ARHGAP42 promotes cell migration and invasion involving PI3K/Akt signaling pathway in nasopharyngeal carcinoma by Qian Hu, Xiao Lin, Linxiaoxiao Ding, Yinduo Zeng, Danmei Pang, Nengtai Ouyang, Yanqun Xiang, Herui Yao

“…Western blot and immunohistochemical staining were used for detecting the expression of ARHGAP42 protein in nasopharyngeal carcinoma tissues and cell lines. …”
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Integrated analysis of genomic and transcriptomic profiles identified a prognostic immunohistochemistry panel for esophageal squamous cell cancer by Yue Yu, Zhihua Li, Chenjun Huang, Haisheng Fang, Fei Zhao, Yue Zhou, Xianglong Pan, Qifan Li, Yu Zhuang, Liang Chen, Jing Xu, Wei Wang

“…Results Three genes were selected, namely, ANO1, GAL, and MMP3, which were aberrantly expressed in ESCC tumor tissues (P < .001). …”
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Transcriptomic Signatures of Antibody-mediated Rejection in Early Biopsies With Negative Histology in HLA-incompatible Kidney Transplantation by Petra Hruba, PhD, Jiri Klema, PhD, Petra Mrazova, PhD, Eva Girmanova, PhD, Katerina Jaklova, MS, Ludek Voska, MD, Martin Kment, MD, Martina Mackova, PhD, Klara Osickova, MD, Vladimir Hanzal, MD, Philip F. Halloran, MD, PhD, Ondrej Viklicky, MD, PhD

“…RNA sequencing from biopsies selected from the biobank was used in cohort 1 (n = 32) and microarray, including the molecular microscope (Molecular Microscope Diagnostic System [MMDx]) algorithm, in recent cohort 2 (n = 30). …”
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Expression and prognostic significance of MLH1 and GPRC5C in resectable hepatocellular carcinoma by Jun Lu, Lei Li, Qing Chen, Bingqi Li, Siqian Ren, Meng Yuan, Meng Meng, Jian Lei, Yuntao Bing, Hangyan Wang, Zhaolai Ma, Dianrong Xiu, Chunhui Yuan

“…However, their expression and prognostic significance in hepatocellular carcinoma (HCC) has not been elucidated, especially for GPRC5C. Methods We detected MLH1 and GPRC5C expression using the tissue microarray-based immunohistochemical staining in tumor and matched adjacent non-tumor liver (ANL) specimens from 230 patients who underwent radical resection for HCC. …”
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Overexpression of cyclin‐dependent kinase 1 in esophageal squamous cell carcinoma and its clinical significance by Han‐Jie Zhang, Gang Chen, Shang‐Wei Chen, Zong‐Wang Fu, Hua‐Fu Zhou, Zhen‐Bo Feng, Jun‐Xian Mo, Chang‐Bo Li, Jun Liu

“…Microarray and external RNA‐seq data from 664 cases of ESCC and 1733 cases of control tissues were used to verify the difference in CDK1 expression between the two groups. …”
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Maternal plasma cell-free DNA nucleosome footprints can reveal changes in gene expression profiles during pregnancy and pre-eclampsia by Kun Li, Zhiwei Guo, Fenxia Li, Shijing Lu, Min Zhang, Xingyu Wei, Chao Sheng, Wenbo Hao, Xuexi Yang

“…These results are consistent with prior microarray and RNA-sequencing data. Conclusions The depth of the cfDNA nucleosome footprint in maternal plasma can be used to reflect changes in the gene expression profile during pregnancy and pre-eclampsia. …”
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CircATP5C1 promotes triple-negative breast cancer progression by binding IGF2BP2 to modulate CSF-1 secretion by Hongbo Liu, Haoqi Wang, Wei Gao, Yang Yuan, Tiantian Tang, Meixiang Sang, Fei Liu, Cuizhi Geng

