M2-like macrophage-derived exosomes inhibit osteoclastogenesis via releasing miR-1227-5p by Shan Chen, Jian Liu, Lilei Zhu

“…The molecular mechanism was evaluated using microarray analysis, RT-qPCR, dual-luciferase reporter analysis, and RNA pull-down assay. …”
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Identification of novel antiviral host factors by functional gene expression analysis using in vitro HBV infection assay systems. by Takuto Nosaka, Tatsushi Naito, Yu Akazawa, Kazuto Takahashi, Hidetaka Matsuda, Masahiro Ohtani, Tsutomu Nishizawa, Hiroaki Okamoto, Yasunari Nakamoto

“…RNA microarray was performed using HBV-infected PXB cells with STAT1 knockdown. …”
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Identification of ZIC2 as a Potential Biomarker Linked with the Clinical Progression and Immune Infiltration of Oral Cancer: A Multicenter Study by Li Gao, Shi-Bai Yan, Fang-Cheng Jiang, Zhi-Guang Huang, Dong-Ming Li, Yu-Lu Tang, Jia-Yuan Luo, Gang Chen, Dan-Ming Wei

“…We explored the expression pattern and clinicopathological significance of ZIC2 in oral cancer through performing in-house tissue microarray and integrated analysis global RNA-seq and microarrays containing large samples. …”
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Transcription factor binding site analysis identifies FOXO transcription factors as regulators of the cutaneous wound healing process. by Karl Markus Roupé, Srinivas Veerla, Joshua Olson, Erica L Stone, Ole E Sørensen, Stephen M Hedrick, Victor Nizet

“…The search for significantly overrepresented and co-occurring transcription factor binding sites in the promoter regions of the most differentially expressed genes in microarray data sets could be a powerful approach for finding key regulators of complex biological processes. …”
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Global gene expression analysis of canine osteosarcoma stem cells reveals a novel role for COX-2 in tumour initiation. by Lisa Y Pang, Emma L Gatenby, Ayako Kamida, Bruce A Whitelaw, Ted R Hupp, David J Argyle

“…We found that COX-2 inhibition had no effect on CSC growth, or resistance to chemotherapy. …”
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Development and characterization of synthetic glucopyranosyl lipid adjuvant system as a vaccine adjuvant. by Rhea N Coler, Sylvie Bertholet, Magdalini Moutaftsi, Jeff A Guderian, Hillarie Plessner Windish, Susan L Baldwin, Elsa M Laughlin, Malcolm S Duthie, Christopher B Fox, Darrick Carter, Martin Friede, Thomas S Vedvick, Steven G Reed

“…We report here on the characterization of a synthetic hexaacylated lipid A derivative, denoted as glucopyranosyl lipid adjuvant (GLA). We assessed the effects of GLA on murine and human dendritic cells (DC) by combining microarray, mRNA and protein multiplex assays and flow cytometry analyses. …”
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A plant diterpene counteracts juvenile hormone-mediated gene regulation during Drosophila melanogaster larval development. by Sang Woon Shin, Jun Hyoung Jeon, Seon Ah Jeong, Ji-Ae Kim, Doo-Sang Park, Yunhee Shin, Hyun-Woo Oh

“…Gene ontology analysis also suggested that some of the genes activated-by-JHA/repressed-by-JHD play roles in spermatogenesis. Affymetrix microarray-based analysis indicated that the expression of genes activated-by-JHA/repressed-by-JHD was testis-specific. …”
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Investigation of griffithsin's interactions with human cells confirms its outstanding safety and efficacy profile as a microbicide candidate. by Joseph Calvin Kouokam, Dana Huskens, Dominique Schols, Andrew Johannemann, Shonna K Riedell, Wendye Walter, Janice M Walker, Nobuyuki Matoba, Barry R O'Keefe, Kenneth E Palmer

“…In addition, GRFT appears to retain antiviral activity once bound to the surface of PBMC. Finally, RNA microarray studies show that, while CV-N and ConA regulate expression of a multitude of cellular genes, GRFT treatment effects only minimal alterations in the gene expression profile of a human ectocervical cell line. …”
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Evaluating IL22RA1 expression as a predictive indicator in human colon cancer progression by Xuan Yin, Renhao Geng, Junjun Chen, Bin Xu, Hui Ma, Yingting Liu, Xiao Zheng, Lujun Chen

“…Methods In this study, we utilized a multi-color immunohistochemistry (mIHC) assay to examine the expression patterns of IL22RA1, IL22, CD155, and IL22BP in a tissue microarray (TMA) comprising 90 colon cancer samples. …”
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Immunopeptidomics identified antigens for mRNA-lipid nanoparticle vaccines with alpha-galactosylceramide in multiple myeloma therapy by Eline Menu, Lorenzo Franceschini, Karin Vanderkerken, Elke De Bruyne, Karine Breckpot, Kim De Veirman, Arne Van der Vreken, Fabien Thery, Chenggong Tu, Kevin Mwangi, Sofie Meulewaeter, Lien De Beck, Edith Janssens, Francis Impens, Rein Verbeke, Ine Lentacker

