Ultradian cortisol pulsatility encodes a distinct, biologically important signal. by Andrew McMaster, Maryam Jangani, Paula Sommer, Namshik Han, Andy Brass, Stephen Beesley, Weiqun Lu, Andrew Berry, Andrew Loudon, Rachelle Donn, David W Ray

“…In addition, effects on glucocorticoid receptor (GR) expression levels and phosphorylation, as a potential mediator, were measured.…”
Get full text

Stabilization of Transcription Factor, HIF-1α by Prolylhydroxylase 1 Knockout Reduces Cardiac Injury After Myocardial Infarction in Mice by Mahesh Thirunavukkarasu, Seetur R. Pradeep, Babatunde Oriowo, Sue Ting Lim, Monica Maloney, Shayan Ahmed, Nicole Taylor, David M. Russell, Pavayee Socrates, Ethan Batko, Matan Berkovsky, John Alexander Palesty, Nilanjana Maulik

“…Our current work investigates the protective effects of PHD1 knockout in mice against myocardial infarction. …”
Get full text

Maternal bisphenol a exposure impacts the fetal heart transcriptome. by Kalyan C Chapalamadugu, Catherine A Vandevoort, Matthew L Settles, Barrie D Robison, Gordon K Murdoch

“…Herein, we evaluate the effects of daily, oral BPA exposure of pregnant rhesus monkeys (Macaca mulatta) on the fetal heart transcriptome. …”
Get full text

Hub genes and associated drugs for multiple myeloma with 1q21+: identified by bioinformatic analysis by Zhiqiang Xu, Jieni Yu, Yamei Chen

“…While 1q21+ was common genetic alteration and found to have adverse effect on prognosis, the underlying genes remain unclear. …”
Get full text

Local anesthetics induce apoptosis in human thyroid cancer cells through the mitogen-activated protein kinase pathway. by Yuan-Ching Chang, Yi-Chiung Hsu, Chien-Liang Liu, Shih-Yuan Huang, Meng-Chun Hu, Shih-Ping Cheng

“…Recent evidence suggests that local anesthetics have a broad spectrum of effects including inhibition of cell proliferation and induction of apoptosis in neuronal and other types of cells. …”
Get full text

Gene expression in human hippocampus from cocaine abusers identifies genes which regulate extracellular matrix remodeling. by Deborah C Mash, Jarlath ffrench-Mullen, Nikhil Adi, Yujing Qin, Andrew Buck, John Pablo

“…The chronic effects of cocaine abuse on brain structure and function are blamed for the inability of most addicts to remain abstinent. …”
Get full text

Parallel clustering algorithm for large-scale biological data sets. by Minchao Wang, Wu Zhang, Wang Ding, Dongbo Dai, Huiran Zhang, Hao Xie, Luonan Chen, Yike Guo, Jiang Xie

“…The runtime is reduced from serval hours to a few seconds, which indicates that parallel algorithm is capable of handling large-scale data sets effectively. The parallel affinity propagation also achieves a good performance when clustering large-scale gene data (microarray) and detecting families in large protein superfamilies.…”
Get full text

The impact of the nucleosome code on protein-coding sequence evolution in yeast. by Tobias Warnecke, Nizar N Batada, Laurence D Hurst

“…We identify nucleosome positioning as a likely candidate to set up such a DNA-level selective regime and use high-resolution microarray data in yeast to compare the evolution of coding sequence bound to or free from nucleosomes. …”
Get full text

M2-like macrophage-derived exosomes inhibit osteoclastogenesis via releasing miR-1227-5p by Shan Chen, Jian Liu, Lilei Zhu

“…The molecular mechanism was evaluated using microarray analysis, RT-qPCR, dual-luciferase reporter analysis, and RNA pull-down assay. …”
Get full text

Identification of novel antiviral host factors by functional gene expression analysis using in vitro HBV infection assay systems. by Takuto Nosaka, Tatsushi Naito, Yu Akazawa, Kazuto Takahashi, Hidetaka Matsuda, Masahiro Ohtani, Tsutomu Nishizawa, Hiroaki Okamoto, Yasunari Nakamoto

“…RNA microarray was performed using HBV-infected PXB cells with STAT1 knockdown. …”
Get full text

Identification of ZIC2 as a Potential Biomarker Linked with the Clinical Progression and Immune Infiltration of Oral Cancer: A Multicenter Study by Li Gao, Shi-Bai Yan, Fang-Cheng Jiang, Zhi-Guang Huang, Dong-Ming Li, Yu-Lu Tang, Jia-Yuan Luo, Gang Chen, Dan-Ming Wei

“…We explored the expression pattern and clinicopathological significance of ZIC2 in oral cancer through performing in-house tissue microarray and integrated analysis global RNA-seq and microarrays containing large samples. …”
Get full text

Transcription factor binding site analysis identifies FOXO transcription factors as regulators of the cutaneous wound healing process. by Karl Markus Roupé, Srinivas Veerla, Joshua Olson, Erica L Stone, Ole E Sørensen, Stephen M Hedrick, Victor Nizet

