Bioactive matters based on natural product for cardiovascular diseases by Linfang Zhong, Xiaoying Tan, Wenhui Yang, Peishan Li, Lianbao Ye, Qi Luo, Honghao Hou

Get full text

Energy filtering enables macromolecular MicroED data at sub-atomic resolution by Max T. B. Clabbers, Johan Hattne, Michael W. Martynowycz, Tamir Gonen

“…While direct electron detection essentially eliminates the read-out noise during MicroED data collection, other sources of noise remain and limit the measurement of faint high-resolution reflections. …”
Get full text

3D printing-biomimetic local stiff niche enhances glycolysis to boost PDAC cell stem-like phenotype via N6-methyladenosine-suppressed YAP1 mRNA decay by Di Wu, Xiaoqi Guan, Tao Yang, Jiashuai Yan, Biwen Zhu, Junchao Zhou, Yibing Guo, Yuhua Lu

“…However, the stiffness heterogeneity of TME within PDAC functions on tumor cell stem-like phenotypes remains unclear. …”
Get full text

Trends and advances in Leptospira, a bibliometric analysis by Wei Wang, Wei Wang, Wei Wang, Yamin Gao, Yamin Gao, Yamin Gao, Jianyu Ji, Jianyu Ji, Jianyu Ji, Zhai Huang, Zhai Huang, Bin Xiong, Bin Xiong, Shulin Xiang, Shulin Xiang

“…Prominent research areas included restriction endonucleases, monoclonal antibodies, outer membrane proteins, water environments, detection methods, and antimicrobial agents. Research focus has shifted from early genomic and antigenic studies to investigations into outer membrane protein functions and environmental persistence, culminating in recent advances in molecular mechanisms and diagnostic technology development.ConclusionThis bibliometric analysis provides a comprehensive snapshot of leptospirosis research, emphasizing collaborations and impact among authors, countries, institutions, and journals. …”
Get full text

Trade-offs and synergies for urban Production-Living-Ecological spatial Patterns-Comparison study between Fuzhou, China, and Saskatoon, Canada by Xi Wang, Xiaomei Li, Jinming Sha, Hao Zhang, Eshetu Shifaw, Xulin Guo, Shuhui Lai, Jinliang Wang

“…First, the paper identified the PLE spaces by integrating multi-source data, then analyzed the PLE spatial agglomeration characteristics by using the average nearest neighbor and kernel density analysis, finally detected the trade-offs and synergies between functional spaces by Spearman correlation and bivariate spatial autocorrelation. …”
Get full text

CFD investigation and ANN prediction of heat transfer coefficient for fully developed turbulent air flow around double V-baffle turbulators by Abdulaziz Alasiri, H.E. Fawaz

“…The process of training incorporates the analysis of the loss function on training and validation data for controlling the weights and biases using backpropagation while feed forward propagate the selected input parameters. …”
Get full text

A competing risk analysis of predictors of time to lost to follow-up among adults with TB/HIV coinfection in Bahir Dar by Robel Demelash, Getachew Hailu, Taye Abuhay, Zemenu Addis, Ayenew Tega, Degarege Nibret, Yitagesu Habtu

“…Overestimating effect sizes when considering mutually exclusive events, like LTFU from ART and anti-TB treatment, can occur if sources of error are not properly accounted for in competing events. …”
Get full text

A Systematic Review of risk factors for major adverse cardiovascular events in patients with coronary heart disease who underwent percutaneous coronary intervention by You Zhai, Hongcai Shang, Yan Li, Nan Zhang, Jisi Zhang, Shangwen Wu

“…ObjectiveThis study aims to systematically review the risk factors for major adverse cardiovascular events (MACE) in patients with coronary heart disease who have undergone percutaneous coronary intervention (PCI).DesignSystematic review and meta-analysis.Data sourcesThe Cochrane Library, PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang Database, and VIP Database for Chinese Technical Periodicals (VIP) were screened until December 2024.Eligibility criteria for selecting studiesCase-control studies or cohort studies on the risk factors for MACE in patients with coronary heart disease who underwent PCI. …”
Get full text

A novel model-based meta-analysis to indirectly estimate the comparative efficacy of two medications: an example using DPP-4 inhibitors, sitagliptin and linagliptin, in treatment o... by Yan Gong, James Rogers, Christian Friedrich, Sanjay Patel, Alexander Staab, Jorge Luiz Gross, Daniel Polhamus, William Gillespie, Brigitta Ursula Monz, Silke Retlich

“…Comparison of two oral dipeptidyl peptidase (DPP)-4 inhibitors, sitagliptin and linagliptin, for type 2 diabetes mellitus (T2DM) treatment was used as an example.Design Systematic review with MBMA.Data sources MEDLINE, EMBASE, http://www.ClinicalTrials.gov, Cochrane review of DPP-4 inhibitors for T2DM, sitagliptin trials on Food and Drug Administration website to December 2011 and linagliptin data from the manufacturer.Eligibility criteria for selecting studies Double-blind, randomised controlled clinical trials, ≥12 weeks’ duration, that analysed sitagliptin or linagliptin efficacies as changes in glycated haemoglobin (HbA1c) levels, in adults with T2DM and HbA1c >7%, irrespective of background medication.Model development and application A Bayesian model was fitted (Markov Chain Monte Carlo method). …”
Get full text

