O-GlcNAcylation of glutaminase isoform KGA inhibits ferroptosis through activation of glutaminolysis in hepatoblastoma by Sijia Fang, Guoqing Zhu, Yi Xie, Miao Ding, Ni Zhen, Jiabei Zhu, Siwei Mao, Xiaochen Tang, Han Wu, Qi Zhang, Aijia Zhang, Xin Ni, Qiuhui Pan, Ji Ma

“…The O-GlcNAcylation of KGA isoform ensures its stability and glutaminase function in HB cells, which can serve as a promising therapeutic target for KGA-mediated glutaminolysis in HB.…”
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A Refined Terrace Extraction Method Based on a Local Optimization Model Using GF-2 Images by Guobin Kan, Jie Gong, Bao Wang, Xia Li, Jing Shi, Yutao Ma, Wei Wei, Jun Zhang

“…Finally, we utilized multi-source RS data along with terrain elements for correction and optimization to generate a 1 m resolution terrace distribution map in the Zuli River Basin (TDZRB). …”
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Alaska Upper Crustal Velocities Revealed by Air-to-Ground Coupled Waves From the 2022 Hunga Tonga-Hunga Ha’apai Eruption by Kenneth Macpherson, David Fee, Stefan Awender, Bryant Chow, Juliann Colwell, Sam Delamere, Matt Haney

“…This type of air-to-ground coupled wave was observed globally following the largest explosion of the instrumental age, the climactic eruption of the Hunga Tonga-Hunga Ha’apai volcano on 15th January, 2022. We utilize this unprecedented source, along with the presence of colocated seismometers, infrasound sensors, and barometers in Alaska, to examine coupling and reveal elastic parameters beneath the stations. …”
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T cell-related diagnostic model and the underlying mechanism related to PRF1-mediated glycolysis in sepsis: evidences from single-cell, bulk transcriptomics, and experiment validat... by Fu Tian, Hui Chen, Zhicheng Huang, Kai Qiu

“…Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were used for the function and pathways enrichment analysis. Metabolic flux analysis was performed to investigate the underlying metabolic mechanism. …”
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ML-Based Screening of miRNA Inhibitors and Intervention of lncRNA/miRNA/mRNA Axis in Oncogenic KRAS-Associated Colorectal Cancer by Prasanna Srinivasan Ramalingam, Deepak B. Thimiri Govinda Raj, Murugan Subramanian, Sivakumar Arumugam

“…Although the role and function of the lncRNA axis are not clearly understood, various studies have recently focussed on the evaluation of the lncRNA axis role in various cancers. …”
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FAM3C Regulates Glioma Cell Proliferation, Invasion, Apoptosis, and Epithelial Mesenchymal Transition via the Notch Pathway by Xiaochao Xia, Zihao Wang, Lvmeng Song, Yinchuan Cheng, Ping Xiong, Shun Li

“…Herein, we aimed to further investigate the oncological mechanism of FAM3C, specifically in glioma. Methods We utilized open‐source bioinformatics tools and platforms to analyze the transcriptional expression levels, prognosis, and correlation with clinical variables of FAM3C in gliomas, and subsequently, to hypothesize its potential molecular functions and possibly associated signaling pathways. …”
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Development of empirical correlations for sustainable breakup characterization of water and high-viscous oil sheets under acoustic perturbations using high-speed imaging by Aman Singh, Devesh T, Subhash K, Preetam Polavarapu, Jayakrishnan Rahul, Karthick S, Balaji K

“…The key innovation of this study is the design and fabrication of a compact liquid sheet acoustic atomizer that efficiently utilizes acoustic energy to produce high-quality sprays. …”
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Impulse Shaping Method Based on Bayesian Deconvolution by JIA Tonghui, LIU Yi, WANG Ming, MA Yingjie, WANG Bo

“…The initial step of this method entailed expressing the measured pulse signal as the convolution of the current impulse pulse signal and the detection system response function. Then, the measured signal was expressed in the continuous time domain and decomposed into the form of an impulse signal and a double exponential kernel convolution by derivation. …”
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Effects of low-intensity pulsed focal ultrasound-mediated delivery of endothelial progenitor-derived exosomes in tMCAo stroke by Ahmet Alptekin, Mohammad B. Khan, Mahrima Parvin, Hasanul Chowdhury, Sawaiz Kashif, Fowzia A. Selina, Anika Bushra, Justin Kelleher, Santu Ghosh, Dylan Williams, Emily Blumling, Roxan Ara, Asamoah Bosomtwi, Joseph A. Frank, Krishnan M. Dhandapani, Ali S. Arbab

“…The objectives of the proposed studies were to determine whether LIPFUS-mediated increased delivery of EPC-derived exosomes enhances stroke recovery and functional improvement in mice with transient middle cerebral artery occlusion (tMCAo) stroke.MethodsTo enhance exosome delivery to the stroke area, we utilized LIPFUS. …”
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Fuzzy volume fraction model representation of blood-based sisko tri-hybrid nanofluid flow via a stretching cylinder by N. Deepa, P. Kavya, N. Thamaraikannan, S. Madhanraj, P. Asaigeethan, K. Loganathan

