TIM3-blockade synergizes with IL2 in alleviating intra-tumoral CD8+T cell exhaustion by Xuhao Zhang, Yu Gao, Huiping Liao, Wenyan Wang, Zaili Yang, Weian Cao, Ge Li, Jing Wen, Gencheng Han, Yang-Xin Fu

“…Progressive loss of IL2-secretion is an early sign of diminished effector function in TILs, which raises the possibility of IL2 loss driving exhaustion of TILs. …”
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Differential efficacy of olfactory neurospheres from deviated nasal septum and chronic rhinosinusitis patients in regenerating olfactory epithelium by Rong-San Jiang, Chiang-Wen Lee, Yu-Hsuan Lin, Jing-Jie Wang, Jia-Bin Liao, Kuo-Ti Peng, Yao-Chang chiang, Pei-Ling Chi

“…Conclusions These findings highlight the importance of selecting the appropriate ONS source for therapeutic applications, with DNS-ONS showing greater promise for olfactory epithelium repair and olfactory function restoration.…”
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Multi-Omics Analysis Provides Insights into Green Soybean in Response to Cold Stress by Yanhui Lin, Guangping Cao, Jing Xu, Honglin Zhu, Liqiong Tang

“…The DEGs and DEMs were further subjected to KEGG functional analysis. Finally, 11 metabolites (such as sucrose, lactose, melibiose, and dehydroascorbate) and 17 genes (such as <i>GOLS</i>, <i>GLA</i>, <i>UGDH</i>, and <i>ALDH</i>) were selected as candidates associated with cold tolerance. …”
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Bertolotti Syndrome: Does it really exist? systematic review by Acevedo-Gonzalez Juan Carlos, Delgado-Caicedo Mónica Gabriela, Lacouture-Silgado Isabella

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Case Report: Targeted treatment by fluoxetine/norfluoxetine of a KCNC2 variant causing developmental and epileptic encephalopathy by Ping Li, Alice Butler, Yu Zhou, Karl L. Magleby, Christina A. Gurnett, Lawrence Salkoff

“…The Kv3.2 subfamily of voltage activated potassium channels encoded by the KCNC2 gene is abundantly expressed in neurons that fire trains of fast action potentials that are a major source of cortical inhibition. Gain-of-function (GOF) de novo pathogenic variants in KCNC1 and KCNC2, encoding Kv3.1 and Kv3.2 respectively, cause several types of epilepsy including developmental and epileptic encephalopathy (DEE). …”
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High-Sensitivity Determination of K, Ca, Na, and Mg in Salt Mines Samples by Atomic Emission Spectrometry with a Miniaturized Liquid Cathode Glow Discharge by Jie Yu, Zhichao Zhang, Quanfang Lu, Duixiong Sun, Shuwen Zhu, Xiaomin Zhang, Xing Wang, Wu Yang

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Life cycle assessment of an entirely wood floor system designed for carbon negativity, future adaptability, and end-of-life de/re/construction by Muzan Williams Ijeoma, Sovanroth Ou, Amin Nabati, Hao Chen, Michael Stoner, Patricia Layton, Dustin Albright, Brandon Ross, Weichiang Pang, Michael Carbajales-Dale

“…Mass timber offers a promising alternative, with lower embodied carbon (EC) and the potential to function as a carbon sink when sustainably sourced. …”
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Dynamic and efficient vehicular cloud management scheme with privacy protection by Min XIAO, Tao YAO, Yuanni LIU, Yonghong HUANG

“…The vehicular cloud (VC) formed by vehicles is used for localization processing and consumption of traffic sensing data to achieve timely intelligent traffic management.The vehicle cloud is highly dynamic, self-organizing and timely, in which the identity and location privacy of vehicle users need to be protected as this poses challenges to the vehicular cloud management.A dynamic and self-organizing vehicle cloud management scheme based on the asymmetric group key agreement protocol was designed, where the vehicle cloud is automatically formed through the self-organized group key agreement of vehicles.The group key was used to control the provision and access of vehicle cloud services, and the dynamic management of the vehicle cloud was implemented through group key update.The scheme used traceable one-time pseudonym technology to achieve anonymous authentication and conditional privacy protection of vehicle users, and the group key agreement stage only included one bilinear pair operation to achieve high efficiency.In addition, the key negotiation and update process used lightweight signatures, supporting batch verification, to achieve efficient message source authentication and integrity authentication.Then the security and efficiency of vehicle cloud communications in the self-organizing environment can be ensured.The dynamic key update mechanism of the key agreement protocol realized the dynamic joining or exiting of vehicles in the vehicle cloud, adapting to the dynamic characteristics of the vehicle cloud.Under the random oracle model and the difficult assumption of the inverse computational Diffie Hellman (ICDH) problem, it was proved that the asymmetric group key agreement scheme satisfied the selective-plaintext security.The security analysis shows that the scheme can protect the identity and location privacy of vehicle users, realize the legal tracking of malicious vehicles, and ensure the confidentiality, integrity and anti-counterfeiting of communications, as well as the forward security of vehicle cloud dynamic management.The performance comparison analysis shows that this scheme has certain advantages in communication and computing efficiency under the condition of the same function and security level.…”
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Exploring Nonlinear Threshold Effects and Interactions Between Built Environment and Urban Vitality at the Block Level Using Machine Learning by Cong Li, Yajuan Zhou, Manfei Wu, Jiayue Xu, Xin Fu

