Cavin-3 knockout mice show that cavin-3 is not essential for caveolae formation, for maintenance of body composition, or for glucose tolerance. by Libin Liu, Carsten G Hansen, Brian J Honeyman, Benjamin J Nichols, Paul F Pilch

“…We find that loss of cavin-3 has minimal or no effects on the levels of other caveolar proteins, does not appear to play a major role in formation of protein complexes important for caveolar morphogenesis, and has no significant effect on caveolae abundance. …”
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Identification of Stk25 as a genetic modifier of Tau phosphorylation in Dab1-mutant mice. by Tohru Matsuki, Mariam Zaka, Rita Guerreiro, Marcel P van der Brug, Jonathan A Cooper, Mark R Cookson, John A Hardy, Brian W Howell

“…Genomic regions that regulate the phospho Tau phenotype in dab1 mutants have previously been identified. Using a microarray gene expression comparison between dab1-mutants from the high-phospho Tau expressing and low-phospho Tau expressing strains, we identified Stk25 as a differentially expressed modifier of dab1-mutant phenotypes. …”
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Insights into the involvement of noncoding RNAs in 5-fluorouracil drug resistance by Jun Deng, Yi Wang, Jun Lei, Wan Lei, Jian Ping Xiong

“…In this review, we discuss the effects of microRNAs on 5-fluorouracil sensitivity via targeting of metabolic enzymes, the cell cycle, apoptosis, autophagy, the epithelial–mesenchymal transition, and cancer stem cells. …”
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Genomic Profiling of a Human Leukemic Monocytic Cell-Line (THP-1) Exposed to Alpha Particle Radiation by Vinita Chauhan, Matthew Howland

“…Twenty-four hours and three days after exposure gene expression was monitored using microarray technology. A total of 16 genes were dose responsive and classified as early onset due to their expression 24 h after exposure. …”
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Advances in Research on Isothermal Signal Amplification Mediated MicroRNA Detection of Clinical Samples: Application to Disease Diagnosis by Yu Han, Xin Sun, Sheng Cai

“…However, the intrinsic characteristics of miRNAs, including their low abundance, short sequence lengths, and high family-specific sequence homology, render traditional detection methods such as Northern blot hybridization, microarray use, and reverse transcription quantitative PCR (RT-qPCR) inadequate for meeting the stringent requirements of clinical detection in biological samples, a task requiring accuracy, rapidity, high detection power, specificity, and cost-effectiveness. …”
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Dissociation of mitochondrial and ribosomal biogenesis during thallium administration in rat kidney. by Sho Sugahara, Kana Unuma, Shuheng Wen, Takeshi Funakoshi, Toshihiko Aki, Koichi Uemura

“…To obtain insight into Tl toxicity in the kidney, rats were intraperitoneally administered Tl2SO4 (30 mg/kg), and the kidneys were removed 2 or 5 days later to examine the effects of Tl. Transcriptome analysis using DNA microarray of the rat kidney 2 and 5 days after Tl administration showed that cytoplasmic ribosomal proteins are the most upregulated category; many of the genes involved in ribosome biosynthesis were upregulated by Tl administration. …”
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Impacts of Macronutrients on Gene Expression: Recent Evidence to Understand Productive and Reproductive Performance of Livestock by Md. Mahmodul Hasan Sohel, Yusuf Konca, Mehmet Ulas Cinar

“…In order to identify the effects of nutrients on gene expression and to assess the interactions between genes and nutrition by means of various cutting-edge technologies, the interdisciplinary branch ‘Nutrigenomics’ was created. …”
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Non-replicating Mycobacterium tuberculosis elicits a reduced infectivity profile with corresponding modifications to the cell wall and extracellular matrix. by Joanna Bacon, Luke J Alderwick, Jon A Allnutt, Evelina Gabasova, Robert Watson, Kim A Hatch, Simon O Clark, Rose E Jeeves, Alice Marriott, Emma Rayner, Howard Tolley, Geoff Pearson, Graham Hall, Gurdyal S Besra, Lorenz Wernisch, Ann Williams, Philip D Marsh

“…Therefore, the focus of this study was to emulate environmental conditions encountered by M. tuberculosis in the granuloma, and determine the effect of such conditions on the physiology and infectivity of the organism. …”
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Neighbourhood continuity is not required for correct testis gene expression in Drosophila. by Lisa A Meadows, Yuk Sang Chan, John Roote, Steven Russell

“…We compare gene expression in individuals carrying inverted chromosomes with their non-inverted but otherwise identical progenitors using whole-transcriptome microarray analysis, validating these data with specific quantitative real-time PCR assays. …”
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Naloxonazine, an Amastigote-Specific Compound, Affects Leishmania Parasites through Modulation of Host-Encoded Functions. by Géraldine De Muylder, Benoit Vanhollebeke, Guy Caljon, Alan R Wolfe, James McKerrow, Jean-Claude Dujardin

