Simultaneous targeted delivery of doxorubicin and KRAS suppression by a hybrid molecule containing miR-143 and AS1411 aptamer by Khanittha Laowichuwakonnukul, Boonchoy Soontornworajit, Jiraporn Arunpanichlert, Pichayanoot Rotkrua

“…The protein expression of procaspase-3 and Bcl-2 was decreased, while Bax was increased, confirming that Dox-MAH triggered the cell apoptosis. The success of this research proposed a new strategy for a drug delivery system, which has multiple functions simultaneously; CRC cell-specificity, Dox carrier, and miR-143 delivery.…”
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Features of the alpha-cell population organization in pancreas of spontaneously hypertensive rats (SHR) by T. V. Abramova, Yu. M. Kolesnyk

“…At the same time, glucagon-suppressive therapy is defined as the strategically main source of success of therapy for patients with type 2 diabetes mellitus. …”
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Endodontic treatment of teeth with a wide apical opening – a clinical case by V. A. Popov, E. S. Pestova, S. A. Anisimova

“…The presented clinical case demonstrates the successful endodontic treatment of a tooth in a teenager, in which treatment tactics aimed at stimulating apexification were applied. …”
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Consistent microbial insights across sequencing methods in soil studies: the role of reference taxonomies by Niranjana Rose Edwin, Aoife Duff, Coline Deveautour, Fiona Brennan, Florence Abram, Orla O'Sullivan

“…Our findings reveal that both methods offer moderately similar outcomes, providing consistent detection of major phyla, similar microbial community differentiation patterns, and largely identifying the same relationships between the phyla and nitrogen functions. …”
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Analysis of the Possibility of Using Energy Harvesters to Power Wearable Electronics in Clothing by Anna Dąbrowska, Agnieszka Greszta

“…., sensors and diodes) implemented to clothing indicate the possibility of using miniaturized EHs as a power source for such elements. Each of the discussed EH has both disadvantages and advantages. …”
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Bridging Behavioural, Neural, and First-Person Insights into Working Memory Strategies by Anka Slana Ozimič, Nina Purg Suljič, Aleš Oblak, Jurij Bon, Toma Strle, Grega Repovš

“… Working memory is a core cognitive function, yet findings regarding its behavioural and neural underpinnings are often inconsistent. …”
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Coherence in popularized medico-pharmaceutical reports: The case of EPAR summaries for the public by Aage Hill-Madsen

“…The summary for the public reports the gist of the specialized source text in a linguistic register suitable for a lay readership. …”
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Machine learning-based prognostic model of lactylation-related genes for predicting prognosis and immune infiltration in patients with lung adenocarcinoma by Mingjun Gao, Mengmeng Wang, Siding Zhou, Jiaqi Hou, Wenbo He, Yusheng Shu, Xiaolin Wang

“…Finally, we analyzed the expression of KRT81 in LUAD tissues and cell lines using qRT-PCR, WB, and IHC. Changes in KRT81 function in LUAD cells were detected by CCK-8, colony formation, wound healing, transwell, and flow cytometry. …”
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Development of a Rapid UPLC Method for Analysis of Carotenoids in Goji Berry Extract and Evaluation of Their Transformation Affected by Saponification by Bo-Yang Hsu, Chia-Hui Lin, Tsai-Hua Kao

“…This method successfully separates 17 carotenoids and their esters within 21 min using a Sunrise C30 column, with detection at 450 nm, a flow rate of 1.3 mL/min, and a column temperature of 25 °C. …”
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TRIM study protocol - a prospective randomized multicenter Trial to assess the Role of Imaging during follow-up after radical surgery of stage IIB-C and III cutaneous malignant Mel... by Ylva Naeser, Hildur Helgadottir, Yvonne Brandberg, Johan Hansson, Roger Olofsson Bagge, Nils O. Elander, Christian Ingvar, Karolin Isaksson, Petra Flygare, Cecilia Nilsson, Frida Jakobsson, Olga del Val Munoz, Antonis Valachis, Malin Jansson, Charlotte Sparring, Lars Ohlsson, Ulf Dyrke, Dimitrios Papantoniou, Anders Sundin, Gustav J. Ullenhag

“…Early onset of treatment seems to improve outcome, which suggests that early detection of recurrent disease should be beneficial. …”
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Grown up in the face of values. The subjective dimension of shaping values in human life. by Rafał Bodarski

“…This enormous impact of our activity is analyzed in the article from the point of view of selected theories functioning both in psychology and in pedagogy.…”
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Magistrates’ Travelling Libraries: The Circulation of Normative Knowledge in the Portuguese Empire of the Late 18th Century by Airton Ribeiro da Silva Jr.