“…The search for significantly overrepresented and co-occurring transcription factor binding sites in the promoter regions of the most differentially expressed genes in microarray data sets could be a powerful approach for finding key regulators of complex biological processes. …”
Get full text

Global gene expression analysis of canine osteosarcoma stem cells reveals a novel role for COX-2 in tumour initiation. by Lisa Y Pang, Emma L Gatenby, Ayako Kamida, Bruce A Whitelaw, Ted R Hupp, David J Argyle

“…We found that COX-2 inhibition had no effect on CSC growth, or resistance to chemotherapy. …”
Get full text

Development and characterization of synthetic glucopyranosyl lipid adjuvant system as a vaccine adjuvant. by Rhea N Coler, Sylvie Bertholet, Magdalini Moutaftsi, Jeff A Guderian, Hillarie Plessner Windish, Susan L Baldwin, Elsa M Laughlin, Malcolm S Duthie, Christopher B Fox, Darrick Carter, Martin Friede, Thomas S Vedvick, Steven G Reed

“…We report here on the characterization of a synthetic hexaacylated lipid A derivative, denoted as glucopyranosyl lipid adjuvant (GLA). We assessed the effects of GLA on murine and human dendritic cells (DC) by combining microarray, mRNA and protein multiplex assays and flow cytometry analyses. …”
Get full text

High prevalence of multidrug-tolerant bacteria and associated antimicrobial resistance genes isolated from ornamental fish and their carriage water. by David W Verner-Jeffreys, Timothy J Welch, Tamar Schwarz, Michelle J Pond, Martin J Woodward, Sarah J Haig, Georgina S E Rimmer, Edward Roberts, Victoria Morrison, Craig Baker-Austin

“…<h4>Methodology/principal findings</h4>To assess the potential effects of this sustained selection pressure, 127 Aeromonas spp. isolated from warm and cold water ornamental fish species were screened for tolerance to 34 antimicrobials. …”
Get full text

A plant diterpene counteracts juvenile hormone-mediated gene regulation during Drosophila melanogaster larval development. by Sang Woon Shin, Jun Hyoung Jeon, Seon Ah Jeong, Ji-Ae Kim, Doo-Sang Park, Yunhee Shin, Hyun-Woo Oh

“…Gene ontology analysis also suggested that some of the genes activated-by-JHA/repressed-by-JHD play roles in spermatogenesis. Affymetrix microarray-based analysis indicated that the expression of genes activated-by-JHA/repressed-by-JHD was testis-specific. …”
Get full text

Diagnosis of Coronary Heart Diseases Using Gene Expression Profiling; Stable Coronary Artery Disease, Cardiac Ischemia with and without Myocardial Necrosis. by Nabila Kazmi, Tom R Gaunt

“…Interestingly it also showed efficacy in discriminating myocardial infarction patients from patients with clinical symptoms of cardiac ischemia but no myocardial necrosis or stable coronary artery disease, despite the influence of batch effects and different microarray gene chips and platforms.…”
Get full text

Investigation of griffithsin's interactions with human cells confirms its outstanding safety and efficacy profile as a microbicide candidate. by Joseph Calvin Kouokam, Dana Huskens, Dominique Schols, Andrew Johannemann, Shonna K Riedell, Wendye Walter, Janice M Walker, Nobuyuki Matoba, Barry R O'Keefe, Kenneth E Palmer

“…In addition, GRFT appears to retain antiviral activity once bound to the surface of PBMC. Finally, RNA microarray studies show that, while CV-N and ConA regulate expression of a multitude of cellular genes, GRFT treatment effects only minimal alterations in the gene expression profile of a human ectocervical cell line. …”
Get full text

Evaluating IL22RA1 expression as a predictive indicator in human colon cancer progression by Xuan Yin, Renhao Geng, Junjun Chen, Bin Xu, Hui Ma, Yingting Liu, Xiao Zheng, Lujun Chen

“…Methods In this study, we utilized a multi-color immunohistochemistry (mIHC) assay to examine the expression patterns of IL22RA1, IL22, CD155, and IL22BP in a tissue microarray (TMA) comprising 90 colon cancer samples. …”
Get full text

Immunopeptidomics identified antigens for mRNA-lipid nanoparticle vaccines with alpha-galactosylceramide in multiple myeloma therapy by Eline Menu, Lorenzo Franceschini, Karin Vanderkerken, Elke De Bruyne, Karine Breckpot, Kim De Veirman, Arne Van der Vreken, Fabien Thery, Chenggong Tu, Kevin Mwangi, Sofie Meulewaeter, Lien De Beck, Edith Janssens, Francis Impens, Rein Verbeke, Ine Lentacker

“…To our knowledge, immunization with messenger RNA (mRNA) and the iNKT agonist, α-galactosylceramide (αGC), has not been studied in MM, as knowledge on clinically relevant antigens in preclinical MM models is lacking.Methods Microarray data and immunopeptidomics (imPep) were used to identify candidate antigens for immunization in 5TMM models. …”
Get full text