Modulation of homologous recombination gene activity in breast tumor cells in an <i>in vitro</i> model by M. M. Tsyganov, A. A. Frolova, E. A. Kravtsova, I. A. Tsydenova, M. K. Ibragimova

“…To assess the presence of chromosomal aberrations, microarray analysis was performed on DNA chips.Results. …”
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Patient and provider preferences for long-acting TB preventive therapy by M. Vermeulen, K.K. Scarsi, R. Furl, H. Sayles, M.J. Anderson, S. Valawalkar, A. Kadam, S.R. Cox, V. Mave, M. Barthwal, C. Schutz, A. Ward, J. Dountio Ofimboudem, G. Meintjes, S. Rannard, A. Owen, S. Swindells, on behalf of the LONGEVITY consortium

“…CONCLUSION: Injectable LA-TPT may be highly acceptable and feasible if concerns surrounding cost, effectiveness, and safety are addressed.…”
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Vitamin C Treatment Rescues Prelamin A-Induced Premature Senescence of Subchondral Bone Mesenchymal Stem Cells by Yan-Nv Qu, Li Zhang, Ting Wang, He-Yang Zhang, Ze-Ji Yang, Fang-Fang Yuan, Yan Wang, Si-Wei Li, Xiao-Xia Jiang, Xiao-Hua Xie

“…Importantly, after VC treatment, MSC/PLA showed enhanced therapy effect in the hind-limb ischemia model. In conclusion, prelamin A can accelerate SCB-MSC premature senescence by inducing DNA damage. …”
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Acetylation suppresses breast cancer progression by sustaining CLYBL stability by Xinyue Deng, Chenglong Ma, Xingyu Chen, Ming Yi, Qianhua Cao, Ruocen Liao, Xingyu Lei, Longchang Bai, Bin Zhao, Yingnan Wang, Zhuoyang Shen, Liujing Wu, Chenfang Dong, Zhijun Dai

“…Methods CLYBL expression patterns in breast cancer were assessed using a breast cancer tissue microarray, immunohistochemistry, and publicly available datasets. …”
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Exploration of the potential neurotransmitter or neuromodulator-like properties of harmine: evidence from synthesis to synaptic modulation by Zhejun Xie, Ning Cao, Manlin Li, Hanxue Wang, Huida Guan, Xuemei Cheng, Changhong Wang

“…Subsequently, the release, metabolism, and uptake pathways of harmine were investigated using rat brain synaptosomes and primary neural cells through mass spectrometry analysis. A human proteome microarray was employed to screen for harmine-binding receptors, followed by experimental validation.Results:Adipocyte plasma membrane-associated protein isoform X1 (APMAP-X1) could effectively catalyze the Pictet-Spengler reaction in mammals to generate tetrahydroharmine, which was subsequently oxidized by myeloperoxidase (MPO) to produce harmine. …”
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Combining multi-omics analysis with machine learning to uncover novel molecular subtypes, prognostic markers, and insights into immunotherapy for melanoma by Songyun Zhao, Zihao Li, Kaibo Liu, Gaoyi Wang, Quanqiang Wang, Hua Yu, Wanying Chen, Hao Dai, Yijun Li, Jiaheng Xie, Yucang He, Liqun Li

“…Methods We obtained and processed transcriptomic data, including RNA expression profiles, methylation microarray data, gene mutation data, and clinical information, from the TCGA dataset using multi-omics analysis and machine learning techniques. …”
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Pharmacogenomic testing implementation: Tertiary care center experience and results of a pilot of 512 patients by Dana Bakheet, Hana Al Alshaykh, Ghadi Askar, Sateesh Maddirevula, Samya Hagos, Nasir Hamad Alshahrani, Midrar Alhusseini, Amani Moharram, Faries Algadhi, Osama Alswailim, Moatasem Alsulaim, Bandar Alamro, Fadl Elmula Mohamed Fadl Elmula, Bahadur Khan, Ahmed Almustafa, Ahmed Alshehri, Dimpna Brotons, Fahad Alajlan, Mohammed Alnahedh, Abdullah Alsuwaidan, Salah Baz, Ahmed Alfares

“…We used the PharmacoScan microarray-based test to perform genotyping. Results: To date, 512 patients have been tested. 97.5% of all patients have at least 1 gene with altered function. …”
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DSN1 may predict poor prognosis of lower-grade glioma patients and be a potential target for immunotherapy by Yulong Jia, Meiling Liu, Han Liu, Wenjia Liang, Qingyun Zhu, Chao Wang, Yake Chen, Yanzheng Gao, Zhendong Liu, Xingbo Cheng

