-
421
Exploration of the shared gene signatures and comorbidity mechanisms of primary aldosteronism and atrial fibrillation
Published 2024-12-01“…These hub genes were subsequently validated via two independent external datasets: GSE60042 (PA microarray dataset) and GSE41177 (AF microarray dataset). …”
Get full text
Article -
422
SPP1 mRNA Expression Is Associated with M2 Macrophage Infiltration and Poor Prognosis in Triple-Negative Breast Cancer
Published 2024-11-01“…Additionally, we examined SPP1 mRNA expression datasets available in the Kaplan–Meier plotter and investigated the SPP1 protein expression patterns in our own tissue microarray cohort via immunohistochemistry. (3): The results revealed that genes associated with the Toll-like receptor signaling pathway showed a significant increase in activity in TNBC tissues when compared to normal breast tissues. …”
Get full text
Article -
423
Biomarkers and potential therapeutic targets driving progression of non-alcoholic steatohepatitis to hepatocellular carcinoma predicted through transcriptomic analysis
Published 2024-12-01“…Despite its widespread impact, effective treatments to prevent the progression of NASH remain elusive, highlighting the critical importance of innovative molecular techniques in both the diagnosis and management of this disease.MethodsSix microarray datasets available in GEO were used to perform Robust Rank Aggregation (RRA) to identify differentially expressed genes (DEGs).We identified 62 robust upregulated genes and 24 robust downregulated genes. …”
Get full text
Article -
424
TRIM13 prevents cardiomyocyte injury by affecting apoptosis through interacting with CD3D in myocardial infarction
Published 2025-08-01“…We aim to develop potential and more effective therapeutic strategies for treating and preventing MI. …”
Get full text
Article -
425
CaGe: A Web-Based Cancer Gene Annotation System for Cancer Genomics
Published 2012-03-01“…High-throughput genomic technologies (HGTs), including next-generation DNA sequencing (NGS), microarray, and serial analysis of gene expression (SAGE), have become effective experimental tools for cancer genomics to identify cancer-associated somatic genomic alterations and genes. …”
Get full text
Article -
426
Expression of RNA-binding motif 10 is associated with advanced tumor stage and malignant behaviors of lung adenocarcinoma cancer cells
Published 2017-03-01“…Complementary DNA microarray was used to profile RNA-binding motif 10–regulated genes. …”
Get full text
Article -
427
Identification of Key Biomarkers and Candidate Molecules in Non-Small-Cell Lung Cancer by Integrated Bioinformatics Analysis
Published 2023-01-01“…From the Gene Expression Omnibus database, GSE118370 and GSE10072 microarray datasets were obtained. Identifying the differentially expressed genes (DEGs) between lung adenocarcinoma and normal samples was done. …”
Get full text
Article -
428
Clinicopathologic implications of Myb and Beta-catenin expression in adenoid cystic carcinoma
Published 2020-07-01“…In this study, we aim to analyze the impact of Myb and β-catenin expression on prognosis in ACC. Methods A tissue microarray constructed from archival tissue from 64 patients with ACC was stained for Myb and β-catenin; both localization and intensity were evaluated. …”
Get full text
Article -
429
M2BPgs-HCC: An Automated Multilectin Bead Array Indicating Aberrant Glycosylation Signatures Toward Hepatitis C Virus-Associated Hepatocellular Carcinoma Prognosis
Published 2024-11-01“…Regular monitoring of patients with a history of hepatitis C virus (HCV) infection is critical for the detection and management of hepatocellular carcinoma (HCC). …”
Get full text
Article -
430
The Influence of Adalimumab and Cyclosporine A on the Expression Profile of the Genes Related to TGFβ Signaling Pathways in Keratinocyte Cells Treated with Lipopolysaccharide A
Published 2020-01-01“…The expression profile of mRNA related to TGFβ paths was indicated by microarray and RTqPCR analyses. The ELISA test was used to analyze changes on the proteome level. …”
Get full text
Article -
431
HuoXueJieDu Formula Alleviates Diabetic Retinopathy in Rats by Inhibiting SOCS3-STAT3 and TIMP1-A2M Pathways
Published 2017-01-01“…HuoXueJieDu (HXJD) formula exerts protective effects against diabetic retinopathy (DR) in rats, but its underlying mechanism remains unknown. …”
Get full text
Article -
432
Intratumoral IL-1R1 expression delineates a distinctive molecular subset with therapeutic resistance in patients with gastric cancer
Published 2022-02-01“…IL-1R1 mRNA expression was directly acquired from public datasets, and we also detected IL-1R1 protein expression on tumor microarray by immunohistochemistry. …”
Get full text
Article -
433
Spheroid Culture of Mesenchymal Stem Cells
Published 2016-01-01“…Mesenchymal stem cells (MSCs) cultured in spheroids have enhanced anti-inflammatory, angiogenic, and tissue reparative/regenerative effects with improved cell survival after transplantation. …”
Get full text
Article -
434
Analysis of Result Variability from High-Density Oligonucleotide Arrays Comparing Same-Species and Cross-Species Hybridizations
Published 2002-09-01“…The data reveal that a large fraction of probe sets are effective at transcript detection in the cross-species hybridization, validating the application of cross-species hybridizations for nonhuman primate genomics research.…”
Get full text
Article -
435
Pharmacologic inhibition of CSF-1R suppresses intrinsic tumor cell growth in osteosarcoma with CSF-1R overexpression
Published 2025-08-01“…Immunohistochemistry (IHC) was utilized to analyze human tissue microarray samples of osteosarcoma. We then investigated the anti-tumor effect and the mechanisms of action of pharmacologic inhibition of CSF-1R activity by pimicotinib (ABSK021), a highly potent and selective small molecule inhibitor of CSF-1R, in osteosarcoma models both in vitro and in vivo. …”
Get full text
Article -
436
Prenatal Diagnosis of 17p13.1p13.3 Duplication
Published 2012-01-01“…This was further defined as a chromosome 17p13.1p13.3 duplication by FISH and genomic microarray analysis (GMA). In addition Prenatal BACs-on-Beads (PN_BoBs) assay was performed, which detected the duplication clearly. …”
Get full text
Article -
437
Ultrasensitive Peptide-Based Electrochemical Biosensor for Universal Diagnostic of Dengue
Published 2025-04-01“…An identified linear B-cell epitope (DENV/18) specific for DENV 1–4 serotypes recognized by IgG in patient sera was selected as a target molecule after a microarray of peptides using the SPOT-synthesis methodology. …”
Get full text
Article -
438
QKI-induced circ_0001766 inhibits colorectal cancer progression and rapamycin resistance by miR-1203/PPP1R3C/mTOR/Myc axis
Published 2025-04-01“…However, no circRNA-based therapies have yet entered clinical development, underscoring the need for comprehensive detection and mechanistic studies of circRNAs in CRC. …”
Get full text
Article -
439
Uncovering genetic contributors to developmental delay and intellectual disability: a focus on CNVs in pediatric patients
Published 2025-06-01“…BackgroundDevelopmental delay (DD) and intellectual disability (ID) are prevalent in children and often have genetic causes, particularly copy number variations (CNVs). Chromosomal microarray analysis (CMA) and whole-exome sequencing (WES) are key diagnostic tools for identifying genetic contributions to these disorders. …”
Get full text
Article -
440
Identification of genes and pathways related to lymphovascular invasion in breast cancer patients: A bioinformatics analysis of gene expression profiles
Published 2017-06-01“…Surgery is the most effective treatment for breast cancer patients. However, some patients developed recurrence and distant metastasis after surgery. …”
Get full text
Article