Genetic analysis of ocular tumour-associated genes using large genomic datasets: insights into selection constraints and variant representation in the population by Jose S Pulido, Mandeep S Sagoo, Omar A Mahroo, Alexander Tanner

“…Haploinsufficiency was determined based on specific criteria: probability of loss of function index ≥0.9 in gnomAD, upper CI O/E limit <0.35 for loss of function variants in gnomAD and/or a DECIPHER pHaplo ≥0.86. …”
Get full text

Providing a Roadmap for the Adaption of Agricultural Sector to Water Scarcity Conditions (Case Study: Selected Crops of Tajan Basin, Iran) by H. Fouladi, H. Amirnejad, S. Shirzadi Laskookalayeh

“…GP is used to perform three types of analysis: Determining the required resources to achieve a desired set of objectives. Determining the degree of attainment of the goals with the available resources. …”
Get full text

Internal university labor market: problem, inevitability or expediency? by S. V. Orekhova, O. M. Nikitina

“…It is shown that the functioning of such a model will be relatively expedient when building the effective work of a university in a loose coupling net of national and international academic community.…”
Get full text

Functional Analysis of Hedges and Boosters in Academic Students Essays: Across Disciplinary Study by آزاده ملاکی, سید فواد ابراهیمی, محمد تقی فروردین

“…Hedging and boosting are significant communicative resources to construe and attain persuasion in different fields and particular genres of academic writing. …”
Get full text

The proteome of circulating extracellular vesicles and their functional effect on platelets vary with the isolation method by Eva M. Fernández-Sáez, Susana B. Bravo, Carmen Pena, Ángel García

“…Abstract Extracellular vesicles (EVs) play a crucial role in cell-to-cell communication and serve as a source of biomarkers in several pathologies. In this study, we aimed to characterize plasma-derived EVs isolated by ultracentrifugation (UC) or size exclusion chromatography (SEC) to define the best method for proteomic and functional studies. …”
Get full text

Crop domestication and improvement reshape root traits and the structure and function of their associated microbiome by Xiaoming HE, Frank HOCHHOLDINGER, Xingping CHEN, Peng YU

Get full text

Longwall top coal caving technological process in the notation of the system-functional approach by Cherkasov P.V.

“…The system-functional modeling made it possible to explicitly define, structure and systematize the functional blocks that control impacts and resources, as well as the mutual influence of the output parameters of the technological process of producing coal from the subsurface. …”
Get full text

Morphological and functional characteristics of Trichinella sp. larvae in bears and badgers in the Kirov Region by O. B. Zhdanova, I. I. Okulova, A. V. Uspensky, L. A. Napisanova

“…For postmortem diagnosis of trichinellosis in the obtained bears and badgers, we can use trichinelloscopy and peptolysis methods which are aimed at detecting infection sources and preventing zoonosis in humans.…”
Get full text

Influence of Lineage-Negative Stem Cell Therapy on Articulatory Functions in ALS Patients by Wioletta Pawlukowska, Bartłomiej Baumert, Monika Gołąb-Janowska, Anna Sobuś, Agnieszka Wełnicka, Agnieszka Meller, Karolina Machowska-Sempruch, Alicja Zawiślak, Karolina Łuczkowska, Sławomir Milczarek, Bogumiła Osękowska, Edyta Paczkowska, Iwona Rotter, Przemysław Nowacki, Bogusław Machaliński

“…Bone marrow-derived stem and progenitor cells (SPCs) may be a valuable source of trophic factors. In this study, we assessed whether adjuvant cellular therapy could affect the levels of selected neurotrophins and proinflammatory factors in the cerebrospinal fluid (CSF) and subsequently prevent the deterioration of articulation. …”
Get full text

Fermentation improves the immune function of the Astragalus membranaceus (Fisch.) Bunge stem and leaf by Zhixun Li, Mingyue Jia, Mengke Sheng, Qing Zhou, Xinhui Peng, Weishuo Ren, Kaijie Hu, Xinyuan Shi

“…Bunge (A. membranaceus, Huang Qi), and to further develop and utilize it, fermentation technology was applied to the stem and leaf of A. membranaceus to enhance its immune function. Methods: In this study, we fermented A. membranaceus stem and leaf (ASL) with probiotics and investigated its immune function. …”
Get full text

FsDAOD: Few-shot domain adaptation object detection for heterogeneous SAR image by Siyuan Zhao, Yong Kang, Hang Yuan, Guan Wang, Hui Wang, Shichao Xiong, Ying Luo

