IL1RAP Expression in Human Atherosclerosis: A Target of Novel Antibodies to Reduce Vascular Inflammation and Adhesion by Madelene Lindkvist, Anna Göthlin Eremo, Geena Varghese Paramel, Sheikh Anisul Haque, Camilla Rydberg Millrud, Sara Rattik, Caitríona Grönberg, David Liberg, Allan Sirsjö, Karin Fransén

“…Background Blockade of IL1RAP (interleukin 1 receptor associated protein) was recently shown to reduce atherosclerosis in mice, but the effect on human vascular cells is largely unknown. …”
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Ischemic Preconditioning Confers Epigenetic Repression of Mtor and Induction of Autophagy Through G9a‐Dependent H3K9 Dimethylation by Olof Gidlöf, Andrea L. Johnstone, Kerstin Bader, Bohdan B. Khomtchouk, Jiaqi J. O'Reilly, Selvi Celik, Derek J. Van Booven, Claes Wahlestedt, Bernhard Metzler, David Erlinge

“…The aim of this study was to investigate the effect of histone methylation in the response to cardiac ischemic preconditioning. …”
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Oncolytic peptide LTX-315 induces anti-pancreatic cancer immunity by targeting the ATP11B-PD-L1 axis by Meng Wang, Xing Huang, Tingbo Liang, Tianyu Tang, Gang Zhang, Minghao Lu, Zhengtao Hong, Junming Huang, Xiao Zhi

“…The expression of programmed cell death ligand 1 (PD-L1) largely determines the efficacy and effectiveness of cancer immunotherapies targeting this specific immune checkpoint. …”
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Exploring the Causal Association Between 91 Circulating Inflammatory Proteins and Neurodegenerative Diseases: A Bidirectional Two‐Sample Mendelian Randomization and Bioinformatics... by Ziwei Gong, Rong Cao, Hong Zhu

“…In MS peripheral blood microarray data, CD40 is significantly downregulated in RRMS. …”
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GTSE1, CDC20, PCNA, and MCM6 Synergistically Affect Regulations in Cell Cycle and Indicate Poor Prognosis in Liver Cancer by Yongchang Zheng, Yue Shi, Si Yu, Yuanyuan Han, Kai Kang, Haifeng Xu, Huajian Gu, Xinting Sang, Yang Chen, Jingyu Wang

“…To investigate underlying molecular mechanism, we generated GTSE1 knockdown HCC cell line and explored the effects of GTSE1 deficiency in cell growth. Between GTSE1 knockdown and wild-type HCC cells, we identified 979 differentially expressed genes (520 downregulated and 459 upregulated genes) in the analysis of microarray-based gene expression profiling. …”
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Immunohistochemistry‐based molecular subtypes of urothelial carcinoma derive different survival benefit from platinum chemotherapy by Csilla Olah, Oleksandr Shmorhun, Gilbert Georg Klamminger, Josefine Rawitzer, Lara Sichward, Boris Hadaschik, Mulham Al‐Nader, Ulrich Krafft, Christian Niedworok, Melinda Váradi, Peter Nyirady, Andras Kiss, Eszter Szekely, Henning Reis, Tibor Szarvas

“…However, high tumor heterogeneity between the primary tumor and metastatic sites can impact the effectiveness of therapies.…”
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MicroRNA-26b inhibits cardiac remodeling after myocardial infarction by targeting ring finger protein 6 expression by Chun-Mei Tang, Qiang Su, Hai-Xia Zhao, He-Huan Sui, Jing Liang, Li-Sha Zhu, Si-Yun Yang, Tao Liu

“…Material and methods An MI rat model was established by left coronary artery ligation. Microarray data were analyzed to distinguish differentially expressed genes in MI. miR-26b was found to be poorly expressed, whereas ring finger protein 6 (RNF6) was highly expressed in MI. …”
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Assessment of NUDT5 in Endometrial Carcinoma: Functional Insights, Prognostic and Therapeutic Implications by Hongfei Yu, Lingling Zu, Yuqin Zang, Fei Teng, Tao Wang, Ming Wu, Yingmei Wang, Fengxia Xue

