahnsen, Manfred Claassen, Markus Templin, Hans Bösmüller, Markus H. Heim, Daniel Dauch, Michael Bitzer

“…However, further data are required to clarify ADORA3 expression patterns in liver cancer, mechanisms of action, and the potential for combination therapies to inform patient selection for future clinical trials. Methods: Patient-derived tissue microarrays and RNA-sequencing were employed to investigate ADORA3 expression. …”
Get full text

MicroRNA profiling in human colon cancer cells during 5-fluorouracil-induced autophagy. by Ni Hou, Jia Han, Jie Li, Yingxun Liu, Yannan Qin, Lei Ni, Tusheng Song, Chen Huang

“…The physiological importance of the miRNA-autophagy interconnection is only beginning to be elucidated. MiRNA microarray technology facilitates analysis of global miRNA expression in certain situations. …”
Get full text

Clinical features and genetic analysis of a family with t(5;9) (p15;p24) balanced translocation leading to Cri-du-chat syndrome in offspring by Jing Zhao, Ping Chen, Yijia Ren, Shurong Li, Weiyi Zhang, Yan Li, Fengyu Wang

“…We characterized individual clinical features and conducted a genetic analysis of the members of a family with t (5; 9) (p15; p24) balanced translocation leading to Cri-du-chat syndrome in the offspring.Study designWe performed a chromosomal karyotyping with high-resolution G-banding on the proband and her family members to detect their chromosomal configurations. We also used chromosomal microarray analyses (CMA) to detect copy number variants. …”
Get full text

Droplets Cas13a‐RPA measurement delineates potential role for plasma circWDR37 in colorectal cancer by Jingsong Xu, Li Cao, Shuang Yang, Ying Jian, Yu Liu, Zhen Shen, Qian Liu, Xiang Chen, Min Li, Shun Li, Xiaolei Zuo, Min Li, Hua Wang

“…However, novel circRNAs as potential biomarkers for CRC still need further exploration and validation, and precise detection methods are yet to be developed. Herein, we report for the first time the use of droplets Cas13a to detect the circWDR37 as a biomarker of CRC. …”
Get full text

Regulation of neutrophil senescence by microRNAs. by Jon R Ward, Paul R Heath, James W Catto, Moira K B Whyte, Marta Milo, Stephen A Renshaw

“…Total RNA from highly purified neutrophils was prepared and subjected to microarray analysis using the Agilent human miRNA microarray V3. …”
Get full text

Aberrant expression of shared master-key genes contributes to the immunopathogenesis in patients with juvenile spondyloarthritis. by Lovro Lamot, Fran Borovecki, Lana Tambic Bukovac, Mandica Vidovic, Marija Perica, Kristina Gotovac, Miroslav Harjacek

“…Microarray results and bioinformatical analysis revealed 745 differentially expressed genes involved in various inflammatory processes, while qRT-PCR analysis of selected genes confirmed data universality and specificity of expression profiles in jSpA patients. …”
Get full text

Cell cycle- and cancer-associated gene networks activated by Dsg2: evidence of cystatin A deregulation and a potential role in cell-cell adhesion. by Abhilasha Gupta, Daniela Nitoiu, Donna Brennan-Crispi, Sankar Addya, Natalia A Riobo, David P Kelsell, Mỹ G Mahoney

“…CSTA was detected at high level throughout the newborn mouse epidermis but dramatically decreased with development and was detected predominantly in the differentiated layers. …”
Get full text

Differentially expressed circular RNAs and their diagnostic value in children with allergic rhinitis by Yuhao Fan, Yilin Li, Miaomiao Xu, Liya Ren, Yong Li, Jing Li

“…Methods Blood samples were collected from allergic rhinitis patients and healthy controls, and circular RNA microarray was performed. The expression of differentially expressed circular RNAs was verified via real-time quantitative reverse transcription polymerase chain reaction, and these RNAs were selected for Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses. …”
Get full text

Etiology and outcomes of fetal renal abnormalities in Southern China: a single-tertiary-center study by Meiying Cai, Yashi Gao, Huili Xue, Xianguo Fu, Hua Cao, Liangpu Xu, Na Lin, Hailong Huang

“…We retrospectively analyzed data from 1,019 cases for which chromosomal microarray analysis (CMA) was performed; 58 CMA-negative fetuses were selected for whole-exome sequencing (WES). …”
Get full text

The efficacy of expanded non‐invasive prenatal testing (NIPT) in a high‐risk twin pregnancies cohort by Meng Meng, Jianping Chen, Yingjun Yang, Yun Zhang, Gang Zou, Fenhe Zhou, Xing Wei, Yuchun Ge, Jia Zhou, Luming Sun

