Cyr61 Mediates Angiotensin II-Induced Podocyte Apoptosis via the Upregulation of TXNIP by Jingxue Ma, Ruiying Ma, Xiaoyue Zhao, Yingxiu Wang, Shengxue Liao, Cong Nong, Fengling Lu, Zhao Liang, Junhui Huang, Yan Huang, Zhengxi Zhu, Junjie Wang

“…Gene microarray was used to analyze the expression of mRNAs after treatment with Ang II. …”
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Metastatic melanoma: An integrated analysis to identify critical regulators associated with prognosis, pathogenesis and targeted therapies. by Zeinab Chaharlashkar, Yousof Saeedi Honar, Meghdad Abdollahpour-Alitappeh, Sepideh Parvizpour, Abolfazl Barzegar, Effat Alizadeh

“…Subsequently, the hub genes were selected using GEPIA. Survival analysis was performed using the TCGA. …”
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Prolonged application of high fluid shear to chondrocytes recapitulates gene expression profiles associated with osteoarthritis. by Fei Zhu, Pu Wang, Norman H Lee, Mary B Goldring, Konstantinos Konstantopoulos

“…Confirmation of the expression patterns of select genes was obtained by qRT-PCR. Using significance analysis of microarrays with a 5% false discovery rate, 71 and 60 non-redundant transcripts were identified to be ≥2-fold up-regulated and ≤0.6-fold down-regulated, respectively, in sheared chondrocytes. …”
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Early Regulation of Profibrotic Genes in Primary Human Cardiac Myocytes by Trypanosoma cruzi. by Aniekanabassi N Udoko, Candice A Johnson, Andrey Dykan, Girish Rachakonda, Fernando Villalta, Sammed N Mandape, Maria F Lima, Siddharth Pratap, Pius N Nde

“…The transcriptome microarray data, validated by quantitative Real-Time PCR, was also confirmed by immunoblotting and customized Enzyme Linked Immunosorbent Assays (ELISA) array showing significant increases in the protein expression levels of fibrogenic EGR1, SNAI1 and IL 6. …”
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Stroma regulates increased epithelial lateral cell adhesion in 3D culture: a role for actin/cadherin dynamics. by Karen F Chambers, Joanna F Pearson, Naveed Aziz, Peter O'Toole, David Garrod, Shona H Lang

“…The upregulated growth factors TGFβ2, CXCL12 and FGF10 were selected for further analysis because of previous associations with morphology. …”
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Identification of novel androgen-regulated pathways and mRNA isoforms through genome-wide exon-specific profiling of the LNCaP transcriptome. by Prabhakar Rajan, Caroline Dalgliesh, Phillippa J Carling, Thomas Buist, Chaolin Zhang, Sushma N Grellscheid, Kelly Armstrong, Jacqueline Stockley, Cedric Simillion, Luke Gaughan, Gabriela Kalna, Michael Q Zhang, Craig N Robson, Hing Y Leung, David J Elliott

“…Androgens drive the onset and progression of prostate cancer (PCa) by modulating androgen receptor (AR) transcriptional activity. Although several microarray-based studies have identified androgen-regulated genes, here we identify in-parallel global androgen-dependent changes in both gene and alternative mRNA isoform expression by exon-level analyses of the LNCaP transcriptome. …”
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Exploring the predictive values of SERP4 and FRZB in dilated cardiomyopathy based on an integrated analysis by Bin Qi, Hai-Yan Wang, Xiao Ma, Yu-Feng Chi, Chun Gui

“…Methods Five DCM-related microarray datasets were downloaded from the Gene Expression Omnibus (GEO). …”
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Interaction of Wnt Signaling with BMP/Smad Signaling during the Transition from Cell Proliferation to Myogenic Differentiation in Mouse Myoblast-Derived Cells by Kumiko Terada, Satomi Misao, Naoki Katase, Shin-ichiro Nishimatsu, Tsutomu Nohno

“…The BMP antagonist noggin effectively stimulated muscle differentiation through binding to endogenous BMPs, and the effect of noggin was enhanced by the presence of Wnt3a and Wnt4. …”
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Interleukin-27 is a potent inhibitor of cis HIV-1 replication in monocyte-derived dendritic cells via a type I interferon-independent pathway. by Qian Chen, Sanjay Swaminathan, De Yang, Lue Dai, Hongyan Sui, Jun Yang, Ronald L Hornung, Yanmei Wang, Da Wei Huang, Xiaojun Hu, Richard A Lempicki, Tomozumi Imamichi

“…Of note, other IL-12 family members (IL-12, IL-23 and IL-35) had no effect on HIV-1 replication. Microarray studies of IL-27 treated DCs showed no up-regulation of Type I (IFN) gene expression. …”
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Anti-Obesity Properties of <i>Boesenbergia rotunda</i> Rhizome Extract: Regulation of Inflammation, Lipid Metabolism, and Insulin Signaling in <i>ob/ob</i> Mice by Muhammad Hermawan Widyananda, Dinia Rizqi Dwijayanti, Airi Fujii, Keita Minamisaka, Yuto Nishidono, Mikio Nishizawa, Nashi Widodo

