Systematic identification and characterization of high efficiency Cas9 guide RNAs for therapeutic targeting of ADAR. by Benjamin G Gowen, Kory Melton, Weng In Leong, Prachi Khekare, Shannon McCawley, Jean Chan, Pierre Boivin, Vihasi Jani, Aaron J Cantor, Akshay Tambe, Mary Haak-Frendscho, Mary J Janatpour, Spencer C Wei

“…These findings provide a resource of well-characterized, high efficiency ADAR-targeting Cas9 guide RNAs suitable for genomic medicines utilizing different delivery modalities and addressing different therapeutic areas.…”
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Novel 3D UAV Path Planning for IoT Services Based on Interactive Cylindrical Vector Teaching–Learning Optimization Algorithm by Xinghe Jiang, Xuanyu Wu, Zhifeng Zhang, Zhaoxi Hong, Xi Xiao, Yixiong Feng

“…The ICVTLBO is compared with other classical and novel algorithms on the CEC2022 benchmark function suite, demonstrating its effectiveness and reliability in solving complex optimization problems. …”
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Prediction of Alzheimer’s Disease Based on Multi-Modal Domain Adaptation by Binbin Fu, Changsong Shen, Shuzu Liao, Fangxiang Wu, Bo Liao

“…<b>Background/Objectives:</b> Structural magnetic resonance imaging (MRI) and 18-fluoro-deoxy-glucose positron emission tomography (PET) reveal the structural and functional information of the brain from different dimensions, demonstrating considerable clinical and practical value in the computer-aided diagnosis of Alzheimer’s disease (AD). …”
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Green synthesis of silver nanoparticles using cocoon extract of Bombyx mori L.: therapeutic potential in antibacterial, antioxidant, anti-inflammatory, and anti-tumor applications by Ahmed H. Elsaffany, Ahmed E. M. Abdelaziz, Abdullah A. Zahra, Alsayed E. Mekky

“…In the present study, a new method for the biosynthesis of silver nanoparticles (AgNPs) was explored by applying Bombyx mori cocoon extract as a sustainable and eco-friendly biological source. Unlike previous studies that primarily utilized plant or microbial extracts, this approach offers a more efficient alternative due to the unique protein and polyphenol content of silk cocoons, which enhances the stability and biological properties of the biosynthesized nanoparticles. …”
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Measurement and Evaluation of Social Resilience Indicators in the Historical Neighborhoods of Tabriz City (Case Study: Sorkhab Neighborhood of Tabriz) by Leila Rahimi, Mahta Choobineh

“…In the analysis section, SPSS software was utilized, employing one-way variance and sample t-test methods to examine the impacts of gender, age, and education on the three functional, social, and cultural dimensions. …”
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Particle track imaging simulation and expected outcomes of the Grid-based energetic neutral atom imager (GENA) for the Queqiao-2 mission by Li Lu, Qing-long Yu, Jin-fa Shao, Yuan Chang, Zhong Xie, Jian Lan, Shuai Jia

“…In this study, a new set of response functions was developed for the instrument's collimation system design to simulate measurement outcomes. …”
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Efficient Electrochemical CO2 Reduction Using AgN3 Single‐Atom Sites Embedded in Free‐Standing Electrodes for Flow Cell Applications by M. Nur Hossain, Ali Malek, Zhangsen Chen, Lei Zhang, Shuhui Sun, Hanshuo Liu, Roberto Neagu, Jigang Zhou, Hui Yuan, Christopher S. Allen, Gianluigi Botton

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Network security traffic detection and legal supervision based on adaptive metric learning algorithm by Liu Zhen

“…Using the vertex weighted function algorithm, we can analyze the Time complexity of the original algorithm and calculate more accurate time values. …”
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Determination of the reduced electric field in surface dielectric barrier discharge plasmas by А.А. Муталип, Е.А. Усенов, А.К. Акильдинова, М.Қ. Досболаев, М.Т. Габдуллин, Т.С. Рамазанов

“…The main transport properties of electrons, such as mobility, mean average energy, and diffusion coefficients were calculated using the BOLSIG+ open source software. The dependence of the ratio of intensities of the nitrogen spectral lines on the reduced electric field, the dependence of the E/n on plasma power, and the dependence of the electron energy distribution function (EEDF) on E/n were obtained. …”
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Somatic 'soluble' adenylyl cyclase isoforms are unaffected in Sacy tm1Lex/Sacy tm1Lex 'knockout' mice. by Jeanne Farrell, Lavoisier Ramos, Martin Tresguerres, Margarita Kamenetsky, Lonny R Levin, Jochen Buck

