Unlocking the potential of CRISPR tools and databases for precision genome editing by Pooja Saraswat, Rajiv Ranjan

“…This review gives an overview of these new resources that have been developed, grouped based on their functionalities like design of guide RNA, off-target predictions, genome-wide screens, and visualizations of the data. …”
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Systematic analyses of the MIR172 family members of Arabidopsis define their distinct roles in regulation of APETALA2 during floral transition. by Diarmuid S Ó'Maoiléidigh, Annabel D van Driel, Anamika Singh, Qing Sang, Nolwenn Le Bec, Coral Vincent, Enric Bertran Garcia de Olalla, Alice Vayssières, Maida Romera Branchat, Edouard Severing, Rafael Martinez Gallegos, George Coupland

“…Through genome editing and detailed confocal microscopy, we show that the activity of miR172 at the shoot apex is encoded by 3 MIR172 genes, is critical for floral transition of the shoot meristem under noninductive photoperiods, and reduces accumulation of AP2 and TARGET OF EAT2 (TOE2), an AP2-LIKE TF, at the shoot meristem. Utilizing the genetic resources generated here, we show that the promotion of flowering by miR172 is enhanced by the MADS-domain TF FRUITFULL, which may facilitate long-term silencing of AP2-LIKE transcription, and that their activities are partially coordinated by the TF SQUAMOSA PROMOTER-BINDING-LIKE PROTEIN 15. …”
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A case study of environmental considerations and opportunities in cyber physical systems by Mario Cortes‐Cornax, Paula Lago, Claudia Roncancio

“…Our research in progress targets a design approach to converge into an equilibrium between utility, performance, and minor environmental impact of smart systems.…”
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A Quantum Framework for Combinatorial Optimization Problem over Graphs by Meng Shi, Sai Wu, Ying Li, Gongsheng Yuan, Chang Yao, Gang Chen

“…In this paper, we propose a general quantum algorithm framework searching for approximate solutions to combinatorial optimization problems with linear objective functions. Our framework provides APIs (application programming interfaces) that enable developers to encode weighted graph structures onto quantum circuits and utilize variational algorithms to generate approximate solutions. …”
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Digital Governance Policy Implementation Model Through Electronification of Land and Building Acquisition Fees (E-BPHTB) at the Baubau City Regional Revenue Agency by Rahmawati Rahmawati

“…The results of the study indicate that the implementation of the Electronic policy (Land and Building Acquisition Fee) at Bapenda Baubau City is quite good, but not as expected: Organization in terms of budgeting, and methods are good but the human resources owned are still lacking, not adequate especially in the field of determination in the process of completing duties and functions. …”
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Cooperative Operational Optimization of Water and Power Systems under Extreme Conditions by Gal Perelman, Tomer Shmaya, Stelios Vrachimis, Mathaios Panteli, Demetrios G. Eliades, Avi Ostfeld

“…The optimization framework offers a novel approach to managing flexible resources during emergencies by utilizing the mutual links between a WDS and a PDS. …”
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Two-stage strategic optimal planning of distributed generators and energy storage systems considering demand response program and network reconfiguration by Saleh Ba-swaimi, Renuga Verayiah, Vigna K. Ramachandaramurthy, Ahmad K. ALAhmad, Sanjeevikumar Padmanaban

“…Simulation outcomes from various case studies indicate that incorporating optimal DRP and NR scheduling into a hybrid system of RESs and BESSs enhances renewable energy penetration by 17.39% compared to the case utilizing just BESSs. Moreover, the established model, featuring a wind-DG/PV-DG/BESS/DRP/NR configuration, achieves significant improvements in all objective functions, including a 31.14% reduction in total system cost, a 61.67% decrease in power loss, and a 58.11% improvement in voltage deviation, compared to the base case.…”
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Unlocking liver physiology: comprehensive pathway maps for mechanistic understanding by Luiz Ladeira, Anouk Verhoeven, Jonas van Ertvelde, Jian Jiang, Alessio Gamba, Julen Sanz-Serrano, Tamara Vanhaecke, Harm J. Heusinkveld, Ramiro Jover, Mathieu Vinken, Liesbet Geris, Liesbet Geris, Liesbet Geris, Bernard Staumont

“…In this study, we introduce two Liver Physiological Maps (PMs); comprehensive and machine-readable graphical representations of the intricate mechanisms governing two major liver functions.MethodsTwo PMs were developed through manual literature curation, integrating data from established pathway resources and domain expert knowledge. …”
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Establishing a core outcome set for creatine transporter deficiency and guanidinoacetate methyltransferase deficiency by Zahra Nasseri Moghaddam, Emily K. Reinhardt, Audrey Thurm, Beth K. Potter, Maureen Smith, Celeste Graham, Beth H. Tiller, Steven A. Baker, Deborah A. Bilder, Regina Bogar, Jacobus Britz, Rachel Cafferty, Daniel P. Coller, Ton J. DeGrauw, Vicky Hall, Gerald S. Lipshutz, Nicola Longo, Saadet Mercimek-Andrews, Judith S. Miller, Marzia Pasquali, Gajja S. Salomons, Andreas Schulze, Celine P. Wheaton, Kayla F. Williams, Sarah P. Young, Jasmine Li, Sofia Balog, Theresa Selucky, Sylvia Stöckler-Ipsiroglu, Heidi Wallis

