Enhancing Binary Classification Performance in Biomedical Datasets: Regularized ELM with SMOTE and Quantile Transforms Focused on Breast Cancer Analysis by Brilliant Friezka Aina, Meta Kallista, Ig. Prasetya Dwi Wibawa, Ginaldi Ari Nugroho, Ivana Meiska, Syifa Melinda Naf’an

“…Using microarray datasets, this research investigation addresses the problem of unbalanced data in binary classification tasks. …”
Get full text

DNA Methylation Profiles of Blood Cells Are Distinct between Early-Onset Obese and Control Individuals by Je-Keun Rhee, Jin-Hee Lee, Hae Kyung Yang, Tae-Min Kim, Kun-Ho Yoon

“…Therefore, in-depth epigenomic and genomic analyses will advance our understanding of the detailed molecular mechanisms underlying obesity and aid in the selection of potential biomarkers for obesity in youth. …”
Get full text

miR-4780 Derived from N2-Like Neutrophil Exosome Aggravates Epithelial-Mesenchymal Transition and Angiogenesis in Colorectal Cancer by Liang Wang, Yuqiang Shan, Sixin Zheng, Jiangtao Li, Peng Cui

“…To further investigate the molecular mechanism, we analyzed the miRNA expression profile in the N2-like neutrophils, which led to the selection of hsa-miR-4780 for the subsequent experiment. …”
Get full text

Fetal medicine and current practice of prenatal screening by Akshatha Prabhu

“…The option for preimplantation genetic diagnosis (PGD) offers primary prevention by specific wild embryo selection and implantation in an in vitro fertilization cycle, following exclusion of affected embryo for aneuploidy (PGD-A), structural chromosome aberration (PGD-A), and a monogenic Mendelian genetic disease (PGD-M). …”
Get full text

Antibiotic resistance in agroecosystem: Progress and challenges by ZHANG Yusen, YE Jun, SU Jianqiang

“…Application of animal wastes and sludges contributes largely to the increased resistance in agroecosystems via directly introduction of antibiotic resistant bacteria or ARGs, or through introduction of antibiotic residues and selection of indigenous resistant bacteria. However, discriminating their contribution to the ARGs level in agroecosystem is difficult. …”
Get full text

Directional genomic hybridization (dGH™) identifies small inverted duplications in situ by Thomas Liehr, Erin Cross, Stefanie Kankel

“…This technique may be used to identify the presence of small inversions within regions presenting a copy number gain as detected by chromosome microarray. Distinguishing small inverted duplications from direct duplications may have an impact on topologically associating domains (TADs) and, thus, on clinical outcome.…”
Get full text

Identification of Potential Biomarkers of Septic Shock Based on Pathway and Transcriptome Analyses of Immune-Related Genes by Jie Wang, Jie Cai, Linlin Yue, Xixi Zhou, Chunlin Hu, Hongquan Zhu

“…Our aim was to explore potential biomarkers for SS by pathway and transcriptional analyses of immune-related genes to improve early detection. GSE57065 and GSE95233 microarray data were used to screen differentially expressed genes (DEGs) in SS. …”
Get full text

Shannon entropy approach reveals relevant genes in Alzheimer's disease. by Alfonso Monaco, Nicola Amoroso, Loredana Bellantuono, Eufemia Lella, Angela Lombardi, Anna Monda, Andrea Tateo, Roberto Bellotti, Sabina Tangaro

“…Since complex diseases are often the result of combinations of gene interactions, microarray data and gene co-expression analysis can provide tools for addressing complexity. …”
Get full text

c-Triadem: A constrained, explainable deep learning model to identify novel biomarkers in Alzheimer's disease. by Sherlyn Jemimah, Ferial Abuhantash, Aamna AlShehhi

“…We trained the model with blood genotyping data, microarray, and clinical features from the Alzheimer's Neuroimaging Disease Initiative (ADNI). …”
Get full text

Penaeus vannamei Genetic Evaluation for Growth and Survival Traits During White Spot Syndrome Virus Infection Based on 55K SNP Chip by Yijing HE, Mianyu LIU, Sheng LUAN, Jie KONG, Xupeng LI, Baoxiang CAO, Kun LUO, Jian TAN, Jiawang CAO, Ping DAI, Guangfeng QIANG, Zhaoxin WANG, Juan SUI, Xianhong MENG

