Systematic discovery of linear binding motifs targeting an ancient protein interaction surface on MAP kinases by András Zeke, Tomas Bastys, Anita Alexa, Ágnes Garai, Bálint Mészáros, Klára Kirsch, Zsuzsanna Dosztányi, Olga V Kalinina, Attila Reményi

“…We used a structurally consistent model on kinase‐docking motif interactions to facilitate the discovery of short functional sites in the structurally flexible and functionally under‐explored part of the human proteome and applied experimental tools specifically tailored to detect low‐affinity protein–protein interactions for their validation in vitro and in cell‐based assays. …”
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Linguistic Features of the Ergonomic Space of the Central Streets of Yoshkar-Ola and Kazan by Iraida G. Ivanova, Flera Ya. Khabibullina

“…Urbanonyms as names of objects of various functional profiles are an indicator of preferred languages for naming urban objects, and act as a marker of the spheres of functioning of languages in a given territory. …”
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Presenting the Physical Pattern of Today's Housing by Taking Advantage of the Desirable Qualities of Historical Houses (Case Study: Kerman City) by Amjad Bahredar, Ramin Madani, Mohsen Afshari

“…These qualities, in addition to meeting their functional needs, seek to solve the superior needs of the residents. …”
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Implementation of a wireless sensor network for irrigation management in drip irrigation systems by Mehmet Kamil Meriç

“…By providing real-time data and remote-control capabilities, the integrated system offers a tool for optimizing water usage and conserving water resources.…”
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Development of Cyber Security Platform for Experiential Learning by Abhishek Vaish, Ravindra Kumar, Samo Bobek, Simona Sternad

“…The proposed platform CySecLearn is a collection of various functionalities and features that ensures experiential learning, will help the learner to develop critical thinking and expertise in network security and promote digital literacy in the domain of cyber security.…”
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The Design of Food Safety Management System (FSMS) Plan for Rice Fortification Kernel (RFK) Factory – A Case Study by T. Khatun, M. Asaduzzaman

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Effectiveness of exercise therapy in patients with knee osteoarthritis: an overview of systematic reviews by Daisuke Sasaki, Takashi Kitagawa, Yuichi Isaji, Kunihiro Onishi, Masateru Hayashi, Wataru Okuyama

“…Objective This study aimed to assess the methodological quality of published systematic reviews of exercise therapy in knee osteoarthritis and summarise their reported effectiveness on quality of life, knee joint function, or adverse events.Design Overview of systematic reviews.Data sources PubMed, Embase, CINAHL, Web of Science and CENTRAL (searched on 14 April 2025), plus grey literature (PROSPERO, Epistemonikos, OpenGrey).Eligibility criteria for selecting studies We included systematic reviews of randomised controlled trials in patients diagnosed with knee osteoarthritis by imaging or clinical criteria and treated conservatively with exercise therapy; we excluded reviews that enrolled patients scheduled for surgery, with acute inflammation or osteoarthritis of other joints (hand, hip, ankle), for which relevant author data could not be obtained after one contact attempt, or that did not report at least one primary outcome (quality of life, knee joint function or adverse events).Data extraction and synthesis Two reviewers independently extracted data on study characteristics, interventions and outcomes, and assessed methodological quality using the AMSTAR 2 (A MeaSurement Tool to Assess systematic Reviews 2) tool. …”
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Comparative metabolomic profiling of Lupinus albus and L. angustifolius harvest residues: exploring chemical diversity and valorization potential by Salma Halime, Salma Halime, Jenny Renaut, Stéphanie Zimmer, Hanna Heidt, Cédric Jacquard, Kjell Sergeant

“…This study highlights the distinct valorization opportunities of Lupinus residues: L. albus, rich in antioxidants and defense-related metabolites, holds promise for nutraceutical, pharmaceutical, and functional food applications as well as plant protection strategies. …”
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Effect of Dry, Vacuum, and Modified Atmosphere Ageing on Physicochemical Properties of Roe Deer Meat by Natalia Kasałka-Czarna, Róża Biegańska-Marecik, Jędrzej Proch, Aleksandra Orłowska, Magdalena Montowska

“…Roe deer meat, due to the natural origin, is a source of organic and healthy meat. The selection of suitable storage conditions and times plays an important role in a deterioration of the meat's functional and nutritional values. …”
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A SERS‐Based Antibody‐Aptamer Sandwich Assay for Extracellular Vesicle‐Associated Tau Detection Using Gold Nanoparticles by Saqer Al Abdullah, Samaneh Ghadami, Md. Arifur Rahman Khan, Farbod Ebrahimi, Kyle Nowlin, Tetyana Ignatova, Kristen Dellinger

