Medicinal Phytocompounds as Potential Inhibitors of p300-HIF1α Interaction: A Structure-Based Screening and Molecular Dynamics Simulation Study by Muhammad Suleman, Abrar Mohammad Sayaf, Sohail Aftab, Mohammed Alissa, Abdullah Alghamdi, Suad A. Alghamdi, Mohammed A. Alshehri, Kar Kheng Yeoh, Sergio Crovella, Abdullah A. Shaito

“…<b>Methods:</b> Consequently, we used drug design and molecular simulation techniques to screen phytochemical databases, including traditional Chinese and African medicine sources, for compounds that could disrupt the p300/HIF-1 interaction. …”
Get full text

Research Progress on the Effect of Dissolved Organic Matter on the Environmental Behavior of Cadmium in Environmental Remediation by Jiabao MA, Siwen LIU, Bo WANG, Di WU, Jixin WEI, Qing SUN, Chenge MA, Yi HUANG, Taotao YAN

“…The various active functional groups contained in DOM, such as carboxyl, hydroxyl, and phenolic groups, are ligands and migration carriers for many heavy metals in the environment. …”
Get full text

Personality and Personality Disorders in Medication-Overuse Headache: A Controlled Study by SWAP-200 by Federica Galli, Annalisa Tanzilli, Alessandra Simonelli, Cristina Tassorelli, Grazia Sances, Micol Parolin, Patrizia Cristofalo, Ivan Gualco, Vittorio Lingiardi

“…At levels of specific PDs, MOH patients showed higher obsessive and dysphoric traits and better overall psychological functioning than SUD and PD patients. Conclusion. Although MOH, SUD, and PD populations have been evaluated in multiple sites with different levels of expertise, the study supported the presence of a specific constellation of personality in MOH patients including obsessive (perfectionist) and dysphoric characteristics, as well as good enough psychological resources. …”
Get full text

Health-related quality of life, physical and mental capacity at one year follow up of COVID-19 ICU patients: A prospective cohort study by Anders Ersson, Henrik Överengen Reuterborg, Anestis Divanoglou, Richard Levi, Lotti Orwelius

“…Abstract Purpose In 2020 as COVID-19 rapidly overwhelmed ICU resources, patient care capacity was reduced thus increasing the risk of development of post intensive care syndrome (PICS). …”
Get full text

Predicting the course of localized periodontitis of traumatic etiology after complex treatment by Aleksandra V. Smirnova, Diana A. Kuzmina, Natalia A. Sokolovich, Ekaterina S. Mikhailova, Svetlana V. Sverdlova, Ivan V. Grigoriev

“…We employed clinical, radiological, and functional methods of examining periodontal condition, and investigated laboratory blood parameters (complete blood count, C-reactive protein). …”
Get full text

Impacts of Mechanical Injury on Volatile Emission Rate and Composition in 45 Subtropical Woody Broad-Leaved Storage and Non-Storage Emitters by Yali Yuan, Yimiao Mao, Hao Yuan, Ming Guo, Guomo Zhou, Ülo Niinemets, Zhihong Sun

Get full text

Whole-genome sequencing and genomic analysis of four Akkermansia strains newly isolated from human feces by Wenjing Lu, Biqing Zha, Jie Lyu, Chenxi LingHu, Jing Chen, Sisi Deng, Xiangling Zhang, Liang Li, Guoqing Wang

“…Two annotated regions of secondary metabolite biosynthesis genes, both belonging to Terpene, were detected using the antiSMASH online tool.ConclusionThese findings indicate that the four Akkermansia isolates, which belong to a phylogroup distinct from the model strain DSM 22959, exhibit lower genetic risk and may serve as potential probiotic resources for future research.…”
Get full text

Probabilistic linkages of propagation from meteorological to agricultural drought in the North African semi-arid region by Younes Dahhane, Victor Ongoma, Abdessamad Hadri, Mohamed Hakim Kharrou, Oualid Hakam, Abdelghani Chehbouni

“…Statistical measures such as Spearman correlation (R), root mean square error (RMSE), and mean absolute error (MAE), are utilized to assess the performance of the meteorological drought index to detect the agricultural drought. The propagation time from meteorological drought to agricultural drought was identified, and probabilistic linkages between the two types of droughts were investigated using the copula function and Bayesian network. …”
Get full text

Chloroplast genome features and intraspecific variation of Rosa praelucens by WANG Qigang1, CAO Shirui1,2, WANG Huichun1, MA Changle2, YAN Huijun1, QIU Xianqin1, JING Weikun1, JIAN Hongying1*

“…The genomes encoded 132 function genes, mainly related with photosynthesis and self-replication. …”
Get full text

WEB SERVICE OF WORKS PLANNING USING NETWORK GRAPH by Інна Грод, Надія Балик, Ярослав Василенко, Сергій Мартинюк, Василь Олексюк, Ольга Барна

“…During the study, a set of theoretical, empirical, and modeling methods were applied, in particular: systematic analysis of scientific and methodological sources, the results of domestic and foreign experience on the problem, review of existing software to determine the problem solution state and select development tools of web service, analysis of methods and technologies network graphs construction, generalization of information on the problem. …”
Get full text

Dissecting the genetic basis of response to salmonid alphavirus in Atlantic salmon by Domniki Manousi, Dorota Monika Jaskula, Fabian Grammes, Tim Martin Knutsen, Shahmir Naseer, Samuel AM Martin, Thomas Moen, Marie Saitou, Sigbjørn Lien

“…Additionally, another QTL on Ssa07 was detected, linked to infection-specific response. Transcriptomics analysis of the genes overlapping the Ssa03 QTL region revealed significant expression differences among three tandemly duplicated gig1-like genes, whereas allele-specific expression analysis detected several SNPs with putative functional impact on the particular genes. …”
Get full text

