Exploring Autophagy-Related Gene Expression in Hepatocellular Carcinoma via TCGA, GEPIA2, and HPA Databases: Implications for Prognosis by Gu X, Chen Y, Hu X, Li Y, Zhu R, Li H, Yuan Z, Wang Y

“…RT-qPCR analysis further confirmed significant upregulation of mRNA expression levels of randomly selected BAG3, EIF2AK2, KIF5B, and RAB24 in HCC cell lines, consistent with the bioinformatics analysis findings.Conclusion: This study showed that the 41 obtained ARGs, such as ATG16L1, ATG4B, BAG3, KIF5B, MAPK1, RAB24, and SOGA1, these findings suggest that ARGs may serve as prognostic biomarkers for HCC, warranting further validation in clinical cohorts and functional studies.Keywords: hepatocellular carcinoma, bioinformatics, autophagy, prognostic markers, TCGA…”
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Intratumoural aldosterone and CYP11B2 expression levels among different genotypes of aldosterone producing tumours by Tobias Åkerström, Branislav Klimàcek, Matilda Annebäck, Olov Norlén, Peter Stålberg

“…Primary aldosteronism is the most common endocrine cause of hypertension, affecting 5–10% of hypertensive patients. Determining the source of aldosteronism is necessary for correct diagnosis and further molecular analysis. …”
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Creation of Souvenir Products as a Means of Promotion of Historical and Cultural Heritage of the City by Uliana P. Efremova, Olga A. Tsesevichene, Anastasia A. Seldusheva

“…The methodological basis of the project was theoretical research methods, such as: analysis used to identify and clarify the target audience of the project, and select similar examples, as well as the souvenir market to highlight competitive advantages; synthesis - to identify optimal design solutions and formulate conclusions; comparison - to work with information sources when determining the functionality of the souvenir and its application. …”
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Effect of discontinuing antipsychotic medications on the risk of hospitalization in long-term care: a machine learning-based analysis by Mikko Nuutinen, Riikka-Leena Leskelä, Daniela Fialova, Ira Haavisto, Harriet Finne-Soveri, Jokke Häsä, Johanna Edgren, Hein van Hout, Daniel E. da Cunha Leme, John P. Hirdes, Graziano Onder, Rosa Liperoti

“…The use of restraints, age, and functional impairment were relevant variables in all ITE models in influencing the predicted ITE. …”
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THE PLACE OF PROFESSIONAL EDUCATION SYSTEM IN FORMATION OF GRADUATES’ COMPETITIVENESS by G. F. Shafranov-Kutsev, G. Z. Efimova

“…The review and synthesis of scientific sources content corresponding to the announced subject and research problems were performed at theoretical stage of the research. …”
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Viewing Global Changes in the Heliosheath with IMAP’s Energetic Neutral Atom Imagers by E. J. Zirnstein, J. Heerikhuisen, D. J. McComas, J. Bower, G. Clark, M. A. Dayeh, H. O. Funsten, M. Gkioulidou, D. G. Mitchell, D. B. Reisenfeld, N. A. Schwadron

“…We aim to answer the following: (i) What are the time delays as a function of energy and direction; (ii) at what energies can we observe changes the soonest; and (iii) what might the ENA source distributions affecting the time delays look like? …”
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Exploring the Possibility of Medical Device Surveillance in Patients on Peritoneal Dialysis Using a Common Data Model by Seon Min Kim, Sooin Choi, You Kyoung Lee, Cheol Wan Lim, Byung Chul Yu, Moo Yong Park, Jin Kuk Kim, Seng Chan You, Seo Jeong Shin, Soo Jeong Choi

“…After implementing amended matching, these data were detected. <i>Conclusions</i>: While some PD-related medical data recorded in EHRs were misrepresented or omitted during the CDM database extraction, transformation, and loading process, the CDM shows potential to serve as a source of real-world data for active surveillance.…”
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Reassessing Adaptational Lag in Eriophorum vaginatum: Short-Term Responses to Reciprocal Transplant and Passive Warming Experiments in Northern Alaska by Jennifer Lynn Chandler, James B McGraw, Michael L Moody, Jianwu Tang, Janice Voltzow, Ned Fetcher

“…This study’s short duration likely limited our ability to detect differences in tiller population growth as a function of garden or ecotype, emphasizing the need for long-term monitoring.…”
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Multi-Channel Optical Coherence Elastography Using Relative and Absolute Shear-Wave Time of Flight. by Eli Elyas, Alex Grimwood, Janine T Erler, Simon P Robinson, Thomas R Cox, Daniel Woods, Peter Clowes, Ramona De Luca, Franco Marinozzi, Jérémie Fromageau, Jeffrey C Bamber

“…A needle, embedded in the gel, was excited to vibrate along its long axis and the displacement as a function of time and distance from the needle associated with the resulting shear waves was detected using four M-mode images acquired simultaneously using a commercial four-channel swept-source OCT system. …”
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Data-Governance Approach Implemented in the Activities of State Supervisory Authorities of the Russian Federation by Ekaterina Sviridova

