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2041
Identification and characterization of the powdery mildew resistance in cultivated emmer wheat accession Lxd-682 via bulked segregant RNA sequencing
Published 2025-05-01“…Molecular markers JS717/JS718 and WGRC1096 were confirmed to be available for marker-assisted selection (MAS) of PmLxd-682 in breeding practices. …”
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2042
Genome‐wide association study and BSR‐seq identify nitrate reductase–related genes in rice landraces (Oryza sativa L.)
Published 2025-06-01“…These findings will provide valuable genetic resources for NUE genetic improvement in rice breeding.…”
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2043
BDNF Val66Met polymorphism moderates associations between physical activity and neurocognitive outcomes in older adults
Published 2025-04-01“…In moderated mediation analyses examining cognitive outcomes, plasma p‐tau181 selectively mediated the relationship between PA and executive function in Val/Val participants. …”
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2044
Genome-wide association mapping of aluminum toxicity tolerance and fine mapping of a candidate gene for Nrat1 in rice.
Published 2018-01-01“…Our research indicated that minor alleles are important for QTL mapping and its application in rice breeding when natural gene resources are used.…”
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2045
Key technologies of efficient extraction of coalbed methane (gas) in Guizhou coal mine area
Published 2025-03-01“…It innovated and explored the following high efficiency extraction technology of “four zones” linked Wells in coal mining areas with Guizhou characteristics: ① By laying multi-functional pumping vertical Wells or small inclination oriented Wells in the goaf, it was the first time in Guizhou to realize efficient extraction and development of pressure relief gas in the overlying coal-covered strata and coal-bed methane in the sweet coal seam below the goaf; ② Taking advantage of the characteristics of spatial and temporal dislocation in the production area, the multi-mode extraction mode of “coalbed methane well + relief well + underground drilling” is adopted for the first coal seam mined in the upper protective layer, which realizes the purpose of the upper and lower vertical combined extraction of coalbed methane (gas) Wells and effectively solves the problem of multi-source gas flooding into coal mining roadway and gas accumulation in the upper corner during coal mining under the condition of coal seam group development in Guizhou; ③ In the preparation area and planning area, combined with the terrain and geological characteristics of the two areas, the horizontal well “well factory” + “two pairs of right and wrong” overlapping well layout mode is adopted to realize the efficient extraction of coal bed methane in the plane in advance and pre-pumping of the sweet coal seam and the pressure relief gas in the overlying coal-laden rock in the subsequent mining process, and at the same time to achieve the goal of “replacing the roadway with Wells”; ④ In view of the development of multi-thin coal seam groups in the study area and the development characteristics of “three zones” in the overlying strata after mining, due to the continuous change of the role of “four zones”, the surface coalbed methane Wells are initially deployed in the production area or preparation area, and the “bridge plug bottom sealing + layer selection perforation” technology is adopted to innovate the “transformation” technology of well structure to achieve the purpose of “multi-purpose in one well”; It also provides new technical ideas and accumulated valuable engineering experience for gas management in coal mine area under the condition of multi-thin coal seam group development in Guizhou.…”
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2046
Long-read sequencing of 945 Han individuals identifies structural variants associated with phenotypic diversity and disease susceptibility
Published 2025-02-01“…Abstract Genomic structural variants (SVs) are a major source of genetic diversity in humans. Here, through long-read sequencing of 945 Han Chinese genomes, we identify 111,288 SVs, including 24.56% unreported variants, many with predicted functional importance. …”
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2047
Evaluating Factors Affecting Interior Architectural Space Quality to Enhance Spatial Resilience and Human Productivity: An Application of Maslow’s Hierarchy of Needs
Published 2025-06-01“…</p> <p style="text-align: left;"><strong>Methodology.3</strong></p> <p style="text-align: left;">In the present study, the data and information was collected through document analysis, in-depth semi-structured interviews and formation of a focus group. The sample selection was done using snowball sampling method. …”
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2048
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2049
Submillimeter and Mid-infrared Variability of Young Stellar Objects in the M17 H II Region
Published 2025-01-01“…Our findings showcase the utility of multiwavelength observations to better capture the complex variability phenomena inherent to star formation processes and demonstrate the importance of years-long monitoring of a diverse selection of star-forming environments.…”
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2050
Behaviour change interventions to promote physical activity in people with intermittent claudication: the OPTIMA systematic review
Published 2025-05-01“…Secondary outcomes: clinical-/patient-reported outcomes. Data sources Seven primary studies databases; Cochrane Database of Systematic Reviews, the Database of Abstracts of Reviews of Effects, Health Technology Assessment Database and Trial Registers to 31 August 2023. …”
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2051
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2052
The Challenges of Safety Culture: No more risk!
Published 2016-12-01“…These factors by themselves are the definite source of disaster. People are not able to avoid their impacts: different crashes, accidents, fires. …”
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2053
Demand and Influencing factors for community health services during chemotherapy of patients with advanced cancer
Published 2024-06-01“…Logistic regression analysis showed that educational level and disposable monthly household income significantly influenced psychological demand, while age and source of medical expenses influenced medical care demand, and age and patient group participation affected social support demand (P < 0.05). …”
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2054
Subtype cluster analysis unveiled the correlation between m6A- and cuproptosis-related lncRNAs and the prognosis, immune microenvironment, and treatment sensitivity of esophageal c...
Published 2025-02-01“…Data on 23 m6A regulators and 25 cuproptosis-related genes were sourced from the latest literature. The m6aCRLncs linked to EC were identified through co-expression analysis. …”
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2055
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2056
Targeting hyperlipidemia: A polarity-driven ternary extraction of Apium graveolens bioactives—A coupled in-vivo, in-vitro and in-silico investigation
Published 2025-08-01“…The findings of the in-silico studies revealed that the 3 top performing compounds (i.e. apiumoside, apiin and graveobioside B) showed high binding affinity to selected anti hyperlipidemic targets HMG CoA reductase and peroxisome proliferator-activated receptor-Alpha (PPAR-Alpha) with a very stable condition in the molecular dynamic simulation against the selected targets. …”
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2057
GWAS and WGCNA analysis uncover candidate genes associated with drought in Brassica juncea L.
Published 2025-04-01“…To screen drought-tolerant germplasm resources and key functional genes related to drought tolerance in Brassica juncea L.(193 accessions), three treatments were applied at the germination and seedling stages:control(CK), moderate drought stress (M), and severe drought stress (S). …”
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2058
Optimizing Nav1.7‐Targeted Analgesics: Revealing Off‐Target Effects of Spider Venom‐Derived Peptide Toxins and Engineering Strategies for Improvement
Published 2024-11-01“…Spider venom‐derived peptide toxins are recognized as significant sources of Nav1.7 inhibitors. However, their development has been impeded by limited selectivity. …”
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2059
Dimeric natural product panepocyclinol A inhibits STAT3 via di-covalent modification
Published 2025-01-01“…Homo- or heterodimeric compounds that affect dimeric protein function through interaction between monomeric moieties and protein subunits can serve as valuable sources of potent and selective drug candidates. …”
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2060
Comparison of Fuzzy-AHP and ANP Decision Making Methods to Assess the Ecological Capability of Ecotourism Application (Case study: Dehloran National Natural Monuments)
Published 2018-11-01“…Then, to combine the layers, the model of overlapping index or linear weight composition was used. 3-Results and Discussion Using the GIS on the slope of the linear reduction subscription function, the trajectory linear membership function layer and the temperature layer, an incremental linear membership function was applied. …”
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