“…DSN1 has been previously found to be positively correlated with various cancers. However, the effect of DSN1 or its methylation on the prognosis, molecular characteristics, and immune cell infiltration of low-grade glioma (LGG) has not yet been studied. …”
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Droplets Cas13a‐RPA measurement delineates potential role for plasma circWDR37 in colorectal cancer by Jingsong Xu, Li Cao, Shuang Yang, Ying Jian, Yu Liu, Zhen Shen, Qian Liu, Xiang Chen, Min Li, Shun Li, Xiaolei Zuo, Min Li, Hua Wang

“…The arraystar circRNA microarray assays, functional experiments in vitro and in vivo, and qPCR were performed to discover and validate that circWDR37 is a biomarker for early screening and prognosis evaluation of CRC. …”
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Molecular mechanism and biological pathway of high-expressed RAD51 in regulating cell adhesion and potentially affecting oral squamous cell carcinoma by Yu-Xing Tang, Yu-Yan Pang, Yan Cui, Guo-Jiao Wu, Lin-Qing Huang, Chang-Zhan Zhou, Bin Li, Qi Li, Bang-Teng Chi, Rong-Quan He, Di-Yuan Qin, Jian-Di Li, Gang Chen, Dong-Ming Li, Yi-Wu Dang

“…Methods Bulk RNA (RNA-seq and microarray), immunohistochemistry (IHC), and single-cell sequencing (scRNA-seq) were used to assess RAD51 expression and its clinical relevance in OSCC. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells by Nihal AlMuraikhi, Dalia Ali, Radhakrishnan Vishnubalaji, Muthurangan Manikandan, Muhammad Atteya, Abdulaziz Siyal, Musaad Alfayez, Abdullah Aldahmash, Moustapha Kassem, Nehad M. Alajez

“…Global gene expression profiling was conducted using the Agilent microarray platform, and data normalization and bioinformatics were performed using GeneSpring software. …”
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IGF2BP3/ESM1/KLF10/BECN1 positive feedback loop: a novel therapeutic target in ovarian cancer via lipid metabolism reprogramming by Anbo Gao, Juan Zou, Tian Zeng, Mei Qin, Xing Tang, Ting Yi, Guangming Song, Jie Zhong, Yuhuan Zeng, Wenchao Zhou, Qin Gao, Qunfeng Zhang, Juan Zhang, Yukun Li

“…This study tended to investigate the effects of endothelial cell-specific molecule 1 (ESM1) in OC. …”
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Bioinformatics analysis and experimental validation of potential targets and pathways in chronic kidney disease associated with renal fibrosis by Cui Huimin, Zhao Yuxin, Wang Peng, Gong Wei, Lin Hong, Li Na, Yang Jianjun

“…Conversely, when CHUK was further overexpressed, the inhibitory effect of miR-223-3p on epithelial-mesenchymal transition (EMT) was attenuated, confirming the specific interaction between miR-223-3p and CHUK. …”
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A nomogram for predicting 3-year total weight loss percentage following LSG: insights from visceral adipose tissue inflammatory methylation sites by Zhehong Li, Liang Wang, Zheng Wang, Qiqige Wuyun, Buhe Amin, Dongbo Lian, Guangzhong Xu, Nengwei Zhang, Dezhong Wang

“…Comparative analyses of 850K methylation microarrays from VAT samples were performed to identify methylation sites associated with INF-related genes. …”
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Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function. by Wenbo Tang, Matthew Kowgier, Daan W Loth, María Soler Artigas, Bonnie R Joubert, Emily Hodge, Sina A Gharib, Albert V Smith, Ingo Ruczinski, Vilmundur Gudnason, Rasika A Mathias, Tamara B Harris, Nadia N Hansel, Lenore J Launer, Kathleen C Barnes, Joyanna G Hansen, Eva Albrecht, Melinda C Aldrich, Michael Allerhand, R Graham Barr, Guy G Brusselle, David J Couper, Ivan Curjuric, Gail Davies, Ian J Deary, Josée Dupuis, Tove Fall, Millennia Foy, Nora Franceschini, Wei Gao, Sven Gläser, Xiangjun Gu, Dana B Hancock, Joachim Heinrich, Albert Hofman, Medea Imboden, Erik Ingelsson, Alan James, Stefan Karrasch, Beate Koch, Stephen B Kritchevsky, Ashish Kumar, Lies Lahousse, Guo Li, Lars Lind, Cecilia Lindgren, Yongmei Liu, Kurt Lohman, Thomas Lumley, Wendy L McArdle, Bernd Meibohm, Andrew P Morris, Alanna C Morrison, Bill Musk, Kari E North, Lyle J Palmer, Nicole M Probst-Hensch, Bruce M Psaty, Fernando Rivadeneira, Jerome I Rotter, Holger Schulz, Lewis J Smith, Akshay Sood, John M Starr, David P Strachan, Alexander Teumer, André G Uitterlinden, Henry Völzke, Arend Voorman, Louise V Wain, Martin T Wells, Jemma B Wilk, O Dale Williams, Susan R Heckbert, Bruno H Stricker, Stephanie J London, Myriam Fornage, Martin D Tobin, George T O'Connor, Ian P Hall, Patricia A Cassano

