PD-L1 quantification across tumor types using the reverse phase protein microarray: implications for precision medicine by Mariaelena Pierobon, Johann De Bono, Ruth Riisnaes, Giuseppe Giaccone, Matthew Blackburn, Lance Liotta, Vienna Ludovini, Neil J Shah, Giuseppina Improta, Antonella Ravaggi, Niven Mehra, Angelo Sidoni, Elisa Baldelli, K Alex Hodge, Guido Bellezza, Guido Gambara, Martina Mandarano, Chamodya Ruhunusiri, Bryant Dunetz, Maysa Abu-Khalaf, Julia Wulfkuhle, Rosa I Gallagher, Franco Odicino, Maria Isabella Sereni, Angela Zupa, Perry Demsko, Lucio Crino', Emanuel F Petricoin

“…Using a high throughput immunoassay, the reverse phase protein microarray (RPPA), coupled with a fluorescence-based detection system, this study compared the performance of six anti-PD-L1 antibody clones on 666 tumor samples.Methods PD-L1 expression was measured using five antibody clones (22C3, 28–8, CAL10, E1L3N and SP142) and the therapeutic antibody atezolizumab on 222 lung, 71 ovarian, 52 prostate and 267 breast cancers, and 54 metastatic lesions. …”
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Substantia nigra and blood gene signatures and biomarkers for Parkinson’s disease from integrated multicenter microarray-based transcriptomic analyses by Hui-Hui Fan, Na-Na Hou, Na-Na Hou, Dao-Lu Zhang, Dan-Ni Liu, Rong-Ting Tang, Hai-Tao Luo, Ya-Dan Song, Lei Cui, Xiong Zhang, Jian-Hong Zhu, Jian-Hong Zhu

“…PD diagnosis depends on clinical manifestation of symptoms but is lack of effective biomarker.MethodsAvailable human microarray-based transcriptomic datasets of the substantia nigra and blood were acquired for PD cases and controls. …”
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Critical evaluation of the reliability of DNA methylation probes on the Illumina MethylationEPIC v1.0 BeadChip microarrays by Wei Zhang, Juan I. Young, Lissette Gomez, Michael A. Schmidt, David Lukacsovich, Achintya Varma, X. Steven Chen, Brian Kunkle, Eden R. Martin, Lily Wang

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Local Mean Normalization of Microarray Element Signal Intensities across an Array Surface: Quality Control and Correction of Spatially Systematic Artifacts by Carlo Colantuoni, George Henry, Scott Zeger, Jonathan Pevsne

“…Here we present a methodology for the normalization of element signal intensities to a mean intensity calculated locally across the surface of a DNA microarray. These methods allow the detection and/or correction of spatially systematic artifacts in microarray data. …”
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CD14 and complement crosstalk and largely mediate the transcriptional response to Escherichia coli in human whole blood as revealed by DNA microarray. by Corinna Lau, Ståle Nygård, Hilde Fure, Ole Kristoffer Olstad, Marit Holden, Knut Tore Lappegård, Ole-Lars Brekke, Terje Espevik, Eivind Hovig, Tom Eirik Mollnes

“…Combined inhibition of a key complement component (C3 and C5) and TLR-co-receptor CD14 has been shown to attenuate certain systemic inflammatory responses. Using DNA microarray and gene annotation analyses, we aimed to decipher the effect of combined inhibition of C3 and CD14 on the transcriptional response to bacterial challenge in human whole blood. …”
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Mapping quantitative trait loci regions associated with Marek’s disease on chicken autosomes by means of selective DNA pooling by Ehud Lipkin, Jacqueline Smith, Morris Soller, David W. Burt, Janet E. Fulton

“…Distribution of P and LD values were used to assess the QTLR causative elements. Allele substitution effects were calculated based on both pooled SNP microarray genotypes, and individual genotypes of QTLRs markers. …”
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Multiplex peptide microarray profiling of antibody reactivity against neglected tropical diseases derived B-cell epitopes for serodiagnosis in Zimbabwe. by Arthur Vengesai, Thajasvarie Naicker, Herald Midzi, Maritha Kasambala, Tariro L Mduluza-Jokonya, Simbarashe Rusakaniko, Francisca Mutapi, Takafira Mduluza

“…In this framework, we present a pilot study to design and produce a peptide microarray for the integrated surveillance of neglected tropical diseases. …”
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Microarray-Based Comparisons of Ion Channel Expression Patterns: Human Keratinocytes to Reprogrammed hiPSCs to Differentiated Neuronal and Cardiac Progeny by Leonhard Linta, Marianne Stockmann, Qiong Lin, André Lechel, Christian Proepper, Tobias M. Boeckers, Alexander Kleger, Stefan Liebau

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Microarray analysis of LTR retrotransposon silencing identifies Hdac1 as a regulator of retrotransposon expression in mouse embryonic stem cells. by Judith Reichmann, James H Crichton, Monika J Madej, Mary Taggart, Philippe Gautier, Jose Luis Garcia-Perez, Richard R Meehan, Ian R Adams

