COL6A2 in clear cell renal cell carcinoma: a multifaceted driver of tumor progression, immune evasion, and drug sensitivity by Yashuang Yang, Ruixin Fan, Boming Zhang, Kai Liu

“…Methods The mRNA and protein expression data for ccRCC were sourced from TCGA, GEO, CPTAC, and ICPC. Single-cell and spatial transcriptomic data were processed using Seurat with quality control measures. …”
Get full text

Microarray-Based Comparisons of Ion Channel Expression Patterns: Human Keratinocytes to Reprogrammed hiPSCs to Differentiated Neuronal and Cardiac Progeny by Leonhard Linta, Marianne Stockmann, Qiong Lin, André Lechel, Christian Proepper, Tobias M. Boeckers, Alexander Kleger, Stefan Liebau

“…Numerous families of ion channels are present in the organism which can be distinguished by means of, for example, ion selectivity, gating mechanism, composition, or cell biological function. …”
Get full text

TIM3-blockade synergizes with IL2 in alleviating intra-tumoral CD8+T cell exhaustion by Xuhao Zhang, Yu Gao, Huiping Liao, Wenyan Wang, Zaili Yang, Weian Cao, Ge Li, Jing Wen, Gencheng Han, Yang-Xin Fu

“…Progressive loss of IL2-secretion is an early sign of diminished effector function in TILs, which raises the possibility of IL2 loss driving exhaustion of TILs. …”
Get full text

Differential efficacy of olfactory neurospheres from deviated nasal septum and chronic rhinosinusitis patients in regenerating olfactory epithelium by Rong-San Jiang, Chiang-Wen Lee, Yu-Hsuan Lin, Jing-Jie Wang, Jia-Bin Liao, Kuo-Ti Peng, Yao-Chang chiang, Pei-Ling Chi

“…Conclusions These findings highlight the importance of selecting the appropriate ONS source for therapeutic applications, with DNS-ONS showing greater promise for olfactory epithelium repair and olfactory function restoration.…”
Get full text

WHSC1/NSD2 regulates immune infiltration in prostate cancer by Kunle Odunsi, Junko Matsuzaki, Takemasa Tsuji, Sebastiano Battaglia, Richard C. Koya, Prashant K Singh, Muzamil Y Want, James L Thorne, Ellen Karasik, Bryan Gillard, Eduardo Cortes Gomez, Amit Lugade

Get full text

Numerical analysis of spectroscopic studies using supercontinuum generated by noise-like pulses by Christian A. Salcedo-Rodriguez, Eloisa Gallegos-Arellano, Julian M. Estudillo-Ayala, Juan M. Sierra-Hernandez, Jose D. Filoteo-Razo, Maximino R. Tapia-Garcia, Daniel A. Ramos-Gonzalez, Roberto Rojas-Laguna, Juan C. Hernandez-Garcia

“…Simulations were also performed for CH4, showing a visible absorption spectrum, thereby substantiating that these sources powered by NLPs can detect various gases with a high degree of selectivity.…”
Get full text

Smart Fault Detection, Classification, and Localization in Distribution Networks: AI-Driven Approaches and Emerging Technologies by Jianxian Wang, Hazlie Mokhlis, Nurulafiqah Nadzirah Mansor, Hazlee Azil Illias, Agileswari K. Ramasamy, Xingyu Wu, Siqi Wang

“…The insights offered herein are expected to provide practical guidance for engineers and researchers for selecting and deploying intelligent fault diagnosis strategies in future distribution networks with high distributed generation penetration.…”
Get full text

Vitamin D and Osteoporosis in HIV/HCV Coinfected Patients: A Literature Review by Paola Di Carlo, Lucia Siracusa, Giovanni Mazzola, Piero Colletti, Maurizio Soresi, Lydia Giannitrapani, Valentina Li Vecchi, Giuseppe Montalto

“…The final 12 articles selected are homogeneous in terms of age but heterogeneous in terms of sample size, participant recruitment, and data source. …”
Get full text

Integrated microbiome and metabolome approaches reveal the resistant mechanisms of leaf blight resistant plum cultivar by Xinyan Zhou, Yufei Wei, Yu Zhu, Jiaoming Li, Runche Zhou, Qingju Xiao, Ruihong Luo, Shangdong Yang

“…By harnessing these natural microbial and metabolic resources, it may be possible to develop sustainable, eco-friendly strategies for managing leaf blight, ultimately reducing the dependency on chemical pesticides. …”
Get full text

Metagenome Analysis Identified Novel Microbial Diversity of Sandy Soils Surrounded by Natural Lakes and Artificial Water Points in King Salman Bin Abdulaziz Royal Natural Reserve,... by Yahya S. Al-Awthan, Rashid Mir, Fuad A. Alatawi, Abdulaziz S. Alatawi, Fahad M. Almutairi, Tamer Khafaga, Wael M. Shohdi, Amal M. Fakhry, Basmah M. Alharbi

“…Results: In this study, sandy soil samples from the surroundings of natural and artificial water resources of two distinct natures were used. Based on 16S rRNA sequencing, a total of 24,563 OTUs were detected. …”
Get full text

The TRPA1 cation channel is upregulated by cigarette smoke in mouse and human macrophages modulating lung inflammation by Anita Steib, Katalin Rozmer, Éva Szőke, József Kun, Nelli Farkas, Diána Feller, Judit Pongrácz, Krisztina Pohóczky, Zsuzsanna Helyes

