A multi-omics Mendelian randomization identifies putatively causal genes and DNA methylation sites for asthma by Jia Wang, MD, Jinxin Hu, MS, Dan Qin, MD, Dan Han, MD, Jiapeng Hu, MD

“…Employing Summary Data-based Mendelian Randomization (SMR) and Two-Sample Mendelian Randomization (TSMR), we pinpointed asthma causal genes, causal DNA methylation sites, and methylation sites affecting gene expression, cross validated with at least 2 large-scale GWAS from each source. We utilized colocalization for genetic associations, meta-analysis for data integration, two-step MR for methylation-gene-asthma mediation mechanism. …”
Get full text

How does soil carbon sequestration affect greenhouse gas emissions from a sheep farming system? Results of an life cycle assessment case study by Pasquale Arca, Enrico Vagnoni, Pierpaolo Duce, Antonello Franca

“… • Extensification of dairy sheep systems determines lower environmental impact per hectare of utilized agricultural area. • Enteric methane emissions are the main source of GHG emissions of the sheep milk life cycle…”
Get full text

Segmental Renal Ischemia following Transplantation of Horseshoe Kidney as Separate Allografts by J. T. Foster, P. E. Morrissey

“…Technical descriptions in the literature of successful back-table preparation strategies should help more transplant surgeons to begin to utilize this resource. Conclusion. This study concludes that horseshoe kidneys can be successfully used for transplantation and provides a technical strategy to salvage the transplant after a unique complication associated with these donor kidneys.…”
Get full text

Harmonic and Interharmonic Measurement Method Using Two-Fold Compound Convolution Windows and Zoom Fast Fourier Transform by Xiangui Xiao, Lei Zhao, Shengjun Zhou, Haijun Liu, Zhong Fu, Dan Hu

“…With the rapidly increasing penetration of new energy resources, the power grid faces significant threats from harmonics. …”
Get full text

Human cancer-targeted immunity via transgenic hematopoietic stem cell progeny by Theodore S. Nowicki, Nataly Naser Al Deen, Cole W. Peters, Begoña Comin-Anduix, Egmidio Medina, Cristina Puig-Saus, Ignacio Baselga Carretero, Paula Kaplan-Lefko, Mignonette H. Macabali, Ivan Perez Garcilazo, Daniel Chen, Jia Pang, Beata Berent-Maoz, Salem Haile, Jonathan Rodriguez, Moe Kawakami, Conner K. Kidd, Ameya Champhekar, Giuseppe Carlucci, Agustin Vega-Crespo, Bartosz Chmielowski, Arun Singh, Noah Federman, Gary M. Schiller, Sarah J. Larson, Martin Allen-Auerbach, Alexandra M. Klomhaus, Jerome Zack, David Baltimore, Lili Yang, Donald B. Kohn, Owen N. Witte, Antoni Ribas

“…These results demonstrate the utility of transgenic HSCs to generate a self-renewing source of tumor-specific cellular immunotherapy in human participants. …”
Get full text

Chromosome-scale assembly of the Xenocypris davidi using PacBio HiFi reads and Hi-C technologies by Tiezhu Yang, Liangjie Zhao, Chaoqun Su, Xusheng Guo, Xinliang Peng, Shijie Yang, Gaoyou Yao

“…We identified 27,360 protein-coding genes, of which 26,672 were functionally annotated. This genome sequence provides a valuable resource for exploring the molecular basis of agronomic traits in X. davidi and will facilitate its genetic enhancement.…”
Get full text

Economic Dispatch in Electrical Systems with Hybrid Generation Using the Differential Evolution Algorithm: A Comparative Analysis with Other Optimization Techniques Under Energy Li... by Jorge Cadena-Albuja, Carlos Barrera-Singaña, Hugo Arcos, Jorge Muñoz

“…To estimate their behavior, the Monte Carlo method is applied, utilizing probability distribution functions to predict resource availability throughout the planning horizon. …”
Get full text

Indigenous fire practices in Wasur National Park Merauke, South Papua by Budiningsih Kushartati, Ridho Nurrochmat Dodik, Wibowo Agung, Ekayani Meti, Nurfatriani Fitri, Yori Kondolangit Enrico

“…This research seeks to understand the traditional burning practices of the Kanume people utilizing a traditional ecological knowledge framework. …”
Get full text

A system for generating chatbots to support learning in the field of exact sciences using generative artificial intelligence models by Oleksandr Prokhorov, Dmytro Shymko, Olena Kuzminska, Andrey Chukhray, Oleksii Shatalov, Oleksandr Kholodniak

“…The effectiveness of the proposed approach is illustrated through examples of creating an assistant bot, a bot for generating variants of mathematical problems and step-by-step explanations of their solutions, and testing bots, which demonstrated cost optimization and more efficient resource utilization. A significant advantage is the convenience of tools for creating and configuring chatbots, as well as their use through a showcase of ready-made chatbots in messengers.…”
Get full text

Regulatory effects of Poria cocos polysaccharides on gut microbiota and metabolites: evaluation of prebiotic potential by Xu Zhou, Yangyou Li, Yuhan Yang, Li Wei, Chen Wang, Jiahui Xu, Jiajia Song, Shijian Liu, Junying Bai, Huayi Suo

