555 Design, development, and implementation of an investigator-focused CRM platform for managing navigation, consults, services, and delivery by Brian Sevier, Kacey L. Richards, Erica Rocco, Christine Chaisson

“…Discussion/Significance of Impact: YCCI’s CRM platform advances the CTS mission by streamlining PI support, enhancing resource utilization, and fostering inter-team collaboration within the research ops and administration teams. …”
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TGFβ1 Restores Energy Homeostasis of Human Trophoblast Cells Under Hyperglycemia In Vitro by Inducing PPARγ Expression, AMPK Activation, and HIF1α Degradation by Nihad Khiat, Julie Girouard, Emmanuelle Stella Kana Tsapi, Cathy Vaillancourt, Céline Van Themsche, Carlos Reyes-Moreno

“…Trophoblast cells predominantly utilize glucose as an energy source, metabolizing it through glycolysis in the cytoplasm and oxidative respiration in the mitochondria to produce ATP. …”
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In-vitro transcriptomic profiling of indigenous Gaddi vis-à-vis exotic Labrador dogs: insights from systems biology by Jaswinder Kaur, Manu Mohan, Bilawal Singh, Ram Saran Sethi, Deepti Narang, Simarjeet Kaur, Chandra Sekhar Mukhopadhyay

“…Despite its vital role, it remains unrecognized by the National Bureau of Animal Genetic Resources (NBAGR). This study addresses the gaps in understanding the genetics and immune responses of Indigenous breeds, emphasizing their importance as holders of unique genetic heritage. …”
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Costs and Outcomes of a Therapist-Guided Internet-Delivered Cognitive Behavioral Therapy: Multicenter Observational Study by Zareen Abbas Khan, Jørn Heggelund, Stian Lydersen, Kristian Kidholm, Henrik Pedersen, Imre Janszky, Tine Nordgreen, Vidar Halsteinli

“…Regarding work and social functioning, 97 (33.0%) patients responded positively to the treatment and 60 (23.0%) achieved remission, as measured by the WSAS. …”
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Order assignment mechanism based on hierarchical decomposition and element matching by ZHANG Xinyue, LYU Weimin, WEI Dingjiang, YANG Dongsheng

“…This integrates and coordinates operational tasks, ensures no resource conflicts, and provides alternatives for responding to battlefield variables. …”
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Establishing a core outcome set for creatine transporter deficiency and guanidinoacetate methyltransferase deficiency by Zahra Nasseri Moghaddam, Emily K. Reinhardt, Audrey Thurm, Beth K. Potter, Maureen Smith, Celeste Graham, Beth H. Tiller, Steven A. Baker, Deborah A. Bilder, Regina Bogar, Jacobus Britz, Rachel Cafferty, Daniel P. Coller, Ton J. DeGrauw, Vicky Hall, Gerald S. Lipshutz, Nicola Longo, Saadet Mercimek-Andrews, Judith S. Miller, Marzia Pasquali, Gajja S. Salomons, Andreas Schulze, Celine P. Wheaton, Kayla F. Williams, Sarah P. Young, Jasmine Li, Sofia Balog, Theresa Selucky, Sylvia Stöckler-Ipsiroglu, Heidi Wallis

“…Conclusions Development of this COS illustrates a patient-centered approach for clinical trial readiness for CTD and GAMT that if utilized will make clinical trial results comparable, minimize bias in clinical trial outcome selection, and promote efficient use of resources.…”
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Design, Manufacture, and Performance Testing of a Water Hammer Pump with Five Different Air Chambers by Marco Fidel Romero Zárate, Héctor Flores-Breceda, Juan Arredondo-Valdez, Urbano Luna-Maldonado, Wilgince Apollon, Alejandro Isabel Luna-Maldonado

“…In Mexico, despite abundant overall water resources, many arid areas still lack access to reliable water. …”
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Extraction of degraded proteins from red and green macroalgae using ultrasonic-assisted extraction and Fenton's reagent in combination by Lin Ching I, Chang Chia Hsin, Fan Chih Hsuan, Chiu Pei Chia, Tsai Shu Hsien, Chien Chuan Chi, Lee Shih Chi, Chung Cheng Pei, Lee Ming Yi

“…This study utilized two common macroalgae species from Taiwanese waters, green algae Ulva lactuca (Ulva) and red algae Sarcodia suae (Sarcodia), to evaluate the feasibility and efficacy of a novel cell wall disruption technique combining Fenton reagent and ultrasound-assisted extraction (UAE). …”
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DETERMINATION OF CHEWING EFFICIENCY IN PATIENTS WITH RESTORED TOOTH CROWN PART by V.V. Nikolov, D M. Korol, D.D. Kindiy, M.D. Korol

“…In most cases preparation is confined to the ledge creation. Its function is to provide a smooth transition of orthopedic restoration to a tooth root and prevent the traumatization of marginal paradontium. …”
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Clinical efficacy and safety of sodium-glucose cotransporter protein-2 (SGLT-2) inhibitor, glucagon-like peptide-1 (GLP-1) receptor agonist, and Finerenone in type 2 diabetes melli... by Jingyi Guo, Maoying Wei, Wenhua Zhang, Yijia Jiang, Aijing Li, Churan Wang, Dan Yin, Anning Sun, Yanbing Gong