“…Here we show, and experimentally verify, that cryptic repetitive element probes present in Illumina and Affymetrix gene expression microarray platforms can accurately and sensitively monitor repetitive element expression data. …”
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Prenatal diagnosis and molecular cytogenetic analysis of pure chromosome 10p15.3 microdeletion using chromosomal microarray analysis by Na Zhang, Nan Huang, Yu’e Chen, Xinying Chen, Jianlong Zhuang

“…Karyotyping and chromosomal microarray analysis (CMA) was conducted to assess chromosomal abnormalities and detect copy number variations (CNVs) within the families, respectively. …”
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A microarray assessment of the modulation of human oxidative stress gene expression by rooibos and honeybush tea extracts in UVB-irradiated keratinocytes by Lana Keet, Nashia Deepnarain, Danicke Willemse, Stefan Abel, Ann Louw, Mariska Lilly

“…Microarray was used to investigate the expression of 84 oxidative stress response genes in response to rooibos and honeybush tea extracts and the effect of pre-exposure to extracts prior to UVB exposure was assessed. …”
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Microarray Analysis of Visceral Adipose Tissue in Obese Women Reveals Common Crossroads Among Inflammation, Metabolism, Addictive Behaviors, and Cancer by Rolando Martínez-Romero, Susana Aideé González-Chávez, Victor Roberto Urías-Rubí, Víctor Manuel Gómez-Moreno, Manlio Favio Blanco-Cantero, Héctor Mario Bernal-Velázquez, Arturo Luévano-González, César Pacheco-Tena

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A Comparative Analysis of the Roles of von Willebrand Factor and ADAMTS13 in Hepatocellular Carcinoma: A Bioinformatics and Microarray-Based Study by Durmuş Ayan, Şerife Buket Bozkurt Polat, Ergül Bayram, Esma Özmen, Fatma Esin Aydın, Serpil Ersan

“…In this study, we aimed to investigate the effects of von Willebrand factor (VWF) and <i>ADAMTS13</i> on HCC prognosis, using bioinformatics tools. …”
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A systems approach to prion disease by Daehee Hwang, Inyoul Y Lee, Hyuntae Yoo, Nils Gehlenborg, Ji‐Hoon Cho, Brianne Petritis, David Baxter, Rose Pitstick, Rebecca Young, Doug Spicer, Nathan D Price, John G Hohmann, Stephen J DeArmond, George A Carlson, Leroy E Hood

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Mechanism and relevance of necroptosis to immune microenvironment of periodontitis: A pilot study by ZHENG Zhanglong, LI Jia, JIANG Jirui, SHAN Zhengnan, LI Shengjiao

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Genome Array on Differentially Expressed Genes of Skin Tissue in Cashmere Goat at Early Anagen of Cashmere Growth Cycle Using DNA Microarray by Jiang DI, Xin-ming XU, Lazate Ainiwaer, Yan-hua ZHANG, Ke-chuan TIAN, Li-juan YU, Wei-wei WU, Hanikezi Tulafu, Xue-feng FU, Marzeya Yasen

“…Approximately 10 200 probe sets were detected in skin tissue of 2-yr-old cashmere goat. …”
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Interdigitated Microarray Electrodes Based on Boron-doped Amorphous Carbon for Highly Sensitive Electroanalysis of Redox Analytes Having a Higher Standard Potential by Kensuke HONDA, Shinpei OHTOMO

“…Interdigitated microarray electrodes were developed based on boron-doped amorphous carbon (B-a-C-IDA) that shows extremely higher overpotential for H2 and O2 evolution. …”
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Candidate Anxiety‐Related Genes in the Hippocampus of Hatano Male Rats: Anxiolytic Action of Neuromedin U in the Hippocampus by Kaito Sato, Atsuhiro Ishii, Shohei Kobayashi, Taichi Hatakeyama, Gen Watanabe, Tomoko Soga, Ishwar Parhar, Takashi Matsuwaki, Shogo Moriya, Ryo Ohta, Shuichi Chiba, Maiko Kawaguchi

“…The present study focuses on the hippocampus, which is associated with anxiety‐like behavior, and used microarray analysis and RT‐qPCR to select genes with differential expression in the hippocampus between HAA and LAA (Experiment 1). …”
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Sequential transcriptome profiling: comparative analysis of normal and canine lymphoma preceding detailed T-cell and B-cell subtype comparison by Yeji Kim, Yeji Kim, Jihyun Kim, Jihyun Kim, Yunji Song, Yunji Song, Keunhwan Jang, Se Eun Kim, Se Eun Kim, Se Eun Kim, Ha-Jung Kim, Ha-Jung Kim

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Prenatal diagnosis and genetic assessment of fetuses with single umbilical artery using chromosomal microarray analysis: a seven-year single-center retrospective study by Jianlong Zhuang, Nan Huang, Yu’e Chen, Jialing Wu, Xiaofang Ye, Chunnuan Chen

“…Amniocentesis was carried out in all affected cases, with samples analyzed via conventional karyotyping and chromosomal microarray analysis (CMA) to detect any chromosomal abnormalities. …”
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