“…The Russian market for IT solutions in the field of data and metadata management is analyzed, and their functionality is described. Open source solutions that can also be used for data management are also considered. …”
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Elevated heterotrophic activity in Guaymas Basin hydrothermal plumes influences deep-sea carbon cycling by Andrew Montgomery, Guang-Chao Zhuang, Zhichao Zhou, Marguerite V. Langwig, María del Carmen Millán-Motolinía, Hannah Y. L. Choi, Kimberley S. Hunter, Carlos A. Mortera-Gutiérrez, Christelle Hyacinthe, Zachary Marinelli, Karthik Anantharaman, Andreas Teske, Samantha B. Joye

“…Metatranscriptomic analysis of functional genes for heterotrophic metabolisms implicates Gammaproteobacteria and diverse heterotrophs in hydrothermally-sourced organic carbon degradation. …”
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Identifying accounting control issues from online employee reviews by Lukui Huang, Alan Abrahams, Juthamon Sithipolvanichgul, Richard Gruss, Peter Ractham

“…This paper presents and describes an approach to generate innovative labeled datasets that enable automated text classifiers to automatically detect online employee reviews referring to accounting control deficiencies, facilitating supplementary monitoring for auditors and management. …”
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Whole-genome sequencing and genomic analysis of four Akkermansia strains newly isolated from human feces by Wenjing Lu, Biqing Zha, Jie Lyu, Chenxi LingHu, Jing Chen, Sisi Deng, Xiangling Zhang, Liang Li, Guoqing Wang

“…Moreover, 2,184 shared homologous genes were identified among the four isolates. Functional annotation using the COG, KEGG, and CAZy databases indicated that the functional genes of the four isolates were primarily associated with metabolism. …”
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Terahertz photoconductive atomic force microscopy of few-layer graphene flakes by Erica Fragomeni, Fritz Berkmann, Maria Eleonora Temperini, Leonetta Baldassarre, Michele Ortolani, Valeria Giliberti, Valeria Giliberti, Tommaso Venanzi

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Peripheral immune cell dysregulation following diffuse traumatic brain injury in pigs by Kathryn L. Wofford, Kevin D. Browne, David J. Loane, David F. Meaney, D. Kacy Cullen

“…Indeed, secondary infections following TBI worsen neurological outcomes and are a major source of mortality and morbidity. Despite the compelling link between the damaged brain and peripheral immune functionality, little is known about how injury severity affects the peripheral immune system in closed-head diffuse TBI, the most common clinical presentation including all concussions. …”
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OGLE-2011-BLG-0462: An Isolated Stellar-mass Black Hole Confirmed Using New HST Astrometry and Updated Photometry by Kailash C. Sahu, Jay Anderson, Stefano Casertano, Howard E. Bond, Martin Dominik, Annalisa Calamida, Andrea Bellini, Thomas M. Brown, Henry C. Ferguson, Marina Rejkuba

“…We have reanalyzed the data, including the new HST astrometry, and photometry obtained with 16 different telescopes. The source lies only $0\mathop{.}\limits^{^{\prime\prime} }4$ from a bright neighbor, making it crucial to perform precise subtraction of its point-spread function (PSF) in the astrometric measurements of the source. …”
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Assessing the impact of a rare synonymous variant in the <i>KNG1</i> gene on the development of hereditary angioedema by N. A. Pechnikova, Yu. V. Ostankova, M. A. Saitgalina, A. M. Bebyakov, A. A. Totolian

“…Therefore, (1) the mutant high-molecular-weight kininogen is more easily activated by kallikrein and becomes a source of bradykinin formation through the kallikrein-kinin system; (2) the mechanism of bradykinin formation undergoes significant changes and results in the formation of functionally active but aberrant bradykinin, which alters its inactivation by enzymes with a consequent increase in its half-life, (3) the changes in positions 380-389 bring about modifications in Lys-bradykinin reproduction such that in subsequent steps it is “easily” cleaved to bradykinin by arginine aminopeptidase. …”
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De Novo Synthesis of Anticholinergic Hyoscyamine and Scopolamine in <i>Nicotiana benthamiana</i> Based on Elucidating Tropane Alkaloid Biosynthetic Pathway of <i>Anisodus luridus</... by Mengling Wen, Junlan Zeng, Fei Qiu, Fangyuan Zhang, Zhihua Liao

“…Its high yield of hyoscyamine makes <i>A. luridus</i> a valuable plant source for commercially producing TAs. In this study, we conduct homologous gene research across transcriptome data of different tissues together with functionally tested sequences in <i>Atropa belladonna</i> as a reference and identify 13 candidate genes for TAs biosynthesis in <i>A. luridus</i>. …”
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FREQ‐NESS Reveals the Dynamic Reconfiguration of Frequency‐Resolved Brain Networks During Auditory Stimulation by Mattia Rosso, Gemma Fernández‐Rubio, Peter Erik Keller, Elvira Brattico, Peter Vuust, Morten L Kringelbach, Leonardo Bonetti

“…In this study, FREQ‐NESS is applied to source‐reconstructed magnetoencephalography (MEG) data during resting state and isochronous auditory stimulation. …”
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rangr: An R package for mechanistic, spatially explicit simulation of species range dynamics by Katarzyna Markowska, Katarzyna Malinowska, Lechosław Kuczyński

“…Several mechanistic, spatially explicit models have been proposed to address this issue, but they do not cover the full range of potential functionalities. We present a new open‐source R package called rangr, which integrates population dynamics and dispersal into a mechanistic virtual species simulator. …”
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