Tumor immune microenvironment permissive to metastatic progression of ING4-deficient breast cancer. by Emily Tsutsumi, Anne M Macy, Janine LoBello, Karen T Hastings, Suwon Kim

“…To characterize the tumor immune microenvironment associated with ING4-deficient tumors, three approaches were employed in this study: First, tissue microarrays composed of 246 primary breast tumors including 97 ING4-deficient tumors were evaluated for the presence of selective immune markers, CD68, CD4, CD8, and PD-1, using immunohistochemical staining. …”
Get full text

Long Noncoding RNA and mRNA m6A Modification Analyses of Periodontal Ligament Stem Cells from the Periodontitis Microenvironment Exposed to Static Mechanical Strain by Weifu Sun, Jia Liu, Xu Zhang, Xiaochen Zhang, Jie Gao, Xin Chen, Xian Wang, Wen Qin, Zuolin Jin

“…However, the regulatory effects of lncRNA and mRNA m6A modification on PDLSCs have not been studied. …”
Get full text

Pericytes in castration-resistant prostate cancer associated with disease progression and immunotherapy response: insights from single-cell analysis by Yifeng Qiu, Yuhan Wang, Jiahe Liu, Kai Sun, Shigeo Horie, Zhitong Bing, Qi Hou

“…Our investigation is designed to decipher the biological effects of pericytes on CRPC and their interactions with the tumor microenvironment. …”
Get full text

Therapeutic role of aripiprazole in cartilage defects explored through a drug repurposing approach by Jun-Ku Lee, Hyunjeong Yeo, Sujin Choi, Kyeong Mi Kim, Hannah Kim, Sung-Sahn Lee, Hyun Il Lee, Younghoon Jeong, Hyun-Ju An, Soonchul Lee

“…Furthermore, aripiprazole effectively enhanced cartilage regeneration in the rat model. …”
Get full text

LncRNA-mRNA co-expression network in the mechanism of butylphthalide treatment for ischemic stroke by Yangfang An, Lingyun Huang, Jun Li, Zhuo Chen, Jizhang Cai, Biao Wang, Qiong Zhou

“…This study investigated the effects of butylphthalide treatment on the lncRNA-mRNA co-expression network in ischemic stroke patients. …”
Get full text

Exogenous TSG-6 treatment alleviates DSS-induced colitis in mice by modulating Pou2f3 and promoting tuft cells differentiation by Shaopeng Yang, Yuqi Li, Rongwei Ruan, Jiangping Yu, Bo Zhu, Haibin Lou, Xiaolan Zhang, Shi Wang

“…Results TSG-6 treatment significantly attenuated DSS-induced colitis symptoms and inflammatory cell infiltration. Microarray analysis revealed that TSG-6 decreased pro-inflammatory cytokine levels in colon tissue. …”
Get full text

Identification of CD36 as a contributor in inflammatory response of rheumatoid arthritis and screening of feasible bioactive drugs targeting it by Dan Xuan, Xiaowan Wang, Dandan Feng, Li Wang, Yonghui Xia

“…Methods RA-related microarray datasets (GSE77298 and GSE206848) and inflammatory genes (IRGs) were downloaded from Gene Expression Omnibus database and GeneCards database, respectively. …”
Get full text

Upregulated MicroRNA-155 Expression in Peripheral Blood Mononuclear Cells and Fibroblast-Like Synoviocytes in Rheumatoid Arthritis by Li Long, Ping Yu, Yanying Liu, Shiyao Wang, Ru Li, Jinxia Shi, Xiaoping Zhang, Yanmei Li, Xiaolin Sun, Bin Zhou, Liufu Cui, Zhanguo Li

“…This study was to screen for the miRNAs differently expressed in peripheral blood mononuclear cells (PBMC) of RA, to further identify the expression of miR-155 in RA PBMC and fibroblast-like synoviocytes (FLS), and to evaluate the function of miR-155 in RA-FLS. Methods. Microarray was used to screen for differentially expressed miRNAs in RA PBMC. miR-155 expression in PBMC and FLS of RA were identified by real-time PCR. …”
Get full text