“…Abstract Dietary polysaccharides have long been recognized for their capacity to modulate gut microbiota composition and metabolic activities, making them promising resources for functional food development. In this study, we investigated the effects of Poria cocos (P. cocos) polysaccharides on the structure and metabolism of human gut microbiota using an in vitro fecal fermentation model. …”
Get full text

An Adiabatic-Expansion-Induced Perturbation Study on Gas–Aerosol Partitioning in Ambient Air—Formation of NH₄NO₃ and Microdroplet Nitrogen Fixation (2) by Yating Gao, Qinchu Fan, Yujiao Zhu, Hengqing Shen, Qi Yuan, Yang Gao, Huiwang Gao, Xiaohong Yao

“…Recent observations have increasingly challenged the conventional understanding of atmospheric NH₃ and its potential sources in remote environments. Laboratory studies suggest that the microdroplet redox generation of NH₃ could offer an alternative explanation. …”
Get full text

Microwave-assisted extraction of essential oils from basil leaves (Ocimum basilicum L.) and coriander seeds (Coriandrum sativum L.): A comparative study on chemical composition, an... by G.M. Masud Rana, Subarna Sandhani Dey, Bijoy Chandra Ghos, Md. Jasim Uddin, Tahmina Akter Chowdhury, Md. Tariqul Islam, Toufikur Rahman, Md. Jobayear Hossain, Jaytirmoy Barmon, Mst. Sarmina Yeasmin

“…Essential oils (EOs), known for their aromatic and bioactive properties, are widely utilized in the cosmetic and food industries. Microwave-assisted extraction (MAE) has emerged as a green, efficient and rapid technique for extracting EOs from plant sources. …”
Get full text

Barcoded Hybrids of Extracellular Vesicles and Lipid Nanoparticles for Multiplexed Analysis of Tissue Distribution by Alena Ivanova, Renata Chalupska, Ana Filipa Louro, Mike Firth, Hernán González‐King Garibotti, Leif Hultin, Franziska Kohl, Elisa Lázaro‐Ibáñez, Julia Lindgren, Gentian Musa, Erik Oude Blenke, Andreia M. Silva, Louis Szeponik, Agnes Taylor, Ida Viken, Xiaoqin Wang, Karin Jennbacken, John Wiseman, Niek Dekker

“…To examine this possibility further, it is shown that HAP1 hEV loaded with Cre mRNA displayed functional delivery to the lungs. Overall, the barcoded hEV technology enables rapid profiling of biodistribution across EV cell sources, which is poised to improve throughput and extent of EV studies, while reducing the number of animals required for research.…”
Get full text

Evaluation of Drinking Water Quality Using Fuzzy Logic in Sulaimani City, Kurdistan, Iraq. by Zeren Jamal Ghafour

Get full text

Microbiome analysis reveals dynamic changes of gut microbiota in Guizhou horse and Dutch Warmblood horses by Yanfang Lan, Yaonan Li, Yang Wang

“…China possess abundant horse breed resources, particularly Guizhou horses, which play vital roles in local agriculture, tourism, and transportation. …”
Get full text

Participatory Leadership of The Principal in Improving Teacher Competence by Isthifa Kemal, Firmanda Arlita, Salim Aktar

“…Professional competence, the teacher understands the main tasks and functions. The teacher implements various strategies and ways of managing classes, and plans and utilizes various available learning resources. …”
Get full text

Does city-county merger improve urban carbon emission efficiency? An empirical analysis based on the difference-in-differences model by Xuechen Fan, Shuhua Xu

“…The administrative boundary adjustment (ABA) functions as an effective instrument for hierarchical network governance in China, possessing the capacity to accomplish this objective through its redistributive impact on urban spatial resources. …”
Get full text

Business environment and its impact on high-quality economic development: A configurational analysis of enhancement pathways. by Guanyu Hou, Chengji Sun, Zishun Lu

“…Concurrently, a business environment index system has been constructed, capturing the nuances of government functionality, social context, and market dynamics. Employing system theory and a configurational approach, this research utilizes the fsQCA method to decode the intricate mechanisms, dynamic pathways, and synergistic interactions among diverse elements within the business environment that influence high-quality economic development. …”
Get full text

Strategies for Digital Economy Operation of Urban Parks Guided by Gamification Methods by Zhaochen WANG

“…However, due to constraints such as construction scale, resource endowment, location and transportation, customer base, as well as external factors like public welfare attributes, funding sources, and policies, existing urban park operation strategies can hardly fully utilize the potential value of green spaces and achieve the ideal revenue capacity needed to support continuous park operation. …”
Get full text

Preparation and Applications of Biochar Materials from Organic Solid Waste by Yufei TANG, Jiacheng SONG, Yuhang GUO, Jialu QU, Jian XIONG, Yina QIAO, Xuebin LYU

“…This surge exacerbates environmental pollution and leads to significant resource waste. Efficient and sustainable management of such waste has become a critical research topic in global environmental governance and resource utilization. …”
Get full text