“…The triangular membership function (TMF) is utilized to analyze the variability of uncertainty, while the α− cut is responsible for controlling the TFNs. …”
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Jacobian-Free Newton Krylov Methods for Steady and Transient Neutron Transport Models by ZHANG Yangyi, ZHANG Tiancheng, ZHOU Xiafeng

“…To rapidly construct the unified JFNK residuals, the parallel KBA transport sweep methods and physics-based preconditioning techniques were utilized to improve the computational efficiency. To rapidly construct the unified JFNK residuals, the parallel KBA transport sweep methods and physics-based preconditioning techniques were utilized. …”

Wild ActionFormer: Enhancing wildlife action recognition for 11 endangered species in Wolong by Dan Liu, Qianqian Sun, Jin Hou, Bochuan Zheng, Jindong Zhang, Desheng Li, Tomas Norton, Jifeng Ning

“…We constructed a differential dispersion regularization loss function to maintain the alignment of self-supervised learning features and improve the network’s robustness against interference. …”
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Viewing Global Changes in the Heliosheath with IMAP’s Energetic Neutral Atom Imagers by E. J. Zirnstein, J. Heerikhuisen, D. J. McComas, J. Bower, G. Clark, M. A. Dayeh, H. O. Funsten, M. Gkioulidou, D. G. Mitchell, D. B. Reisenfeld, N. A. Schwadron

“…We aim to answer the following: (i) What are the time delays as a function of energy and direction; (ii) at what energies can we observe changes the soonest; and (iii) what might the ENA source distributions affecting the time delays look like? …”
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Effects of hydroxyproline-taurine-cholesterol supplementation on the liver health and lipid metabolisms of turbot Scophthalmus maximus fed Chlorella vulgaris by Daisong Ma, Nan Bai, Shihui Pan, Chuwen Chen, Min Gu

“…Seven experimental diets were formulated. The control diet utilized fishmeal as the exclusive protein source. …”
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The Multifunctional Catalytic Hemoglobin from <i>Amphitrite ornata</i>: Protocols on Isolation, Taxonomic Identification, Protein Extraction, Purification, and Characterization by Anna L. Husted, Victoria R. Sutton, Lauren A. Presnar, R. Kevin Blackburn, Joseph L. Staton, Stephen A. Borgianini, Edward L. D’Antonio

“…The multifunctional catalytic hemoglobin from the terebellid polychaete <i>Amphitrite ornata</i>, also named dehaloperoxidase (<i>Ao</i>DHP), utilizes the typical oxygen transport function in addition to four observed activities involved in substrate oxidation. …”
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Unraveling the impact of blood RANKL and OPG levels on Alzheimer's disease: Independent of bone mineral density and inflammation by Xingzhi Guo, Wenzhi Shi, Juanjuan Lu, Peng Tang, Rui Li

“…Three distinct AD genome‐wide association study (GWAS) data sets from the International Genomics of Alzheimer's Project (IGAP), UK Biobank (UKB), and FinnGen were utilized. Summary‐level data on blood sRANKL and OPG were sourced from deCODE Genetics. …”
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Intrapleural tissue plasminogen activator and deoxyribonuclease in complex pleural effusion and empyema, clinical outcomes, and predictors by Yub Raj Sedhai, Priyanka Bhat, Roshan Acharya, Nada Qaisar Qureshi, Fawaz Mohammed, Irfan Waheed, Tahir Muhammad Abdullah Khan, Muhammad Altaf Ahmed, Nisarfathima Kazimuddin, Akinchan Kafle, Rodney T. Steff, Karan Singh

“…We have tested the clinical role RAPID score (Renal function measured as urea, Age, fluid Purulence, Infection source, Dietary status measured as albumin) to predict treatment success, and all-cause mortality at 6 months. …”
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Metagenomic and phylogenetic analyses reveal gene-level selection constrained by bacterial phylogeny, surrounding oxalate metabolism in the gut microbiota by Sromona D. Mukherjee, Mangesh Suryavanshi, John Knight, Dirk Lange, Aaron W. Miller

“…The frc gene was primarily allocated to the Pseudomonodota phylum, particularly the Bradyrhizobium genus, which is a species capable of utilizing oxalate as a sole carbon and energy source. …”
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Leveraging artificial intelligence for photo identification to aid CITES enforcement in combating illegal trade of the endangered humphead wrasse (Cheilinus undulatus) by C. Y. Hau, W. K. Ngan, Y. Sadovy de Mitcheson, Y. Sadovy de Mitcheson, Y. Sadovy de Mitcheson

“…A Licence to Possess system for CITES is implemented in the city to regulate the quota of live wild-sourced CITES specimens, including humphead wrasse, held at each registered trading premise and ensure traceability through documentation. …”
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Software with artificial intelligence-derived algorithms for detecting and analysing lung nodules in CT scans: systematic review and economic evaluation by Julia Geppert, Peter Auguste, Asra Asgharzadeh, Hesam Ghiasvand, Mubarak Patel, Anna Brown, Surangi Jayakody, Emma Helm, Dan Todkill, Jason Madan, Chris Stinton, Daniel Gallacher, Sian Taylor-Phillips, Yen-Fu Chen

“…Information required to populate the models included the prevalence of lung nodules, risk of lung cancer with different nodule sizes, sensitivity and specificity for nodule detection, nodule type and size distributions in different population, resource use, costs and utilities. Where possible, parametrisation was driven by findings from the test accuracy review. …”
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