Proteomic analysis of plasma unravels dynamic pathways and potential biomarkers indicating disease stages following Mtb infection by Zonglei Zhou, Jie Tian, Yuying He, Haiyan Xiong, Weibing Wang

“…ABSTRACT Tuberculosis (TB) stages depend greatly on the interaction between Mycobacterium tuberculosis (Mtb) and the host response. As a non-negligible source of active tuberculosis (ATB), individuals with latent Mtb infection (LTBI) are insidious and hard to be detected due to limited biomarkers. …”
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Effect of the diet level of whole-plant corn silage on the colonic microflora of Hezuo pigs by Qiaoli Yang, Longlong Wang, Pengfei Wang, Zunqiang Yan, Qiong Chen, Pengxia Zhang, Jie Li, Rui Jia, Yao Li, Xitong Yin, Shuangbao Gun

“…Background Whole-plant corn silage (WPCS) is an important roughage source for livestock, and have critical influences on rumen or intestinal microbiota, thus affecting the growth performance and feed efficiency. …”
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Dietary supplementation with L-carnitine elevates intracellular carnitine levels and affects gene expression of SLC25A20 and COX4I1, as well as non-mitochondrial respiration of bov... by Leonie Seemann, Susanne Kersten, Susanne Bühler, Fabian Billenkamp, Ulrich Meyer, Christian Visscher, Korinna Huber, Erika Most, Klaus Eder, Sven Dänicke, Jana Frahm

“…The same applied for PBMC mitochondrial functionality and metabolic activity as assessed by ex vivo approaches, whereas non-mitochondrial respiration rate was significantly affected by L-carnitine supplementation over time. …”
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Beyond access: assessing WASH service delivery models in healthcare facilities of North Mecha, Dera, and Farta, Ethiopia by Abireham Misganaw Ayalew

“…A total of 384 citizens were selected through a systematic random sampling technique to participate in the survey. …”
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Multi-omics analyses reveal fecal microbial community and metabolic alterations in finishing cattle fed probiotics-fermented distiller’s grains diets by Rong Zhang, Shihui Mei, Guangxia He, Miaozhan Wei, Lan Chen, Ze Chen, Min Zhu, Bijun Zhou, Kaigong Wang, Zhentao Cheng, Chunmei Wang, Erpeng Zhu, Chao Chen

“…ABSTRACT Distiller’s grains (DG) are a potential source of animal feeds, and many studies have indicated positive regulatory roles of feeding DG diets in animal breeding. …”
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Trade-offs and synergies for urban Production-Living-Ecological spatial Patterns-Comparison study between Fuzhou, China, and Saskatoon, Canada by Xi Wang, Xiaomei Li, Jinming Sha, Hao Zhang, Eshetu Shifaw, Xulin Guo, Shuhui Lai, Jinliang Wang

“…First, the paper identified the PLE spaces by integrating multi-source data, then analyzed the PLE spatial agglomeration characteristics by using the average nearest neighbor and kernel density analysis, finally detected the trade-offs and synergies between functional spaces by Spearman correlation and bivariate spatial autocorrelation. …”
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Cytotoxicity to cells revealed the virulence-associated protein E gene as a potential virulence factor in methicillin-resistant Staphylococcus aureus by Dengyuan Li, Yu Shi, Ning Zou, Tingting Yang, Wenpeng Gu, Feng Liao

“…The aim of this study was to explore the structure and function of the virE gene of MRSA, and to provide a basis for subsequent in-depth study of this gene. …”
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The Experience of Using a Combination of Febuxostat and Canakinumab in Tophaceous Gout Complicated by Chronic Kidney Disease in a Teenage Patient: A Case Study by Maria I. Kaleda, Irina P. Nikishina, Nurali Z. Zokirov, Alina V. Charlamova, Maxim S. Eliseev

“…Late initiation of urate-lowering therapy in children with gout increases the risk of severe disability due to the state of the musculoskeletal system and kidney function. Description of a Clinical Case. At the age of 13 years and 9 months, the boy first experienced acute pain, hyperthermia, and restriction of movement in the right elbow joint. …”
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Epithelial-to-mesenchymal transition (EMT) and cancer metastasis: the status quo of methods and experimental models 2025 by Heike Allgayer, Samikshya Mahapatra, Barnalee Mishra, Biswajit Swain, Suryendu Saha, Sinjan Khanra, Kavita Kumari, Venketesh K. Panda, Diksha Malhotra, Nitin S. Patil, Jörg H. Leupold, Gopal C. Kundu

“…Metastasis still needs to be better understood functionally in its major but complex steps of migration, invasion, intravasation, dissemination, which contributes to the establishment of minimal residual disease (MRD), extravasation, and successful seeding and growth of metastatic lesions at microenvironmentally heterogeneous sites. …”
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Uncovering the role of Gpr45 in obesity regulation by Eva O. Karolczak, Chia Li, Ivan C. Alcantara, Isabel M. Cohen, Claire Gao, Cuiying Xiao, Abigail I. Goldschmidt, Cynthia A. Pinkus, Junjie Li, Monica M. Li, Ryan M. Esquejo, Jean-Philippe Fortin, Kendra K. Bence, Marc L. Reitman, Michael J. Krashes

“…Underscoring this, agonists for GPCRs have recently revolutionized the treatment of diabetes and obesity. The rampant success of these compounds has invigorated interest in identifying additional GPCRs that modulate appetite and body weight homeostasis. …”
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Effects of exercise with music in frail older adults: a systematic review and meta-analysis by NamHee Kim, Gwang Suk Kim, Min Kyung Park, Layoung Kim, Jae Jun Lee, Seungbum Yang

