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Genetic feature selection algorithm as an efficient glioma grade classifier
Published 2025-05-01“…Genetic testing is a rapidly evolving modality for cancer management. The advent of DNA microarrays enabled the utility of computational analyses in such management on a molecular basis. …”
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Identification of potential biomarkers and pathways related to major depressive disorder by integrated bioinformatic analysis and experimental validation
Published 2025-05-01“…Objective: To identify promising biomarkers for the pathogenesis of major depressive disorder (MDD). Methods: Microarray chips of MDD patients, including the GSE98793, GSE52790, and GSE39653 datasets, were obtained from the Gene Expression Omnibus database. …”
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CFS-MOES Ensemble Model on Metaheuristic Search-Based Feature Selection
Published 2024-01-01“…The application of several classification and feature selection methods on microarray gene expression datasets helps learn models that are able to predict a given disease. …”
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Expression of long non-coding RNA in patients with non-IgA mesangial proliferative glomerulonephritis
Published 2015-01-01“…Objective To study differential expression profile of mRNA and long non-coding RNA(IncRNA) through microarray analysis between non-IgA mesangial proliferative glomerulonephritis(MsPGN) patients and the controls,and then explore the potential role of IncRNA in the pathogenesis of non-IgA MsPGN.Methods Through simple random sampling,4 patients with non-IgA MsPGN and 2 controls were selected as disease group and control group,respectively.Renal cortical tissues from two groups were collected.Total RNA was extracted,quantified and prepared to ds-cDNA through reverse transcription ds-cDNA was labeled with NimbleGen one-color DNA labeling kit and used for array hybridization.All experimental data were processed through GO analysis,Pathway analysis and the gene loci correlation analysis of mRNA and IncRNA.Some IncRNAs that were closely related to non-IgA MsPGN were screened out.Finally,part of the array results was detected by PCR to verify the reliability of array test Results By fold change filtering,4317 differentially expressed mRNAs and 3502 differentially expressed IncRNAs were screened out.Five IncRNAs were found to play potential roles in the pathogenesis of non-IgA MsPGN:AF1180924(close to coding gene FGG),AK092233(close to coding gene COL18A1),AK130579(close to coding gene CREBBP),AK023598(close to coding gene LEPR),and AK055915(close to coding gene CDC42EP3).These results provided an important basis for revealing the pathogenesis of non-IgA MsPGN.Conclusions Some IncRNAs can potentially regulate related genes and plays an important role in the pathogenesis and development of non-IgA MsPGN.…”
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Assessment of the carcinogenic potential of particulate matter generated from 3D printing devices in Balb/c 3T3-1-1 cells
Published 2024-10-01“…Various assays, such as the comet assay, cell transformation assays, microarray analysis, and glucose consumption measurement, were employed. …”
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A Highly Discriminative Hybrid Feature Selection Algorithm for Cancer Diagnosis
Published 2022-01-01“…To examine the proposed algorithm, many tests have been carried out on four cancerous microarray datasets, employing in the process 10-fold cross-validation and hyperparameter tuning. …”
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127
RETRACTED ARTICLE: Multi-stage biomedical feature selection extraction algorithm for cancer detection
Published 2023-04-01“…Early cancer detection is greatly aided by machine learning and artificial intelligence (AI) to gene microarray data sets (microarray data). Despite this, there is a significant discrepancy between the number of gene features in the microarray data set and the number of samples. …”
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128
The Gene Expression Profile of Milk Somatic Cells of Small Ruminant Lentivirus-Seropositive and -Seronegative Dairy Goats (<i>Capra hircus</i>) During Their First Lactation
Published 2025-07-01“…Statistical analysis was performed in GeneSpring 12 software. Results: Microarrays showed reduced expression of <i>DUSP26</i>, <i>PRLR</i>, <i>SCARA3</i>, <i>APBB2</i>, and <i>OR4F4</i> genes in SRLV-SP goats. …”
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A decade of change – lessons learned from prenatal diagnostics in Central Denmark region in 2008–2018
Published 2023-11-01“…This retrospective study summarizes 11 years of using chromosomal microarray in invasive prenatal testing and presents the effect on diagnostic yield and turnaround time. …”
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131
Genetic etiology and pregnancy outcomes of fetal hyperechoic kidneys: a retrospective analysis
Published 2025-08-01“…Chromosome karyotyping and chromosomal microarray analysis (CMA) were performed on fetuses displaying this phenotype on prenatal ultrasound. …”
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132
A Comparative Analysis of Swarm Intelligence Techniques for Feature Selection in Cancer Classification
Published 2014-01-01“…Feature selection in cancer classification is a central area of research in the field of bioinformatics and used to select the informative genes from thousands of genes of the microarray. …”
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133
Mathematical modelling and deep learning algorithms to automate assessment of single and digitally multiplexed immunohistochemical stains in tumoural stroma
Published 2024-12-01“…This study aimed to develop a robust method to automate stromal stain analyses using 2 of the commonest stromal stains (SMA and desmin) employed in clinical pathology practice as examples. An effective computational method capable of automatically assessing and quantifying tumour-associated stromal stains was developed and applied on cores of colorectal cancer tissue microarrays. …”
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An efficient leukemia prediction method using machine learning and deep learning with selected features.
Published 2025-01-01“…The suggested work predicts and classifies leukemia subtypes in gene data CuMiDa (GSE9476) using feature selection and ML techniques. The Curated Microarray Database (CuMiDa) collected 64 samples representing five classes of leukemia genes out of 22283 genes. …”
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136
Cost-effective solutions for high-throughput enzymatic DNA methylation sequencing.
Published 2025-05-01“…While costs are decreasing, whole-genome DNA methylation profiling remains prohibitively expensive for most population-scale studies, creating a need for cost-effective, reduced representation approaches (i.e., assays that rely on microarrays, enzyme digests, or sequence capture to target a subset of the genome). …”
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A Novel Feature Selection Method for Classification of Medical Data Using Filters, Wrappers, and Embedded Approaches
Published 2022-01-01“…For this purpose, the proposed research focused on analyzing and identifying effective feature selection algorithms. A novel framework is proposed which utilizes different feature selection methods from filters, wrappers, and embedded algorithms. …”
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Enhanced leukemia prediction using hybrid ant colony and ant lion optimization for gene selection and classification
Published 2025-06-01“…Gene selection plays a crucial role in the pre-processing of microarray data, aiming to identify a small set of genes that enhances classification accuracy and reduces costs. …”
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Drug and cell type-specific regulation of genes with different classes of estrogen receptor beta-selective agonists.
Published 2009-07-01“…U2OS cells stably transfected with ERalpha or ERbeta were treated with E(2) or the ERbeta-selective compounds for 6 h. Microarray data demonstrated that ERB-041, MF101 and liquiritigenin were the most ERbeta-selective agonists compared to estradiol, followed by nyasol and then diarylpropionitrile. …”
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Enucleation-Induced Rat Adrenal Gland Regeneration: Expression Profile of Selected Genes Involved in Control of Adrenocortical Cell Proliferation
Published 2014-01-01“…Factors encoded by these genes obscure possible priming effects of various cytokines on initiation of regeneration. …”
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