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401
A regulatory mutant on TRIM26 conferring the risk of nasopharyngeal carcinoma by inducing low immune response
Published 2018-08-01“…Significance analysis of microarray suggested that TRIM26 downregulation was related to low immune response in NPC. …”
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402
Analysis of Result Variability from High-Density Oligonucleotide Arrays Comparing Same-Species and Cross-Species Hybridizations
Published 2002-09-01“…There exists a significant limitation in the variety of organisms for which microarrays have been developed because of a lack of genomic sequence data. …”
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403
FGFR3-TACC3 fusion gene promotes glioblastoma malignant progression through the activation of STAT3 signaling pathway
Published 2025-04-01“…A series of phenotypic experiments, including CCK-8, EdU, colony-formation assay, wound healing assay, and transwell assay were conducted to detect the effects of F3-T3 on proliferation, invasion, and migration of glioma cells. …”
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404
MicroRNAs as novel biomarkers for prenatal fetal congenital heart disease – systematic literature review
Published 2025-07-01“…The included studies utilized advanced technologies, such as next-generation sequencing (e.g., Illumina HiSeq, NovaSeq) and microarrays, for discovery-phase experiments, while validation predominantly employed qRT-PCR techniques. …”
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405
Value of Optical Genome Mapping (OGM) for Diagnostics of Rare Diseases: A Family Case Report
Published 2025-03-01“…Optical genome mapping (OGM) is a novel method enabling the detection of structural genomic variants. The method is based on the laser image acquisition of single, labeled, high-molecular-weight DNA molecules and can detect structural genomic variants such as translocations, inversions, insertions, deletions, duplications, and complex structural rearrangements. …”
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406
Novel genotyping algorithms for rare variants significantly improve the accuracy of Applied Biosystems™ Axiom™ array genotyping calls: Retrospective evaluation of UK Biobank array...
Published 2022-01-01“…The UK Biobank genotyped about 500k participants using Applied Biosystems Axiom microarrays. Participants were subsequently sequenced by the UK Biobank Exome Sequencing Consortium. …”
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407
Novel Hypomorphic Mutation in FANCD2 Gene Observed in a Fetus with Multiple Congenital Anomalies
Published 2016-01-01“…The case illustrates that patients/families affected by rare monogenic disorders may benefit from application of modern technologies like microarrays and NGS.…”
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408
Effect of PM2.5 exposure on susceptibility to allergic asthma in elderly rats treated with allergens
Published 2025-02-01“…Ten metabolites and 11 metabolic pathways were uniquely detected in OVA-treated rats before PM2.5 exposure. …”
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409
Microsatellite Instability and Loss of Heterozygosity in CCND1 Microsatellite loci at Chr.11q13 in OSCC Patients with Therapeutic Validation
Published 2024-07-01“…Molecular laboratory techniques like microarrays, microsatellites, and single-nucleotide polymorphisms (SNPs) have created new opportunities for diagnosing diseases, identifying chromosomal aberrations, and detecting point mutations for medical verification. …”
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410
MMP14 and DDR2 are potential molecular markers for metastatic triple-negative breast cancer
Published 2025-07-01“…Here, we utilized TNBC tissue microarrays to determine the protein expression of seven matrix metalloproteinases (MMPs) and Discoidin domain receptor 2 (DDR2) in metastatic and non-metastatic TNBC to identify potential targets for immunotherapy. …”
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411
Evaluation of the diagnostic concordance of FDA-approved PD-L1 assays in clear cell renal cell carcinoma
Published 2025-07-01“…In this study, we constructed tissue microarrays from 286 clear cell renal cell carcinoma (ccRCC) tissue samples and evaluated PD-L1 expression using the 22C3, 28 − 8, SP142, and SP263 PD-L1 assays. …”
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412
HERV activation segregates ME/CFS from fibromyalgia while defining a novel nosologic entity
Published 2025-05-01“…By using HERV-V3 high-density microarrays (including over 350k HERV elements and more than 1500 immune-related genes) to interrogate the transcriptomes of peripheral blood mononuclear cells from female patients diagnosed with ME/CFS, FM, or both, and matched healthy controls (n = 43), this study fills this gap of knowledge. …”
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413
A Narrative Review of Molecular, Immunohistochemical and In-Situ Techniques in Dermatopathology
Published 2024-12-01“…Gene expression profiling techniques, such as microarrays and RNA sequencing, have provided insights into dysregulated pathways and molecular signatures associated with conditions ranging from inflammatory skin disorders to cutaneous malignancies. …”
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414
Survivin Expression in Placentas with Intrauterine Growth Restriction
Published 2025-06-01“…<b>Methods</b>: Survivin presence was determined in 153 archival formalin-fixed and paraffin-embedded placental tissues from IUGR (N = 122) and uncomplicated (N = 31) term pregnancies. Tissue microarrays (TMAs) were constructed, and survivin expression was assessed using immunohistochemistry (IHC). …”
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415
Multi-institutional TSA-amplified Multiplexed Immunofluorescence Reproducibility Evaluation (MITRE) Study
Published 2021-07-01“…Serial sections from tonsil and breast carcinoma and non-small cell lung cancer (NSCLC) tissue microarrays (TMAs), TSA-Opal fluorescent detection reagents, and antibodies were distributed to the six sites equipped with a Leica Bond Rx autostainer and a Vectra Polaris multispectral imaging platform. …”
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416
Effects of tumour-associated macrophages on cardia carcinoma progression
Published 2025-07-01“…The THP-1 monocyte cell line was used to induce differentiation into M2-type TAMs, co-cultured with gastric cancer cell lines AGS and MKN-45, and the effect of TAMs on the invasive ability of gastric cancer cells was detected by Transwell assay. Western blotting was used to detect the expression of matrix metalloproteinase-2 (MMP-2) and its inhibitor tissue inhibitor of metalloproteinase-3 (TIMP-3) in the microarrayed tissues. …”
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417
Applicability of epigenetic age models to next-generation methylation arrays
Published 2024-10-01“…As new methylation microarrays are developed and older models discontinued, existing epigenetic clocks might become obsolete. …”
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418
The Maestro (Mro) gene is dispensable for normal sexual development and fertility in mice.
Published 2008-01-01“…We have previously used DNA microarrays to screen for novel genes controlling the developmental fate of the indifferent embryonic mouse gonad. …”
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419
Hsa_circ_0000423 promotes colorectal cancer EMT and immune escape by competitive adsorption of miR-369-3p mediating CCND1 expression
Published 2024-11-01“…Cell proliferation was measured by MTT and colony formation assay assays, apoptosis was detected by flow cytometry, migration and invasion were detected by Transwell, and expression of EMT-related proteins was detected by Western Blot. …”
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420
Diagnosing Autoimmune Bullous Diseases—An Indian Perspective
Published 2025-05-01“…It uses microarrays with multiple antigenic substrates to simultaneously screen common AIBDs. …”
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