Clustering nuclear receptors in liver regeneration identifies candidate modulators of hepatocyte proliferation and hepatocarcinoma. by Michele Vacca, Simona D'Amore, Giusi Graziano, Andria D'Orazio, Marica Cariello, Vittoria Massafra, Lorena Salvatore, Nicola Martelli, Stefania Murzilli, Giuseppe Lo Sasso, Renato Mariani-Costantini, Antonio Moschetta

“…Twenty-nine NR transcripts were significantly modified in their expression during LR, including fatty acid (peroxisome proliferator-activated receptors, PPARs) and oxysterol (liver X receptors, Lxrs) sensors, circadian masters RevErbα and RevErbβ, glucocorticoid receptor (Gr) and constitutive androxane receptor (Car). In order to detect the NRs that better characterize proliferative status vs. proliferating liver, we used the novel Random Forest (RF) analysis to selected a trio of down-regulated NRs (thyroid receptor alpha, Trα; farsenoid X receptor beta, Fxrβ; Pparδ) as best discriminators of the proliferating status. …”
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On the usage of artificial intelligence in leprosy care: A systematic literature review. by Hilson Gomes Vilar de Andrade, Elisson da Silva Rocha, Kayo H de Carvalho Monteiro, Cleber Matos de Morais, Danielle Christine Moura Dos Santos, Dimas Cassimiro Nascimento, Raphael A Dourado, Theo Lynn, Patricia Takako Endo

“…The persistent stigma and social exclusion associated with leprosy complicate eradication efforts exacerbate the wider challenges faced by NTDs in sourcing the necessary resources and attention for control and elimination. …”
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Wave-packet manipulation of He Rydberg states by a seeded free-electron laser by Mathieu Dumergue, Paolo Antonio Carpeggiani, Tamás Csizmadia, Miltcho Danailov, Alexander Demidovich, Giovanni De Ninno, Michele Di Fraia, Per Eng-Johnsson, Dominik Ertel, Hikaru Fujise, Mizuho Fushitani, Luca Giannessi, Harshitha Nandiga Gopalakrishna, Akiyoshi Hishikawa, Heide Ibrahim, Sergei Kühn, Francois Légaré, Yu Luo, Praveen Kumar Maroju, Johan Mauritsson, Matteo Moioli, Anna Olofsson, Jasper Peschel, Oksana Plekan, Stephen T. Pratt, Lorenzo Raimondi, Primož Rebernik Ribič, Shu Saito, Giuseppe Sansone, Ronak Shah, Emma R. Simpson, Daehyun You, Marco Zangrando, Carlo Callegari, Kiyoshi Ueda, Kevin C. Prince

“…The He atoms were postionized by infrared (IR) pulses, and the ion yield was measured as a function of XUV phase and IR arrival time. We tagged and sorted the relative phase of the XUV pulse pair on a single-shot basis by fitting each FEL spectrum with a suitable function that accounts for nonidealities of the XUV pulse pairs, associated with the seeding process; more generally, the fit returns the time-dependent electric field of the FEL spectra. …”
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Identification method of roof rock interface based on response characteristics of drilling parameters by LI Dianshang, LIU Cancan, WANG Chuanbing, REN Bo, REN Shuai, KANG Zhipeng

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Reprogrammed Cell‐based Therapy for Liver Disease: From Lab to Clinic by Amir Mehdizadeh, Masoud Darabi

“…The generation of human functional hepatocytes in high quantities for liver cell therapy is an important goal for ongoing therapies in regenerative medicine. …”
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Epidemic preparedness and response capacity against infectious disease outbreaks in 186 countries, 2018–2022 by Paul Eze, Judith Chidumebi Idemili, Friday Onwubiko Nwoko, Nigel James, Lucky Osaheni Lawani