“…Publicly available microarray data confirmed differential expression of all three genes in lung samples from COPD patients compared with controls. …”
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A novel polypeptide encoded by circSPIRE1 promotes prostate cancer proliferation and migration by restraining the ubiquitin-dependent degradation of LRP5 by Jintao Hu, Juanyi Shi, Junjie Wang, Yunfei Xiao, Degeng Kong, Mingchao Gao, Tianlong Luo, Shizhong Xu, Zhihan Yuan, Xinyi Ma, Xueseng Dong, Jingang Huang, Cheng Liu, Kewei Xu

“…This study characterizes a novel circRNA-encoded protein, rtSPIRE1, and investigates its mechanistic role in prostate cancer proliferation and migration, as well as its diagnostic and therapeutic potential. Methods RNA microarray identified circSPIRE1 in prostate cancer tissues. …”
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circKCNQ5 promotes the proliferation of DNA-methyltransferase 3A R882 mutated acute myeloid leukemia cells by elevating high-mobility group box 1 expression by Yijian Chen, Xiaodan Zhu, Chuanming Lin, Rong Xu, Pengxiang Xu, Liuyan Xin, Lin Li, Liqun Zhang

“…Background Patients with acute myeloid leukemia (AML) harboring the DNA-methyltransferase 3 A (DNMT3A) R882 mutation (DR882MUT) usually have a high recurrence rate and poor prognosis. circKCNQ5 levels were aberrantly elevated in patients with AML according to the microarray platform. Therefore, the purpose of this study is to investigate the effect and mechanism of circKCNQ5 on DR882MUT AML cell proliferation.Methods A DR882MUT cell line model was established. circKCNQ5 expression in AML cells expressing wild-type DNMT3A (DNMT3A-WT) or DR882MUT was analyzed using RT-qPCR. …”
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The NR_109/FUBP1/c-Myc axis regulates TAM polarization and remodels the tumor microenvironment to promote cancer development by Baoen Shan, Cong Zhang, Guogui Sun, Hongtao Zhang, Xiaoya Li, Sisi Wei, Suli Dai, Huixia Wang, Lianmei Zhao

“…Long noncoding RNAs (lncRNAs) have been implicated in various physiological and pathological processes, yet the underlying mechanism on how lncRNAs manipulate the polarization states of TAMs is still unclear and remains to be further investigated.Methods Microarray analyses were employed to characterize the lncRNA profile involved in THP-1-induced M0, M1 and M2-like macrophage. …”
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Identifying critical modules and biomarkers of intervertebral disc degeneration by using weighted gene co‐expression network by Daqian Zhou, Tao Liu, Yongliang Mei, Jiale Lv, Kang Cheng, Weiye Cai, Silong Gao, Daru Guo, Xianping Xie, Zongchao Liu

“…Additionally, we predicted miRNAs involved in hub gene co‐regulation and analyzed miRNA microarray data from GSE116726 to identify four differentially expressed miRNAs. …”
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PARP9-PARP13-PARP14 axis tunes colorectal cancer response to radiotherapy by Rimvile Prokarenkaite, Karolina Kuodyte, Greta Gudoityte, Elzbieta Budginaite, Daniel Naumovas, Egle Strainiene, Kristijonas Velickevicius, Audrius Dulskas, Ernestas Sileika, Jonas Venius, Virginijus Tunaitis, Augustas Pivoriunas, Vytaute Starkuviene, Vaidotas Stankevicius, Kestutis Suziedelis

“…The transcriptomes of nonirradiated and irradiated cells were analyzed using microarrays. Gene set enrichment analysis was conducted to determine the pathways in which PARP13 is engaged. …”
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