Exploring the classification and treatment of osteoporosis from the perspectives of natural medicines, molecular targets, and symptom clusters by Yili Zhang, Xiangyun Guo, Kai Sun, Liang Wang, Siyuan Huang, Yiwen Gan, Jinran Qin, Qingqing Liu, Yan Li, Zikai Jin, Liguo Zhu, Xu Wei

“…We used compounds and targets, applying Summary data-based Mendelian Randomisation (SMR) analysis for biological process and molecular function enrichment. Additionally, we employed Phenome-Wide Association Studies (PheWAS) to select two natural drugs—Rhizoma Drynariae (RD) and Lycii Fructus (LF)—for case analysis. …”
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BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity by Eliana MC Tacconi, Xianning Lai, Cecilia Folio, Manuela Porru, Gijs Zonderland, Sophie Badie, Johanna Michl, Irene Sechi, Mélanie Rogier, Verónica Matía García, Ankita Sati Batra, Oscar M Rueda, Peter Bouwman, Jos Jonkers, Anderson Ryan, Bernardo Reina‐San‐Martin, Joannie Hui, Nelson Tang, Alejandra Bruna, Annamaria Biroccio, Madalena Tarsounas

“…Abstract Maintenance of genome integrity requires the functional interplay between Fanconi anemia (FA) and homologous recombination (HR) repair pathways. …”
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Dimeric natural product panepocyclinol A inhibits STAT3 via di-covalent modification by Li Li, Yuezhou Wang, Yiqiu Wang, Xiaoyang Li, Qihong Deng, Fei Gao, Wenhua Lian, Yunzhan Li, Fu Gui, Yanling Wei, Su-Jie Zhu, Cai-Hong Yun, Lei Zhang, Zhiyu Hu, Qingyan Xu, Xiaobing Wu, Lanfen Chen, Dawang Zhou, Jianming Zhang, Fei Xia, Xianming Deng

“…Homo- or heterodimeric compounds that affect dimeric protein function through interaction between monomeric moieties and protein subunits can serve as valuable sources of potent and selective drug candidates. …”
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Pyrene‐diaminomaleonitrile‐based fluorescent probe for the turn‐on detection and bioimaging of hypochlorite by Bingbing Yue, Ruida Shi, Huiwen Yang, Caifeng Ding, Haitao Yu, Yanyu Qi

“…Abstract Hypochlorous acid (HClO), a key member of the reactive oxygen species, has an impact on both normal and abnormal functioning of a wide range of organisms. To deeply investigate the function of HClO in organisms and its impact on health status, there is an urgent need to develop efficient detection techniques in the biomedical field. …”
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Relationship between ecological spatial network and vegetation carbon use efficiency in the Yellow River Basin, China by Chenglong Xu, Xiang Chen, Qiang Yu, Buyanbaatar Avirmed, Jikai Zhao, Wei Liu, Weijie Sun

“…Subsequently, the interrelationship between topological metrics and vegetation CUE was analyzed, and optimization strategies were proposed based on the significance of the structure and function. The findings revealed that: (1) Vegetation CUE exhibited a spatially decreasing trend from the western to eastern regions, with spatial patterns correlated with vegetation types, temperature, and precipitation distribution; (2) The ecological spatial network demonstrated a denser configuration in the upper and middle reaches and a sparser and shorter pattern in the lower reaches, with seamless connectivity among all regions; (3) Significant correlations were observed between topological metrics and vegetation CUE, prompting the adoption of ecological construction and protection measures when functional importance is deficient, and enhancing the connectivity of ecological sources through the augmentation of ecological corridors when structural importance is lacking. …”
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NaCl-induced soil stress regulates the diversity of soil bacteria and their ability to metabolize low molecular weight organic acids by Adhari Al-Kalbani, Daniel Menezes-Blackburn, Jinan Waladwadi, Said Al-Ismaily, Buthaina Al-Siyabi

“…This study demonstrated that soil salinity is a strong regulator of soil microbial diversity and function, as reflected by a marked decrease in the responsiveness of soil microbes to various root exudate carbon sources.…”
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Contemporary techniques and outcomes of surgery for locally advanced renal cell carcinoma with focus on inferior vena cava thrombectomy: The value of a multidisciplinary team by Riccardo Campi, Paolo Barzaghi, Alessio Pecoraro, Maria Lucia Gallo, Damiano Stracci, Alberto Mariotti, Saverio Giancane, Simone Agostini, Vincenzo Li Marzi, Arcangelo Sebastianelli, Pietro Spatafora, Mauro Gacci, Graziano Vignolini, Francesco Sessa, Paolo Muiesan, Sergio Serni

“…Our experience confirms that provided careful patient selection, surgery in experienced hands can achieve favourable perioperative, oncological, and functional outcomes.…”
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Optimisation of bioaerosol sampling using an ultralight aircraft: A novel approach in determining the 3-D atmospheric biodiversity by Maria P. Plaza, Athanasios Charalampopoulos, Vivien Leier-Wirtz, Pia Viuf Ørby, Mathilde Kloster, Michael Dines Christiansen, Claudia Traidl-Hoffmann, Athanasios Damialis, Ulrich Gosewinkel

“…Moreover, biomonitoring campaigns often take place in urban environments, although sources can be located outside cities’ borders with ampler vegetation. …”
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Feasibility, Added Value, and Radiation Dose of Combined Coronary CT Angiography and Stress Dynamic CT Myocardial Perfusion Imaging in Moderate Coronary Artery Disease: A Real-Worl... by Marco Fogante, Enrico Paolini, Fatjon Cela, Paolo Esposto Pirani, Liliana Balardi, Gian Piero Perna, Nicolò Schicchi

