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Medicinal Phytocompounds as Potential Inhibitors of p300-HIF1α Interaction: A Structure-Based Screening and Molecular Dynamics Simulation Study
Published 2025-04-01“…<b>Methods:</b> Consequently, we used drug design and molecular simulation techniques to screen phytochemical databases, including traditional Chinese and African medicine sources, for compounds that could disrupt the p300/HIF-1 interaction. …”
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Trends and advances in Leptospira, a bibliometric analysis
Published 2025-01-01“…Prominent research areas included restriction endonucleases, monoclonal antibodies, outer membrane proteins, water environments, detection methods, and antimicrobial agents. Research focus has shifted from early genomic and antigenic studies to investigations into outer membrane protein functions and environmental persistence, culminating in recent advances in molecular mechanisms and diagnostic technology development.ConclusionThis bibliometric analysis provides a comprehensive snapshot of leptospirosis research, emphasizing collaborations and impact among authors, countries, institutions, and journals. …”
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Research Progress on the Effect of Dissolved Organic Matter on the Environmental Behavior of Cadmium in Environmental Remediation
Published 2025-05-01“…The various active functional groups contained in DOM, such as carboxyl, hydroxyl, and phenolic groups, are ligands and migration carriers for many heavy metals in the environment. …”
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WEB SERVICE OF WORKS PLANNING USING NETWORK GRAPH
Published 2022-05-01“…During the study, a set of theoretical, empirical, and modeling methods were applied, in particular: systematic analysis of scientific and methodological sources, the results of domestic and foreign experience on the problem, review of existing software to determine the problem solution state and select development tools of web service, analysis of methods and technologies network graphs construction, generalization of information on the problem. …”
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Direct-fed microbials optimize ruminal fermentation, microbial ecosystem and milk quality to enhance the lactation performance of Sanhe dairy cows
Published 2025-07-01“…Dairy cows are the most important source of milk production, with billions of microorganisms present in the rumen. …”
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Frontotemporal lobar degeneration changes neuronal beta-frequency dynamics during the mismatch negativity response
Published 2024-01-01“…Across bvFTD and PSP groups, the beta response to deviant stimuli (relative to standard stimuli) correlated with clinical severity, but not with atrophy of the prefrontal source region. These findings confirm the proposed importance of higher-order cortical regions, and their beta-power generators, in sensory change detection and context-updating during oddball paradigms. …”
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A novel multi-timescale comprehensive drought index for drought monitoring in the Xijiang River Basin
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Genicular Nerve Ultrasound-Guided Cryoanalgesia for the Treatment of Chronic Knee Joint Pain: An Observational Retrospective Study
Published 2025-03-01“…Larger prospective, controlled trials are necessary to confirm these findings and to refine patient selection and technique optimization.…”
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Cacao Agroforestry in Mahakam Ulu: Transformation Strategy from Traditional to Good Agricultural Practices and Smart Agroforestry System
Published 2025-06-01“…We also obtained secondary data from local government sources in East Kalimantan. Data were processed using qualitative descriptive analysis, gender, and SWOT analysis. …”
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WHSC1/NSD2 regulates immune infiltration in prostate cancer
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PhenoVision: A framework for automating and delivering research‐ready plant phenology data from field images
Published 2025-08-01“…We close by discussing next steps, including automating phenology annotations, adding new phenology targets, for example leaf phenology, and further integration with other resources to form a global central database integrating all in situ plant phenology resources.…”
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Diverse ancestral representation improves genetic intolerance metrics
Published 2025-03-01“…These findings highlight the need for enhanced population representation in genomic resources to fully realize the potential of precision medicine and drug discovery. …”
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Patient-reported outcome measures for fatigue in patients with chronic kidney disease: a systematic review
Published 2025-07-01“…The characteristics, dimensions of fatigue and psychometric properties of these measures were extracted and analysed.Data sources We searched MEDLINE, Embase, PsycINFO and CINAHL from database inception to February 2023.Eligibility criteria for selecting studies All studies that reported fatigue in patients with CKD stages 1–5 not receiving KRT.Results We identified 97 studies (20 (21%) randomised trials, 2 (2%) non-randomised trials and 75 (77%) observational studies). 27 different measures were used to assess fatigue, of which three were author-developed measures. …”
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Assessment of EMF Exposure Induced by Wireless Cellular Phones in Various Usage Scenarios in France
Published 2025-01-01“…According to the type of sources, RF-EMF exposure can be categorized into uplink (device-to-base station) and downlink (base station-to-device) transmissions. …”
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DistB-Condo: Distributed Blockchain-Based IoT-SDN Model for Smart Condominium
Published 2020-01-01“…Condominium network refers to intra-organization networks, where smart buildings or apartments are connected and share resources over the network. Secured communication platform or channel has been highlighted as a key requirement for a reliable condominium which can be ensured by the utilization of the advanced techniques and platforms like Software-Defined Network (SDN), Network Function Virtualization (NFV) and Blockchain (BC). …”
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