Effectiveness of exercise therapy in patients with knee osteoarthritis: an overview of systematic reviews by Daisuke Sasaki, Takashi Kitagawa, Yuichi Isaji, Kunihiro Onishi, Masateru Hayashi, Wataru Okuyama

“…Objective This study aimed to assess the methodological quality of published systematic reviews of exercise therapy in knee osteoarthritis and summarise their reported effectiveness on quality of life, knee joint function, or adverse events.Design Overview of systematic reviews.Data sources PubMed, Embase, CINAHL, Web of Science and CENTRAL (searched on 14 April 2025), plus grey literature (PROSPERO, Epistemonikos, OpenGrey).Eligibility criteria for selecting studies We included systematic reviews of randomised controlled trials in patients diagnosed with knee osteoarthritis by imaging or clinical criteria and treated conservatively with exercise therapy; we excluded reviews that enrolled patients scheduled for surgery, with acute inflammation or osteoarthritis of other joints (hand, hip, ankle), for which relevant author data could not be obtained after one contact attempt, or that did not report at least one primary outcome (quality of life, knee joint function or adverse events).Data extraction and synthesis Two reviewers independently extracted data on study characteristics, interventions and outcomes, and assessed methodological quality using the AMSTAR 2 (A MeaSurement Tool to Assess systematic Reviews 2) tool. …”
Get full text

Effect of Dry, Vacuum, and Modified Atmosphere Ageing on Physicochemical Properties of Roe Deer Meat by Natalia Kasałka-Czarna, Róża Biegańska-Marecik, Jędrzej Proch, Aleksandra Orłowska, Magdalena Montowska

“…Roe deer meat, due to the natural origin, is a source of organic and healthy meat. The selection of suitable storage conditions and times plays an important role in a deterioration of the meat's functional and nutritional values. …”
Get full text

De Novo Assembly of the Polyhydroxybutyrate (PHB) Producer <i>Azohydromonas lata</i> Strain H1 Genome and Genomic Analysis of PHB Production Machinery by Daniele Traversa, Carlo Pazzani, Pietro D’Addabbo, Lucia Trisolini, Matteo Chiara, Marta Oliva, Angelo Marzella, Camilla Mandorino, Carla Calia, Guglielmina Chimienti, Caterina Manzari, Graziano Pesole, Maria Scrascia

“…In addition to the <i>phaCAB</i> operon, single genes ascribable to PhaC and PhaA functions and auxiliary genes were also detected. A comparative genomic analysis of the available genomes of the genus <i>Azohydromonas</i> revealed the presence of <i>phaCAB</i> and auxiliary genes in all <i>Azohydromonas</i> species investigated, suggesting that the PHB production is a common feature of the genus. …”
Get full text

Synthesis of aluminum oxide nanoparticles using seeds of Carica papaya and evaluation of it for antimicrobial, antioxidant, and photocatalysis activity by Indrani Laskar, Rajib Saha

“…The presence of an absorption peak at a wavelength of 272 nm in the synthesized nanoparticles was detected by UV–Vis spectroscopy analysis. The results of the FTIR study confirmed the existence of various chemicals and functional groups in the 500–4000 cm−1 range. …”
Get full text

A Validation Tool (VaPCE) for Postcoordinated SNOMED CT Expressions: Development and Usability Study by Tessa Ohlsen, Viola Hofer, Josef Ingenerf

“…When errors are detected, the tool processes the SNOMED CT Concept Model in JSON format and applies predefined error categories. …”
Get full text

<i>In silico</i> prediction of the transcription factor-enhancer interaction as a first stage of axonal growth regulation by D. D. Kotelnikov, I. A. Sinyakin, E. A. Borodin, T. A. Batalova

“…The enhancer sequence of DCC and SHH protein genes were taken from the NCBI open-source database in FASTA format. Ensembl database was used for enhancer mapping, GeneCards was used for screening and selection of potentially appropriate enhancers and transcription factors associated with these enhancers. …”
Get full text

