Potent Antimicrobial Azoles: Synthesis, In Vitro and In Silico Study by Zeynep Özdemir, Yaren Nur Zenni, Arzu Karakurt, Suat Sari, Selma Saraç, Mevlüt Akdağ, İrem Bozbey Merde, Didem Kart, Roberto Venanzoni, Giancarlo Angeles Flores, Paola Angelini, Muzammil Kabier, Bijo Mathew, Simone Carradori

“…<b>Conclusions</b>: As a result, the title compounds emerged as promising entities with broad antifungal and antibacterial effects, highlighting the utility of oxime ether function in the azole scaffold.…”
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Therapeutic effects of raw rhubarb on gastrointestinal complications in ischemic stroke: An integrated analysis of gut microbiota, metabolomics, and network pharmacology by Zhanhao Ye, Dongmin Cao, Wenxing Ao, Ting Li, Minghua Xian, Shumei Wang

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A Proposed Diagnostic and Treatment Algorithm for the Management of Lumbar Discogenic Pain by Lorio MP, Beall DP, Myers TJ, Naidu RK, McRoberts WP, Davis TT, Gage EG, Calodney AK, Verrills P, De Palma MJ, Amirdelfan K, Block JE

“…Morgan P Lorio,1 Douglas P Beall,2 Thomas J Myers,3 Ramana K Naidu,4 W Porter McRoberts,5 Timothy T Davis,6 Emmanuel G Gage,7 Aaron K Calodney,8 Paul Verrills,9 Michael J De Palma,10 Kasra Amirdelfan,11 Jon E Block12 1Orlando College of Osteopathic Medicine, Winter Garden, FL, USA; 2Comprehensive Specialty Care, Edmond, OK, USA; 3Paradigm Health System, Slidell, LA, USA; 4MarinHealth Spine Institute, Larkspur, CA, USA; 5Holy Cross Medical Group, Fort Lauderdale, FL, USA; 6Source Healthcare, Santa Monica, CA, USA; 7Centurion Spine &amp; Pain Centers, Waycross, GA, USA; 8Precision Spine Care, Tyler, TX, USA; 9MetroPain Group, Clayton, VIC, Australia; 10Virginia iSpine Physicians, Richmond, VA, USA; 11Boomerang Healthcare, Inc., Walnut Creek, CA, USA; 12Private Practice, San Francisco, CA, USACorrespondence: Jon E Block, Private Practice, 2210 Jackson Street, Ste. 401, San Francisco, CA, 94115, USA, Tel +1 415-775-7947, Email jb@drjonblock.comBackground: There is renewed interest in the intervertebral disc as a target for treatments aimed at ameliorating lumbar discogenic pain by restoring and preserving the natural structure and function of this component of the vertebral motion segment.Methods: Using a modified Delphi methodology involving a panel of 11 experts, we developed a simple, understandable clinical algorithm to serve as a foundation for objective decision making regarding the diagnosis and treatment of lumbar discogenic pain throughout the entire continuum of care. …”
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Bisoprolol for patients with chronic obstructive pulmonary disease at high risk of exacerbation: the BICS RCT by Graham Devereux, Seonaidh Cotton, Mintu Nath, Nicola McMeekin, Karen Campbell, Rekha Chaudhuri, Gourab Choudhury, Anthony De Soyza, Shona Fielding, Simon Gompertz, John Haughney, Amanda Lee, Graeme MacLennan, Alyn Morice, John Norrie, David Price, Philip Short, Jorgen Vestbo, Paul Walker, Jadwiga Wedzicha, Andrew Wilson, Olivia Wu, Brian Lipworth

“…Total number of major adverse cardiovascular events. Lung function (NB, during the COVID-19 pandemic, lung function could not be assessed in participants). …”
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TGFβ1 Restores Energy Homeostasis of Human Trophoblast Cells Under Hyperglycemia In Vitro by Inducing PPARγ Expression, AMPK Activation, and HIF1α Degradation by Nihad Khiat, Julie Girouard, Emmanuelle Stella Kana Tsapi, Cathy Vaillancourt, Céline Van Themsche, Carlos Reyes-Moreno

