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521
Amogel: a multi-omics classification framework using associative graph neural networks with prior knowledge for biomarker identification
Published 2025-03-01“…Abstract The advent of high-throughput sequencing technologies, such as DNA microarray and DNA sequencing, has enabled effective analysis of cancer subtypes and targeted treatment. …”
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522
Differentially expressed miR-3680-5p is associated with parathyroid hormone regulation in peritoneal dialysis patients.
Published 2017-01-01“…Total RNA from 15 patients (7 and 8 patients in the low and high iPTH groups, respectively) underwent miRNA microarray analysis, and three differentially upregulated (>2-fold change) miRNAs previously associated with human disease were selected for real-time quantitative PCR (qPCR) analysis. …”
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523
FGFR3-TACC3 fusion gene promotes glioblastoma malignant progression through the activation of STAT3 signaling pathway
Published 2025-04-01“…A series of phenotypic experiments, including CCK-8, EdU, colony-formation assay, wound healing assay, and transwell assay were conducted to detect the effects of F3-T3 on proliferation, invasion, and migration of glioma cells. …”
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524
TRIM22 promotes glioblastoma development by ubiquitinating Bcl-2
Published 2025-12-01“…A TRIM22-overexpressing ubiquitination microarray identified TRIM22 as a potential activator of Bcl-2. …”
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525
Predictive and prognostic significance of loss of heterozygosity in ABC transporter genes in breast cancer
Published 2022-11-01“…Material and methods. a total of 130 breast cancer patients were included in the study. microarray analysis was performed on Affymetrix Cytoscantm HD Array high-density DNA chips to assess LOH status. …”
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526
FAM111B knockdown attenuates tumorigenesis of ovarian cancer via the downregulation of MYC
Published 2025-08-01“…Immunohistochemical analyses conducted on tissue-microarray samples obtained from patients with serous ovarian cancer indicated that elevated levels of FAM111B expression were associated with unfavorable prognostic outcomes. …”
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527
Global challenges and solutions to achieving and sustaining measles and rubella elimination
Published 2024-12-01“…Progress will be supported through technological innovations such as microarray patch vaccines. Whether this holistic approach will be more effective than vertical initiatives at achieving measles and rubella elimination remains to be seen. …”
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528
Investigation on the Electron Emission Regularity of Sputtered Boron Nitride Thin Films and Microstructured Array Surfaces
Published 2025-03-01“…The results of laser etching on the BN bulk surface to form microarray structures show that the EEC of BN bulk decreases significantly with the increase of the average aspect ratio of the microstructures. …”
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529
Poly-β-D-(1,6)-N-acetyl-glucosamine (PNAG) glycan vaccines with broad spectrum neutralizing activities
Published 2025-07-01“…Glycan microarray analysis shows that dPNAG glycans with DP8 and DP12 are optimal, with corresponding protein conjugates eliciting the highest IgG titers. …”
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530
Genetic testing for oral clefts: reflections based on a single Brazilian public genetics service
Published 2025-08-01“…They also show the need to improve public health policies for genetic evaluation, diagnostic tests, and genetic counseling for an effective NPCCPRD.…”
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531
Identification of Novel Molecular Panel as Potential Biomarkers of PAN-Gastrointestinal Cancer Screening: Bioinformatics and Experimental Analysis
Published 2025-07-01“…In the present study, using integrated transcriptomics, RNA-Seq and microarray data, from the TCGA and GEO databases, respectively, were combined to discover and validate a global biomarker panel for PAN-gastrointestinal cancers. …”
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532
Metformin inhibits high glucose‐induced apoptosis of renal podocyte through regulating miR‐34a/SIRT1 axis
Published 2024-01-01“…A conditionally immortalized human podocyte cell line was cultivated in d‐glucose (30 mM). Results Microarray and RT‐qPCR revealed that miR‐34a was downregulated in HG‐treated podocytes. …”
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533
Prenatal Diagnosis of Fetal Visceral Situs Abnormalities: A Retrospective Study
Published 2025-07-01“…Moreover, for fetuses diagnosed with visceral situs abnormalities and pregnant women with normal chromosomal results, WES remains essential to improve the detection rates of PCD or other genetic abnormalities.…”
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534
Potential role of SLC6A3 in neurodevelopmental impairments associated with corpus callosum abnormalities: insights from CNV analysis and clinical phenotyping
Published 2025-08-01“…Methods From January 2021 to July 2023, 13 children with MRI-confirmed CCAs underwent chromosomal microarray analysis (CMA) for CNV detection. We performed bioinformatic analyses (Gene Ontology, STRING network) to identify neurodevelopmental genes within pathogenic CNVs, and clinical follow up assessed neurobehavioral outcomes. …”
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535
Identification of PECAM1 as a Prognostic Biomarker for Lung Adenocarcinoma
Published 2025-04-01“…<b>Methods</b>: We examined three microarray datasets from the Gene Expression Omnibus (GSE10072, GSE33356, and GSE18842) to detect DEGs between tumor and normal lung tissues. …”
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536
Long-read genome sequencing resolves complex genomic rearrangements in rare genetic syndromes
Published 2024-12-01“…Abstract Long-read sequencing can often overcome the deficiencies in routine microarray or short-read technologies in detecting complex genomic rearrangements. …”
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537
The Necessity of Prenatal Diagnosis by CMA for the Women with NIPS-Positive Results
Published 2020-01-01“…Single nucleotide polymorphism array testing was performed on a commercial 750K microarray chip (Affymetrix CytoScan 750K Array). Results. …”
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538
VEGF Contributes to Mesenchymal Stem Cell-Mediated Reversion of Nor1-Dependent Hypertrophy in iPS Cell-Derived Cardiomyocytes
Published 2021-01-01“…Phenylephrine (PE) was used to induce hypertrophy in murine iPS-CM, and markers of hypertrophy were identified by microarray analysis. Murine MSCs were treated with IFN-γ and IL-1β to enhance their paracrine activity, and transcriptional profiling was performed by microarray analysis. …”
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539
Exploration of the shared gene signatures and comorbidity mechanisms of primary aldosteronism and atrial fibrillation
Published 2024-12-01“…These hub genes were subsequently validated via two independent external datasets: GSE60042 (PA microarray dataset) and GSE41177 (AF microarray dataset). …”
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540
Downregulation of sorting nexin 10 is associated with overexpression of miR-30d during liver cancer progression in rats
Published 2017-04-01“…The identification of molecules that might be molecular markers or therapeutic targets is urgently needed to improve clinical management. Based on a microarray analysis performed in our laboratory, we selected six genes—namely, ANXA2, DYNLT1, PFKP, PLA2G7, KRT19 , and SNX10 —as candidates for validation as tumor markers of liver cancer in a rat model. …”
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