Optimizing Nav1.7‐Targeted Analgesics: Revealing Off‐Target Effects of Spider Venom‐Derived Peptide Toxins and Engineering Strategies for Improvement by Sen Luo, Xi Zhou, Meijing Wu, Gongxin Wang, Li Wang, Xujun Feng, Hang Wu, Ren Luo, Minjuan Lu, Junxian Ju, Wenxing Wang, Lei Yuan, Xiaoqing Luo, Dezheng Peng, Li Yang, Qingfeng Zhang, Minzhi Chen, Songping Liang, Xiuming Dong, Guoliang Hao, Yunxiao Zhang, Zhonghua Liu

“…Spider venom‐derived peptide toxins are recognized as significant sources of Nav1.7 inhibitors. However, their development has been impeded by limited selectivity. …”
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Female Regency Rule in Western Pomerania Exemplified by Duchess Elizabeth, the Wife of Warcisław IV (1326–ca. 1350) by Patrycja Jędrzejewska-Michalak

“…An important aspect is also the presentation of how Elizabeth dealt with the problems she encountered during her rule, as well as the assessment of her actions. The source base consists mainly of selected documents that the duchess exhibited or co-exhibited with her sons.…”
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Between Astronomy and Revelation: Reassessing the Star of Bethlehem in Matthew 2:1–12 by Sugihyono, Nicolien Meggy Sumakul, Mangiring Sinaga, Natassa Sandriana, Norlina Rambu Jola Kalunga, Mulyani Susana

“…Employing a qualitative, literature-based method, the research critically examines various astronomical hypotheses—including planetary conjunctions, comets, and supernovae—alongside symbolic and theological readings grounded in biblical and patristic sources. The findings demonstrate that naturalistic explanations fail to fully account for the unique characteristics of the star, such as its guided movement, selective visibility, and stationary positioning above a specific location. …”
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On Euphemisms, Linguistic Creativity, and Humor by Craig Hamilton, Anne-Sophie Foltzer

“…Euphemisms are also a source of creativity, and studying their form and function uncovers an interesting interface where syntax and semantics meet. …”
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Nano selenium in broiler feeding: physiological roles and nutritional effects by Babak Hosseintabar-Ghasemabad, Olga Vilorievna Kvan, Elena Vladimirovna Sheida, Artem Vladimirovich Bykov, František Zigo, Alireza Seidavi, Mona Mohamed Mohamed Yasseen Elghandour, Moises Cipriano-Salazar, Maximilian Lackner, Abdelfattah Zeidan Mohamed Salem

“…Nutrition of permitted and optimal levels is very important in the consumption of nano selenium form and as it can have significant beneficial functional and health effects, in case of errors in the selected levels and doses, irreparable side effects and adverse results can occur. …”
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Seq2scFv: a toolkit for the comprehensive analysis of display libraries from long-read sequencing platforms by Marianne Bachmann Salvy, Luca Santuari, Emanuel Schmid-Siegert, Nikolaos Lykoskoufis, Ioannis Xenarios, Bulak Arpat

“…To address this methodological gap, we introduce Seq2scFv, a novel open-source toolkit designed for analyzing in vitro display libraries from long-read sequencing platforms. …”
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Founders Can Increase Determinism of Community Assembly by Yi‐Ting Cheng, Wei Deng, Xiao‐Yan Yang, Kun Tan, Wen Xiao

“…This study used sterilized and nonsterilized paocai soup (a traditional Chinese fermented vegetable soup) from the same source to simulate initial environments with and without founders. …”
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Deep learning approach to the estimation of the ratio of reproductive modes in a partially clonal population by T. A. Nikolaeva, A. A. Poroshina, D. Yu. Sherbakov

“…Genetic diversity among biological entities, including populations, species, and communities, serves as a fundamental source of information for understanding their structure and functioning. …”
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Genetic and biotechnological characterization of folate-producing probiotics isolated from local dairy products by Rahma Ali Hassan Abubakr, Mohammed Hassan Abdel A’al, Gihan Mohamed El Moghazy, Ashraf Bakry Abd Elrazik, Samir Abdel Aziz Ibrahim

“…The findings support strain selection for folate-enriched functional foods.…”
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Interdisciplinary medical education practices: building a case-driven interdisciplinary simulation system based on public datasets by Kangli Qiu, Tianshu Zeng, Wenfang Xia, Miaomiao Peng, Wen Kong