“…This study evaluated the impact of exercise with music on the physical and emotional health of frail, community-dwelling older adults.Design A systematic review and meta-analysis were conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines.Data sources MEDLINE, Cumulative Index to Nursing and Allied Health Literature, Embase, Cochrane Library, PsycINFO, Google Scholar and the Virginia Henderson International Nursing Library were last searched on 14 March 2025.Eligibility criteria for selecting studies We included randomised controlled trials (RCTs) and non-RCTs that applied exercise with music to community-dwelling frail older adults.Data extraction and synthesis Five independent reviewers used standardised methods to search, screen and code included studies. …”
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Understanding the political economy of reforming global health initiatives – insights from global and country levels by Sophie Witter, Natasha Palmer, Rosemary Jouhaud, Shehla Zaidi, Severine Carillon, Rene English, Giulia Loffreda, Emilie Venables, Shifa Salman Habib, Jeff Tan, Fatouma Hane, Maria Paola Bertone, Seyed-Moeen Hosseinalipour, Valery Ridde, Asad Shoaib, Adama Faye, Lilian Dudley, Karen Daniels, Karl Blanchet

“…Funders have not collaborated to enable reforms, despite concerns amongst a number of them, because of the helpful functional role of GHIs, which serves funder interests. …”
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Computational Phenotyping of Obstructive Airway Diseases: A Systematic Review by Bashir MBA, Milani GP, De Cosmi V, Mazzocchi A, Zhang G, Basna R, Hedman L, Lindberg A, Ekerljung L, Axelsson M, Vanfleteren LEGW, Rönmark E, Backman H, Kankaanranta H, Nwaru BI

“…COPD phenotypes involved lung function, emphysematous changes, smoking, comorbidities, and daily life impairment. …”
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Viable but nonculturable state in the zoonotic pathogen Bartonella henselae induced by low-grade fever temperature and antibiotic treatment by Yuze Gou, Yuze Gou, Dongxia Liu, Dongxia Liu, Yuxian Xin, Yuxian Xin, Ting Wang, Jiaxin Li, Yiwen Xi, Xiaoling Zheng, Tuanjie Che, Ying Zhang, Ying Zhang, Tingting Li, Jie Feng, Jie Feng

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Fusions of Tumor-derived Endothelial Cells with Dendritic Cells Induces Antitumor Immunity by Yingying Huang, Qiqi Mao, Jian He, Jing Su, Yi Peng, Wei Liang, Zixi Hu, Sufang Zhou, Xiaoling Lu, Yongxiang Zhao

“…Purified ECs (CD105+) took the function of endothelial cells, then successfully fused with DCs. …”
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Gut Microbiota Modulation by Lysozyme as a Key Regulator of Vascular Inflammatory Aging by Chenyang Zhang, Xin Zhao, Hang Zhang, Tongtong Wang, Zhenyu Zhang, Yilin Yin, Hui Wang, Xiao Tong, Yuzheng Xue, Yahong Zhou, Fenglai Yuan, Xiuwu Bian, Hong Wei, Yuan Huang, Tianhao Liu

“…Lyz1 deficiency led to vascular inflammatory aging, including damage to indicators related to oxidative stress, vascular function, and inflammation in the serum and vascular tissues of wild-type (WT) and Lyz1−/− mice. …”
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Identification of a Rare Mutation in the SRD5A2 Gene in an Iranian Family with Sex Development Disorder by Atiyeh Ataei, Peyman Eshraghi, Atiyeh Eslahi, Zeinab Khazaei, Masoome Alerasool, Sara Jamali, Faranak Ghadamyari, Majid Mojarrad

“…According to WES result and Sanger sequencing a homozygote loss of function mutation (c.16C>T; p.Gln6Ter) in SRD5A2 has been detected. …”
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The BoRG-JWST Survey: Abundance and Mass-to-light Ratio of Luminous z = 7–9 Galaxies from Independent Sight Lines with NIRSpec by Sofía Rojas-Ruiz, Micaela Bagley, Guido Roberts-Borsani, Tommaso Treu, Steven L. Finkelstein, Takahiro Morishita, Nicha Leethochawalit, Charlotte Mason, Eduardo Bañados, Michele Trenti, Massimo Stiavelli, L. Y. Aaron Yung, Pablo Arrabal Haro, Rachel S. Somerville, Christian Soto

“…We present new results on the rest-frame UV luminosity function (UVLF) and stellar mass-to-light ( M / L ) ratio of bright ( M _UV  ≲ −20 mag) spectroscopically confirmed galaxies at z  = 7–9 derived from the BoRG-JWST survey, a unique data set of NIRSpec prism follow-up of Hubble Space Telescope (HST)–selected sources from random-pointing imaging. …”
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Analysing the contribution of trees and green spaces to household nutrition security in eThekwini, KwaZulu-Natal, South Africa by Qhelile Ntombikayise Bhebhe, Qhelile Ntombikayise Bhebhe, Muthulisi Siwela, Temitope O. Ojo, Temitope O. Ojo, Simphiwe Innocentia Hlatshwayo, Simphiwe Innocentia Hlatshwayo, Tafadzwanashe Mabhaudhi, Tafadzwanashe Mabhaudhi, Rob Slotow, Mjabuliseni S. C. Ngidi, Mjabuliseni S. C. Ngidi, Mjabuliseni S. C. Ngidi

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Hepatic epithelioid hemangioendothelioma, a rare liver tumor: a case report and review of the literature by Chao Deng, Yulong An, Yulong An, Jinli Liu, Jinli Liu, Chao Wang, Haoxian Gou, Jinpeng Zhang, Minghui Gu, Mengmeng Li, Tao Wang, Hao Luo

“…Multiple space-occupying lesions in the liver were incidentally detected through ultrasound imaging, despite the patient being asymptomatic. …”
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