Bidirectional Transcriptome Analysis of Rat Bone Marrow-Derived Mesenchymal Stem Cells and Activated Microglia in an In Vitro Coculture System by Da Yeon Lee, Moon Suk Jin, Balachandran Manavalan, Hak Kyun Kim, Jun Hyeok Song, Tae Hwan Shin, Gwang Lee

“…Bone marrow-derived mesenchymal stem cells (BM-MSCs) have been shown to have therapeutic effects, resulting from the regulation of inflammatory conditions in the brain. …”
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The potential radiosensitization target PFKFB3 is related to response to radiotherapy in SweBCG91RT: a randomized clinical trial with long-term follow-up by Moa Egelberg, Tommaso De Marchi, Niklas Schultz, Lena Tran, Per Karlsson, Erik Holmberg, Gyula Pekar, Fredrika Killander, Emma Niméus

“…Methods Nuclear protein levels of PFKFB3 were assessed with immunohistochemistry in primary breast tumors (n = 970) and whole-cell RNA levels with microarray gene expression (n = 765). Multivariable competing risks regression analysis was employed for the effect of radiotherapy on incidence of ipsilateral breast tumor recurrence (IBTR), depending on PFKFB3 levels. …”
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Prevalence and Diversity of <i>Staphylococcus aureus</i> in Bulk Tank Milk from Community-Based Alpine Dairy Pastures in Tyrol, Austria by Nasrin Ramezanigardaloud, Igor Loncaric, Patrick Mikuni-Mester, Masoumeh Alinaghi, Monika Ehling-Schulz, Johannes Lorenz Khol, Tom Grunert

“…Other common bovine-associated subtypes were also detected, including CC97, CC151, and CC479. While antimicrobial resistance was rare, enterotoxin-producing genes were detected in all CC8bov-associated <i>spa</i> types. …”
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MiR-223-3p regulates erythropoiesis by targeting TGFBR3/Smad signaling pathway in hemoglobin H-Constant Spring disease by Lan Lan, Xinyu Wang, Simeng Zhang, Dan Zeng, Limin Mo, Qiao Feng, Jun Li, Chunjiang Zhu

“…The present study analyzed miRNAs differential expression profile between patients with HbH-CS disease and healthy subjects by Arraystar Human small RNA Microarray.Methods The differential expression profiles of miRNAs between HbH-CS patients and healthy individuals were analyzed using Arraystar human small RNA microarrays. …”
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Identification of GBP6 as a potential prognostic biomarker in esophageal carcinoma by integrated bioinformatics analysis and experiment validation by Shilin Fang, Yang Ding, Yifan Jia, Liping Gao, Yumei Ning, Guifang Wu, Jun Fang, Yongxi Zhang, Haizhou Wang, Hengning Ke

“…Immunohistochemistry was used to validate the results in an ESCA tissue microarray. The proliferative activity of ESCA cells was evaluated using cell counting kit 8 assay. …”
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Patterns of Human Respiratory Viruses and Lack of MERS-Coronavirus in Patients with Acute Upper Respiratory Tract Infections in Southwestern Province of Saudi Arabia by Ahmed A. Abdulhaq, Vinod Kumar Basode, Anwar M. Hashem, Ahmed S. Alshrari, Nassrin A. Badroon, Ahmed M. Hassan, Tagreed L. Alsubhi, Yahia Solan, Saleh Ejeeli, Esam I. Azhar

“…MERS-CoV was not detected in any of the samples. Human rhinovirus (hRV) was the most detected pathogen (40.9%) followed by non-MERS-CoV human coronaviruses (19.3%), influenza (Flu) viruses (15.9%), and human respiratory syncytial virus (hRSV) (13.6%). …”
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PM2.5 Exposure in the Respiratory System Induces Distinct Inflammatory Signaling in the Lung and the Liver of Mice by Soi Jeong, Sang A Park, Inwon Park, Pilhan Kim, Nam Hoon Cho, Jin Won Hyun, Young-Min Hyun

“…We then conducted mRNA microarray analysis to further observe how PM2.5 affects gene expression patterns in the lung and the liver. …”
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L-serine-O-sulfate alters cellular ultrastructure and mitigates the capacity of biofilm formation in Streptococcus mutans UA159 via interfering with glutamate racemase by Jianying Zhang, He-Ling Wang, Tianyu Ding, Yingjie Sun, Shaotai Wang, Chengcheng Yin

“…LSOS exhibited concentration-dependent bactericidal effects, with 5.0 mM completely suppressing growth and 2.5 mM significantly extending doubling time (11.37 hrs vs. 5.68 hrs in controls). …”
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Identification of Hub Biomarkers and Immune and Inflammation Pathways Contributing to Kawasaki Disease Progression with RT-qPCR Verification by Hongjun Ba, Lili Zhang, Huimin Peng, Xiufang He, Yuese Lin, Xuandi Li, Shujuan Li, Ling Zhu, Youzhen Qin, Xing Zhang, Yao Wang

“…Patients and Methods. Gene microarray data were collected from the Gene Expression Omnibus database. …”
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HDAC1 Mediates Immunosuppression of the Tumor Microenvironment in Non-Small Cell Lung Cancer by Fan Y, Ji X, Yuan K, Wu Q, Lou M