“…Materials and Methods: This retrospective study included 65 patients (mean age: 51.2 ± 11.5 years; 21 female) with moderate CAD, selected from the Radiological Database of our hospital between May 2022 and December 2024. …”
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TET3-facilitated differentiation of human umbilical cord mesenchymal stem cells into oligodendrocyte precursor cells for spinal cord injury recovery by Yubo Zhang, Zhibin Peng, Man Guo, Yangyang Wang, Jingsong Liu, Yishu Liu, Mi Li, Tianli Wei, Pengfei Li, Yingwei Zhao, Yansong Wang

“…Owing to the poor regenerative capabilities of endogenous oligodendrocyte precursor cells (OPCs) following SCI, there is a growing interest in alternative sources, such as human umbilical cord mesenchymal stem cells (HUCMSCs). …”
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Stealth missiles with precision guidance: A novel multifunctional nano-drug delivery system based on biomimetic cell membrane coating technology by Yuyan Zhou, Xinyue Wang, Xiaorong Tian, Deyu Zhang, Hanxiao Cui, Wei Du, Zhenghui Yang, Jiayu Li, Wanshun Li, Jiaheng Xu, Ying Duanmu, Ting Yu, Fengping Cai, Wenhao Li, Zhendong Jin, Wencheng Wu, Haojie Huang

“…This approach enables nanocarriers to inherit the intrinsic biological properties of different cell sources, endowing them with immune evasion, prolonged circulation, dynamic targeting, biocompatibility, and biodegradability, while supporting the integration of diverse biomedical functions. …”
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Pediatric Renal Transplantation in the Jordanian Population: The Clinical Outcome Measures During Long-term Follow-up Period by Sireen Shilbayeh, Issa Hazza

“…Conclusion: The average result of pediatric renal transplantation in Jordan is more successful than the average results of this procedure in many developed countries, especially in terms of early graft function, acute rejection episodes as well as long-term patient and graft survivals. …”
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THE RESULTS OF COMPARATIVE CLINICAL EVALUATION OF THE USE OF PLASTIC FOR TEMPORARY NON-REMOVABLE PROSTHESIS by O.S. Kyrmanov

“…First of all, a restoration and maintenance functions (aesthetics, phonetics, chewing function, etc.), as well as talent-teeth and periodontal stabilization and adjustment of aproximal occlusal contacts. …”
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Development of FBG Inclination Sensor: A Study on Attitude Monitoring of Hydraulic Supports in Coal Mines by Minfu Liang, Kewei Li, Xinqiu Fang, Daqian Zheng, Xinze Lu, Gang Wu, Haiyang Lu

“…It not only fulfills the inclination measurement function but also employs passive sensing technology, rendering it safer and more reliable compared to electromagnetic inclinometers. …”
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Chemical reprogramming culture for the expansion of salivary gland epithelial basal progenitor cells by Ye Jin Jeong, Yongpyo Hong, Yeo-Jun Yoon, Nam Suk Sim, Seung-Min Hong, Jae-Yol Lim

“…The treatment successfully restored SG function. Conclusion Our findings demonstrate that our CRC system is an effective method for the long-term culture of SG-BPCs. …”
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Inhaled Nitric Oxide as an Adjunct to Thrombolytic Therapy in a Patient with Submassive Pulmonary Embolism and Severe Hypoxemia by Omesh Toolsie, Umut Gomceli, Gilda Diaz-Fuentes

“…Inhaled nitric oxide (iNO) is a selective pulmonary vasodilator with limited indications in adults. …”
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In Vivo Detection of Staphylococcus aureus Infections Using Radiolabeled Antibodies Specific for Bacterial Toxins by María Isabel González, Mario González-Arjona, Lorena Cussó, Miguel Ángel Morcillo, John Jairo Aguilera-Correa, Jaime Esteban, Martha Kestler, Daniel Calle, Carlos Cerón, Marta Cortes-Canteli, Patricia Muñoz, Emilio Bouza, Manuel Desco, Beatriz Salinas

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Targeting NADPH oxidase-driven oxidative stress in diabetic cardiomyopathy: mechanisms and therapeutic perspectives by Zilv Ye, Zilv Ye, Sutong Wang, Zhengdong Wan, Birun Huang, Jiawei Guo, Jiawei Guo

“…Emerging strategies, such as selective NOX inhibitors, antioxidant therapies, and agents modulating signaling transduction, offer promising avenues for mitigating oxidative injury and improving cardiac function. …”
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Identification and Comprehensive Evaluation of Drought Tolerance in Sorghum During Germination and Seedling Stages by Manhong Wang, Irshad Ahmad, Bin Qin, Lei Chen, Weicheng Bu, Guanglong Zhu, Guisheng Zhou

“…In this study, 19 sorghum varieties from both domestic and international sources were selected as experimental materials. At the seedling stage, 11 above-ground and below-ground phenotypic traits were investigated. …”
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Construction and characterization of bioluminescent Salmonella Reading outbreak and non-outbreak strains by Abubakar Shitu Isah, Reshma Ramachandran, Anuraj Theradiyil Sukumaran, Aaron S. Kiess, Claudia D. Castañeda, Timothy Boltz, Kenneth S. Macklin, Hossam Abdelhamed, Li Zhang

“…However, growth was notably different in the presence of chloramphenicol, indicating successful plasmid retention and function. This study successfully created stable bioluminescent S. …”
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