“…<b>Methods</b>: This study analyzed gene expression data from The Cancer Genome Atlas and performed tissue microarray validation to assess <i>NUDT5</i> expression in EC samples. …”
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Targeting FGFR4 abrogates HNF1A-driven metastasis in pancreatic ductal adenocarcinoma by Katherine J. Crawford, Kennedy S. Humphrey, Eduardo Cortes, Jianxin Wang, Vishnu Kumarasamy, Yin Wan, Mark D. Long, Michael E. Feigin, Agnieszka K. Witkiewicz, Karen M. Mann, Erik S. Knudsen, Ethan V. Abel

“…Single-cell RNA sequencing (scRNA-seq), tissue microarray (TMA) data, and UMAP spatial profiling were used to identify FGFR4 as an HNF1A target gene upregulated in metastatic cells. …”
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Highly proliferating cancer cells function as novel prognostic biomarkers for lung adenocarcinoma with particular usefulness for stage IA risk stratification by Yanlu Xiong, Yongfu Ma, Jie Lei, Jianfei Zhu, Nianlin Xie, Feng Tian, Qiang Lu, Miaomiao Wen, Qian Zheng, Yong Han, Tao Jiang, Yang Liu

“…Next, we analysed the OS predictive effect of HPCs at different LUAD stages, especially for stage I risk stratification. …”
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miR-21-5p Enriched Exosomes from Human Embryonic Stem Cells Promote Osteogenesis via YAP1 Modulation by Huang X, Zhao Z, Zhan W, Deng M, Wu X, Chen Z, Xie J, Ye W, Zhao M, Chu J

“…Xinqia Huang,1,&ast; Ziquan Zhao,1,&ast; Weiqiang Zhan,1 Mingzhu Deng,1 Xuyang Wu,1 Zhoutao Chen,1 Jiahao Xie,2 Wei Ye,3 Mingyan Zhao,1,4 Jiaqi Chu3,4 1Orthopaedic Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524001, People’s Republic of China; 2Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524001, People’s Republic of China; 3Department of Obstetrics and Gynecology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524001, People’s Republic of China; 4Stem Cell Research and Cellular Therapy Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524001, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jiaqi Chu; Mingyan Zhao, Affiliated Hospital of Guangdong Medical University, No. 57 Renmin Avenue South Road, Zhanjiang, Guangdong, 524001, People’s Republic of China, Email chujiaqi@gdmu.edu.cn; mingyan.zhao@gdmu.edu.cnPurpose: To investigate the osteogenic potential of human embryonic stem cell-derived exosomes (hESC-Exos) and their effects on the differentiation of human umbilical cord mesenchymal stem cells (hUCMSCs).Methods: hESC-Exos were isolated and characterized using transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), and Western blotting. hUCMSCs were cultured with hESC-Exos to assess osteogenic differentiation through alizarin red staining, quantitative PCR (qPCR), and Western blotting. miRNA profiling of hESC-Exos was performed using miRNA microarray analysis. …”
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Spatially resolved analysis of TGF/BMP signalling in pancreatic ductal adenocarcinoma by digital pathology identifies patient subgroups with adverse outcome by Konstantin Bräutigam, Philipp Zens, Stefan Reinhard, Jessica L. Rohrbach, Simon J. Leedham, Anna S. Wenning, Beat Gloor, Viktor H. Koelzer, Martin Wartenberg

“…Methods We performed a spatially resolved analysis of PDAC on a multi-region tissue microarray cohort of 117 curatively resected PDAC specimens consisting of tumour centre (TC), tumour front (TF), and stromal(-predominant) tissue cores each. …”
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Expression, clinical significance and biological function of CDC7 in osteosarcoma by CHEN Peijun, MAN Yunan, HE Mingwei, LIANG Bumin, HE Maolin