“…We found a novel circRNA named circATP5C1, whose function in TNBC remains uncovered. Tissue microarray was used to analyze the association between the expression of circATP5C1 and the prognoses of TNBC patients. …”
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Identifying 4 Novel lncRNAs as Potential Biomarkers for Acute Rejection and Graft Loss of Renal Allograft by Zedan Zhang, Yanlin Tang, Hongkai Zhuang, Enyu Lin, Lu Xie, Xiaoqiang Feng, Jiayi Zeng, Yanjun Liu, Jiumin Liu, Yuming Yu

“…Then, 4 optimal DElncRNAs, ATP1A1-AS1, CTD-3080P12.3, EMX2OS, and LINC00645, were selected from 17 prognostic DElncRNAs to establish the 4-lncRNA risk score model. …”
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Establishment and Genetic Profiling of Platinum/Taxane Doublet-Resistant Cells Generated by Hybridizing Single Resistant Cells by Seiji Isonishi, Rika Saito, Noriko Yamaguchi, Saburo Saito

“…The resistant cells were selected through repeated exposure to cisplatin and paclitaxel. …”
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Mechanism of immune escape mediated by receptor tyrosine kinase KIT in thyroid cancer by Zhen Luo, Jin Xu, Dayong Xu, Jiaojiao Xu, Rongjun Zhou, Keping Deng, Zheng Chen, Fang Zou, Libo Yao, Yuqin Hu

“…Methods The expression microarray of TC was acquired through the GEO database, and the difference analysis and Kyoto encyclopedia of genes and genomes pathway enrichment analysis were carried out. …”
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Linking oxysterols and different stages of mild cognitive impairment: insights from gut metabolites and N6-methyladenosine by Wenjing Feng, Mengwei Ju, Tao Wang, Shanshan Cui, Kexin Yang, Zhiting Guo, Miao Liu, Jiaxuan Tao, Huiyan Yu, Rong Xiao

“…Methods Liquid chromatography-mass spectrometry, untargeted metabolomic analysis, and m6A mRNA Epitranscriptomic Microarray were used to detect the characteristics of serum oxysterols (n = 35/group), fecal gut metabolites (n = 30/group), and m6A in whole blood (n = 4/group) respectively. …”
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Cystatin B Promotes the Proliferation, Migration, and Invasion of Intrahepatic Cholangiocarcinoma by Dai Zhang, Bao-Ye Sun, Jing-Fang Wu, Zhu-Tao Wang, Su-Su Zheng, Guo-Qiang Sun, Xu-Kang Gao, Jian Zhou, Jia Fan, Bo Hu, Shuang-Jian Qiu, Bo-Heng Zhang

“…The clinical significance of CSTB was analyzed through immunohistochemical staining of a tissue microarray. Subsequently, the biological effects of CSTB overexpression or knockdown on iCCA cells were evaluated in vitro and in vivo. …”
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Associations between pathophysiological traits and symptom development in retrospective analysis of V30M and V122I transthyretin amyloidosis by Sameer U. Kini, Ha My Thi Vy, Madhav Subramanian, Parasuram M. Krishnamoorthy, Son Q. Duong, Ghislain Rocheleau, Jagat Narula, Ron Do, Girish N. Nadkarni

“…This retrospective analysis of microarray and biobank data helped establish clinical biomarkers for early hATTR detection. …”
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Radiation suppresses liver metastases via exosome secretion in pancreatic cancer cells by Ai Nakaoka, Mohammed Salah, Zhangzhu Ruixian, Makiko Nakahana, Yasuyuki Shimizu, Qin Qin, Qu Zhang, Naritoshi Mukumoto, Kana Kobayashi, Yukihiro Ikegaki, Hiroaki Akasaka, Sachiko Inubushi, Yu-ichiro Koma, Takeaki Ishihara, Daisuke Miyawaki, Takashi Sasayama, Ryohei Sasaki