Activity tracking devices in pregnancy: Understanding the participant experience in a longitudinal birth cohort by Ashley Redding, Dionne Coates, Andrea E. Cassidy-Bushrow, Jennifer K. Straughen, Sara Santarossa

“…REACH-Fitbit participants had to be <20 weeks gestation with access to a Bluetooth-enabled device. Recruitment (self-selection) for focus groups occurred from completed REACH-Fitbit participants (e.g., delivered their baby). …”
Get full text

Bioinformatics analysis to explore biomarkers and mechanisms of action associated with endoplasmic reticulum stress and ferroptosis in Parkinson's disease. by Hao Wang, Lijuan Feng, Limeng He, Nan Liu, Yan Wan, Wei Zhang

“…<h4>Methods</h4>Data for PD and ERS, as well as information on ferroptosis, were sourced from public databases and relevant literature. …”
Get full text

HERV-derived epitopes represent new targets for T-cell-based immunotherapies in ovarian cancer by Qing Wang, Maha Ayyoub, Olivia Le Saux, Paola Bonaventura, Isabelle Treilleux, Nicolas Chopin, Clarisse Dubois, Virginie Mutez, Nicolas Chuvin, Yann Estornes, Jenny Valladeau-Guilemond, Stephane Depil, Nicolas Gadot, Marie Michelas, Audrey Page, Olivier Tabone, Marie Delles, Sarah Moran, Thibault Richard, Marjorie Lacourrège, Dina M Tawfik, Ema Etchegaray, Adrian Valente, Rasha E Boulos, Gabriel Jimenez Dominguez

“…Human endogenous retroviruses (HERVs) are aberrantly expressed by tumor cells and may represent a source of shared T-cell epitopes for cancer immunotherapy regardless of the tumor mutational burden.Methods A transcriptomic analysis based on RNA sequencing was developed to quantify the expression of HERV-K sequences containing the selected epitopes. …”
Get full text

Comprehensive Phenotypic Characterization and Genomic Analysis Unveil the Probiotic Potential of <i>Bacillus velezensis</i> K12 by Yingying Tang, Tian Li, Yihong Huang, Liangliang Wu, Xiaobo Liu, Ruichao Yue, Jianmin Yuan

“…The complete genome sequencing of <i>B. velezensis</i> K12 revealed a genomic length of 3,973,105 base pairs containing 4123 coding genes, among which 3973 genes were functionally annotated. The genomic analysis identified genes associated with acid and bile tolerance, adhesion, antioxidants, and secondary metabolite production, whereas no functional genes related to enterotoxins or transferable antibiotic resistance were detected, thereby confirming the probiotic properties of <i>B. velezensis</i> K12. …”
Get full text

Wuling capsule alleviates hyperuricaemia and protects UA- injured HK-2 cells by regulating uric acid transporter proteins by Nan Li, Hongna Liu, Zhongxing Song, Rui Zhou, Zhishu Tang, Zhishu Tang, Hongbo Xu, Xinbo Shi, Yanru Liu, Jian Ni

Get full text

Digital Platforms for the Built Environment: A Systematic Review Across Sectors and Scales by Michele Berlato, Leonardo Binni, Dilan Durmus, Chiara Gatto, Letizia Giusti, Alessia Massari, Beatrice Maria Toldo, Stefano Cascone, Claudio Mirarchi

“…Unlike existing reviews focused on single technologies or sectors, this work offers a cross-sectoral synthesis, highlighting shared challenges and opportunities across disciplines and lifecycle stages. It identifies the functional roles, enabling technologies and systemic barriers affecting digital platform adoption, such as fragmented data sources, limited interoperability between systems and siloed organizational processes. …”
Get full text

Oxidative Stress Markers and C-Reactive Protein Are Related to Severity of Heart Failure in Patients with Dilated Cardiomyopathy by Celina Wojciechowska, Ewa Romuk, Andrzej Tomasik, Bronisława Skrzep-Poloczek, Ewa Nowalany-Kozielska, Ewa Birkner, Wojciech Jacheć