The significance of Trk receptors in pancreatic cancer by Matthew D Johnson, Brandon Stone, Bryan J Thibodeau, Andrew M Baschnagel, Sandra Galoforo, Laura E Fortier, Billie Ketelsen, Samreen Ahmed, Zakiya Kelley, Alaa Hana, Thomas G Wilson, John M Robertson, Robert P Jury, George D Wilson

“…A specific inhibitor of TrkA, B, and C, AstraZeneca 1332, was investigated in vitro and in vivo in combination with radiation. A tissue microarray was constructed from 77 pancreatic ductal adenocarcinoma patients who had undergone neoadjuvant chemoradiation and the Trk receptor, and neurogenic differentiation 1 expression was assessed and correlated with overall survival. …”
Get full text

Involvement of Urokinase-Type Plasminogen Activator Receptor in the Formation of a Profibrotic Microenvironment in the Epicardial Region by K. V. Dergilev, Z. I. Tsokolayeva, I. B. Beloglazova, Yu. D. Vasilets, D. O. Traktuyev, B. N. Kulbitsky, E. V. Parfenova

“…We used histological and immunofluorescent staining, microarray analysis of proinflammatory cytokine levels, and a method for assessing the migratory properties of epicardial cells.Results. …”
Get full text

Hyperuricemia suppresses lumican, exacerbating adverse remodeling after myocardial infarction by promoting fibroblast phenotype transition by Zehao Zhuang, Ao Liu, Jinghong Zhang, Shuangjian Han, Lu Tang, Tingting Yu, Yiping Shi, Hui Li, Heng Yang, Peiyuan Bai, Yanhua Tang

“…Objectives We aimed to trigger hyperuricemia by administering potassium oxonate in a mouse model of MI to evaluate the role of hyperuricemia in MI pathogenesis. Methods Microarray datasets and single-cell sequencing data from gout patients, heart failure patients, and model mice were used to identify the underlying mechanisms responsible for the effect of hyperuricemia on MI progression. …”
Get full text

Identification and characterization of the anti-viral interferon lambda 3 as direct target of the Epstein-Barr virus microRNA-BART7-3p by Juliane Blümke, Marcus Bauer, Christoforos Vaxevanis, Andreas Wilfer, Ofer Mandelboim, Claudia Wickenhauser, Barbara Seliger, Simon Jasinski-Bergner

“…To determine novel targets of EBV-miRs involved in immune surveillance, ebv-miR-BART7-3p, an EBV-encoded miR with high expression levels during the different lytic and latent EBV life cycle phases, was overexpressed in human HEK293T cells. Using a cDNA microarray-based comparative analysis, 234 (229 downregulated and 5 upregulated) deregulated human transcripts were identified in ebv-miR-BART7-3p transfectants, which were mainly involved in cellular processes and molecular binding. …”
Get full text

Expression and prognostic significance of MLH1 and GPRC5C in resectable hepatocellular carcinoma by Jun Lu, Lei Li, Qing Chen, Bingqi Li, Siqian Ren, Meng Yuan, Meng Meng, Jian Lei, Yuntao Bing, Hangyan Wang, Zhaolai Ma, Dianrong Xiu, Chunhui Yuan

“…Methods We detected MLH1 and GPRC5C expression using the tissue microarray-based immunohistochemical staining in tumor and matched adjacent non-tumor liver (ANL) specimens from 230 patients who underwent radical resection for HCC. …”
Get full text

TRIM21 functions as an oncogene in glioblastoma by transactivating FOSL1 and promoting the ubiquitination of p27 by Vanajothi Ramar, Rajveer Singh Sidhu, Osei Pako, Cheyenne R. Cisse, Alyssa A. Guo, Jason Li, Kelcey Stapleton, Shanchun Guo, Guangdi Wang, Mingli Liu