“…We evaluated here whether this compound could present a host cell-dependent mechanism of action. Microarray profiling of THP-1 macrophages treated with naloxonazine showed upregulation of vATPases, which was further linked to an increased volume of intracellular acidic vacuoles. …”
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Gene Expression Changes Induced by PPAR Gamma Agonists in Animal and Human Liver by Alexandra Rogue, Catherine Spire, Manuel Brun, Nancy Claude, André Guillouzo

“…Although PPARγ is expressed at a much lower level in liver than in adipose tissue, PPARγ agonists exert various PPARγ-dependent effects in liver in addition to PPARγ-independent effects. …”
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The apoptotic and genomic studies on A549 cell line induced by silver nitrate by Ayse Kaplan, Gulsen Akalin Ciftci, Hatice Mehtap Kutlu

“…The influences of silver nitrate were studied via MTT assay, flow cytometry, immunocytochemical, confocal and transmission electron microscopy, and microarray assays. Silver nitrate showed inhibitory effects against A549 cells in a dose- and time-dependent manner for 24, 48, and 72 h and induced apoptosis. …”
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Pain-stimulated ultrasound vocalizations and their impact on pain response in mice. by Satoka Kasai, Saki Ukai, Junpei Kuroda, Tsugumi Yamauchi, Daisuke Yamada, Akiyoshi Saitoh, Satoshi Iriyama, Masashi Suzuki, Kazuki Arita, Yoshio Nakano, Satoru Miyazaki, Kazumi Yoshizawa

“…We also examined the effects of psychological stress caused by the ultrasound on an inflammatory pain model of mice. …”
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Differential and directional estrogenic signaling pathways induced by enterolignans and their precursors. by Yun Zhu, Kayoko Kawaguchi, Ryoiti Kiyama

“…All the enterolignans/precursors examined showed activation of the Erk1/2 and PI3K/Akt pathways, indicating the involvement of rapid signaling through the non-genomic estrogen signaling pathway. However, when their effects on specific cell functions, cell cycle progression and chemokine (MCP-1) secretion were examined, positive effects were observed only for enterolactone, suggesting that signals are given in certain directions at a position closer to cell functions. …”
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Comparative linkage meta-analysis reveals regionally-distinct, disparate genetic architectures: application to bipolar disorder and schizophrenia. by Brady Tang, Tricia Thornton-Wells, Kathleen D Askland

“…Since it is likely a majority of common variants of modest effect have been identified through the application of tagSNP-based microarray platforms (i.e., GWAS), alternative approaches robust to detection of low-frequency (1-5% MAF) and rare (<1%) variants are of great importance. …”
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Analysis of Gene Expression in Human Dermal Fibroblasts Treated with Senescence-Modulating COX Inhibitors by Jeong A. Han, Jong-Il Kim

“…To figure out causal factors for the senescence-modulating effect of the inhibitors, we here performed cDNA microarray experiment and subsequent Gene Set Enrichment Analysis. …”
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Genes that act downstream of sensory neurons to influence longevity, dauer formation, and pathogen responses in Caenorhabditis elegans. by Marta M Gaglia, Dae-Eun Jeong, Eun-A Ryu, Dongyeop Lee, Cynthia Kenyon, Seung-Jae Lee

“…However, the mechanisms underlying these effects are incompletely understood. Using whole-genome microarray analysis, we identified transcripts whose levels are altered by mutations in the intraflagellar transport protein daf-10, which result in impaired development and function of many sensory neurons in C. elegans. …”
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Constitutional Chromothripsis on Chromosome 2: A Rare Case with Severe Presentation by Afia Hasnain, Laura L. Thompson, Nicole L. Hoppman, Karine Hovanes, Jing Liu, Bita Hashemi

“…We concluded that the complexity of the genomic rearrangement and the combined dosage/structural effect of these copy number variants are likely explanations for the severe presentation in our patient.…”
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RRHGE: A Novel Approach to Classify the Estrogen Receptor Based Breast Cancer Subtypes by Ashish Saini, Jingyu Hou, Wanlei Zhou

“…We propose a novel method to measure and extract the reliable (biologically true or valid) interactions from gene interaction networks and incorporate the extracted reliable gene interactions into our proposed RRHGE algorithm to identify significant gene signatures from microarray gene expression data for classifying ER+ and ER− breast cancer samples. …”
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Integrated multiomics analysis identifies potential biomarkers and therapeutic targets for autophagy associated AKI to CKD transition by Yaojun Wang, Qiang Li

“…We performed weighted correlation network analysis (WGCNA) using two microarray datasets (GSE139061 and GSE66494) in the GEO database and identified autophagy signatures by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG), and GSEA enrichment analysis. …”
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