“…From the 2022 submissions, 116 (62%) countries reported functional (Level 4 or 5) prevention capacity, 162 (87%) had functional detection capacity, 118 (63%) had functional response capacity, 121 (65%) had functional enabling resources and coordination capacity, and 133 (72%) had functional operational readiness against public health events. …”
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Research review of digital modeling technologies with 3D spatial visualization for pipelines by Xin LIU, Shengwen TU, Yanfang HOU, Dong LIN, Jie SHU, Yu TANG

“…These developments have resulted in more comprehensive functionalities for visualization systems and improved operational and maintenance efficiency. …”
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An effective fluorescence strategy based on xanthine oxidase catalysis and the carbon dots’ specific response to ·OH for aminophylline pharmacokinetic studies by Chenfang Miao, Menghan Zhang, Ying Zheng, Xiaoyan Lin, Shuangying Yang, Linlin Xu, Sitong Lu, Zhengjun Huang, Jianyong Huang, Yanjie Zheng, Shaohuang Weng

“…However, efficient and sensitive detection methods remain limited. In this study, high quantum yield carbon dots (CA/EDA-CDs) were synthesized via a hydrothermal method using riboflavin as the carbon source, citric acid and ethylenediamine as functionalizing agents and dopants. …”
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Study of Complex Impedance Dispersion Model for Two-Phase Laminar Flow by CHENG Linfeng, KE Shizhen, SHI Hongwei, ZHANG Yuhang, LUO Hu, TAO Jie

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Partner-Inflicted Brain Injury: Intentional, Concurrent, and Repeated Traumatic and Hypoxic Neurologic Insults by Julianna M. Nemeth, Clarice Decker, Rachel Ramirez, Luke Montgomery, Alice Hinton, Sharefa Duhaney, Raya Smith, Allison Glasser, Abigail (Abby) Bowman, Emily Kulow, Amy Wermert

“…Our aims were to 1. characterize the lifetime co-occurrence of strangulation and intentional head trauma exposures from all abuse sources to the same survivor and within select physical episodes of IPV and 2. establish the lifetime prevalence of PIBI. (2) Methods: Survivors seeking DV services in the state of Ohio in the United States of America (U.S.) completed interview-administered surveys in 2019 (<i>n</i> = 47). …”
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Low-Cost Monitoring of Airborne Heavy Metals Using Lichen Bioindicators: Insights from Opole, Southern Poland by Liubomyr Bahinskyi, Paweł Świsłowski, Oznur Isinkaralar, Kaan Isinkaralar, Małgorzata Rajfur

“…., a species whose vital functions or morphological structure can reveal the qualitative state of the environment. …”
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Effect of zeolites modification on their adsorption properties by L. G. Eprikashvili, T. N. Kordzakhia, M. G. Zautashvili, N. V. Pirtskhalava, M. A. Dzagania, G. P. Tsintskaladze, T. V. Sharashenidze

“… Atmospheric air pollution is determined by the functioning of both technogenic and natural sources of pollution. …”
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Unravelling the Impact of an Additional Sex Chromosome in an Adult Female by Sigin George, Vikas Dagar, Barun Kumar Chakrabarty, N. Nagaraja

“…Chromosomal microarray, which is a more expensive test, substantiated the presence of additional X chromosomes but failed to detect the presence of low level of mosaicism. Our case study emphasised the recommendation of performing a strategy-based cost-effective cytogenetic evaluation of all cases of decreased ovarian reserve or low anti-Müllerian hormone levels in a resource-constrained setting. …”
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Effects of exercise with music in frail older adults: a systematic review and meta-analysis by NamHee Kim, Gwang Suk Kim, Min Kyung Park, Layoung Kim, Jae Jun Lee, Seungbum Yang