“…Conclusions Development of this COS illustrates a patient-centered approach for clinical trial readiness for CTD and GAMT that if utilized will make clinical trial results comparable, minimize bias in clinical trial outcome selection, and promote efficient use of resources.…”
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Exploring the impact of Plantago lanceolata mucilage edible coating enhanced with Lacticaseibacillus rhamnosus CWKu-12 postbiotics on the shelf life of lamb meat slices by Abbas Mirzaei, Abas Abdeshahi, Behrooz Alizadeh Behbahani, Fereshteh Falah

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Development and optimization of a neural network model using genetic algorithm to predict the performance of a packed bed reactor treating sulphate-rich wastewater by Manoj Kumar, Rohil Saraf, Shishir Kumar Behera, Raja Das, Mansi Aliveli, Arindam Sinharoy, Eldon R. Rene, Ravi Krishnaiah, Kannan Pakshirajan

“…Using genetic algorithm (GA) with appropriate objective functions, optimal sets of inputs were obtained to ensure maximum RE at a minimum HRT. …”
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Multi-Timescale Nested Hydropower Station Optimization Scheduling Based on the Migrating Particle Whale Optimization Algorithm by Mi Zhang, Guosheng Zhou, Bei Liu, Dajun Huang, Hao Yu, Li Mo

“…Validation on classical test functions and the Jiangpinghe River of the multi-timescale nested optimal scheduling model demonstrates that MPWOA exhibits faster convergence and stronger optimization capabilities and significantly improves power generation. …”
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Japanese Family Conditions Demonstrating Family Resilience: Directed Content Analysis Based on Literature and Family Interviews by Naohiro Hohashi, Natsumi Kijima

“…<b>Background/Objectives:</b> When experiencing a variety of negative family events, families that, as a whole, have high family resilience maintain and improve family functioning. It is important, therefore, for nursing professionals to be able to assess families lacking in family resilience in order to prevent, reduce, or ameliorate family symptoms (such as family-perceived problems, issues, difficulties, or suffering). …”
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Tax Exemptions and R;D Expenditures in Iran Saeed Dorokhshi Moghaddam by Saeed Dorokhshi Moghaddam, Bahram Sahabi, Hassan Heydari, Sajad Barkhordari

“…However, mechanisms must be in place to foster reaching much more qualified human resources and to a greater extent finance. Financial incentives should be utilized in a manner that minimizes costs and maximizes economic growth and productivity. …”
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Architecture and the Time of Space by Deborah Hauptman

“…As Foucault suggested, one of the great problems that arose in the 1950s was that of the political status of science and the ideological functions that it could serve. Another rebuke can be seen as the challenge to the primacy of truth as an adequation of subject to thing. …”
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Ensemble learning driven Kolmogorov-Arnold Networks-based Lung Cancer classification. by Abdul Rahaman Wahab Sait, Eid AlBalawi, Ramprasad Nagaraj

“…In addition, limited resources are required to classify PET / CT images. …”
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Effects of enhanced fermentation with high-yielding strains of Tetramethylpyrazine on flavor quality of Douchiba by Panpan Yang, Qin Wang, Yurou Yang, Anyan Wen, Haiying Zeng, Na Liu, Likang Qin

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Participatory Leadership of The Principal in Improving Teacher Competence by Isthifa Kemal, Firmanda Arlita, Salim Aktar

“…Professional competence, the teacher understands the main tasks and functions. The teacher implements various strategies and ways of managing classes, and plans and utilizes various available learning resources. …”
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Oncology Clinicians' Perspectives of a Remote Patient Monitoring Program: Multi-Modal Case Study Approach by Ann Marie Mazzella-Ebstein, Robert Daly, Jennie Huang, Camila Bernal, Clare Wilhelm, Katherine S Panageas, Jessie Holland, Rori Salvaggio, Jill Ackerman, Jennifer Cracchiolo, Gilad Kuperman, Jun Mao, Aaron Begue, Margaret Barton-Burke

“…Improvements to address RPM challenges include functional changes to enhance the program’s utility, such as input from patients about temporal changes in their symptoms and technical resources for home monitoring devices.…”
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Trade-off between resistance and persistence in high cell density cultures by F. Beulig, J. Bafna-Rührer, P. E. Jensen, S. H. Kim, A. Patel, V. Kandasamy, C. Steffen, K. Decker, D. Zielinski, L. Yang, E. Özdemir, S. Sudarsan, B. Palsson

“…We suggest that this trade-off explains observed growth arrests in high-density cultures and that it results from the disruption of cellular homeostasis, due to re-allocation of limited cellular resources from resistance functions toward increased maintenance requirements. …”
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