“…Methods The mRNA microarray data from the Gene Expression Omnibus (GEO) database was used to analyze the expression of CDC7 in OS tissues. …”
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Hypoxia‐induced PGK1 expression promotes esophageal squamous cell carcinoma progression via stimulating MYH9‐mediated GSK3β/β‐catenin signalling by Jia‐cheng Xu, Lin‐feng Wu, Tian‐yin Chen, Yan‐bo Liu, Yi‐fei Zhang, Ping‐hong Zhou, Yi‐qun Zhang

“…Methods Esophageal cancer bioinformatics analysis and tissue microarray analysis were employed to elucidate the aberrant expression of PGK1 during ESCC progression. …”
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IL-6-induced long noncoding RNA MIR3142HG promotes tumorigenesis by interacting with thioredoxin-1 and STAT3 in human colorectal cancer by Daoquan Fang, Qian Feng, Baojian Zhou, Yangyang Liu, Yichu Lian, Yihui Zhang, Dichen Yang, Xintong Liu, Xiaomeng Shi, Wuhua Ni, Lei Jiang

“…Bioinformatics analysis and tissue microarray were utilized for evaluating the clinical value of MIR3142HG in CRC. …”
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TCL1A in naïve B cells as a therapeutic target for type 1 diabetesResearch in context by Siweier Luo, Lina Zhang, Chunfang Wei, Chipeng Guo, Zhe Meng, Honghui Zeng, Lele Hou, Le Wang, Zulin Liu, Yufei Du, Shiyu Tan, Yating Zhang, Xiaoding Xu, Liyang Liang, Yiming Zhou

“…Using a protein phosphorylation microarray, we confirmed that TCL1A knockdown specifically impaired AKT2 phosphorylation and affected B cell survival and proliferation. …”
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Clinical significance and gene prediction of a novel classification system based on tacrolimus concentration-to-dose ratio in the early post-liver transplant period by Junwei Fan, Junwei Fan, Peihao Wen, Liyun Yuan, Yan Xia, Shijie Hu, Xiaoqing Zhang, Zhihai Peng, Zhihai Peng

“…All recipients and their corresponding donor livers from center 1 were genotyped using an Affymetrix DMET Plus microarray, and association analysis was performed using trough blood concentration/weight-adjusted-dose ratios (CDR, (ng/mL)/(mg/kg)). …”
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Modulation of homologous recombination gene activity in breast tumor cells in an <i>in vitro</i> model by M. M. Tsyganov, A. A. Frolova, E. A. Kravtsova, I. A. Tsydenova, M. K. Ibragimova

“…To assess the presence of chromosomal aberrations, microarray analysis was performed on DNA chips.Results. …”
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Patient and provider preferences for long-acting TB preventive therapy by M. Vermeulen, K.K. Scarsi, R. Furl, H. Sayles, M.J. Anderson, S. Valawalkar, A. Kadam, S.R. Cox, V. Mave, M. Barthwal, C. Schutz, A. Ward, J. Dountio Ofimboudem, G. Meintjes, S. Rannard, A. Owen, S. Swindells, on behalf of the LONGEVITY consortium

“…CONCLUSION: Injectable LA-TPT may be highly acceptable and feasible if concerns surrounding cost, effectiveness, and safety are addressed.…”
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Vitamin C Treatment Rescues Prelamin A-Induced Premature Senescence of Subchondral Bone Mesenchymal Stem Cells by Yan-Nv Qu, Li Zhang, Ting Wang, He-Yang Zhang, Ze-Ji Yang, Fang-Fang Yuan, Yan Wang, Si-Wei Li, Xiao-Xia Jiang, Xiao-Hua Xie

“…Importantly, after VC treatment, MSC/PLA showed enhanced therapy effect in the hind-limb ischemia model. In conclusion, prelamin A can accelerate SCB-MSC premature senescence by inducing DNA damage. …”
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