Metastatic melanoma: An integrated analysis to identify critical regulators associated with prognosis, pathogenesis and targeted therapies. by Zeinab Chaharlashkar, Yousof Saeedi Honar, Meghdad Abdollahpour-Alitappeh, Sepideh Parvizpour, Abolfazl Barzegar, Effat Alizadeh

“…Subsequently, the hub genes were selected using GEPIA. Survival analysis was performed using the TCGA. …”
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MicroRNA controlled adenovirus mediates anti-cancer efficacy without affecting endogenous microRNA activity. by Ryan Cawood, Suet-Ling Wong, Ying Di, Dilair F Baban, Leonard W Seymour

“…These were then filtered to select mRNAs that were only altered by Ad5mir122 and the remaining 21 mRNAs were compared to predicted mir122 targets. …”
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Prolonged application of high fluid shear to chondrocytes recapitulates gene expression profiles associated with osteoarthritis. by Fei Zhu, Pu Wang, Norman H Lee, Mary B Goldring, Konstantinos Konstantopoulos

“…Confirmation of the expression patterns of select genes was obtained by qRT-PCR. Using significance analysis of microarrays with a 5% false discovery rate, 71 and 60 non-redundant transcripts were identified to be ≥2-fold up-regulated and ≤0.6-fold down-regulated, respectively, in sheared chondrocytes. …”
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Early Regulation of Profibrotic Genes in Primary Human Cardiac Myocytes by Trypanosoma cruzi. by Aniekanabassi N Udoko, Candice A Johnson, Andrey Dykan, Girish Rachakonda, Fernando Villalta, Sammed N Mandape, Maria F Lima, Siddharth Pratap, Pius N Nde

“…The transcriptome microarray data, validated by quantitative Real-Time PCR, was also confirmed by immunoblotting and customized Enzyme Linked Immunosorbent Assays (ELISA) array showing significant increases in the protein expression levels of fibrogenic EGR1, SNAI1 and IL 6. …”
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miR-4780 Derived from N2-Like Neutrophil Exosome Aggravates Epithelial-Mesenchymal Transition and Angiogenesis in Colorectal Cancer by Liang Wang, Yuqiang Shan, Sixin Zheng, Jiangtao Li, Peng Cui

“…Differentially expressed miRNA in neutrophil exosomes have been sequenced by microarray profile, and the effect of N2-like neutrophil-derived exosomal miR-4780 on epithelial-mesenchymal transition (EMT) and angiogenesis was investigated. …”
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Stroma regulates increased epithelial lateral cell adhesion in 3D culture: a role for actin/cadherin dynamics. by Karen F Chambers, Joanna F Pearson, Naveed Aziz, Peter O'Toole, David Garrod, Shona H Lang

“…The upregulated growth factors TGFβ2, CXCL12 and FGF10 were selected for further analysis because of previous associations with morphology. …”
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HSPA6 augments garlic extract-induced inhibition of proliferation, migration, and invasion of bladder cancer EJ cells; Implication for cell cycle dysregulation, signaling pathway a... by Seung-Shick Shin, Jun-Hui Song, Byungdoo Hwang, Dae-Hwa Noh, Sung Lyea Park, Won Tae Kim, Sung-Soo Park, Wun-Jae Kim, Sung-Kwon Moon

“…In addition, GE impeded the migration and invasion of EJ cells via inhibition of MMP-9 expression followed by decreased binding activities of AP-1, Sp-1, and NF-κB motifs. Based on microarray datasets, we selected Heat shock protein A6 (HSPA6) as the most up-regulated gene responsible for the inhibitory effects of GE. …”
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Identification of novel androgen-regulated pathways and mRNA isoforms through genome-wide exon-specific profiling of the LNCaP transcriptome. by Prabhakar Rajan, Caroline Dalgliesh, Phillippa J Carling, Thomas Buist, Chaolin Zhang, Sushma N Grellscheid, Kelly Armstrong, Jacqueline Stockley, Cedric Simillion, Luke Gaughan, Gabriela Kalna, Michael Q Zhang, Craig N Robson, Hing Y Leung, David J Elliott

“…Androgens drive the onset and progression of prostate cancer (PCa) by modulating androgen receptor (AR) transcriptional activity. Although several microarray-based studies have identified androgen-regulated genes, here we identify in-parallel global androgen-dependent changes in both gene and alternative mRNA isoform expression by exon-level analyses of the LNCaP transcriptome. …”
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Fetal medicine and current practice of prenatal screening by Akshatha Prabhu

“…The fetal sample is used for various genetic tests, such as chromosome microarray analysis (CMA), targeted clinical exome sequencing (CES), or whole exome sequencing (WES) depending upon the abnormality noted or the suspected genetic condition. …”
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Exploring the predictive values of SERP4 and FRZB in dilated cardiomyopathy based on an integrated analysis by Bin Qi, Hai-Yan Wang, Xiao Ma, Yu-Feng Chi, Chun Gui

