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Discovery of CMNPD31124 as a novel marine-derived PKMYT1 inhibitor for pancreatic ductal adenocarcinoma therapy: computational and biological insights
Published 2025-04-01“…Despite these promising results, toxicity predictions indicate potential hepatotoxicity and neurotoxicity, highlighting the need for further structural optimization. This work lays a solid foundation for the rational design of PKMYT1 inhibitors by integrating computational methods with insights from marine natural products.…”
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Text2Layout: Layout Generation From Text Representation Using Transformer
Published 2024-01-01Get full text
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SGA-Driven feature selection and random forest classification for enhanced breast cancer diagnosis: A comparative study
Published 2025-03-01“…To evaluate the effectiveness of the proposed method, we compared it with other classifiers, including Linear Regression (LR), Support Vector Machine (SVM), and K-Nearest Neighbors (KNN). …”
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Improving health-promoting workplaces through interdisciplinary approaches. The example of WISEWORK-C, a cluster of five work and health projects within Horizon-Europe
Published 2025-07-01“…The impact of COVID-19-related work stress on the mental health of primary healthcare workers: the mediating effects of social support and resilience. …”
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High-Speed All-Optical Encoder and Comparator at 120 Gb/s Using a Carrier Reservoir Semiconductor Optical Amplifier
Published 2025-04-01“…All-optical encoders and comparators are essential components for high-speed optical computing, enabling ultra-fast data processing with minimal latency and low power consumption. …”
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REENGINEERING OF OPEN SOFTWARE SYSTEM OF 3D MODELING BRL-CAD
Published 2019-09-01“…Computer Graphics is an up-to-date industry in the design and application of rapidly evolving computing systems. …”
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Detailed Transfer Line Beam Characteristics at an Operational Proton Therapy Center [version 2; peer review: 2 approved]
Published 2025-03-01“…The work resulted in an improved understanding of the beams and beam transfer lines to support further beamline optimization and design activities. …”
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Presenting an Innovative Method Based on Ensemble Learning for a Credit Approval System
Published 2025-06-01“…The findings of the suggested methodology are compared with those of several methodologies, including Random Forest (RF), Gaussian Kernel (GK), Support Vector Machines (SVM), Adaptive Boosting (AdaBoost), and Multi-Layer Perceptron (MLP). …”
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Economywide impact of climate shock on agricultural sector, women employment and poverty: a Burkina Faso case study
Published 2025-08-01“…In this framework, climate change is modelled by decreased agricultural crop yields under scenarios of moderate and severe climate shocks.ResultsFindings are that under both moderate and severe scenarios, there are negative impacts that become more detrimental in the severe climate shock scenario. Rural areas compared to urban areas experience reductions in the rate of participation in economic activities and increase the burden of domestic work, particularly for women and, more so, for skilled women. …”
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Application of professional standards for training in methods and technologies of software engineering at the higher education institutions
Published 2018-05-01“…This training direction emerged in Russia from recommendations of the standard of Computing Curricula: Software Engineering. It is supposed that graduates of this direction will be engaged in the future in development and support of difficult program systems, and therefore during educational process they have to receive broad basis of knowledge and skills to be able to develop software, create projects of development of a software product, as well as program documentation; manage the processes of programs’ life cycle, work in groups and manage team of performers in the process of production of software products. …”
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Acceleration of Urdu Optical Character Recognition on Zynq UltraScale+ MPSoC Using Deep Convolutional Neural Network
Published 2025-01-01“…Deploying deep learning–based optical character recognition (OCR) systems for low-resource, complex-script languages like Urdu remains a major challenge due to high computational costs, lack of annotated datasets, and limited hardware support for real-time applications. …”
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