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  1. 81

    Chinese Massage (Tuina) Attenuates Knee Osteoarthritis by Modulating Autophagy-Related Cytokines: A Multidisciplinary Methodological Investigation by Wang Z, Zhao C, Li M, Zhang L, Diao J, Wu Y, Yang T, Shi M, Lei Y, Wang Y, Li M, Bian Y, Zhou Y, Xu H

    Published 2025-08-01
    “…Zhen Wang,1,* Chi Zhao,1,2,* Mengmeng Li,1,2,* Lili Zhang,1,* Jieyao Diao,1 Yiming Wu,2 Tao Yang,2 Mingwei Shi,2 Yang Lei,2 Yu Wang,3 Miaoxiu Li,4 Yanqin Bian,5 Yunfeng Zhou,1 Hui Xu1,2 1College of Acupuncture and Massage, Henan University of Chinese Medicine, Zhengzhou, People’s Republic of China; 2Acupuncture and Massage Department, The Third Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, People’s Republic of China; 3College of Computer Science, Xidian University, Xian, People’s Republic of China; 4College of Acupuncture and Massage, Shanghai University of Chinese Medicine, Shanghai, People’s Republic of China; 5Orthopaedic Research Laboratory, University of California, Davis, CA, USA*These authors contributed equally to this workCorrespondence: Hui Xu, Email 15036065036@163.comBackground: Tuina therapy has demonstrated its potential in modulating autophagy-related factors in knee osteoarthritis (KOA); however, its core therapeutic targets and specific mechanisms require systematic elucidation through interdisciplinary research.Objective: This study investigated the mechanism by which Tuina alleviates KOA progression using multidimensional approaches, including Mendelian randomization (MR), in vivo experiments, and machine learning.Methods: Genetic data from genome-wide association studies of 60 cytokines and KOA were analyzed using MR analysis to identify autophagy-related factors significantly associated with KOA. …”
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    The protocol for a multicentre prospective randomized noninferiority trial of surgical reduction versus non-surgical casting for displaced distal radius fractures in children: Chil... by Daniel C. Perry, Juul Achten, James Mason, Daphne Kounail, Nicolas Nicolaou, David Metcalfe, Mark Lyttle, Elizabeth Tutton, Duncan Appelbe, Phoebe Gibson, Matthew L. Costa

    Published 2025-05-01
    “…The primary outcome is the PROMIS Upper Extremity Score at three months post-randomization. All data will be obtained through electronic questionnaires completed by the participants and/or parents/guardians. …”
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