“…The present study focuses on the lists of books of eleven magistrates appointed to judicial posts in a range of locations throughout Portuguese America between 1799 and 1807. Censorship sources allow us to identify the books chosen by these itinerant magistrates as being indispensable for the exercise of their judicial function. …”
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State of accounting methods and cost of maintenance and improving water management facilities by L.V. Syrovatchenko, T.M. Shapoval

“…The researcher finds out that the accounting cost of maintaining and improving water management facilities depends on the sources of financing of such costs as general or special funds of budget institutions. …”
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Cascaded Directional Coupler-Based Triplexer Working on Spectroscopically Relevant Wavelengths for Multiple Gas Detection by Ajmal Thottoli, Gabriele Biagi, Artem S. Vorobev, Antonella D’Orazio, Giovanni Magno, Liam O’Faolain

“…The device is designed to combine the wavelengths of 1530 nm, 1653.7 nm, and 2003 nm for use in spectroscopy systems targeting the detection of ammonia, methane, and carbon dioxide gases, respectively. The triplexer’s functions focus on enhancing the coupling efficiency and selectivity, while facilitating the on-chip integration of diode lasers. …”
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A Study of Directional Patterns of Ultrasonic Parametric Array by Denis Sergeevich RAKOV, Aleksandr S. RAKOV, Andrey N. KUDRYAVTSEV, Nikolay P. KRASNENKO, Yury A. CHURSIN, Maksim A. MURIN

“…The results of selecting and functional testing of unit elements are described in this paper. …”
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Genomics and integrative clinical data machine learning scoring model to ascertain likely Lynch syndrome patients by Ramadhani Chambuso, Takudzwa Nyasha Musarurwa, Alessandro Pietro Aldera, Armin Deffur, Hayli Geffen, Douglas Perkins, Raj Ramesar

“…Annovar, Intervar, Variant Effect Predictor (VEP), and OncoKB software tools were used to functionally annotate and interpret somatic variants detected. …”
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On the usage of artificial intelligence in leprosy care: A systematic literature review. by Hilson Gomes Vilar de Andrade, Elisson da Silva Rocha, Kayo H de Carvalho Monteiro, Cleber Matos de Morais, Danielle Christine Moura Dos Santos, Dimas Cassimiro Nascimento, Raphael A Dourado, Theo Lynn, Patricia Takako Endo

“…It can result in physical disabilities and functional loss and is particularly prevalent amongst the most vulnerable populations in tropical and subtropical regions worldwide. …”
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Distribution, Occupancy, and Habitat of the Endangered Carolina Madtom: Implications for Recovery of an Endemic Stream Fish by W. Robert Cope, Thomas J. Kwak, Tyler R. Black, Krishna Pacifici, Jennifer M. Archambault, W. Gregory Cope

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Transcriptome-wide identification of 5-methylcytosine by deaminase and reader protein-assisted sequencing by Jiale Zhou, Ding Zhao, Jinze Li, Deqiang Kong, Xiangrui Li, Renquan Zhang, Yuru Liang, Xun Gao, Yuqiang Qian, Di Wang, Jiahui Chen, Liangxue Lai, Yang Han, Zhanjun Li

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Reconstruction of U.S. Regional-Scale Soybean SIF Based on MODIS Data and BP Neural Network by YAO Jianen, LIU Haiqiu, YANG Man, FENG Jinying, CHEN Xiu, ZHANG Peipei

“…Through the activation functions in the BP neural network, it enhanced the understanding of the complex nonlinear relationships between the original SIF data and these MODIS products. …”
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