“…This creates a closed-loop practice that spans data sample selection and processing to front-end interaction. …”
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A probabilistic approach for building disease phenotypes across electronic health records by David Vidmar, Jessica De Freitas, Will Thompson, John M. Pfeifer, Brandon K. Fornwalt, Noah Zimmerman, Riccardo Miotto, Ruijun Chen

“…In this paper, we develop multiple heuristic “labeling functions’’ (LFs) for 4 diseases across de-identified EHR data and aggregate their votes through a majority vote approach (MV), a popular open-source approach (Snorkel OSS), and our proposed probabilistic approach (LEVI). …”
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Classification analysis of modern bioreactor systems (review). Part 1. Classification of bioreactors by design parameters by A. A. Dosaev, R. R. Safarov, N. V. Menshutina

“…Due to the active use of bioreactors, in order to optimize production processes and reduce operating costs, new highly efficient automated devices with a variety of functions are being developed using modern automation technologies, artificial intelligence and 3-D printing. …”
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Deepmol: an automated machine and deep learning framework for computational chemistry by João Correia, João Capela, Miguel Rocha

“…On 22 benchmark datasets, DeepMol obtained competitive pipelines compared with those requiring time-consuming feature engineering, model design and selection processes. As one of the first AutoML tools specifically developed for the computational chemistry domain, DeepMol stands out with its open-source code, in-depth tutorials, detailed documentation, and examples of real-world applications, all available at https://github.com/BioSystemsUM/DeepMol and https://deepmol.readthedocs.io/en/latest/ . …”
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Extraction and characterization of humic acid from low-rank coal mined reserves in South Sumatra and its application on red chili (Capsicum annuum L.) in fertilizer exhausted soil by Mega Kartika Hermawan, Emma Trinurani Sofyan, Rija Sudirja, Anne Nurbaity

“…Laboratory-scale characterization revealed that locally sourced HA shares many functional groups with commercial leonardite-based HA. …”
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A Dataset for Investigations of Amine-Impregnated Solid Adsorbent for Direct Air Capture by Eryu Wang, Liping Luo, Jiachuan Wang, Jiaxin Dai, Shuangyin Li, Lei Chen, Jia Li

“…Existing literature serves as a valuable source for the investigation of amine-functionalized solid adsorbents. …”
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Modular assembly of self-healing flexible thermoelectric devices with integrated cooling and heating capabilities by Xiaolong Sun, Yue Hou, Zheng Zhu, Bo Zhu, Qianfeng Ding, Wenjie Zhou, Sijia Yan, Zhanglong Xia, Yong Liu, Youmin Hou, Yuan Yu, Ziyu Wang

“…Yet, current devices lack functional module expansion, which limits the customization for diverse energy-harvesting heat sources and complicates their assembly to meet the specific power requirements of electrical appliances. …”
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Perovskite spin light-emitting diodes with simultaneously high electroluminescence dissymmetry and high external quantum efficiency by Shuai He, Weixi Lin, De Yu, Junwei Shi, Zhen Yin, Changjiu Sun, Haoliang Liu, Chen Zhang, Jianyu Yuan, Sai Bai, Shumin Xiao, Guankui Long, Mingjian Yuan, Yuanzhi Jiang, Yimu Chen, Qinghai Song

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Infrastructure of interconnected microgrids: A review by Moshammed Nishat Tasnim, Tofael Ahmed, Shameem Ahmad, GM Shafiullah

“…All these analyses and comparisons are expected to serve as a reference in the field of IMG infrastructure to select a suitable framework based on the necessary functionalities. …”
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Low pressure amide hydrogenation enabled by magnetocatalysis by Sheng-Hsiang Lin, Sihana Ahmedi, Aaron Kretschmer, Carlotta Campalani, Yves Kayser, Liqun Kang, Serena DeBeer, Walter Leitner, Alexis Bordet

“…Widely available and commercial platinum on alumina (Pt/Al2O3) was functionalized with iron carbide nanoparticles (ICNPs) to allow for localized and rapid magnetic induction heating resulting in the activation of neighboring Pt sites by thermal energy transfer. …”
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GASTROINTESTINAL BLEEDING WITH THE USE OF NEW ORAL ANTICOAGULANTS: EPIDEMIOLOGY, RISK FACTORS, TREATMENT, AND PREVENTION by E. V. Moroz, A. E. Karateev, E. V. Kryukov, V. A. Chernetsov

“…Novel oral anticoagulants (NOACs), such as the direct thrombin inhibitor dabigatran and the selective factor Xa inhibitors rivaroxaban and apixaban, are increasingly used as an effective antithrombotic drug in real clinical practice. …”
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