“…Abstract Extracellular vesicles (EVs) have emerged as sources of promising, minimally invasive biomarkers for diagnosing and monitoring diseases like Alzheimer's. …”
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Synthesis of aluminum oxide nanoparticles using seeds of Carica papaya and evaluation of it for antimicrobial, antioxidant, and photocatalysis activity by Indrani Laskar, Rajib Saha

“…The presence of an absorption peak at a wavelength of 272 nm in the synthesized nanoparticles was detected by UV–Vis spectroscopy analysis. The results of the FTIR study confirmed the existence of various chemicals and functional groups in the 500–4000 cm−1 range. …”
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A Validation Tool (VaPCE) for Postcoordinated SNOMED CT Expressions: Development and Usability Study by Tessa Ohlsen, Viola Hofer, Josef Ingenerf

“…When errors are detected, the tool processes the SNOMED CT Concept Model in JSON format and applies predefined error categories. …”
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<i>In silico</i> prediction of the transcription factor-enhancer interaction as a first stage of axonal growth regulation by D. D. Kotelnikov, I. A. Sinyakin, E. A. Borodin, T. A. Batalova

“…The enhancer sequence of DCC and SHH protein genes were taken from the NCBI open-source database in FASTA format. Ensembl database was used for enhancer mapping, GeneCards was used for screening and selection of potentially appropriate enhancers and transcription factors associated with these enhancers. …”
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Activity tracking devices in pregnancy: Understanding the participant experience in a longitudinal birth cohort by Ashley Redding, Dionne Coates, Andrea E. Cassidy-Bushrow, Jennifer K. Straughen, Sara Santarossa

“…REACH-Fitbit participants had to be <20 weeks gestation with access to a Bluetooth-enabled device. Recruitment (self-selection) for focus groups occurred from completed REACH-Fitbit participants (e.g., delivered their baby). …”
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Bioinformatics analysis to explore biomarkers and mechanisms of action associated with endoplasmic reticulum stress and ferroptosis in Parkinson's disease. by Hao Wang, Lijuan Feng, Limeng He, Nan Liu, Yan Wan, Wei Zhang

“…<h4>Methods</h4>Data for PD and ERS, as well as information on ferroptosis, were sourced from public databases and relevant literature. …”
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Re-use of Building Products in the Netherlands by Loriane Icibaci

“…Reuse of building products has seen limited regulatory changes and remained a vague procedure within the resource efficiency discourse in the Netherlands. …”
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Wuling capsule alleviates hyperuricaemia and protects UA- injured HK-2 cells by regulating uric acid transporter proteins by Nan Li, Hongna Liu, Zhongxing Song, Rui Zhou, Zhishu Tang, Zhishu Tang, Hongbo Xu, Xinbo Shi, Yanru Liu, Jian Ni

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Digital Platforms for the Built Environment: A Systematic Review Across Sectors and Scales by Michele Berlato, Leonardo Binni, Dilan Durmus, Chiara Gatto, Letizia Giusti, Alessia Massari, Beatrice Maria Toldo, Stefano Cascone, Claudio Mirarchi

“…Unlike existing reviews focused on single technologies or sectors, this work offers a cross-sectoral synthesis, highlighting shared challenges and opportunities across disciplines and lifecycle stages. It identifies the functional roles, enabling technologies and systemic barriers affecting digital platform adoption, such as fragmented data sources, limited interoperability between systems and siloed organizational processes. …”
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Integrating Ambient In-Home Sensor Data and Electronic Health Record Data for the Prediction of Outcomes in Amyotrophic Lateral Sclerosis: Protocol for an Exploratory Feasibility S... by William E Janes, Noah Marchal, Xing Song, Mihail Popescu, Abu Saleh Mohammad Mosa, Juliana H Earwood, Vovanti Jones, Marjorie Skubic

“…Sensor data are subjected to a multidimensional streaming clustering algorithm to detect changes in health status. Specific health outcomes are identified in the EHR and extracted via the REDCap (Research Electronic Data Capture; Vanderbilt University) Fast Healthcare Interoperability Resource directly into a secure database. …”
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Genomic Signatures of Positive Selection and Local Adaptation in Ethiopian Sheep Populations by B. E. Demissie, G. M. Tarekegn, H. Dadi, Z. Edea, A. A. Woldesemayat, K-S Kim, S. Girma, T. Seyoum, K. Melaku, S. Keskes

“…Fixation index (FST) and cross-population extended haplotype homozygosity (XPEHH) methods were used to detect signatures of positive selection. Functional analysis revealed genes related to plateau adaptation, immune response, and tail fat formation. …”
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