“…Methods Five DCM-related microarray datasets were downloaded from the Gene Expression Omnibus (GEO). …”
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Antibiotic resistance in agroecosystem: Progress and challenges by ZHANG Yusen, YE Jun, SU Jianqiang

“…Both culture-dependent and culture-independent technologies, including metagenomic, microarray and high-throughput quantitative polymerase chain reaction have been utilized in the characterization of ARGs in agroecosystem, and each has its strength and weakness. …”
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Dual-targeting and steric hindrance resolution in HER2 IHC: a novel approach to improve diagnostic sensitivity by Li Luo, Xi Zhang, Linqiong Chen, Zhuohan Chen, Yuchen Wang, Kaihao Huang, Xiaoyun Lin, Hongxiang Zhu, Wangqi Du

“…We assessed the detection performance of Nby-Aby in BC tissues and compared it with conventional HER2 diagnostic antibodies using tissue microarrays (TMAs). …”
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Identification of Novel Biomarkers in Huntington’s Disease Based on Differential Gene Expression Meta-Analysis and Machine Learning Approach by Nayan Dash, Md Abul Bashar, Jeonghan Lee, Raju Dash

“…Therefore, to discover the key biomarkers associated with the progression of HD, we employed bioinformatics and machine learning (ML) to create a robust pipeline that integrated differentially expressed gene (DEG) analysis with ML to select potential biomarkers. We performed a meta-analysis to identify DEGs using three Gene Expression Omnibus (GEO) microarray datasets from different platforms related to HD-affected brain tissue, applying both relaxed and strict criteria to identify differentially expressed genes. …”
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Distinctive profile of IsomiR expression and novel microRNAs in rat heart left ventricle. by Mary K McGahon, Janet M Yarham, Aideen Daly, Jasenka Guduric-Fuchs, Lyndsey J Ferguson, David A Simpson, Anthony Collins

“…The expression of known miRNAs in the heart has been studied at length by microarray and quantitative PCR but it is becoming evident that microRNA isoforms (isomiRs) are potentially physiologically important. …”
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Circulating exosomal microRNAs as biomarkers of colon cancer. by Hiroko Ogata-Kawata, Masashi Izumiya, Daisuke Kurioka, Yoshitaka Honma, Yasuhide Yamada, Koh Furuta, Toshiaki Gunji, Hideki Ohta, Hiroyuki Okamoto, Hikaru Sonoda, Masatoshi Watanabe, Hitoshi Nakagama, Jun Yokota, Takashi Kohno, Naoto Tsuchiya

“…<h4>Experimental design</h4>Microarray analyses of miRNAs in exosome-enriched fractions of serum samples from 88 primary CRC patients and 11 healthy controls were performed. …”
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Omics Multi-Layers Networks Provide Novel Mechanistic and Functional Insights Into Fat Storage and Lipid Metabolism in Poultry by Farzad Ghafouri, Abolfazl Bahrami, Abolfazl Bahrami, Mostafa Sadeghi, Seyed Reza Miraei-Ashtiani, Maryam Bakherad, Herman W. Barkema, Samantha Larose

“…In the analysis of microarray and RNA-Seq data, 1,835 genes were detected by comparing the identified genes with significant expression differences (p.adjust &lt; 0.01, fold change ≥ 2 and ≤ −2). …”
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Alternative splicing of TCF7L2 gene in omental and subcutaneous adipose tissue and risk of type 2 diabetes. by Ludmila Prokunina-Olsson, Lee M Kaplan, Eric E Schadt, Francis S Collins

“…A pathway enrichment analysis on transcripts significantly co-expressed with TCF7L2 in a microarray set combined with individual expression assays, suggested tissue-specific roles of TCF7L2 splicing forms in regulation of transcription, signal transduction and cell adhesion.…”
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Integrated bioinformatic analysis of the shared molecular mechanisms between ANCA-associated vasculitis and atherosclerosis by Xun Hu, Inmaculada Xu Lou, Qilan Chen

“…This study aims to explore the mechanisms underlying the concurrent occurrence of ANCA and AS. Methods Microarray data of AAV and AS were examined in a comprehensive gene expression database. …”
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Comparison of monocyte gene expression among patients with neurocysticercosis-associated epilepsy, Idiopathic Epilepsy and idiopathic headaches in India. by Vasudevan Prabhakaran, Douglas A Drevets, Govindan Ramajayam, Josephine J Manoj, Michael P Anderson, Jay S Hanas, Vedantam Rajshekhar, Anna Oommen, Hélène Carabin

“…Fifteen genes up-regulated in NCC patients compared with other groups were selected based on possible relevance to NCC, and analyzed by qPCR in all patients' samples. …”
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Long-Term Oocyte-Like Cell Development in Cultures Derived from Neonatal Marmoset Monkey Ovary by Bentolhoda Fereydouni, Gabriela Salinas-Riester, Michael Heistermann, Ralf Dressel, Lucia Lewerich, Charis Drummer, Rüdiger Behr

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