“…Heterogeneous Synthetic Aperture Radar (SAR) image object detection task with inconsistent joint probability distributions is occurring more and more frequently in practical applications. …”
Get full text

Network security traffic detection and legal supervision based on adaptive metric learning algorithm by Liu Zhen

Get full text

App-DDoS detection method using partial binary tree based SVM algorithm by Bin ZHANG, Zihao LIU, Shuqin DONG, Lixun LI

“…As it ignored the detection of ramp-up and pulsing type of application layer DDoS (App-DDoS) attacks in existing flow-based App-DDoS detection methods,an effective detection method for multi-type App-DDoS was proposed.Firstly,in order to fast count the number of HTTP GET for users and further support the calculation of feature parameters applied in detection method,the indexes of source IP address in multiple time windows were constructed by the approach of Hash function.Then the feature parameters by combining SVM classifiers with the structure of partial binary tree were trained hierarchically,and the App-DDoS detection method was proposed with the idea of traversing binary tree and feedback learning to distinguish non-burst normal flow,burst normal flow and multi-type App-DDoS flows.The experimental results show that compared with the conventional SVM-based and naïve-Bayes-based detection methods,the proposed method has more excellent detection performance and can distinguish specific App-DDoS types through subdividing attack types and training detection model layer by layer.…”
Get full text

Design and investigation of charge plasma-based TMD heterojunction TFET biosensor for ultrasensitive detection by Monika Kumari, Niraj Kumar Singh, Vinay Kantipudi, Manodipan Sahoo

Get full text

Self-Powered Microsystem for Ultra-Fast Crash Detection via Prestressed Triboelectric Sensing by Yiqun Wang, Yuhan Wang, Xinzhi Liu, Xiaofeng Wang, Keren Dai, Zheng You

“…We further developed a self-powered, compact (<4.5 cm3) microsystem that integrates the shock sensor, a signal processing module, airbag triggering circuitry, and a high-g-resistant supercapacitor as a backup power source. The microsystem achieves ultra-fast shock detection and airbag activation with a delay of less than 0.2 ms. …”
Get full text

Comparison of genotyping assays for detection of targeted CRISPR/Cas mutagenesis in highly polyploid sugarcane by Eleanor J. Brant, Eleanor J. Brant, David May, David May, Ayman Eid, Ayman Eid, Fredy Altpeter, Fredy Altpeter

Get full text

YOLOv9-GDV: A Power Pylon Detection Model for Remote Sensing Images by Ke Zhang, Ningxuan Zhang, Chaojun Shi, Qiaochu Lu, Xian Zheng, Yujie Cao, Xiaoyun Zhang, Jiyuan Yang

“…Finally, the Variable Minimum Point Distance Intersection over Union (VMPDIoU) loss is proposed to optimize the model’s loss function. This method employs variable input parameters to directly calculate key point distances between predicted and ground-truth boxes, more accurately reflecting positional differences between detection results and reference targets, thus effectively improving the model’s mean Average Precision (mAP). …”
Get full text

Sex‐Specific Ultraviolet Radiation Tolerance Across Drosophila by James E. Titus‐McQuillan, Brandon A. Turner, Rebekah L. Rogers

“…Adaptation and genetic innovation arise in the genome from a variety of sources. Functional genomics requires both genetic discoveries and empirical testing to observe adaptation between lineages. …”
Get full text

Host selection is not a universal driver of phyllosphere community assembly among ecologically similar native New Zealand plant species by Anya S. Noble, Jaber Abbaszadeh, Charles K. Lee

“…Abstract Background A growing body of evidence demonstrates that host-associated microbial communities of plant leaf surfaces (i.e. the phyllosphere) can influence host functional traits. However, it remains unclear whether host selection is a universal driver of phyllosphere community assembly. …”
Get full text

A diagnosis method based on graph neural networks embedded with multirelationships of intrinsic mode functions for multiple mechanical faults by Bin Wang, Manyi Wang, Yadong Xu, Liangkuan Wang, Shiyu Chen, Xuanshi Chen

“…Additionally, a graph-level based fault diagnosis network model is designed to enhance feature learning capabilities for graph samples and enable flexible application across diverse signal sources and devices. Experimental validation with datasets including independent vibration signals for gear fault detection, mixed vibration signals for concurrent gear and bearing faults, and pressure signals for hydraulic cylinder leakage characterization demonstrates the model's adaptability and superior diagnostic accuracy across various types of signals and mechanical systems.…”
Get full text