The role of CD47 in immune escape of colon cancer and its correlation with heterogeneity of tumor immune microenvironment by Qiu-Si Tian, ChunMei Zhang, Zhi-Jun Bao, ZhiGang Pei

“…The Tumor Immune Estimation Resource and Kaplan-Meier plotter were utilized to assess the relationship between CD47 expression, patient prognosis, and immune infiltration. …”
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Rapid Prediction of Multi-physics Coupling in Heat Pipe ReactorBased on Neural Network by ZHANG Junda, LIU Xiaojing, XIONG Jinbiao, CHAI Xiang, ZHANG Tengfei

“…Concurrently, the neural network models utilized in rapid predictions have less stringent computational resource requirements and offer greater adaptability to varied environments. …”

Current practices in physiotherapy management of COPD in Pakistan by Sajjan Iqbal Memon, Fahad Tanveer, Gulzar Usman, Misbah Shakeel

“…Various studies have demonstrated that breathing exercises are efficacious in enhancing the strength of the muscles involved in inhalation and increasing the ability to engage in physical activity for those diagnosed with COPD.2 Physiotherapists routinely utilize the active cycle of breathing approach as a non-pharmacological method for airway clearance.3 Furthermore, the effects of oscillatory positive expiratory pressure therapy on the quality of life and objective signs of cough and sleep disturbance in COPD patients with regular sputum production have been investigated.4 The combination of postural drainage techniques and chest mobilization has been proven to effectively manage pneumonia and enhance postural alignment in patients with COPD.5 Several investigations are conducted to compare the postural alignment of COPD patients with that of healthy individuals and to establish a correlation between pulmonary function and postural alignment in the COPD group that has accounted for favorable results.6 In addition, the existing evidence suggests that active breathing strategies, such as the active cycle of breathing techniques, autogenic drainage, and forceful expiration, can be effective in managing COPD.7 At present, COPD management in Pakistan faces practical challenges such as resource limitations and training access for physiotherapists. …”
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Biological crusts increase soil microbial biomass and alter bacterial and fungal community compositions under pine restored over ten years in a Pisha sandstone soil by Qi Le, Qi Le, Meng Ru, Meng Ru, Ren Weibo, Ren Weibo, Zhang Min, Zhang Min, Mi Wentao, Mi Wentao, Yuan Ting, Yuan Ting, Liu Yaling, Yuan Feng

“…These abundant soil nutrients provide a carbon source for microorganisms, promoting the growth and metabolic activity of soil microorganisms, thereby significantly enhancing soil microbial diversity and biomass. …”
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Pathway for Renewable Energy Application in Urban Green Space under the Low Carbon Perspective by Kailun WANG, Tonggang NIU, Lian LIU, Zhongjie WANG

“…The research provides a detailed analysis of energy application types and methods, as well as energy consumption models for each of the aforesaid three types of green spaces.ResultsThe research identifies three core challenges in the application of renewable energy in urban green spaces: 1) How to scientifically select the most appropriate renewable energy types and optimize spatial layouts in accordance with natural resource constraints and the functional requirements of green spaces in order to improve energy efficiency; 2) how to effectively integrate the technical functions of energy facilities with landscape and ecological values, so as to achieve a seamless integration of energy infrastructure with landscape, thereby enhancing both environmental adaptability and public acceptance; and 3) how to develop flexible energy utilization and management strategies tailored to the energy consumption characteristics of different green space types, thus ensuring long-term, stable, and sustainable energy supply. …”
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GINS1 is a prognostic biomarker and correlated with methylation and immune escape in liver hepatocellular carcinoma by Mingchao Liang, Tianqi Lai, Tianqi Lai, Zhen Li, Wei Yu, Mingrong Cao, Nan Yao, Youzhu Hu, Youzhu Hu, Tongzheng Liu, Junjie Liang

“…Enrichment analyses were conducted to investigate the functions of GINS1. To assess the genetic alterations, methylation, and prognostic value, cBioPortal, and MethSurv databases were utilized. …”
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Integrated analysis of single-cell and bulk transcriptomics reveals cellular subtypes and molecular features associated with osteosarcoma prognosis by Feng Liu, Tingting Zhang, Yongqiang Yang, Kailun Wang, Jinlan Wei, Ji-Hua Shi, Dong Zhang, Xia Sheng, Yi Zhang, Jing Zhou, Faming Zhao

“…Moreover, the study investigated the impact of ATF6α in OS aggressiveness through genetic and pharmacological loss of function analyses. Lastly, the CellChat algorithm was employed to investigate cell-cell communications. …”
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Characterization of a GH43 Bifunctional Glycosidase from Endophytic <i>Chaetomium globosum</i> and Its Potential Application in the Biotransformation of Ginsenosides by Yao Lu, Qiang Jiang, Yamin Dong, Runzhen Ji, Yiwen Xiao, Du Zhu, Boliang Gao

“…The GH43 family of glycosidases represents an important class of industrial enzymes that are widely utilized across the food, pharmaceutical, and various other sectors. …”
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A Novel Signature Composed of Hypoxia, Glycolysis, Lactylation Related Genes to Predict Prognosis and Immunotherapy in Hepatocellular Carcinoma by Feng Yi, Shichao Long, Yuanbing Yao, Kai Fu

“…Subsequently, the single sample Gene Set Enrichment Analysis (ssGSEA), Tumor Immune Estimation Resource (TIMER) and Tumor Immune Dysfunction and Exclusion (TIDE) algorithms were utilized to assess immune infiltration and immune evasion. …”
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ESSegNeXt: A Novel Building Extraction Framework Based on Generalized SamGeo and SegNeXt Models Using High-Resolution Remote Sensing Images by Qi Lu, Wensong Liu, Lianpeng Zhang, Erzhu Li, Junlong Qiu, Lei Wang

