Construction of cartilaginous organoids based on cartilage extracellular matrix microcarriers to promote articular cartilage regeneration through immune regulation by Hongyu Jiang, Wei Liu, Jiajie Chen, Yue Tian, Zhibo Jia, Yanbin Wu, Yanjun Guan, Leijia Chen, Wenjing Xu, Haoye Meng, Yingjie Xiong, Jianting Ye, Cheng Huang, Ruichao He, Sice Wang, Yufei Ding, Wei Fan, Yunkang Yang, Jiang Peng, Aiyuan Wang

“…Functionalized CORGs were successfully constructed based on CEMMs. …”
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Comparison of Clinical Outcomes Between Fluoroscopic and Computer Tomographic Guidance in Concurrent Use of Radiofrequency Ablation and Vertebral Augmentation in Spinal Metastases:... by Qing Zhao Ruan, Syena Sarrafpour, Jamal Hasoon, R. Jason Yong, Christopher L. Robinson, Matthew Chung

“…This combination therapy of RFA with VA, which could be performed under CT or fluoroscopy, has in recent years been recognized as highly successful for pain control and functional restoration of metastatic spine lesions. …”
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Energy efficient gateway based routing with maximized node coverage in a UAV assisted wireless sensor network. by Bilal Ahmad, Masroor Ahmed, Nadeem Anjum, Masood Ur Rehman, Naeem Ramzan

“…This approach is superior to simply electing cluster head nodes on the basis of some probability function. The nodes that fail to achieve any successful outcome from the game theory matching model fail to get any association. …”
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Experimental Study of a New Metallic Damper Using Hourglass Fuse by Mohammad Hossein Afridoon, Reza Aghayari, Mohammad Hosein Adibrad, Mehrzad Tahamouliroudsari

“…The experimental results indicate that the bars successfully performed their function as energy absorbers and fuses in all specimens, but the way HSP is connected to supporting plates can greatly affect its behavior. …”
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One of the Short-Chain Fatty Acids (SCFAs), Sodium Propionate, Can Reduce the Dosage of Sishen Pill in Regulating the Intestinal Microbiota in Diarrhea with Kidney-Yang Deficiency... by Guo M, Di J, Tan Z, Xiao N, Peng M

“…After the successful establishment of the model, the mice in the model group were randomly assigned to one of the following treatment groups: natural recovery group, sodium propionate group, 75% Sishen Pill combined with 60 mg/kg sodium propionate group, or Sishen Pill group.Results: The 75% Sishen Pill combined with 60 mg/kg sodium propionate demonstrated significantly better therapeutic effects compared to the Sishen Pill alone and sodium propionate alone groups. …”
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The EQ-5D and EQ-HWB fit the perceptions of quality of life from a Chinese perspective: a concept mapping study by Yifan Ding, Zhuxin Mao, Zhihao Yang, Siliu Feng, Jan Busschbach

“…Methods This study employed three successive rounds of participant recruitment to refine the concept mapping process. …”
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Parallel Jacobian Computation Based on Distance-2 Algorithm and Its Application in Coupling Problems by LIU Lixun, ZHANG Han, PENG Xinru, DOU Qinrong, WU Yingjie, GUO Jiong, LI Fu

“…Besides, the serial graph coloring algorithm has been utilized to achieve an efficient computation of Jacobian. …”

Commercial chip-based tunneling magnetoresistance sensor for green-synthesized magnetic nanoparticles assay by Pinaka Elda Swastika, Harlina Ardiyanti, Zurnansyah, Deska Lismawenning Puspitarum, Nurul Imani Istiqomah, Nur Aji Wibowo, Edi Suharyadi

“…The sensor system successfully detected MNPs at different stray field intensities. …”
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Mesangial cell-derived CircRNAs in chronic glomerulonephritis: RNA sequencing and bioinformatics analysis by Ji Hui Fan, Xiao Min Li

“…The hub mRNAs from CeRNA network were identified using LASSO algorithms. Furthermore, utilizing protein–protein interaction (PPI), gene ontology (GO), pathway enrichment (KEGG), and GSEA analyses to explore the potential biological function of target genes from CeRNA network. …”
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Dynamic survival prediction of end-stage kidney disease using random survival forests for competing risk analysis by Daniel Christiadi, Daniel Christiadi, Daniel Christiadi, Kevin Chai, Aaron Chuah, Bronwyn Loong, Thomas D. Andrews, Aron Chakera, Giles Desmond Walters, Giles Desmond Walters, Giles Desmond Walters, Simon Hee-Tang Jiang, Simon Hee-Tang Jiang, Simon Hee-Tang Jiang

