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981
Pan-cancer landscape of ITGAV and its potential role in gastric cancer
Published 2025-08-01“…Gene enrichment analysis was performed to explore potential functions of ITGAV in gastric cancer (GC). GC tissue microarrays and in vitro cell experiments were used to verify the prediction results in GC. …”
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982
Distribution of Recessive Genetic Defect Carriers in Holstein Friesian Cattle: A Polish Perspective
Published 2024-11-01“…The studies were performed using Illumina Infinium microarrays. Among both bulls and cows, the highest numbers of carriers were detected for HH5 (appropriately 6.7% and 5.4%). …”
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983
Transcriptomic analysis of neural stem and progenitor cells in comparison with glioblastoma stem cells
Published 2023-12-01“…To conduct a comparative transcriptomic analysis of CD133+-NSPCs and CD133+-GSCs to study the molecular genetic differences between the phenotypes of these cells and identify potential targets for therapeutic effects on GSCs.Materials and methods. Used: highly sensitive transcriptomic analysis on high-density microarrays, cellular technologies, modern bioinformatics analysis.Results. …”
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984
Multi-institutional TSA-amplified Multiplexed Immunofluorescence Reproducibility Evaluation (MITRE) Study
Published 2021-07-01“…Serial sections from tonsil and breast carcinoma and non-small cell lung cancer (NSCLC) tissue microarrays (TMAs), TSA-Opal fluorescent detection reagents, and antibodies were distributed to the six sites equipped with a Leica Bond Rx autostainer and a Vectra Polaris multispectral imaging platform. …”
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985
GPX3 promotes cisplatin resistance in TNBC by manipulating ROS-TGFB1-ZEB2
Published 2025-07-01“…The correlation between the expression level of GPX3, TGFB1, and ZEB2 was analyzed using breast cancer microarrays and the TCGA database. The effect of GPX3 on platinum sensitivity in TNBC was studied using a mouse xenograft model. …”
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986
Phosphoribosyl transferase domain containing 1: A prognostic biomarker in testicular germ cell tumors
Published 2025-06-01“…Immunohistochemistry on tissue microarrays validated PRTFDC1’s predictive value in clinical samples. …”
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987
Imputation of variants from the 1000 Genomes Project modestly improves known associations and can identify low-frequency variant-phenotype associations undetected by HapMap based i...
Published 2013-01-01“…Our data provide important proof of principle that 1000 Genomes imputation will detect novel, low frequency-large effect associations.…”
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988
Targeting Mesothelin Enhances Personalized Neoantigen Vaccine Induced Antitumor Immune Response in Orthotopic Pancreatic Cancer Mouse Models
Published 2025-03-01“…Abstract The immunosuppressive microenvironment in pancreatic cancer, characterized by low tumor‐specific T cells and excessive fibrosis, limits the effectiveness of immunotherapy. Here, three datasets and multi‐immunofluorescence staining of tissue microarrays in pancreatic cancer indicate that mesothelin (MSLN) expression negatively correlates with cytotoxic T cells in tumor. …”
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989
Silibinin attenuates ferroptosis in acute kidney injury by targeting FTH1
Published 2024-11-01“…Finally, the inhibitory effects of silibinin on ferroptosis were reversed by knocking down FTH1 in vitro. …”
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990
Platelet-derived exosomal LINC00183 facilitate colorectal cancer malignant progression driven by histone lactylation through stabilizing ENO1
Published 2025-08-01“…Analysis of CRC tissue microarrays and TCGA-CRC patient data indicated that LINC00183 is often overexpressed in CRC, in association with advanced tumor stage and poor survival. …”
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991
Applicability of epigenetic age models to next-generation methylation arrays
Published 2024-10-01“…As new methylation microarrays are developed and older models discontinued, existing epigenetic clocks might become obsolete. …”
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992
Identification of vascular and hematopoietic genes downstream of etsrp by deep sequencing in zebrafish.
Published 2012-01-01“…Several novel genes expressed in vasculature have been identified through transcriptional profiling of zebrafish embryos overexpressing etsrp by microarrays. Here we re-examined this transcriptional profile by Illumina RNA-sequencing technology, revealing a substantially increased number of candidate genes regulated by etsrp. …”
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993
p53 activation by knockdown technologies.
Published 2007-05-01“…Interestingly, quantitative reverse-transcriptase PCR, microarrays and whole-mount in situ hybridization assays show that MO off-targeting effects are accompanied by diagnostic transcription of an N-terminal truncated p53 isoform that uses a recently recognized internal p53 promoter. …”
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994
Inhibition of PDK modulates radiotherapy resistance in gastric cancer
Published 2025-05-01“…Abstract To explore the effect of sodium dichloroacetate (DCA), a pyruvate dehydrogenase kinase (PDK) inhibitor, on the progression of gastric cancer and resistance to radiotherapy, we analyzed histopathological microarrays from 60 gastric cancer and paracancerous tissues to determine PDK expression and its prognostic significance. 5-Ethynyl-2′-deoxyuridine (EdU) incorporation assay and Transwell migration assay were used to investigate the effects of PDK inhibition on gastric cancer cell proliferation and migration. …”
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995
The transcription factor SOX18 regulates the expression of matrix metalloproteinase 7 and guidance molecules in human endothelial cells.
Published 2012-01-01“…Knock-down of SOX18 using RNA interference was then used to confirm the effect of the transcription factor on selected genes that included the guidance molecules ephrin B2 and semaphorin 3G. …”
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996
Serum LncRNAs Profiles Serve as Novel Potential Biomarkers for the Diagnosis of HBV-Positive Hepatocellular Carcinoma.
Published 2015-01-01“…<h4>Methods</h4>lncRNA microarrays were utilized to measure the differential expression of lncRNAs between tumor tissues and corresponding non-tumor tissues in HBV-positive hapatocellular carcinoma. uc001ncr and AX800134 were selected as candidate lncRNAs and detected in three independent cohorts containing a total of 684 participants (healthy individuals and chronic HBV patients and HBV-positive HCC patients) who were recruited between March 2011 and December 2012. …”
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997
Identification and analysis of genetic variations in pri-miRNAs expressed specifically or at a high level in sheep skeletal muscle.
Published 2015-01-01“…In this study, we used microarrays to detect 261 miRNAs that are expressed in sheep skeletal muscle. …”
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998
The Impact of Antenatal and Postnatal Factors on the Development of the Pulmonary Microvasculature in Preterm Infants
Published 2025-05-01“…<b>Methods</b>: The investigation analyzed 67 cases of preterm infants, whose lifespans ranged from 1 day to 149 days. After selecting the cases from the autopsy database, two lung tissue microarrays were created. …”
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999
The lncRNA H19/miR-766-3p/S1PR3 Axis Contributes to the Hyperproliferation of Keratinocytes and Skin Inflammation in Psoriasis via the AKT/mTOR Pathway
Published 2021-01-01“…Methods. miRNA and lncRNA microarrays were performed using IL-22-induced HaCaT cells and psoriatic lesions, respectively. …”
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1000
Advanced strategies for screening and identifying RNA-targeted small molecules: Bridging therapeutic potential and innovation
Published 2025-05-01“…However, their dynamic nature and structural complexity have historically posed challenges in developing small molecules with high affinity and selectivity. In recent years, significant advancements in screening methodologies, such as high-throughput screening (HTS), small molecule microarrays (SMMs), and DNA-encoded libraries (DELs), have facilitated the identification of RNA-binding small molecules with enhanced specificity. …”
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