Willingness to participate in COVID-19 vaccine trials; a survey among a population of healthcare workers in Uganda. by Jonathan Kitonsa, Onesmus Kamacooko, Ubaldo Mushabe Bahemuka, Freddie Kibengo, Ayoub Kakande, Anne Wajja, Vincent Basajja, Alfred Lumala, Edward Ssemwanga, Robert Asaba, Joseph Mugisha, Benjamin F Pierce, Robin Shattock, Pontiano Kaleebu, Eugene Ruzagira

“…Data were analysed descriptively and a binomial generalised linear model with a log link function used to investigate factors associated with unwillingness to participate.…”
Get full text

Persistence in the socio-economic development of the regions of the Siberian Federal District by Misak S. Arzumanyan

“…The term «persistence» originally has a biological and medical origin, as a property of microorganisms (bacteria, viruses) to survive and function in an aggressive environment (e.g., when exposed to antibiotics). …”
Get full text

The inconclusive superiority debate of allogeneic versus autologous MSCs in treating patients with HFrEF: a systematic review and meta-analysis of RCTs by Omar T. F. Ahmed, Ziyad Tarek Ahmed, Abdulrahman W. Dairi, Maha Saad Zain Al-Abeden, Mohammed H. Alkahlot, Rana H. Alkahlot, Ghazi I. Al Jowf, Lars M. T. Eijssen, Khawaja Husnain Haider

“…The data were then plotted for various outcomes, including death, hospitalization, major adverse cardiac events, pump function parameters, and 6-min walk distance. Results The safety of MSC-based treatment has been consistently demonstrated with MSCs from autologous (AutoMSCs) and allogeneic (AlloMSCs) sources. …”
Get full text

Intratumoural aldosterone and CYP11B2 expression levels among different genotypes of aldosterone producing tumours by Tobias Åkerström, Branislav Klimàcek, Matilda Annebäck, Olov Norlén, Peter Stålberg

“…Primary aldosteronism is the most common endocrine cause of hypertension, affecting 5–10% of hypertensive patients. Determining the source of aldosteronism is necessary for correct diagnosis and further molecular analysis. …”
Get full text

Antioxidant Profiling of Botryocladia leptopoda Based on In Silico and In Vitro Studies by Fenny Crista Anastasia Panjaitan, Huey-Jine Chai

“…Thus, B. leptopoda can be considered a promising source of antioxidative products in the functional food and pharmaceutical industries.…”
Get full text

Rock Fracture Monitoring Based on High-Precision Microseismic Event Location Using 3D Multiscale Waveform Inversion by Yi Wang, Xueyi Shang, Kang Peng, Rui Gao

“…Results show that the source-time function based on the fractional-order Gaussian function wavelet can better fit complex recording waveforms compared with the conventional Ricker wavelet-based source-time function, and the waveform misfit during the L-BFGS iteration decreased rapidly. …”
Get full text

Construction of a Multi-level Blue-Green Infrastructure Network in a Riverside City: A Case Study of Shaoxing by Meizi Zhou, Yong He, Zhi Qiu

“…To address this gap, this study proposes a framework for constructing a multi-level BGI network. We selected Shaoxing City, a typical riverside city in the Yangtze River Delta region of China, as the study area and integrated water-related ecosystem services into the identification of ecological sources. …”
Get full text

Viewing Global Changes in the Heliosheath with IMAP’s Energetic Neutral Atom Imagers by E. J. Zirnstein, J. Heerikhuisen, D. J. McComas, J. Bower, G. Clark, M. A. Dayeh, H. O. Funsten, M. Gkioulidou, D. G. Mitchell, D. B. Reisenfeld, N. A. Schwadron

“…We aim to answer the following: (i) What are the time delays as a function of energy and direction; (ii) at what energies can we observe changes the soonest; and (iii) what might the ENA source distributions affecting the time delays look like? …”
Get full text

Assessing motor control and movement quality in patients with non-specific low back pain: a scoping review and development of an ICF-based conceptual framework by Kerstin Luedtke, Agnes Sturma, Georg Pfluegler, Meike Klinger, Clemens Ley, Beate Schüßler

“…A thematic approach was used in an iterative process to identify broader themes in the data synthesis.Data sources MEDLINE, CINAHL, EMBASE, Web of Science, Scopus, Cochrane Library, COSMIN database and DiTA were systematically searched as part of a three-step search strategy (last search: 22 April 2025).Eligibility criteria for selecting studies Various types of evidence (qualitative and quantitative, primary and secondary) exploring and discussing movement tasks for assessing lumbopelvic motor control and movement quality in adult patients with non-specific LBP were considered. …”
Get full text

Advanced Microgrid Protection Utilizing Zero Sequence Components With Hard-Ware-in-the-Loop Testing by Zahra Ghanem, Feras Alasali, Naser El-Naily, Hassen Loukil, Haytham Y. Mustafa, Saad M. Saad, Abdelaziz Salah Saidi, William Holderbaum

“…Secondly, the study demonstrates the use of Configurable Function Blocks (CFCs) in digital relays to dynamically adjust relay settings based on zero sequence current detection. …”
Get full text

SentemQC - A novel and cost-efficient method for quality assurance and quality control of high-resolution frequency sensor data in fresh waters [version 1; peer review: 1 approved,... by Sofie Gyritia Madsen van't Veen, Joachim Audet, Eti Ester Levi, Brian Kronvang, Søren Erik Larsen, Erik Jeppesen, Esben Astrup Kristensen, Anders Nielsen, Thomas Alexander Davidson, Jane Rosenstand Laugesen, Peter Mejlhede Andersen

“…The SentemQC method is computationally efficient and features a six-step user-friendly setup for anomaly detection. The method marks anomalies in data using five moving windows. …”
Get full text