“…External validation with 8,729 patients confirmed these results.ConclusionWe successfully developed and validated a dynamic survival prediction model using common longitudinal clinicopathological data. …”
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Spatial Analysis of the Relationship between Ecological Factors and Housing Prices in Tehran by Atefeh Kolyaei, Tahir Prizadi, Habibollah Fasihi

“…ArcGIS software was employed, utilizing Spatial Analyst, Spatial Join, and Zonal Statistics functions to create the necessary datasets. …”
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FBN2 pathogenic mutation in congenital contractural arachnodactyly with severe skeletal manifestations by Yazhou Huang, Xingxin Fang, Linya Ma, Jibo Zhang, Chao Wang, Taoran Gao, Dan Peng

“…In vitro, both the wild-type and mutant minigenes were successfully inserted into the pcMINI and pcMINI-C vectors to verify the impact of this variant on FBN2 mRNA splicing. …”
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Detection and prediction of real-world severe asthma phenotypes by application of machine learning to electronic health records by Mehmet Furkan Bağcı, MSc, Toan Do, MD, Samantha R. Spierling Bagsic, PhD, Rahul F. Gomez, MD, Judy H. Jun, MD, Anna L. Ritko, MA, MPhil, Sally E. Wenzel, MD, Truong Nguyen, PhD, Yusuf Öztürk, PhD, Brian D. Modena, MD, MSc

“…Results: Three principal components (PCs) emerged, reflecting lung function (PC1), blood inflammatory markers (PC2), and systemic corticosteroid receipt (PC3). …”
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Photonics-Aided THz Integrated Sensing and Communication System Based on a Subcarrier-Chirp Inter-Embedded Waveform by Junhao Zhang, Mingzheng Lei, Min Zhu, Qingzhi Zhou, Bingchang Hua, Yuancheng Cai, Hao Li, Jiao Zhang, Zhengyi Liang, Yang Li, Xingyu Chen, Junjie Ding, Qing Zhong, Sha Zhu, Jianjun Yu

“…By fully utilizing the idle time-frequency resources of the LFMCW, a density of information-resolution quotient of up to 46.2 × 10-2 bit·s/m2 has been achieved. …”
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Rapid cleavage of 6-[18F]fluoronicotinic acid prosthetic group governs BT12 glioblastoma xenograft uptake: implications for radiolabeling design of biomolecules by Pyry Dillemuth, Abiodun Ayo, Xiaoqing Zhuang, Petter Lövdahl, Heidi Liljenbäck, Salli Kärnä, Tatsiana Auchynnikava, Jonne Kunnas, Jesse Ponkamo, Maxwell W. G. Miner, Johan Rajander, Jessica M. Rosenholm, Anne Roivainen, Anu J. Airaksinen, Pirjo Laakkonen, Xiang-Guo Li

“…Among them, activated esters of 6-[18F]fluoronicotinic acid ([18F]FNA) have been prepared and successfully employed for 18F-labeling of diverse biomolecules, including peptides. …”
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Comprehensive multi‐tissue epigenome atlas in sheep: A resource for complex traits, domestication, and breeding by Deyin Zhang, Jiangbo Cheng, Xiaolong Li, Kai Huang, Lvfeng Yuan, Yuan Zhao, Dan Xu, Yukun Zhang, Liming Zhao, Xiaobin Yang, Zongwu Ma, Quanzhong Xu, Chong Li, Xiaojuan Wang, Chen Zheng, Defu Tang, Fang Nian, Xiangpeng Yue, Wanhong Li, Huibin Tian, Xiuxiu Weng, Peng Hu, Yuanqing Feng, Peter Kalds, Zhihua Jiang, Yunxia Zhao, Xiaoxue Zhang, Fadi Li, Weimin Wang

“…We constructed the first multi‐tissue epigenome atlas in terms of functional elements, chromatin states, and their functions and explored the utility of the functional elements in interpreting phenotypic variation during sheep domestication and improvement. …”
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复合纳米生物催化剂Fe3 O4-ZIF-8@ET 2.0的 制备及表征Preparation of composite nano-biocatalyst Fe3O4-ZIF-8@ET 2.0 and its characterization by 李攀登，贺雷雨，孙丽慧 LI Pandeng， HE Leiyu， SUN Lihui