“…Immunohistochemistry on glioma patient tissue microarray (TMA) assessed TRIM21 expression and its association with FOSL1, IDH status, and glioma grade. …”
Get full text

Differential gene expression in patients with anal fistula reveals high levels of prolactin recepetor by Song Yi-Huan, Qiu Jian-Ming, Yang Guan-Gen, Wang Dong, Lin A-Li, Xu Kan

“…In univariate regression analysis, low PRLR expression correlated with fistula complexity; a significant independent effect maintained in multivariate analysis odds ratio [(OR) low to high PRLR expression = 9.52; p = 0.001)]. …”
Get full text

PRMT3 drives PD-L1-mediated immune escape through activating PDHK1-regulated glycolysis in hepatocellular carcinoma by Chen-Hong Ding, Fang-Zhi Yan, Bo-Nan Xu, Hui Qian, Xia-Lu Hong, Shu-Qing Liu, Yuan-Yuan Luo, Si-Han Wu, Ling-Yan Cai, Xin Zhang, Wei-Fen Xie

“…The R363/368 K mutant or inhibition of PDHK1 by JX06 blocked the effect of PRMT3 on lactate production. JX06 treatment also attenuated the tumor-promoting role of PRMT3 in HCC in vitro and in vivo. …”
Get full text

Deciphering the methylation landscape of long noncoding RNAs in hepatocellular carcinoma: a focus on LINC00942 by Zhaoqi Shi, Xiaolong Liu, Duguang Li, Jing Yang, Haonan Chen, Hui Lin, Xiaoxiao Fan

“…Methods We conducted a methylation microarray analysis on 11 HCC samples alongside adjacent non-tumor tissue specimens. …”
Get full text

Genome-wide association studies of the PR interval in African Americans. by J Gustav Smith, Jared W Magnani, Cameron Palmer, Yan A Meng, Elsayed Z Soliman, Solomon K Musani, Kathleen F Kerr, Renate B Schnabel, Steven A Lubitz, Nona Sotoodehnia, Susan Redline, Arne Pfeufer, Martina Müller, Daniel S Evans, Michael A Nalls, Yongmei Liu, Anne B Newman, Alan B Zonderman, Michele K Evans, Rajat Deo, Patrick T Ellinor, Dina N Paltoo, Christopher Newton-Cheh, Emelia J Benjamin, Reena Mehra, Alvaro Alonso, Susan R Heckbert, Ervin R Fox, Candidate-gene Association Resource (CARe) Consortium

“…Genotyping was performed using the Affymetrix 6.0 microarray. Imputation was performed for 2.8 million single nucleotide polymorphisms (SNPs) using combined YRI and CEU HapMap phase II panels. …”
Get full text

Metabolism effector links in diet-induced and genetically-based obesity: A full-transcriptome study of liver tissue in experimental models in rodents by S. A. Apryatin, N. V. Trusov, I. V. Gmoshinski, V. A. Tutelyan

“…We carried out a comparative analysis of the changes in liver transcriptome in rats and mice fed with diets of excessive energy value and exerting lipogenic effect. Data of full-transcriptome profiling using DNA microarray technology have been presented previously in 8 publications.Results. …”
Get full text

CCNY-mediated phosphorylation and TET2-BACH1-driven DNA demethylation activate PRC1 to augment NSCLC progression by Dayu Huang, Xianglin Chu, Chunxiao Wu, Xuan Wang, Mengkun Shi, Xiaofeng Chen, Yubao Lyu, Dapeng Li, Xuyu Gu

“…Subcutaneous xenograft and orthotopic isograft tumor models were generated for in vivo verification. Tissue microarray (TMA) and bioinformatics analyses were employed to evaluate the clinical prognostic value of CCNY, TET2, and PRC1 in NSCLC. …”
Get full text