“…Increased MnSOD activity indicates the mitochondrial source of ROS in patients with advanced heart failure.…”
Get full text

Enhancing Medium-Chain Fatty Acid Delivery Through Bigel Technology by Manuela Machado, Eduardo M. Costa, Sara Silva, Sérgio C. Sousa, Ana Maria Gomes, Manuela Pintado

“…This study presents the development and characterization of medium-chain fatty acid (MCFA)-loaded bigels, using coconut oil as the MCFA source. The bigels exhibited high oil binding capacity, ranging from 87% to 98%, effectively retaining MCFAs within the matrix, with lauric acid (C12) being the main component detected within the bigels at 178.32 ± 0.10 mg/g. …”
Get full text

Integrating Ambient In-Home Sensor Data and Electronic Health Record Data for the Prediction of Outcomes in Amyotrophic Lateral Sclerosis: Protocol for an Exploratory Feasibility S... by William E Janes, Noah Marchal, Xing Song, Mihail Popescu, Abu Saleh Mohammad Mosa, Juliana H Earwood, Vovanti Jones, Marjorie Skubic

“…Sensor data are subjected to a multidimensional streaming clustering algorithm to detect changes in health status. Specific health outcomes are identified in the EHR and extracted via the REDCap (Research Electronic Data Capture; Vanderbilt University) Fast Healthcare Interoperability Resource directly into a secure database. …”
Get full text

Genomic Signatures of Positive Selection and Local Adaptation in Ethiopian Sheep Populations by B. E. Demissie, G. M. Tarekegn, H. Dadi, Z. Edea, A. A. Woldesemayat, K-S Kim, S. Girma, T. Seyoum, K. Melaku, S. Keskes

“…Fixation index (FST) and cross-population extended haplotype homozygosity (XPEHH) methods were used to detect signatures of positive selection. Functional analysis revealed genes related to plateau adaptation, immune response, and tail fat formation. …”
Get full text

Evaluation of allergenic protein profiles in three Chinese high-oleic acid peanut cultivars using NanoLC-Orbitrap mass spectrometry by Xinke Yang, Haochen Bai, Lijun Yin, Jin Wang, Wentong Xue, Xin Jia

Get full text

Identification and Comprehensive Evaluation of Drought Tolerance in Sorghum During Germination and Seedling Stages by Manhong Wang, Irshad Ahmad, Bin Qin, Lei Chen, Weicheng Bu, Guanglong Zhu, Guisheng Zhou

“…In this study, 19 sorghum varieties from both domestic and international sources were selected as experimental materials. At the seedling stage, 11 above-ground and below-ground phenotypic traits were investigated. …”
Get full text

Erythrina lysistemon Hutch. abates deranged metabolic indices linked with diabetic complications in experimental rat model by Kolawole Olofinsan, Veronica Salau, Ochuko Erukainure, Md. Shahidul Islam

“…This study investigated the in vivo activity of E. lysistemon bark extract on animal models of type 2 diabetes (T2D) and complications vis-a-vis the effects on pancreatic functional enzymes and morphology, serum biochemical profile, and hepatic glucose metabolism. …”
Get full text

Femtosecond laser subtractive/additive-integrated biomimetic manufacturing for visible/infrared encryption and stimuli-responsive infrared decryption by Ruijie Liu, Dongshi Zhang, Zhuguo Li

“…The blackening efficiency of this technique can reach ∼11.25 cm ^2 ·min ^−1 , opening opportunities for high-throughput optical/thermal applications. Selectively patterned Chinese characters, Arabic numbers, and English letters are easily fabricable, which are intrinsically invisible-infrared dual-band encrypted but decryptable via static/dynamic environment stimuli (e.g., sample heating/cooling, introducing external hot/cold sources including human hands). …”
Get full text