“…Next, we investigated the anti-obesity effects of BR extract in <i>ob/ob</i> mice, a type 2 diabetes mellitus model. …”
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γ-Synuclein antibodies have neuroprotective potential on neuroretinal cells via proteins of the mitochondrial apoptosis pathway. by Corina Wilding, Katharina Bell, Sabine Beck, Sebastian Funke, Norbert Pfeiffer, Franz H Grus

“…We found a protective effect of γ-synuclein antibody resulting in an increased viability (up to 15%) and decreased reactive oxygen species levels (up to -12%) of glutamate and oxidative stressed RGC-5. …”
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16S Ribosomal Ribonucleic Acid Gene Polymerase Chain Reaction in the Diagnosis of Bloodstream Infections: A Systematic Review and Meta-Analysis. by Guoming Su, Zhuqing Fu, Liren Hu, Yueying Wang, Zuguo Zhao, Weiqing Yang

“…Further prospective studies are needed to assess the diagnostic value of PCR amplification and DNA microarray hybridization of 16S rRNA gene in the future.…”
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Differential roles of ERα and ERβ in normal and neoplastic development in the mouse mammary gland. by Rajendra G Mehta, Michael Hawthorne, Rajeshwari R Mehta, Karen E O Torres, Xinjian Peng, David L McCormick, Levy Kopelovich

“…The data demonstrate distinct roles for ERα and ERβ in normal and neoplastic development in the mouse mammary gland, and suggest that EGF can mimic the ERα-mediated effects of E in this organ.…”
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Identification of Novel Biomarkers in Huntington’s Disease Based on Differential Gene Expression Meta-Analysis and Machine Learning Approach by Nayan Dash, Md Abul Bashar, Jeonghan Lee, Raju Dash

“…Therefore, to discover the key biomarkers associated with the progression of HD, we employed bioinformatics and machine learning (ML) to create a robust pipeline that integrated differentially expressed gene (DEG) analysis with ML to select potential biomarkers. We performed a meta-analysis to identify DEGs using three Gene Expression Omnibus (GEO) microarray datasets from different platforms related to HD-affected brain tissue, applying both relaxed and strict criteria to identify differentially expressed genes. …”
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Fish Collagen Promotes the Expression of Genes Related to Osteoblastic Activity by Mark Luigi Fabian Capati, Ayako Nakazono, Kohei Yamamoto, Kouji Sugimoto, Kajiro Yanagiguchi, Shizuka Yamada, Yoshihiko Hayashi

“…The aim of this study was to confirm the biological effects of TAC in vitro on osteoblastic cells, simulating its clinical application. …”
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The Olive Oil Monophenolic Secoiridoid Ligstroside Aglycone Suppresses Melanoma Progression by Targeting the BRAF Signaling Pathway by Md Ashiq Mahmud, Abu Bakar Siddique, Afsana Tajmim, Judy Ann King, Khalid A. El Sayed

“…A human Clariom S microarray analysis of the collected Malme- 3M tumors identified 571 dysregulated genes, with the downregulation of pathways critical for melanoma cells growth and survival. …”
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Specific Inflammatory Stimuli Lead to Distinct Platelet Responses in Mice and Humans. by Lea M Beaulieu, Lauren Clancy, Kahraman Tanriverdi, Emelia J Benjamin, Carolyn D Kramer, Ellen O Weinberg, Xianbao He, Samrawit Mekasha, Eric Mick, Robin R Ingalls, Caroline A Genco, Jane E Freedman

“…The goal of our study was to compare the differential effects of specific stimuli--two bacterial infections and a Western diet--on platelet responses in ApoE-/- mice, specifically examining inflammatory function and gene expression. …”
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Myo‐inositol oxygenase (MIOX) accelerated inflammation in the model of infection‐induced cardiac dysfunction by NLRP3 inflammasome by Wenjun Zhou, Congyi Yu, Yiwen Long

“…Quantitative analysis of messenger RNAs (mRNAs) and gene microarray hybridization was used to analyze the mRNA expression levels. …”
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Implications of CYP1B1 in the treatment and prognosis of breast cancer by Maria Carolina Stipp, Jeanine Marie Nardin, José Claudio Casali-da-Rocha, Sérgio Ioshii, Alexandra Acco

“…The aim of the present study was to identify the expression and role of this enzyme in progression, prognosis, and clinical features of breast cancer patients. Methods Microarray paraffin-embedded tumor samples from 166 women with breast cancer were analyzed by immunohistochemical for CYP1B1. …”
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Construction of a macrophage-related prognostic signature and assessment of immune checkpoint inhibitor efficacy of HCC by Shouge Zang, Hongwei Chen, Yuqian Han, Di Cui, Jiangtao Yu

“…Tissue microarray immunofluorescence validated PLAUR expression in situ. …”
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