Bioinformatic-based differential expression gene expressions of epithelial mesenchymal transformation in diabetic kidney disease and prediction of traditional Chinese medicine by Liu Wu, Zhou Yi, Yu Fang-ning, Zhang Ning

“…ObjectiveBased upon the bioinformatic analysis of gene chip data between patients with diabetic kidney disease （DKD） and normal controls， differentially expressed genes of epithelial mesenchymal transformation of DKD were screened for elucidating its pathogenesis and predicting the potential therapeutic Chinese medicine for DKD.MethodsGSE23338 microarray data were downloaded from gene expression omnibus， related differentially expressed genes screened by R language and differentially expressed genes analyzed by Gene Ontology， Kyoto Encyclopedia of Genes and Genomes. …”
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Cellular senescence-associated genes in rheumatoid arthritis: Identification and functional analysis. by You Ao, Qing Lan, Tianhua Yu, Zhichao Wang, Jing Zhang

“…In our study, we analyzed RA microarray data from the Gene Expression Omnibus (GEO) and focused on cellular senescence genes from the CellAge database. …”
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Ultradian cortisol pulsatility encodes a distinct, biologically important signal. by Andrew McMaster, Maryam Jangani, Paula Sommer, Namshik Han, Andy Brass, Stephen Beesley, Weiqun Lu, Andrew Berry, Andrew Loudon, Rachelle Donn, David W Ray

“…In addition, effects on glucocorticoid receptor (GR) expression levels and phosphorylation, as a potential mediator, were measured.…”
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Electrochemical Strategies for MicroRNA Quantification Leveraging Amplification and Nanomaterials: A Review by Alexander Hunt, Gymama Slaughter

“…However, conventional detection methods, such as Northern blotting, RT-PCR, and microarrays, are limited by low sensitivity, lengthy protocols, and limited specificity. …”
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DNA familial binding profiles made easy: comparison of various motif alignment and clustering strategies. by Shaun Mahony, Philip E Auron, Panayiotis V Benos

“…Prediction of the identity or the structural class of a protein that binds to a given DNA pattern will enhance the analysis of microarray and ChIP-chip data where frequently multiple putative targets of usually unknown TFs are predicted. …”
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Stabilization of Transcription Factor, HIF-1α by Prolylhydroxylase 1 Knockout Reduces Cardiac Injury After Myocardial Infarction in Mice by Mahesh Thirunavukkarasu, Seetur R. Pradeep, Babatunde Oriowo, Sue Ting Lim, Monica Maloney, Shayan Ahmed, Nicole Taylor, David M. Russell, Pavayee Socrates, Ethan Batko, Matan Berkovsky, John Alexander Palesty, Nilanjana Maulik

“…Our current work investigates the protective effects of PHD1 knockout in mice against myocardial infarction. …”
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Exploration of autophagy-related molecular mechanisms underlying epilepsy using multiple datasets by Yongfei Wang, Haoxuan Zeng, Chongxu Liu, Jianjun Chen, Yihong Huang, Xianju Zhou

“…Methods We analyzed GSE143272 and GSE4290 microarray datasets from the NCBI Gene Expression Omnibus database, which is established based on evaluations of peripheral blood samples. …”
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Integrated Bioinformatics Analysis of Hub Genes and Pathways in Anaplastic Thyroid Carcinomas by Xueren Gao, Jianguo Wang, Shulong Zhang

“…The aim of the present study was to identify hub genes and pathways in ATC by microarray expression profiling. Two independent datasets (GSE27155 and GSE53072) were downloaded from GEO database. …”
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Hub genes and associated drugs for multiple myeloma with 1q21+: identified by bioinformatic analysis by Zhiqiang Xu, Jieni Yu, Yamei Chen

“…While 1q21+ was common genetic alteration and found to have adverse effect on prognosis, the underlying genes remain unclear. …”
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Local anesthetics induce apoptosis in human thyroid cancer cells through the mitogen-activated protein kinase pathway. by Yuan-Ching Chang, Yi-Chiung Hsu, Chien-Liang Liu, Shih-Yuan Huang, Meng-Chun Hu, Shih-Ping Cheng

“…Recent evidence suggests that local anesthetics have a broad spectrum of effects including inhibition of cell proliferation and induction of apoptosis in neuronal and other types of cells. …”
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Gene expression in human hippocampus from cocaine abusers identifies genes which regulate extracellular matrix remodeling. by Deborah C Mash, Jarlath ffrench-Mullen, Nikhil Adi, Yujing Qin, Andrew Buck, John Pablo