“…Additionally, IR-Exos prevented liver metastasis induced by MIAPaCa-2 cells in vivo We detected 2,565 miRNAs in exosomes in a microarray. …”
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Impact of B7-H3 expression on metastasis, immune exhaustion and JAK/STAT and PI3K/AKT pathways in clear cell renal cell carcinoma by Maite Emaldi, Esther Rey-Iborra, Ángela Marín, Lorena Mosteiro, David Lecumberri, Tove Øyjord, Noémie Roncier, Gunhild M. Mælandsmo, Javier C. Angulo, Peio Errarte, Gorka Larrinaga, Rafael Pulido, José I. López, Caroline E. Nunes-Xavier

“…However, many treated patients do not respond, making novel immune checkpoint-based immunotherapies potentially clinically beneficial only for specific groups of patients. We detected high expression of the immune checkpoint protein B7-H3 in clear cell renal cell carcinomas (ccRCCs) and evaluated B7-H3 immunohistochemistry staining in tissue microarray samples from two distinct renal cancer cohorts. …”
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DEAR1 is a dominant regulator of acinar morphogenesis and an independent predictor of local recurrence-free survival in early-onset breast cancer. by Steven T Lott, Nanyue Chen, Dawn S Chandler, Qifeng Yang, Luo Wang, Marivonne Rodriguez, Hongyan Xie, Seetharaman Balasenthil, Thomas A Buchholz, Aysegul A Sahin, Katrina Chaung, Baili Zhang, Shodimu-Emmanu Olufemi, Jinyun Chen, Henry Adams, Vimla Band, Adel K El-Naggar, Marsha L Frazier, Khandan Keyomarsi, Kelly K Hunt, Subrata Sen, Bruce Haffty, Stephen M Hewitt, Ralf Krahe, Ann McNeill Killary

“…<h4>Background</h4>Breast cancer in young women tends to have a natural history of aggressive disease for which rates of recurrence are higher than in breast cancers detected later in life. Little is known about the genetic pathways that underlie early-onset breast cancer. …”
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Expression, clinical significance and biological function of CDC7 in osteosarcoma by CHEN Peijun, MAN Yunan, HE Mingwei, LIANG Bumin, HE Maolin

“…Immunohistochemistry (IHC) was used to detect the expression of CDC7 protein in 39 cases of OS tissues and 8 cases of adjacent normal tissues. …”
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Pitfalls in the diagnosis of apparent homozygous mutations: two cases of IL10RA deficiency inflammatory bowel disease and a literature review by Xiu Shi, Ziqing Ye, Lai Qian, Wenhui Hu, Ye Yang, Chunmeng He, Zhiheng Huang, Bingbing Wu, Ying Huang

“…In patient 1, pedigree analysis, CGH and SNP 4 × 180 K microarray testing identified paternal uniparental diploidy (c.301C > T/11q12.3-11q25del) [upd (11) pat] on chromosome 11. …”
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Digital spatial proteomic profiling reveals immune checkpoints as biomarkers in lymphoid aggregates and tumor microenvironment of desmoplastic melanoma by Ruth Halaban, Kelly Olino, James Clune, David L Rimm, Harriet M Kluger, Dijana Djureinovic, Wael Ibrahim, Raymond Baumann, Anjela Galan, David G Su, David A. Schoenfeld, Raysa Cabrejo, Sajid A Khan

“…These findings might have therapeutic implications and help guide treatment selection in addition to informing potential prognostic significance.…”
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Revealing the role of natural killer cells in ankylosing spondylitis: identifying diagnostic biomarkers and therapeutic targets by Yuling Chen, Yan Li, Yuan Xu, Qing Lv, Yuanchun Ye, Jieruo Gu

“…This study integrated bioinformatics methods with experimental validation to explore the role of natural killer (NK) cells in AS.Methods Two microarray datasets, GSE25101 and GSE73754, were selected, and the scRNA-seq data were obtained from GSE194315 and Liu’s research. …”
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