“…However, there are no studies on the immunological aspects of HDAC1 in non-small cell lung cancer (NSCLC).Methods: In this research, we used the Cancer Genome Atlas (TCGA) public database combined with tissue microarray (TMA) to investigate HDAC1 expression and prognosis in NSCLC. …”
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Transcriptomic Analysis of the Liver Redox Response During Food-Anticipatory Activity Under a Time-Restricted Feeding Protocol in Rats by Adrián Báez-Ruiz, Andy Hernández-Abrego, Mauricio Díaz-Muñoz, Isabel Méndez

“…Daytime-restricted feeding (TRF) exerts outstanding effects on circadian physiology, nutrient utilization, and energy metabolism. …”
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Elucidating the immune infiltration in acne and its comparison with rosacea by integrated bioinformatics analysis. by Lu Yang, Yan-Hong Shou, Yong-Sheng Yang, Jin-Hua Xu

“…<h4>Methods</h4>Five microarray data-sets (GSE108110, GSE53795, GSE65914, GSE14905 and GSE78097) were downloaded from Gene Expression Omnibus. …”
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AXL tyrosine kinase inhibitor TP-0903 induces ROS trigger neuroblastoma cell apoptosis via targeting the miR-335-3p/DKK1 expression by Tsai-Yi Tseng, Shao-Hsuan Kao, Shun-Fa Yang, Yi-Chen Lin, Chu-Liang Lin, Juei-Liang Chen, Chien-Min Chen, Yi-Hsien Hsieh

“…TP-0903, a multi-kinase inhibitor, shows inhibitory effects on NB but the mechanistic act is not completely explored. …”
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In Vitro Examination of Fungal and Root Extracts Inspired by Traditional Medicine for Potential Periorbital Eye Infrastructure Treatments by James V. Gruber, Nicole Terpak, Sebastien Massard, Xiang Chen, John Craffey, Robert Holtz

“…Consumers spend considerable amounts of resources combatting these effects. If consumers could treat some of the sources of these problems, in advance of the inevitable influences of aging, a kind of prejuvenation of the eye infrastructure, then perhaps the inevitable outcomes of aging apparent around the eyes could be slowed. …”
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Parent-of-origin testing of prenatal copy number variations: a retrospective study of 167 family cases by Yuefang Liu, Yuan Peng, Zhe Liang, Qiong Pan

“…Here, among 2273 pregnant women undergoing prenatal diagnosis, 236 CNVs were reported by chromosomal microarray analysis (CMA) including 69 full-penetrance pCNVs, 44 low-penetrance pCNVs, 113 VUS CNVs and 10 LP CNVs. …”
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Overexpression of cyclin‐dependent kinase 1 in esophageal squamous cell carcinoma and its clinical significance by Han‐Jie Zhang, Gang Chen, Shang‐Wei Chen, Zong‐Wang Fu, Hua‐Fu Zhou, Zhen‐Bo Feng, Jun‐Xian Mo, Chang‐Bo Li, Jun Liu

“…Microarray and external RNA‐seq data from 664 cases of ESCC and 1733 cases of control tissues were used to verify the difference in CDK1 expression between the two groups. …”
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Analysis of gene expression difference and biological process in chorionic villi of unexplained recurrent spontaneous abortion by Linling Shi, Lun Wei, Meiqiu Lu, Hongmei Ding, Le Bo

“…Abstract Objective To explore the biological relationship between the regulatory signal pathways involved in differentially expressed genes and recurrent spontaneous abortion (RSA) by analyzing the gene expression microarray data of unexplained RSA. Methods The gene expression profile data of chorionic villi from unexplained recurrent abortion with normal karyotype and selective induced abortion were compared. …”
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Maternal plasma cell-free DNA nucleosome footprints can reveal changes in gene expression profiles during pregnancy and pre-eclampsia by Kun Li, Zhiwei Guo, Fenxia Li, Shijing Lu, Min Zhang, Xingyu Wei, Chao Sheng, Wenbo Hao, Xuexi Yang

“…These results are consistent with prior microarray and RNA-sequencing data. Conclusions The depth of the cfDNA nucleosome footprint in maternal plasma can be used to reflect changes in the gene expression profile during pregnancy and pre-eclampsia. …”
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Targeting glial fibrillary acidic protein in glaucoma: a monoclonal antibody approach to modulate glial reactivity and neuroinflammation for neuroprotection by Chaoqiang Guan, Linglin Zhang, Kristian Nzogang Fomo, Jie Yang, Norbert Pfeiffer, Franz H. Grus

“…This study aimed to assess the neuroprotective effects of a monoclonal antibody (mAb) targeting GFAP in glaucoma and to elucidate the underlying mechanisms. …”
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Cyclooxygenase-1 deletion in 5 × FAD mice protects against microglia-induced neuroinflammation and mitigates cognitive impairment by Jie Wang, Hong Ni, Yu Wang, Luyao Wei, Hanqing Ding, Zhongzhao Guo, Hao Pan, Ying Yu, Jia Luo, Weidong Pan, Deheng Wang, Zun-Ji Ke

“…Methods We conducted backcrossing between COX-1 knockout (KO) and 5 × FAD mice to evaluate the effect of COX-1 deficiency on neuroinflammation. In addition, single-cell sequencing and microarray datasets from public databases and ingenuity pathway analysis in vitro were employed to explore gene expression profiles in the brains of AD mice. …”
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