“…The absence of any major somatic phenotype is inconsistent with the variety of somatic functions identified for sAC using pharmacological inhibitors and RNA interference.…”
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Visual Metaphor: Likeness of Unlike Things in Cartoons by Mohsen Zarifian

“…Guided by Conceptual Metaphor Theory, developed by Lakoff and Johnson as the theoretical framework, this study aims to examine how metaphors in political cartoons function as essential components in conveying complex socio-political messages. …”
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Synergizing BRDF correction and deep learning for enhanced crop classification in GF-1 WFV imagery by Yuanwei Chen, Yang Li, Runze Li, Chongzheng Guo, Jilin Li

“…Accurate crop classification is essential for agricultural management, resource allocation, and food security monitoring. …”
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A comprehensive review on natural convection in various shaped enclosures by FEM: Engineering applications by Asif Hasan, Mohammad Mokaddes Ali, Shakhawat Hossain, Neamul Haque Siam, Asaduzzaman Rony, Al-Amin Shohan

“…The review further explores localized heat sources, vortex formation due to embedded obstacles, porous media effects, and the synergistic influence of thermal and magnetic fields. …”
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Design of a Smart Street Light-Integrated Electromec-hanical System for Willow Catkin Control by Zhou Ting, Yuan Ye, Yin Xue, Liu Yuqian, Sun Junxiu, Qi Fenghua

“…Aiming at the lack of development of extended functions for environmental management and failure to fully utilize the potential of streetlights as urban infrastructure, this study proposes a modular intelligent streetlight system integrating electrostatic adsorption and resource recycling. …”
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Nutritional Value, Ethnopharmacology, Chemistry, and Biological Activities of Species of the Genus <i>Cnidoscolus</i>: An Updated Review by Joice Barbosa do Nascimento, José Jonas Ferreira Viturino, Maria Alice Macêdo Ribeiro, José Galberto Martins da Costa

“…Additionally, certain species like <i>C. aconitifolius</i> have shown potential for human consumption, with leaves being eaten raw or cooked, while <i>C. quercifolius</i> demonstrates nutritional value in its seeds, which can be utilized in the development of functional foods. However, further studies are needed to focus on the isolation and characterization of bioactive compounds found in these species, as well as deeper investigations into the molecular and cellular mechanisms underlying their biological activities and assessments of the safety of long-term consumption in both humans and animals. …”
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Technical stakeholders' perspective of solar photovoltaic system failure in Sub-Saharan Africa: The case of Ghana by Jacob Junior Owusu, Edmund C. Okoroigwe, Chigbo A. Mgbemene, Gabriel Takyi, Onyemaechi Valentine Ekechukwu

“…Alternative electricity-generation fossil-fuel sources are prohibitive. Solar energy photovoltaic systems have great potential in bridging the energy gap in electricity off-grid locations in sub-Saharan Africa and contribute to the region’s energy portfolio at utility and/or domestic levels. …”
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Mechanical and electrical properties of a polymer electrolyte based on zinc oxide for enhancement of Li-ion battery performance by Peng Zhang

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A risk-based approach to reduction of warm air infiltration for energy efficiency optimization in a cold storage system-a case study of a fruit packaging plant by Peter Kibagendi Mokaya, James Wakiru, Josephat Tanui

“…Thermal graphic measurements, electricity bills, and on-site observation of the operation patterns provided source data. An Ishikawa diagram and a risk-based Failure Mode and Effect Analysis (FMEA) were used to identify and prioritize root causes, respectively, and a modified decision tree was then utilized to structure the mitigation strategy. …”
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RANCANG BANGUN MINI LAB FLUIDA SEBAGAI OBJEK PENGAMBILAN DATA UNTUK KEPERLUAN PENELITIAN DI UNIVERSITAS MERCUBUANA KERANGGAN by Aji Gunawan

“…Kata kunci : Lab fluida, perpipaan, pengujian Abstract The fluid lab is functioned as a place for retrieving data in order to learn the process and leading research of fluid. …”
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Advances in Stem Cell Therapy for Huntington’s Disease: A Comprehensive Literature Review by Siddharth Shah, Hadeel M. Mansour, Brandon Lucke-Wold

“…Recent research indicates that NSCs have been the most often utilized stem cell type for treating HD. NSCs have been generated and extracted from a variety of sources, including HD patients’ somatic cells and the brain itself. …”
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