Distinct oligomeric assemblies of STING induced by non-nucleotide agonists by Anant Gharpure, Ariana Sulpizio, Johannes R. Loeffler, Monica L. Fernández-Quintero, Andy S. Tran, Luke L. Lairson, Andrew B. Ward

“…Abstract STING plays essential roles coordinating innate immune responses to processes that range from pathogenic infection to genomic instability. Its adaptor function is activated by cyclic dinucleotide (CDN) secondary messengers originating from self (2’3’-cGAMP) or bacterial sources (3’3’-CDNs). …”
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SIU-ICUD: Principles and Outcomes of Focal Therapy in Localized Prostate Cancer by Alessandro Marquis, Jonathan Olivier, Tavya G. R. Benjamin, Eric Barret, Giancarlo Marra, Claire Deleuze, Lucas Bento, Kae J. Tay, Hashim U. Ahmed, Mark Emberton, Arnauld Villers, Thomas J. Polascik, Ardeshir R. Rastinehad

“…Cancer control rates vary by energy modality, tumor characteristics, and institutional experience, demonstrating comparable outcomes to radical treatments in well-selected patients. The safety profile is excellent, with high rates of urinary continence and sexual function preservation. …”
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Making Blind Robots See: The Synergy Between Fluorescent Dyes and Imaging Devices in Automated Proteomics by Wayne F. Patton

“…Since rare proteins cannot be amplified by any type of PCR method, sensitive detection is critical to proteome projects. Fluorescence methods deliver streamlined detection protocols, superior detection sensitivity, broad linear dynamic range and excellent compatibility with modern microchemical identification methods such as mass spectrometry. …”
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A framework for personal protective equipment use in laboratories: regulatory compliance and employee protection by Segaran P. Pillai, Sarah Bradberry, Marisa Newcomer, Tanya Pittas, Kelsey Mathern

“…The Occupational Safety and Health Administration (OSHA) Personal Protective Equipment (PPE) Standard, outlined in 29 CFR 1910 Subpart I states that Protective gear - including personal protective clothing, respiratory equipment, and barriers or shields- must be supplied, properly used, and kept clean and functional whenever there are hazards present. These hazards may arise from processes, environmental conditions, chemicals, radiation, or mechanical sources that could potentially cause injury or harm bodily functions through skin contact, inhalation, or absorption. …”
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A new fluorescent probe based on BODIPY for testing NO2 released from propellants by Ying-cui Cui, De-bin Xia, Zhong-yu Cui, Yu-jing Li, Jian Zhang, Ping Wang, Ting Guo, Kai-feng Lin, Yu-lin Yang

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Gallium oxide (Ga2O3) as a radiation detector distinguishing neutrons and gammas by D. J. Valdes, L. Rendon, J. Winkelbauer, P. Koehler, S. C. Vogel, K.-X. Sun

“…Gallium oxide (Ga2O3) is a promising ultrawide bandgap semiconductor for radiation detection with the potential of integrating electronic and scintillation functions within a single crystal device. …”
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Bearing Small Sample Fault Diagnosis based on Data Generation and Transfer Learning by Dinghui Wu, Qin Fang, Chuyi Wu

“…First， the source dataset is trained on the training network to obtain the source model， and then a small amount of drive-end data is used as the target dataset to fine-tuning to obtain the target model. …”
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The Intelligent Infectious Disease Active Surveillance and early warning system in China: An application of dengue prevention and control by Liangyu Kang, Jian Hu, Kangning Cai, Wenzhan Jing, Min Liu, Wannian Liang

“…Firstly, the system can proactively capture and integrate heterogeneous surveillance data from multiple sources. Based on these multi-channel data, users can select appropriate warning indicators and AI models to automatically trigger early warnings. …”
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Different sustained and induced alpha oscillations emerge in the human auditory cortex during sound processing by Víctor J. López-Madrona, Agnès Trébuchon, Christian G. Bénar, Daniele Schön, Benjamin Morillon

“…Do alpha oscillations function as a local mechanism within most neural sources to regulate their internal excitation/inhibition balance, or do they belong to separated inhibitory sources gating information across the auditory network? …”
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Effectiveness of care coordination interventions delivered to stroke survivors in low and middle-income countries: Systematic review and meta-analysis protocol. by Stephanopoulos Kofi Junior Osei, Anthony Danso-Appiah

“…<h4>Methods</h4>Electronic databases, trial registries and non-database sources will be searched for published and unpublished studies. …”
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Bioluminescence and environmental light drive the visual evolution of deep-sea shrimp (Oplophoroidea) by Danielle M. DeLeo, Heather D. Bracken-Grissom

“…In pelagic environments, vertically migrating animals can experience drastic changes to their lighting environment across depth, subjecting them to unique selective pressures, possibly to distinguish between changes in ambient light and bioluminescent sources. …”
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GENERATION AND COLLECTION OF TOBACCO AEROSOL FOR SHISHA by N. N. Bubnova, M. V. Shkidyuk