“…The chronic effects of cocaine abuse on brain structure and function are blamed for the inability of most addicts to remain abstinent. …”
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M2-like macrophage-derived exosomes inhibit osteoclastogenesis via releasing miR-1227-5p by Shan Chen, Jian Liu, Lilei Zhu

“…The molecular mechanism was evaluated using microarray analysis, RT-qPCR, dual-luciferase reporter analysis, and RNA pull-down assay. …”
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Identification of novel antiviral host factors by functional gene expression analysis using in vitro HBV infection assay systems. by Takuto Nosaka, Tatsushi Naito, Yu Akazawa, Kazuto Takahashi, Hidetaka Matsuda, Masahiro Ohtani, Tsutomu Nishizawa, Hiroaki Okamoto, Yasunari Nakamoto

“…RNA microarray was performed using HBV-infected PXB cells with STAT1 knockdown. …”
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Identification of ZIC2 as a Potential Biomarker Linked with the Clinical Progression and Immune Infiltration of Oral Cancer: A Multicenter Study by Li Gao, Shi-Bai Yan, Fang-Cheng Jiang, Zhi-Guang Huang, Dong-Ming Li, Yu-Lu Tang, Jia-Yuan Luo, Gang Chen, Dan-Ming Wei

“…We explored the expression pattern and clinicopathological significance of ZIC2 in oral cancer through performing in-house tissue microarray and integrated analysis global RNA-seq and microarrays containing large samples. …”
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Global gene expression analysis of canine osteosarcoma stem cells reveals a novel role for COX-2 in tumour initiation. by Lisa Y Pang, Emma L Gatenby, Ayako Kamida, Bruce A Whitelaw, Ted R Hupp, David J Argyle

“…We found that COX-2 inhibition had no effect on CSC growth, or resistance to chemotherapy. …”
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Development and characterization of synthetic glucopyranosyl lipid adjuvant system as a vaccine adjuvant. by Rhea N Coler, Sylvie Bertholet, Magdalini Moutaftsi, Jeff A Guderian, Hillarie Plessner Windish, Susan L Baldwin, Elsa M Laughlin, Malcolm S Duthie, Christopher B Fox, Darrick Carter, Martin Friede, Thomas S Vedvick, Steven G Reed

“…We report here on the characterization of a synthetic hexaacylated lipid A derivative, denoted as glucopyranosyl lipid adjuvant (GLA). We assessed the effects of GLA on murine and human dendritic cells (DC) by combining microarray, mRNA and protein multiplex assays and flow cytometry analyses. …”
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A plant diterpene counteracts juvenile hormone-mediated gene regulation during Drosophila melanogaster larval development. by Sang Woon Shin, Jun Hyoung Jeon, Seon Ah Jeong, Ji-Ae Kim, Doo-Sang Park, Yunhee Shin, Hyun-Woo Oh

“…Gene ontology analysis also suggested that some of the genes activated-by-JHA/repressed-by-JHD play roles in spermatogenesis. Affymetrix microarray-based analysis indicated that the expression of genes activated-by-JHA/repressed-by-JHD was testis-specific. …”
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R-locus for roaned coat is associated with a tandem duplication in an intronic region of USH2A in dogs and also contributes to Dalmatian spotting. by Takeshi Kawakami, Meghan K Jensen, Andrea Slavney, Petra E Deane, Ausra Milano, Vandana Raghavan, Brett Ford, Erin T Chu, Aaron J Sams, Adam R Boyko

“…The tandem duplication is in an intronic region of usherin gene (USH2A), which was perfectly associated with roaning but absent in non-roaned dogs. We detected strong selection signals in this region characterized by reduced nucleotide diversity (π), increased runs of homozygosity, and extended haplotype homozygosity in Wirehaired Pointing Griffons and Australian Cattle Dogs (typically roaned breeds), as well as elevated genetic difference (FST) between Wirehaired Pointing Griffon (roaned) and Labrador Retriever (non-roaned). …”
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Exploration of the shared pathways and common biomarkers in cervical and ovarian cancer using integrated bioinformatics analysis by Fang Liu, Min Wang, Tian Zhu, Cong Xu, Guangming Wang

“…Results After crossing the common DEGs detected by "Limma" R package with the common module genes identified by WGCNA, 44 shared genes were obtained. …”
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Bioinformatic identification of Single Nucleotide Polymorphisms (SNPs) in keratin-associated protein genes in alpacas (Vicugna pacos) by Deyanira Figueroa, Manuel More, Gustavo Gutiérrez, F. Abel Ponce de León

“…Of these, 35 SNPs were included in the 76K alpaca SNP microarray and 32 SNPs were confirmed in a population of 936 alpacas.…”
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