“…The transient receptor potential ankyrin 1 (TRPA1), a smoking-responsive, non-selective cation channel, is expressed by both capsaicin-sensitive peptidergic sensory nerves and non-neuronal cells of the lung, but there are few and controversial data on its expression and function on macrophages. …”
Get full text

The association between serum albumin–globulin ratio and overactive bladder in American adults: a cross-sectional study by Yuan-Zhuo Du, Jia-Hao Liu, Fu-Chun Zheng, Qiang Zhou, Ju Guo

“…However, despite its widely studied correlations in numerous health fields, the link between AGR and Overactive Bladder (OAB) is still not completely comprehended. Methods Data were sourced from the National Health and Nutrition Examination Survey (NHANES) database, selecting adult samples spanning from 2007 to 2018. …”
Get full text

Application of artificial intelligence in echocardiography from 2009 to 2024: a bibliometric analysis by Yangli Liu, Lei Zhao, Bin Tu, Jie Wang, Yaqun He, Rufang Jiang, Xiaofeng Wu, Wen Wen, Jian Liu

“…The objective of this study is to explore the current status and prevailing research trends in this field from 2009 to 2024 through bibliometric analysis and to forecast future developmental trajectories.MethodsWe selected the Science Citation Index Expanded (SCI-Expanded) from the Web of Science Core Collection (WOSCC) as our primary data source and conducted a comprehensive search encompassing all articles and reviews published between 2009 and 2024 and used the online analysis platform of bibliometrics, CiteSpace and VOSviewer software to analyze countries/regions, institutions, authors, keywords, and references, used Microsoft Excel 2021 to visualize the trends of the number of articles published by year.ResultsBetween 2009 and 2024, a total of 3,411 publications on AI applications in echocardiography were identified, including 3,000 articles (87.9%) and 411 reviews (12.1%), contributed by researchers from 100 countries/regions. …”
Get full text

The evolution and competitive strategies of Akkermansia muciniphila in gut by Ji-Sun Kim, Se Won Kang, Ju Huck Lee, Seung-Hwan Park, Jung-Sook Lee

“…In addition, WapA and anSME, which function in competition and post-translational modification of sulfatase, respectively, have been a particularly important selective pressure in the evolution of group A. …”
Get full text

Utilization of Garcinia mangostana L. Peel as an Immunomodulator to Improve the Quality of Human Resources: A Systematic Review by Yunita Satya Pratiwi, Dina Mustika Rini, Ifwarisan Defri, Tawaffani Qubra, Nadien Mutia Intan Maulidi

“…Background: Mangosteen (Garcinia mangostana L.) is recognized for its immunomodulatory properties, which can rejuvenate, regulate, and modulate immune system function. As a rich source of antioxidants, mangosteen peel has the potential to enhance immune responses and improve overall health status. …”
Get full text

Influence of suturing material on wound healing: Experimental study in dogs by Gazivoda Dragan, Pelemiš Dejan, Vujašković Goran, Đurđević Slaviša

“…When using resorbable materials it is of great importance to determine whether its absorbability and tensile strength help wound healing in function of time. Sutures themselves can become a source of inflammation, that may reduce or compromise the potential of reparation and regeneration. …”
Get full text

Enhancing the socio-cultural valuation of ecosystem services in Mountain animal production: a case study from piedmont’s alpine valley (North-west Italy) by Chiara Costamagna, Valentina Maria Merlino, Danielle Borra, Lorenzo Baima, Paolo Cornale, Luca Maria Battaglini

“…The new principal components were employed to cluster the sample in the function of individuals’ perceptions of ecosystem services. …”
Get full text

Efficacy of Anti-VEGF/VEGFR Agents on Animal Models of Endometriosis: A Systematic Review and Meta-Analysis. by Shuangge Liu, Xiaoyan Xin, Teng Hua, Rui Shi, Shuqi Chi, Zhishan Jin, Hongbo Wang

“…Subgroup analyses were performed to determine the source of heterogeneity in endometriosis scores and follicle numbers.…”
Get full text

Toward Sustainable Agriculture: DPA-UNet for Semantic Segmentation of Landscapes Using Remote Sensing Imagery by J. Kavipriya, G. Vadivu

“…Attention gates are also included into the decoder path to selectively hone feature maps from the encoder to emphasize spatially relevant areas during the upsampling process. …”
Get full text

A Regional Reduction in Ito and IKACh in the Murine Posterior Left Atrial Myocardium Is Associated with Action Potential Prolongation and Increased Ectopic Activity. by Andrew P Holmes, Ting Y Yu, Samantha Tull, Fahima Syeda, Stefan M Kuhlmann, Sian-Marie O'Brien, Pushpa Patel, Keith L Brain, Davor Pavlovic, Nigel A Brown, Larissa Fabritz, Paulus Kirchhof

“…<h4>Methods</h4>We used high-resolution optical mapping and sharp microelectrode recordings to quantify regional differences in electrical activation and repolarisation within the intact, superfused murine left atrium and quantified regional ion channel mRNA expression by Taqman Low Density Array. We also performed selected cellular electrophysiology experiments to validate regional differences in ion channel function.…”
Get full text