“…Trophoblast cells predominantly utilize glucose as an energy source, metabolizing it through glycolysis in the cytoplasm and oxidative respiration in the mitochondria to produce ATP. …”
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Mechanical Design and Motion Analysis of a Hybrid Robot for Equine Rehabilitation by YE Zenglin, DAI Zhonghong, ZHANG Liang'an, WEI Liangguo, CHEN Hua

“…ObjectiveEquine therapy, also referred to as therapeutic riding or equine-assisted therapy, is a clinical methodology that promotes physical, psychological, and social functioning through the integration of horse handling and riding skills. …”
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Remote work – the new normal needs more research by Annina Ropponen

“…Changes in sick leave utilization at an academic medical center during the COVID-19 pandemic. …”
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Submillimeter and Mid-infrared Variability of Young Stellar Objects in the M17 H II Region by Zhiwei Chen, Doug Johnstone, Carlos Contreras Peña, Jeong-Eun Lee, Sheng-Yuan Liu, Gregory Herczeg, Steve Mairs, Geumsook Park, Kee-Tae Kim, Mi-Ryang Kim, Keping Qiu, Yao-Te Wang, Xu Zhang, Megan Reiter, The JCMT Transient Team

“…This mid-IR fractional variability as a function of evolutionary stage result is similar to what has previously been found for YSO variability within the Gould Belt and the intermediate-mass star formation region M17 SWex, though overall less variability is detected in M17 in submillimeter and mid-IR. …”
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Research Progress on the Impact of Nighttime Outdoor Environments on Residents’ Health by Chongxian CHEN, Xinrui XIONG, Guangsi LIN, Jingyi LIU

“…Additionally, nighttime recreational activities function as a vital medium for interaction between individuals and their environment, with the realization of health benefits depending on the combined influence of multiple environmental factors. …”
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Population dynamics and monitoring applied to decision-making by M. J. Conroy, D. C. Lee

“…Second, certain outcomes are assigned value, via an objective or utility function. Both of these features involve factors beyond the usual consideration of ecological modeling; the first implies the presence of one or more “decision makers”, and the second characterizes the societal preferences of each possible outcome resulting from a prospective decision. …”
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Integrated single-cell analysis reveals the regulatory network of disulfidptosis-related lncRNAs in bladder cancer: constructing a prognostic model and predicting treatment respons... by Jiafu Xiao, Jiafu Xiao, Jiafu Xiao, Wuhao Liu, Wuhao Liu, Wuhao Liu, Jianxin Gong, Jianxin Gong, Jianxin Gong, Weifeng Lai, Weifeng Lai, Weifeng Lai, Neng Luo, Neng Luo, Neng Luo, Yingfan He, Junrong Zou, Junrong Zou, Zhihua He, Zhihua He, Zhihua He

“…This study aims to investigate disulfidptosis-related lncRNAs (DRLs) as potential prognostic markers for BLCA patients.MethodsUtilizing single-cell sequencing data, RNA sequencing data, and corresponding clinical information sourced from the GEO and TCGA databases, this study conducted cell annotation and intercellular communication analyses to identify differentially expressed disulfide death-related genes (DRGs). …”
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Spatial Analysis of the Relationship between Ecological Factors and Housing Prices in Tehran by Atefeh Kolyaei, Tahir Prizadi, Habibollah Fasihi

“…ArcGIS software was employed, utilizing Spatial Analyst, Spatial Join, and Zonal Statistics functions to create the necessary datasets. …”
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Examining the cultuling of Iranians’ concerns for others: From apathy to metapathy by Reza Pishghadam, Shima Ebrahimi

“…These utterances were collected from written texts across various sources. Subsequently, the expressions related to concern were carefully analyzed utilizing the conceptual model of cultuling analysis (CLA). …”
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Pancreatic β-cells package double C2-like domain beta protein into extracellular vesicles via tandem C2 domains by Diana Esparza, Carinna Lima, Sarah Abuelreich, Ima Ghaeli, Jinhee Hwang, Eunjin Oh, Ayelet Lenz, Angel Gu, Nan Jiang, Fouad Kandeel, Debbie C. Thurmond, Tijana Jovanovic-Talisman