“…Additionally, an edge-preserving loss function was introduced to enhance the boundary detection capability of the SegNeXt model using edge features extracted by SamGeo during cyclic validation. …”
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Resolving Turbulence Drivers in Two Luminous Obscured Quasars with JWST/NIRSpec Integral Field Unit by Mandy C. Chen, Hsiao-Wen Chen, Michael Rauch, Andrey Vayner, Weizhe Liu, David S. N. Rupke, Jenny E. Greene, Nadia L. Zakamska, Dominika Wylezalek, Guilin Liu, Sylvain Veilleux, Nicole P. H. Nesvadba, Caroline Bertemes

“…In this Letter, we investigate the turbulence and energy injection in the extended nebulae surrounding two luminous obscured quasars, WISEA J100211.29+013706.7 ( z = 1.5933) and SDSS J165202.64+172852.3 ( z = 2.9489). Utilizing high-resolution data from the NIRSpec integral field unit onboard the James Webb Space Telescope, we analyze the velocity fields of line-emitting gas in and around these quasars and construct the second-order velocity structure functions (VSFs) to quantify turbulent motions across different spatial scales. …”
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Unraveling the impact of blood RANKL and OPG levels on Alzheimer's disease: Independent of bone mineral density and inflammation by Xingzhi Guo, Wenzhi Shi, Juanjuan Lu, Peng Tang, Rui Li

“…Three distinct AD genome‐wide association study (GWAS) data sets from the International Genomics of Alzheimer's Project (IGAP), UK Biobank (UKB), and FinnGen were utilized. Summary‐level data on blood sRANKL and OPG were sourced from deCODE Genetics. …”
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Mediator MED23 controls oligodendrogenesis and myelination by modulating Sp1/P300-directed gene programs by Shuai Zhang, Xue Feng, Chong-Hui Li, Yuan-Ming Zheng, Meng-Ya Wang, Jun-Jie Li, Yun-Peng Dai, Naihe Jing, Jia-Wei Zhou, Gang Wang

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Machine learning-based model for acute asthma exacerbation detection using routine blood parameters by Youpeng Chen, Junquan Sun, Yabang Chen, Enzhong Li, Jiancai Lu, Huanhua Tang, Yifei Xie, Jiana Zhang, Lesi Peng, Haojie Wu, Zhangkai J. Cheng, Baoqing Sun

“…Background: Acute asthma exacerbations (AAEs) are a leading cause of asthma-related morbidity and mortality, especially in resource-limited settings where pulmonary function tests are unavailable or when patients are unable to cooperate with testing. …”
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Changes in soil pH on the Tibetan Plateau from the 1980 s to 2020 s by Lirong Zhao, Bo Pang, Jiangtao Hong, Xinxin Zhang, Jinmei Li, Xiaodan Wang

“…Soil pH, as a crucial variable in the soil environment, has a significant impact on the structure and function of terrestrial ecosystems. The Tibetan Plateau is recognized as one of the most sensitive regions to global climate change. …”
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Testing an inverse modeling approach with gradient boosting regression for stroke volume estimation using patient thermodilution data by Vasiliki (Vicky) Bikia, Dionysios Adamopoulos, Dionysios Adamopoulos, Dionysios Adamopoulos, Marco Roffi, Marco Roffi, Georgios Rovas, Stéphane Noble, Stéphane Noble, François Mach, François Mach, Nikolaos Stergiopulos

“…Stroke volume (SV) is a major indicator of cardiovascular function, providing essential information about heart performance and blood flow adequacy. …”
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Parsimonious models of root zone temperature in soilless substrates through ensemble machine learning by James F. Cross, James S. Owen, Jr., Jacob H. Shreckhise, Jeb S. Fields, Lloyd Nackley, James E. Altland, Darren T. Drewry

“…Containerized plant systems using soilless substrates are increasingly vital to global food and horticultural production, offering efficient resource use and expanded crop production in areas where native soils are not suitable. …”
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Comprehensive analysis of potential biomarkers for the diagnosis and prognosis of Cervical squamous cell carcinoma - based on GEO and TCGA databases by Yufen Chen, Qinghua Deng, Tengyue Fu, Yuxiang Huang, Houlin Li, Jingmu Xie, Feng Liao, Feimiao Zeng, Xinyi Fang, Ruiman Li, Zhuming Chen

“…Decision curve analysis (DCA) was performed to assess the nomogram’s clinical utility and net benefit for application in clinical practice. …”
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Half-hourly electricity price prediction model with explainable-decomposition hybrid deep learning approach by Sujan Ghimire, Ravinesh C. Deo, Konstantin Hopf, Hangyue Liu, David Casillas-Pérez, Andreas Helwig, Salvin S. Prasad, Jorge Pérez-Aracil, Prabal Datta Barua, Sancho Salcedo-Sanz

“…Accurate prediction of electricity price (EP) is crucial for energy utilities and grid operators for enhancing the energy trading, grid stability studies, resource allocations and pricing strategies, thereby improving the overall grid reliability, efficiency, and cost-effectiveness. …”
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Improved detection of decreased glucose handling capacities via continuous glucose monitoring-derived indices by Hikaru Sugimoto, Ken-ichi Hironaka, Tomoaki Nakamura, Tomoko Yamada, Hiroshi Miura, Natsu Otowa-Suematsu, Masashi Fujii, Yushi Hirota, Kazuhiko Sakaguchi, Wataru Ogawa, Shinya Kuroda

“…This study assessed the utility of relatively easy-to-measure continuous glucose monitoring (CGM)-derived indices in estimating glucose handling capacities calculated from resource-intensive clamp tests. …”
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