“…This study proposed to develop a comprehensive framework for urban vitality by incorporating multi-source data, and the central urban area of Xi’an, China, was selected as the study area. …”
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Isolation and Screening of Lactic Acid Bacteria From Sumbawa Buffalo Milk (Bubalus bubalis) as Potential Starter Cultures by Deni Harmoko, Tri Ardyati, Yoga Dwi Jatmiko

“…Besides containing nutrients that are very beneficial for human health, buffalo milk is also a potential source of lactic acid bacteria (LAB) with technological and functional properties. …”
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CHARTER OF THE STAVROPOL KRAI: PROBLEM ISSUES AND SEARCH FOR SOLUTION by V. Cherepanov

“…The interpretation of the source of the government of the Stavropol Krai, which is the people of the Stavropol Kraias part of the multinational people of the Russian Federation, has been proposed. …”
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Prevalence and determinants of restrictive lung disorder among quarry workers at the Umuoghara quarry site, Ebonyi State, Nigeria: a cross-sectional study by Ngozika Substance Ike-Samuel, Osaeloka C. Ekwueme, Susan Chioma Udeh

“…Data was collected using a pre-tested semi-structured questionnaire among 300 quarry workers selected by simple random sampling method. Lung function test was performed using a spirometer- spirovit SPI schiller and data was analyzed with the use of IBM SPSS version 23.0. …”
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Peri-Urban Land Transformation in the Global South: Revisiting Conceptual Vectors and Theoretical Perspectives by Shiwaye M. Tesfay, Genet Alem Gebregiorgis, Daniel G. Ayele

“…Data extraction involved detailed coding of study characteristics, theoretical orientations, and thematic insights. Using open and selective coding, 19 thematic codes were identified. …”
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Systemic model of segregation and transformation of urban solid waste by Alex Rengifo Rojas, Nelino Florida Rofner, Luis Morales y Chocano, José Raúl Rodríguez Lichtenheldt, Julio Pedro Atoche Cornejo

“…Simple and cluster random sampling methods were used to select 119 households and 229 non-domestic establishments, in addition to non-random sampling for 26 special establishments. …”
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In silico and in vivo Study of the Anti-Inflammatory Activity of Azomethine Derivatives of 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide and 2-substituted 5,6,7,8-tetra... by Chiriapkin, A.S., Kodonidi, I.P., Abisalova, I.L., Diakova, I.N.

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Features of the morphological structure of plants and biochemical properties of introduced and domestic varieties of Cannabis sativa L. by А. С. Полякова, Л. М. Горшкова, Д. Б. Рахметов

“…Nowadays C. sativa is the main source of phyto material for industrial production of natural CBD. …”
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De Novo Assembly of the Polyhydroxybutyrate (PHB) Producer <i>Azohydromonas lata</i> Strain H1 Genome and Genomic Analysis of PHB Production Machinery by Daniele Traversa, Carlo Pazzani, Pietro D’Addabbo, Lucia Trisolini, Matteo Chiara, Marta Oliva, Angelo Marzella, Camilla Mandorino, Carla Calia, Guglielmina Chimienti, Caterina Manzari, Graziano Pesole, Maria Scrascia

“…In addition to the <i>phaCAB</i> operon, single genes ascribable to PhaC and PhaA functions and auxiliary genes were also detected. A comparative genomic analysis of the available genomes of the genus <i>Azohydromonas</i> revealed the presence of <i>phaCAB</i> and auxiliary genes in all <i>Azohydromonas</i> species investigated, suggesting that the PHB production is a common feature of the genus. …”
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Identification of Cancer Stem Cell (CSC)-Associated Genes, Prognostic Value, and Candidate Drugs as Modulators of CSC-Associated Signaling in Carcinomas Through a Multiomics Data A... by Pallabi Mondal, Poulami Singh, Krishna Mahanti, Sankar Bhattacharyya

“…This ability of CSCs to escape immune responses makes the CSCs a primary source of functionally altered, immune-resistant, chemoresistant, aggressive tumor cells. …”
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Reduction of Total Phenols in Virgin Olive Oil as a Preservation Medium during Cold Storage of Whey Cheese and Tofu by Valerija Majetić Germek, Ivana Gobin, Doris Franjković, Marija Marković, Olivera Koprivnjak

“…Virgin olive oil, known as a good source of health-promoting hydrophilic phenols, is traditionally used as a medium for preserving various foods. …”
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Linking soil microbial genomic features to forest-to-pasture conversion in the Amazon by Andressa M. Venturini, Júlia B. Gontijo, Louis Berrios, Jorge L. Mazza Rodrigues, Kabir G. Peay, Siu M. Tsai

“…These abundant members of the microbial communities diverged across forests and pastures in terms of taxonomic and functional traits. Forest conversion favors organisms with specific genomic features — increased GC content, genome size, and gene number — selecting for microorganisms that can thrive under altered conditions. …”
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