“…This study evaluated the impact of exercise with music on the physical and emotional health of frail, community-dwelling older adults.Design A systematic review and meta-analysis were conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines.Data sources MEDLINE, Cumulative Index to Nursing and Allied Health Literature, Embase, Cochrane Library, PsycINFO, Google Scholar and the Virginia Henderson International Nursing Library were last searched on 14 March 2025.Eligibility criteria for selecting studies We included randomised controlled trials (RCTs) and non-RCTs that applied exercise with music to community-dwelling frail older adults.Data extraction and synthesis Five independent reviewers used standardised methods to search, screen and code included studies. …”
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Understanding the political economy of reforming global health initiatives – insights from global and country levels by Sophie Witter, Natasha Palmer, Rosemary Jouhaud, Shehla Zaidi, Severine Carillon, Rene English, Giulia Loffreda, Emilie Venables, Shifa Salman Habib, Jeff Tan, Fatouma Hane, Maria Paola Bertone, Seyed-Moeen Hosseinalipour, Valery Ridde, Asad Shoaib, Adama Faye, Lilian Dudley, Karen Daniels, Karl Blanchet

“…Funders have not collaborated to enable reforms, despite concerns amongst a number of them, because of the helpful functional role of GHIs, which serves funder interests. …”
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Comparative Genomics of <i>Bifidobacterium animalis</i> subsp. <i>lactis</i> Reveals Strain-Level Hyperdiversity, Carbohydrate Metabolism Adaptations, and CRISPR-Mediated Phage Imm... by Ozge Can, Ismail Gumustop, Ibrahim Genel, Hulya Unver, Enes Dertli, Ibrahim Cagri Kurt, Fatih Ortakci

“…A comparative analysis of spacer sequences revealed distinct strain-specific CRISPR profiles, with certain strains sharing identical spacers that correlate with common phylogenetic clades or similar isolation sources—an indication of exposure to the same phage populations and shared selective pressures. …”
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Secrecy Outage Analysis of Mixed RF-FSO Systems With Channel Imperfection by Hongjiang Lei, Haolun Luo, Ki-Hong Park, Zhi Ren, Gaofeng Pan, Mohamed-Slim Alouini

“…First, the cumulative distribution function and probability density function of FSO links with pointing error and two different detection technologies are derived. …”
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IGFBP7 promotes the proliferation and differentiation of primary myoblasts and intramuscular preadipocytes in chicken by Wanzhuo Geng, Yulong Guo, Botong Chen, Xi Cheng, Shuohan Li, Mohammed Kamal Challioui, Weihua Tian, Hong Li, Yanhua Zhang, Zhuanjian Li, Ruirui Jiang, Yadong Tian, Xiangtao Kang, Xiaojun Liu

“…We then examined the expression patterns of IGFBP7 across different stages of proliferation and differentiation in CPMs and intramuscular preadipocytes via qPCR, and explored the biological functions of IGFBP7 through gain- and loss-of-function experiments and a range of techniques including qPCR, CCK-8, EdU, flow cytometry, Western blot, immunofluorescence, and Oil Red O staining to detect the proliferation, differentiation, and lipid deposition in CPMs and intramuscular preadipocytes. …”
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Who Leads Trends on Q&A Platforms? Identifying and Analyzing Trend Discoverers by Yongning Li, Lun Zhang, Ye Wu, Tianlan Wei

“…Q&A platforms are vital sources of information but often face challenges related to their high ratios of passive to active contributors, which can impede knowledge construction and information exchange on the platforms. …”
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Mito Stress Assay of PBMCs With Seahorse XFe96 Flux Analyzer and Comparison of Poly-D-Lysine and Poly-L-Lysine for Cell Affinity by Kumudu Subasinghe, R. Berry III, Megan Rowe, Ali Winters, Shaohua Yang, Nicole Phillips

“…Recent studies have suggested that these cell populations provide an overview of systemic changes within the body and therefore provide a source of sensitive biomarkers. Assessing mitochondrial function in PBMCs has been shown to provide an indication of metabolic stress associated with diseases such as diabetes and neurodegenerative conditions such as Alzheimer’s disease. …”
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