“…We assessed publication bias using funnel plots and explored potential sources of heterogeneity through subgroup analysis.ResultsA total of 39 studies (99,599 patients) were included. …”
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A Framework for Synergy Measurement Between Transportation and Production–Living–Ecological Space Using Volume-to-Capacity Ratio, Accessibility, and Coordination by Xiaoyi Ma, Mingmin Liu, Jingru Huang, Ruihua Hu, Hongjie He

“…By introducing an improved accessibility evaluation model and developing a coordination measurement algorithm, a three-dimensional evaluation mechanism covering development potential assessment, service efficiency diagnosis, and resource allocation optimization is established. Empirical research indicates that the improved accessibility indicators can precisely identify the transportation location value of regional functional cores, while the composite coordination indicators can deconstruct the spatiotemporal matching characteristics of “transportation facilities—spatial functions,” providing a dual decision-making basis for the redevelopment of existing space. …”
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Advances in In Vitro and In Vivo Bioreactor-Based Bone Generation for Craniofacial Tissue Engineering by Emma Watson, Antonios G. Mikos

“…In vivo bioreactors utilize the patient’s own body as a source of cells and of nutrient transfer and involve the implantation of a scaffold with or without growth factors adjacent to vasculature, followed by the eventual transfer of vascularized, mineralized tissue to the defect site. …”
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A Big Data Approach for the Regional-Scale Spatial Pattern Analysis of Amazonian Palm Locations by Matthew J. Drouillard, Anthony R. Cummings

“…<i>Arecaceae</i> (palms) are an important resource for indigenous communities as well as fauna populations across Amazonia. …”
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RESPONDING TO REVIEWERS – THE CASE OF A GENRE-BASED ACADEMIC WRITING TASK FOR DOCTORAL STUDENTS by Ileana Oana MACARI

“…Cuvinte-cheie: Limbaje specializate (LS), pedagogia genului funcțional; activitate de scriere bazată pe genul funcțional; conștientizarea genului funcțional; scriere academică în L1   Article history: Received 28 March 2024; Revised 24 June 2024; Accepted 15 October 2024; Available online 10 December 2024; Available print 30 December 2024. …”
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Leveraging In-Network Caching in Vehicular Network for Content Distribution by Haiyan Tian, Yusuke Otsuka, Masami Mohri, Yoshiaki Shiraishi, Masakatu Morii

“…The simulation results validate the proposed scheme in four aspects: robustness resisting obstacle buildings, reliability and scalability in different traffic loads, low utilization ratios of RSUs and Internet resource, and efficiency of cache functions.…”
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Towards an accurate electronic structure of single photon emitters in hexagonal boron nitride by Yilin Chen, Haoxiang Chen, Nikolay Bogdanov, Kuang Yu, Ali Alavi, Enge Wang, Ji Chen

“…Furthermore, by computing the low-lying electronic states and analyzing the corresponding many-body wave functions, we identify two potential sources for the mysterious luminescence band in the visible region, including a doublet-doublet transition. …”
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Characterization of two novel chia (Salvia hispanica L.) white and black genotypes via DNA barcoding, physiological, and agronomic traits by Clara R. Azzam, Mokhtar Said Rizk, Soha Sayed Mohammad Mostafa, Ramadan A. Arafa, Mohamed Samy Al-Nabawi, Nahid Abdelaty Ali Morsi, Marwa Mahmoud Nasr El-Din, Enass Hassan Taher, Khaled Adly Khaled

“…Background: Chia (Salvia hispanica L.) is recognized for its nutritional value and health-promoting compounds, including flavonoids. Aim: This study utilized DNA barcoding to identify and differentiate two novel chia genotypes, CACH-W and CACH-B, providing insights for breeding programs and genetic resource conservation (CA refers to the developer and CH refer to Chia). …”
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Food Production and Landscape Reconstruction of Liangzhu Culture Village (5000–4600 B.P.)—Archaeobotanical Evidence from the Site of Zhumucun, Southern China by Xiaoqu Zheng, Fan Yang, Mingli Sun, Qinyu Chen

“…Following an analysis of the plant distribution and utilization patterns at the site, it became clear that the Zhumucun site functioned as a small agricultural settlement. …”
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The Role of Machine Translation in English Language Learning: A Systematic Review by Judelyn Alones

“… This systematic literature review (SLR) examines the functions, limitations, and effectiveness of machine translation (MT) tools in English language learning. …”
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Whole-Genome Sequencing and Fine Map Analysis of <i>Pholiota nameko</i> by Yan He, Bo Liu, Xiaoqi Ouyang, Mianyu He, Hongyan Hui, Bimei Tang, Liaoliao Feng, Min Ren, Guoliang Chen, Guangping Liu, Xiaolong He

“…This study aimed to address that gap by employing Illumina and Nanopore sequencing technologies to perform whole-genome sequencing, de novo assembly, and annotation analysis of the <i>P. nameko</i> ZZ1 strain. Utilizing bioinformatics methods, we conducted a comprehensive analysis of the genomic characteristics of this strain and successfully identified candidate genes associated with its mating type, carbohydrate-active enzymes, virulence factors, pan-genome, and drug resistance functions. …”
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