Identification of novel angiotensin I-converting enzyme inhibitory peptides from walnut (Juglans sigillata Dode) protein hydrolysates and their vascular endothelial protective prop... by Wenyun Xiong, Lixia Guo, Yiting Zhang, Shurui Li, Zihuan Wu, Shengbao Cai

Get full text

Evaluation of meningitis surveillance system in rural area, Rwanda by Solange Nyinawabeza, Jean Claude Niyoyita, Emmanuel Nshimiyimana, Jerome Ndayisenga, Angela Umutoni, Caroline Stamatakis

“…Data collected from clinical registers and eIDSR were used to assess core functions of the meningitis surveillance system including accuracy in detection of cases, laboratory confirmation of cases, and availability of evaluation reports. …”
Get full text

Egyptian pediatric kidney transplantation: highlights on post-transplant follow-up and management of complications by the Egyptian Pediatric Clinical Practice Guidelines Committee... by Bahia Moustafa, Neveen A. Soliman, Ihab Shaheen, Ahmed Badr, Fatma M. Atia, Mohamed K. El Hatw, Engy Adel Mogahed, Mona EL-Ghamrawy, Khaled El Khashab, Noha Shaheen, Mohamad G. Shouman, Abeer Selim, Magdy El-Sharkawy, Tarek Abd El Azeem, Mohamad Esmat, Manal Salman, Bedeir Ali-El-Dein, Mona Abdel Rahim, Muhamed A. El-Hadedy, Moatasem Elsayed Ghoneim, Mai S. Korkor, Tarek E. I. Omar, Yasser Amer, Ashraf Abdel Baky, On Behalf of Egyptian Pediatric Clinical Practice Guideline Committee

“…Chronic allograft nephropathy needs different approaches based on its related causes, allograft pathology, graft function, and availability of re-transplantation. Aim/objectives This national adapted guideline aims to frame evidence-based post-transplant recommendations adopted or adapted from EB source guidelines to optimize post-transplant patient care. …”
Get full text

Identification and outcomes of acute kidney disease in patients presenting in Bolivia, Brazil, South Africa, and Nepal. by Rhys D R Evans, Sanjib K Sharma, Rolando Claure-Del Granado, Brett Cullis, Emmanuel A Burdmann, Fos Franca, Junio Aguiar, Martyn Fredlund, Kelly Hendricks, Maria F Iturricha-Caceres, Mamit Rai, Bhupendra Shah, Shyam Kafle, David C Harris, Mike V Rocco

“…High rates of persistent kidney disease and mortality after discharge highlight the importance of AKD follow-up in low-resource settings.…”
Get full text

Model-Based Electroencephalogram Instantaneous Frequency Tracking: Application in Automated Sleep–Wake Stage Classification by Masoud Nateghi, Mahdi Rahbar Alam, Hossein Amiri, Samaneh Nasiri, Reza Sameni

“…A critical component of sleep analysis is detecting transitions between wakefulness and sleep states. …”
Get full text

Genicular Nerve Ultrasound-Guided Cryoanalgesia for the Treatment of Chronic Knee Joint Pain: An Observational Retrospective Study by Giuliano Lo Bianco, Francesco Paolo D’angelo, Guillherme Ferreira Dos Santos, Agnes Stogicza, Matteo Luigi Giuseppe Leoni, Andrea M. Trescot, Robert Jason Yong, Christopher L. Robinson

“…Larger prospective, controlled trials are necessary to confirm these findings and to refine patient selection and technique optimization.…”
Get full text

Cacao Agroforestry in Mahakam Ulu: Transformation Strategy from Traditional to Good Agricultural Practices and Smart Agroforestry System by Catur Budi Wiati, Eddy Mangopo Angi, Karmilasanti Karmilasanti, Murniati Murniati, Sri Suharti, Indra A.S.L.P. Putri, Aris Pudji Hadi, Muhammad Furkan, Belasius Anyeq, Krista Tala, Veronica Carolina, Awaluddin Aziz, Ria Andiana, Yuliara Limbong, Yosua Naibaho, Mukrimin Mukrimin

“…We also obtained secondary data from local government sources in East Kalimantan. Data were processed using qualitative descriptive analysis, gender, and SWOT analysis. …”
Get full text

PCI-DB: a novel primary tissue immunopeptidome database to guide next-generation peptide-based immunotherapy development by Sven Nahnsen, Hans-Georg Rammensee, Cécile Gouttefangeas, Jonas S Heitmann, Juliane S Walz, Jens Bauer, Marcel Wacker, Annika Nelde, Jonas Scheid, Steffen Lemke, Marissa L Dubbelaar, Patrick Zimmermann, Naomi Hoenisch Gravel, Susanne Jung, Anna Dengler, Yacine Maringer, Sven Fillinger, Tatjana Bilich

Get full text

Patient-reported outcome measures for fatigue in patients with chronic kidney disease: a systematic review by Angela Ju, Karine Manera, Armando Teixeira-Pinto, Germaine Wong, Martin Howell, Adeera Levin, Chandana Guha, David C Wheeler, Allison Jauré, Anastasia Hughes, Rosanna Cazzolli, Luca G Torrisi, Rebecca Wu

“…The characteristics, dimensions of fatigue and psychometric properties of these measures were extracted and analysed.Data sources We searched MEDLINE, Embase, PsycINFO and CINAHL from database inception to February 2023.Eligibility criteria for selecting studies All studies that reported fatigue in patients with CKD stages 1–5 not receiving KRT.Results We identified 97 studies (20 (21%) randomised trials, 2 (2%) non-randomised trials and 75 (77%) observational studies). 27 different measures were used to assess fatigue, of which three were author-developed measures. …”
Get full text