“…Based on the survival time of individual resistance to WSSV within the family line, 590 individuals were uniformly selected and typed using 55K SNP liquid-phase microarrays to obtain genotypic data for certain individuals. …”
Get full text

MicroRNA profiling in human colon cancer cells during 5-fluorouracil-induced autophagy. by Ni Hou, Jia Han, Jie Li, Yingxun Liu, Yannan Qin, Lei Ni, Tusheng Song, Chen Huang

“…The physiological importance of the miRNA-autophagy interconnection is only beginning to be elucidated. MiRNA microarray technology facilitates analysis of global miRNA expression in certain situations. …”
Get full text

Identification of MEG3 and MAPK3 as potential therapeutic targets for osteoarthritis through multiomics integration and machine learning by Bing Ma, Xiaoru Wang, Chengfei Xu, Zelin Xu, Fei Zhang, Wendan Cheng

“…Subsequently, differential expression analysis and WGCNA were applied to synovial tissue microarray datasets obtained from the GEO database. …”
Get full text

Type-2 diabetes epigenetic biomarkers: present status and future directions for global and Indigenous health by Sarah Munns, Sarah Munns, Alex Brown, Alex Brown, Sam Buckberry, Sam Buckberry

“…Recent advances in epigenomics methods, particularly in DNA methylation detection, have enabled the discovery of associations between epigenetic changes and Type-2 diabetes. …”
Get full text

Genetic Analysis of 17q Terminal Partial Trisomy by Huiling Zheng, Lin Zheng, Zhi Huang, Guangping Li, Daili Tang, Xue Yang, Tian Tian

“…We performed G‐banding karyotype and chromosomal microarray analyses. The child in Family 1 had a 31.3 Mb mosaic duplication on chromosome 17. …”
Get full text

Comprehensive analysis of intervention and control studies for the computational identification of dengue biomarker genes. by Jibon Kumar Paul, Mahir Azmal, Tasnim Alam, Omar Faruk Talukder, Ajit Ghosh

“…Although advancements in diagnostic techniques have been made, early detection of severe dengue remains difficult due to the complexity of its clinical presentations. …”
Get full text

Clinical experience of genome-wide non-invasive prenatal testing as a first-tier screening test in a cohort of 59,771 pregnancies. by Jianxin Zhen, Liting Zhang, Huilin Wang, Xi Chen, Weihong Wang, Lili Li, Quanfu Zhang

“…Here, we evaluated the clinical performance of GW-NIPT as a first-tier screening test for detecting fetal aneuploidy and copy number variation (CNV).…”
Get full text

Homozygous Microdeletion Involving Exon 1 of ERCC8 and NDUFAF2 With Uniparental Isodisomy of Chromosome 5 by Kaori Yamoto, Kosuke Yamada, Kenji Shimizu, Sachiko Miyamoto, Mitsuko Nakashima, Hirotomo Saitsu

“…Methods We performed chromosomal microarray analysis, exome sequencing (ES), and RNA sequencing (RNA‐seq) using the patient's urine‐derived cells on a patient with growth retardation and multiple congenital anomalies. …”
Get full text

Molecular profiles of HCV cirrhotic tissues derived in a panel of markers with clinical utility for hepatocellular carcinoma surveillance. by Ricardo C Gehrau, Kellie J Archer, Valeria R Mas, Daniel G Maluf

“…<h4>Background</h4>Early hepatocellular carcinoma (HCC) detection is difficult because low accuracy of surveillance tests. …”
Get full text

Differentially expressed circular RNAs and their diagnostic value in children with allergic rhinitis by Yuhao Fan, Yilin Li, Miaomiao Xu, Liya Ren, Yong Li, Jing Li

“…Methods Blood samples were collected from allergic rhinitis patients and healthy controls, and circular RNA microarray was performed. The expression of differentially expressed circular RNAs was verified via real-time quantitative reverse transcription polymerase chain reaction, and these RNAs were selected for Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses. …”
Get full text

Regulation of neutrophil senescence by microRNAs. by Jon R Ward, Paul R Heath, James W Catto, Moira K B Whyte, Marta Milo, Stephen A Renshaw

“…Total RNA from highly purified neutrophils was prepared and subjected to microarray analysis using the Agilent human miRNA microarray V3. …”
Get full text