“…Qualitative characteristics of tobacco aerosol for shisha are determined by the functional purpose and depend on the component composition of the tobacco mixture and the coal used.The purpose of the research is to develop a methodology for the comprehensive assessment of tobacco for shisha based on modern methods of product quality control and includes the following steps:- monitoring of the studies to determine the component composition of the hookah mixture and the aerosol produced;- analysis of hookah mixture testing modes and development of an aerosol generation protocol;- development of a method for collecting aerosol on a laboratory smoking machine; - quantitative analysis of toxic analytes by HPLC MS / MS method.Methods have been developed for the machine generation and collection of tobacco aerosol for hookah, taking into account low concentrations of the analyzed toxic substances.The expediency of using the HPLC MS / MS method to determine the quantity of the following substances in tobacco aerosol for shisha has been substantiated:- carbonyl compounds (formaldehyde, acetaldehyde, acrolein) by detection on an electrospray source in the negative polarity mode- tobacco specific nitrosoamines (NNN and NNK) by detection on an electrospray source in the positive polarity mode.During the research laboratory and analytical equipment was used: a five-channel linear CERULEAN SM 405 smoking machine; Thermo Scientific Dionex UltiMate 3000 liquid chromatograph and TSQ Quantiva mass spectrometer.Obtaining experimental data on the quantitative determination of the component composition of the aerosol produced by tobacco for shisha using hookah systems is relevant for assessing toxic characteristics of the product.…”
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Conceptual Development of Urban Super-blocks Model in Urban Planning Based on Content Analysis Method by Hafez Mahdnejad

“…The statistical community includes various sources including articles, books, and theses, which were used to select the sources using available and snowball sampling methods. …”
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The therapeutic validity and effectiveness of physiotherapeutic exercise following total hip arthroplasty for osteoarthritis: A systematic review. by Annet Wijnen, Sjoukje E Bouma, Gesine H Seeber, Lucas H V van der Woude, Sjoerd K Bulstra, Djordje Lazovic, Martin Stevens, Inge van den Akker-Scheek

“…Characteristics of the physiotherapeutic exercise interventions and results about joint and muscle function, functional performance and self-reported outcomes were extracted.…”
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The impact of dyadic interventions on psycho-social outcomes for stroke patients and their caregivers: a systematic review and meta-analysis by Xinyue Xing, Liping Pu, Wanyue Hu, Yu Xiao, Hongling Xiao

“…AimsTo describe the details of dyadic interventions and summarize the current evidence on supporting dyadic interventions for psycho-social outcomes of stroke patients and their caregivers.DesignA systematic review and meta-analysis based on PRISMA guidelines.Data sourcesFive English databases (PubMed, Web of Science, CINAHL, Embase and Cochrane Library) were searched to identify eligible studies published from the inception to October 15, 2024.MethodsTwo reviewers independently screened the literature in accordance with the selection criteria. …”
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Regenerative Cartilage Treatment for Focal Chondral Defects in the Knee: Focus on Marrow-Stimulating and Cell-Based Scaffold Approaches by Filippo Migliorini, Francesco Simeone, Tommaso Bardazzi, Michael Kurt Memminger, Gennaro Pipino, Raju Vaishya, Nicola Maffulli

“…Given the limited regenerative capacity of hyaline cartilage, biologically based surgical strategies have emerged to promote tissue repair and restore joint function. This narrative review critically examines current treatment approaches that rely on autologous cell sources and scaffold-supported regeneration. …”
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Investigating the AGN-neutrino connection with public IceCube data by Kuhlmann Julian, Capel Francesca

“…We present the first application of a newly developed hierarchical Bayesian analysis framework for the detection of point-like sources of high-energy neutrinos. …”
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Identification of multiple power quality disturbances in hybrid microgrid using deep stacked auto-encoder based bi-directional LSTM classifier by Ravi Kumar Jalli, Lipsa Priyadarshini, P.K. Dash, Ranjeeta Bisoi

“…Thus to design an effective PQD recognition system, this paper proposes a novel time-frequency analysis method based on adaptively fast complementary ensemble local mean decomposition (AFCELMD) technique that decomposes the multicomponent PQD signal into a series of demodulated product functions (PFs). Out of the several PFs the most sensitive one is selected adaptively and used for feature extraction and classification through a deep stacked auto-encoder (dSAE) hybridized with a time-recursive bi-directional long short term memory (BiLSTM) network classifier. …”
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Construction of an Ecological Security Structure in Fuzhou City of Jiangxi Provicne Based on an MCR Model by Chen Qun, Liu Pinghui, Zhu Chuanmin

“…A minimum cumulative resistance (MCR) model was constructed by selecting various land use factors, soil and water conservation function importance, and ecological sensitivity. …”
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Gut microbiome composition and diversity of wild-caught and hatchery-bred milkfish (Chanos chanos) fry by Gardel Xyza L. Silvederio, Therese F. Javellana, Ande Bryle N. Genciana, Maria Alexandra G. Fontanilla, Rex Ferdinand M. Traifalgar, Fredson H. Huervana, Carmelo S. del Castillo

“…Milkfish is the most produced finfish in the Philippines, with approximately 75 % of its fry sourced from hatcheries. Despite numerous studies on gut microbiota of wild and cultured fish species, the diversity and functional roles of the milkfish fry gut microbiome remain poorly understood. …”
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