“…To our knowledge, immunization with messenger RNA (mRNA) and the iNKT agonist, α-galactosylceramide (αGC), has not been studied in MM, as knowledge on clinically relevant antigens in preclinical MM models is lacking.Methods Microarray data and immunopeptidomics (imPep) were used to identify candidate antigens for immunization in 5TMM models. …”
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Neurotoxicity of high-dose methotrexate in the treatment of non-Hodgkin’s lymphomas in children: clinical and genetic aspects by Z. K. Simavonyan, T. T. Valiev, A. L. Kashanina, V. V. Semenova, A. R. Zheleznyak, L. Serdan Ramos, A. Yu. Ikonnikova, T. V. Nasedkina

“…MTX is associated with a wide range of side effects, manifesting as organ toxicity (hemato-, hepato-, neuro-, nephrotoxicity, mucositis, infectious complications). …”
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TLR3-overexpressing umbilical cord mesenchymal stromal cells suppress immune responses to attenuate high-risk corneal transplantation rejection by Yaqi Cheng, Huaxin Chen, Simin Gu, Weihua Li, Huan Yu, Jianqiang Zhang, Huini Zhang, Jiayi Lin, Haocheng Zhu, Youyu Liu, Wenqiong Li, Ting Fu, Haoyu Zeng, Tao Wang, Shiqi Ling

“…GSEA, CIBERSORT, and flow cytometry analyses were performed to investigate the activation of signaling pathways and immune changes. The microarray dataset GSE68610, which contains transcriptome data for normal human UC-MSCs and UC-MSCs treated with cytokines, was analyzed to evaluate TLR expression and identify the key factors involved in the anti-inflammatory effect of UC-MSCs. …”
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Targeting YY1-DR5 Axis by Pyripyropene O as a Novel Therapeutic Strategy Against Prostate Cancer: Molecular Mechanisms and In Vivo Zebrafish Validation by Wenxuan Fang, Ying Chen, Mingyi Nie, Xuefeng Zhou, Yonghong Liu, Huaming Tao, Bin Yang, Xueni Wang

“…The in vivo results showed that pyripyropene O effectively inhibited the development of prostate cancer in zebrafish; Conclusions: Pyripyropene O has a clear anti-prostate cancer effect at both cellular and animal levels, inhibiting the survival and proliferation of prostate cancer cells by binding to the transcription factor YY1 to activate the expression of DR5 to promote apoptosis, thus exerting an inhibitory effect on prostate cancer.…”
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A first large study of whole-exome sequencing (WES) in 489 patients with suspected rare genetic disorders at a tertiary centre in Malaysia by Lip Hen Moey, Go Hun Seo, Boon Eu Cheah, Wee Teik Keng, Hane Lee, Gaik Siew Ch’ng

“…Therefore, WES is cost effective and fast becoming a routine clinical test worldwide for patients suspected to have rare genetic disorders. …”
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A Potent Chemotherapeutic Strategy with Eg5 Inhibitor against Gemcitabine Resistant Bladder Cancer. by Liang Sun, Jiaju Lu, Zhihong Niu, Kejia Ding, Dongbin Bi, Shuai Liu, Jiamei Li, Fei Wu, Hui Zhang, Zuohui Zhao, Sentai Ding

“…Human OneArray Microarray analysis was performed to obtain broad spectrum information about the genes differentially expressed in RT112 and RT112-Gr cells. …”
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FANCI is involved in the malignant progression of glioma cells by regulating the Akt/Bcl-2 signaling pathway by Hanyun Li, Yinrui Liu, Mingyao Wang, Shaoshao Xu, Jilan Liu, Xianyun Qin, Banban Li, Jikui Sun, Yan Liu, Feng Jin

“…Methods The expression of FANCI in glioma cells was analyzed by bioinformatics and microarray. Lentivirus transfection was used to regulate the expression of FANCI in glioma cells. …”
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Transcriptomics, Proteomics and Bioinformatics in Atrial Fibrillation: A Descriptive Review by Martina Belfiori, Lisa Lazzari, Melanie Hezzell, Gianni D. Angelini, Tim Dong

“…Different devices for processing RNA and proteomic samples vary from RNA sequencing and microarray to a wide range of mass spectrometry techniques such as Orbitrap, Quadrupole, LC-MS, and hybrid systems. …”
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Cell cycle regulation and cytoskeletal remodelling are critical processes in the nutritional programming of embryonic development. by Angelina Swali, Sarah McMullen, Helen Hayes, Lorraine Gambling, Harry J McArdle, Simon C Langley-Evans

“…While these describe processes leading from nutritional insult to development of the actual pathology, the initial underlying cause of the programming effect remains elusive. To establish the primary drivers of programming, this study aimed to capture embryonic gene and protein changes in the whole embryo at the time of nutritional insult rather than downstream phenotypic effects. …”
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Stability indicators in network reconstruction. by Michele Filosi, Roberto Visintainer, Samantha Riccadonna, Giuseppe Jurman, Cesare Furlanello

“…Finally, we demonstrate a strong combined effect of different reconstruction methods and phenotype subgroups on a hepatocellular carcinoma miRNA microarray dataset (240 subjects), and we validate the analysis on a second dataset (166 subjects) with good reproducibility.…”
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Regulation of Myogenesis by MechanomiR-200c/FoxO3 Axis by Junaith S. Mohamed, Aladin M. Boriek

“…Overexpression of mechanomiR-200c revoked the effect of stretch on myoblast differentiation, and the introduction of the mechanomiR-200c antagomir restored the stretch effect. …”
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