“…Participants underwent invasive karyotyping and chromosomal microarray analysis, alongside separate expanded NIPT for research purposes. …”
Get full text

circZNF707 promoted glycolysis and tumor progression through miR-668-3p-PFKM axis in NSCLC by Wei Chen, Shuai Fang, Xianqiao Wu, Tianzheng Fang, Ziyuan Chen, Wenmin Su, Yuchao Zhu, Xiaodong Zhao, Chengwei Zhou

“…Finally, tests using Western blotting, RIP, qRT-PCR, and luciferase reporter gene detection and rescue assays revealed the potential mechanism of circZNF707. …”
Get full text

Genome wide nucleosome mapping for HSV-1 shows nucleosomes are deposited at preferred positions during lytic infection. by Jaewook Oh, Iryna F Sanders, Eric Z Chen, Hongzhe Li, John W Tobias, R Benjamin Isett, Sindura Penubarthi, Hao Sun, Don A Baldwin, Nigel W Fraser

“…Here we perform HSV-1 genome wide nucleosome mapping, at a time when viral replication is in full swing (6 hr PI), using a microarray consisting of 50mer oligonucleotides, covering the whole viral genome (152 kb). …”
Get full text

Gene co-expression module study identifies key genes and pathways underpinning hypercholesterolemia-induced atherosclerosis development by Muhammad-Redha Abdullah-Zawawi, Muhammad Irfan Abdul Jalal, Siti Aishah Sulaiman, Nur Alyaa Afifah Md Shahri, Rahman Jamal, Nor Azian Abdul Murad

“…Methods The Affymetrix microarray dataset (GSE13985), which includes samples from five healthy controls and five FH patients, was obtained from the Gene Expression Omnibus (GEO) database. …”
Get full text

Identification of Key Genes and Potential Therapeutic Targets in Sepsis-Associated Acute Kidney Injury Using Transformer and Machine Learning Approaches by Zhendong Zhai, JunZhe Peng, Wenjun Zhong, Jun Tao, Yaqi Ao, Bailin Niu, Li Zhu

“…Analysis of normalized microarray data from GEO (GSE95233 and GSE69063) identified differentially expressed genes (DEGs), and KEGG/GO enrichment via clusterProfiler revealed key pathways in immune response, protein synthesis, and antigen presentation. …”
Get full text

Haplotype Analysis of Interleukin-8 Gene Polymorphisms in Chronic and Aggressive Periodontitis by Petra Borilova Linhartova, Jan Vokurka, Hana Poskerova, Antonin Fassmann, Lydie Izakovicova Holla

“…Subgingival bacterial colonization was investigated by the DNA-microarray detection kit in a subgroup of subjects (N=247). …”
Get full text

Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant. by Anatoly Urisman, Ross J Molinaro, Nicole Fischer, Sarah J Plummer, Graham Casey, Eric A Klein, Krishnamurthy Malathi, Cristina Magi-Galluzzi, Raymond R Tubbs, Don Ganem, Robert H Silverman, Joseph L DeRisi

“…Given the role of this gene in viral defense, we sought to explore the possibility that a viral infection might contribute to prostate cancer in individuals harboring the R462Q variant. A viral detection DNA microarray composed of oligonucleotides corresponding to the most conserved sequences of all known viruses identified the presence of gammaretroviral sequences in cDNA samples from seven of 11 R462Q-homozygous (QQ) cases, and in one of eight heterozygous (RQ) and homozygous wild-type (RR) cases. …”
Get full text

miRNA-REGULATED PATHWAYS OF CD8+ T CELLS IN TNBC MOUSE MODEL by Müge Öçal Demirtaş, Bala Gür Dedeoğlu

“…Following RNA isolation, miRNA microarray analysis was performed. Differentially expressed miRNAs between the groups were detected. …”
Get full text

Identification of G1-regulated genes in normally cycling human cells. by Maroun J Beyrouthy, Karen E Alexander, Amy Baldwin, Michael L Whitfield, Hank W Bass, Dan McGee, Myra M Hurt

“…<h4>Methodology and findings</h4>We used a robotic mitotic shake-off apparatus to select cells in late mitosis for genome-wide gene expression studies. …”
Get full text

Clustering, Pathway Enrichment, and Protein-Protein Interaction Analysis of Gene Expression in Neurodevelopmental Disorders by Ruchi Yadav, Prachi Srivastava

“…In this study, we have used four samples of microarray neuronal developmental data: control, RV (resveratrol), NGF (nerve growth factor), and RV + NGF. …”
Get full text