“…The microscopic morphology and functional groups of the composite immobilized enzyme were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), and Fourier infrared spectroscopy (FT-IR). …”
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The Anterior-Based Muscle-Sparing Approach for Conversion Total Hip Arthroplasty is Safe and Effective by Catherine M. Call, MD, Johanna Mackenzie, MPH, Zoë A. Walsh, MPH, Bailey Shevenell, BA, George Babikian, MD, Brian J. McGrory, MD, MS, Adam J. Rana, MD

“…Patient-reported outcome measures indicate successful return of function. Operative, hospital, and outcome data were similar between patients receiving the ABMS and posterior approach. …”
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Sustainable nanophytosome-based therapies against multidrug-resistant Escherichia coli in urinary tract infections: an in Vitro and in vivo study by Ming Ming Wen, Ibrahim A. Abdelwahab, Rania Abozahra, Sarah M. Abdelhamid, Kholoud Baraka, Heba Essam Sedky Ahmed, Wessam F. El-Hadidy

“…This study introduces an innovative and sustainable therapeutic approach utilizing rosemary oil nanophytosomes as a targeted drug delivery system to address biofilms in UTIs induced by MDR E. coli. …”
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Effects of sinomenine on PI3K/mTOR signaling pathway and mesangial hyperplasia in rats with adriamycin-induced nephropathy by Liu Yue, Li Peng-yuan, Zhang Qing-hua, Yan Dan

“…Objective To explore the effect of sinomenine on the signal pathway of phosphatidyl-3 kinase（PI3 K）/mammalian target of rapamycin（mTOR）and mesangial hyperplasia in renal tissue of rats with adriamycin-induced nephropathy and elucidate its protective mechanism.Methods A total of 50 SD rats were selected, 10 rats were randomly injected with normal saline via caudal vein as control group, the other 40 rats were injected with adriamycin 5 mg/kg via caudal vein for 7 days to prepare nephrotic syndrome（NS）model.After successful modeling, the rats were randomly divided into the groups of model（NS）,sinomenine low-dose（25 mg/kg）,medium-dose（50 mg/kg）and high-dose（100 mg/kg）（n=10 each）.Control and NS groups received normal saline through abdominal cavity and sinomenine groups were given corresponding doses of drugs once daily for 28 days.At 24 hours after the last administration, blood and urine samples of rats in each group were collected and rats sacrificed, renal tissue samples harvested, serum creatinine（Scr）and urea nitrogen（BUN）were measured by enzyme-linked immunosorbent assay（ELISA）;24-hour urine protein was detected by Coomassie brilliant blue staining; hematoxylin-eosin staining（HE）was utilized for analyzing the pathological changes of kidney and mesangial matrix index（M/G）;transmission electron microscopy for observing the thickening of glomerular basement membrane of kidney; Western blot for detecting the expressions of p-PI3 K/PI3 K,p-mTOR/mTOR,fibronectin（FN）and type IV collagen（COL4）in renal tissue.Results As compared with control group, there were pathological damages such as the increase of glomerular mesangial matrix, the expansion of renal tubule lumen and severe thickening of glomerular basement membrane.M/G and renal function indicators Scr, BUN,24-hour urine protein and renal tissue were elevated.The protein expressions of p-PI3 K,p-mTOR,FN and COL4 rose markedly in NS group（P<0.05）.As compared with NS group, sinomenine high/medium/low dose groups alleviated pathological damage such as glomerular basement membrane thickening, M/G,Scr, BUN,24-hour urine protein, renal tissue p-PI3 K,expressions of mTOR,FN and COL4 proteins declined markedly in sinomenine low/medium/high-dose groups（P<0.05）.As compared with low-dose sinomenine group, glomerular basement membrane thickening was the least pathologically damaged and M/G,Scr, BUN,24-hour urine protein, renal tissue p-PI3 K,p-mTOR,FN and COL4 declined markedly in sinomenine medium/high-dose group（P<0.05）.Conclusions Sinomenine may inhibit the activation of PI3 K/mTOR signaling pathway, reduce the proliferation of glomerular mesangial cells and delay the process of nephrotic syndrome.…”
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