“…Moreover, in rat clonal β-cells, we probed domains required for DOC2B sorting into EVs.MethodUsing Single Extracellular VEsicle Nanoscopy, we quantified EVs derived from clonal β-cells (human EndoC-βH1, rat INS-1 832/13, and mouse MIN6); two other cell types known to regulate glucose homeostasis and functionally utilize DOC2B (skeletal muscle rat myotube L6-GLUT4myc and human neuronal-like SH-SY5Y cells); and human islets sourced from individuals with no diabetes (ND). …”
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µID-TIMS: spatially resolved high-precision U–Pb zircon geochronology by S. Markovic, J.-F. Wotzlaw, D. Szymanowski, J. Reuteler, P. Zeng, C. Chelle-Michou

“…The accuracy and precision of <span class="inline-formula">µ</span>ID-TIMS dates for zircon of any given age depend, as for non-microsampled zircon, on the available mass of U and radiogenic Pb – both a function of sample size. Our accompanying open-source code can aid researchers in estimating the necessary microsample size needed to obtain accurate dates at precision sufficient to resolve the processes under study. …”
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Influence of Emergent Vegetation Layout on Flow Pattern in a Rectangular Shallow Basin by Junnan LYU, Yuxuan JIANG, Zhidong YAO, Chen YE, Xufeng YAN

“…They play critical roles in ecology, water resource management, environmental protection, and enhancing landscape aesthetics. …”
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Environmental Assessment of Cellulose Pulp Production from Wood Waste using Organosolv Treatment by Pazzaglia Aron, Romagnoli Francesco, Castellani Beatrice

“…The dataset utilized for the LCA comprises primary data obtained from in vitro experiments that have been scaling-up, complemented by secondary data sourced from literature and the Ecoinvent life cycle inventory database. …”
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OrthoticS for TReatment of symptomatic flat feet In CHildren (OSTRICH): a randomised controlled trial by Sarah Cockayne, Kalpita Baird, Sally Gates, Caroline Fairhurst, Joy Adamson, Rachel M Bottomley-Wise, Amie Woodward, Michael R Backhouse, Rachel Bye, Nina Davies, Catherine Hewitt, Colin Holton, Peter Knapp, Anne-Maree Keenan, Stewart Morrison, Daniel Parker, Daniel C Perry, Sarah Ronaldson, Mark Smith, Tim Theologis, Victoria Exley, Jane McAdam, David J Torgerson

“…Secondary outcomes included the physical domain subscale at 3, 6 and 12 months, and the ‘School and Play’ and ‘Emotional’ domains of the Oxford Ankle Foot Questionnaire, pain scores, healthcare resource use, EQ-5D-Y and Child Health Utility 9D at all time points. …”
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Citizen scientists for MoveApps: Innovations and insights from volunteer coders in wildlife conservation by Andrea Kölzsch, Kamran Safi, Margaux M. Armfield, Chloe Beaupre, Emily Bennitt, Matthias Böck, William Brown, Christoph Eichler, Wolfgang Fielder, Clemens Hahn, Varalika Jain, Matthew W. Ketchin, Jed A. Long, Alexander V. Merdian‐Tarko, Lauren Minchin, Tomé Neves deMatos, Ambati Rakesh, Ockert Louis vanSchalkwyk, Martin Wikelski, Anne K. Scharf

“…Utilizing the modular, open‐source analysis platform MoveApps, we were able to engage 12 volunteer coders in a challenge to create tools for movement ecology, aimed at animal conservation. …”
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medAL-suite: A software solution for creating and deploying complex clinical decision support algorithms by Ludovico Gennaro Cobuccio, Vincent Faivre, Rainer Tan, Alan Vonlanthen, Fenella Beynon, Emmanuel Barchichat, Alain Fresco, Quentin Girard, Sinan Ucak, Sylvain Schaufelberger, Ibrahim Evans Mtebene, Peter Agrea, Emmanuel Kalisa, Gillian A. Levine, Martin Norris, Sabine Renggli, Alix Miauton, Lisa Cleveley, Kristina Keitel, Julien Thabard, Valérie D’Acremont, Alexandra V. Kulinkina

“…Discussion The medAL-suite focused on democratized development, process-centric design, point-of-care utility, touch-screen interface, low cost, and low power consumption to contribute to sustainable digital systems in low-resource settings. …”
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