Celastrol-loaded ginsenoside Rg3 liposomes boost immunotherapy by remodeling obesity-related immunosuppressive tumor microenvironment in melanoma by Hongyan Zhang, Jingyi Huang, Yujie Li, Wanyu Jin, Jiale Wei, Ninghui Ma, Limei Shen, Mancang Gu, Chaofeng Mu, Donghang Xu, Yang Xiong

“…Obesity usually exacerbates the immunosuppressive tumor microenvironment (ITME), hindering CD8+ T cell infiltration and function, which further represents a significant barrier to the efficacy of immunotherapy. …”
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COL6A2 in clear cell renal cell carcinoma: a multifaceted driver of tumor progression, immune evasion, and drug sensitivity by Yashuang Yang, Ruixin Fan, Boming Zhang, Kai Liu

“…Methods The mRNA and protein expression data for ccRCC were sourced from TCGA, GEO, CPTAC, and ICPC. Single-cell and spatial transcriptomic data were processed using Seurat with quality control measures. …”
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Vocational teacher training in Russia at the present stage: Conceptual aspect by В. A. Fedorov, P. F. Kubrushko, V. V. Dubitskiy, A. V. Feoktistov

“…The third component outlines the expected state indicated by the necessary conditions for the implementation of conceptual principles of vocational teacher training and concerning the selection of teaching content, building the structure of the system of vocational teacher training system supported with relevant management tools.Practical significance. …”
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Effect of Perfluorane on Electric Pulse-Modified Red Blood Cell Membranes by V. V. Moroz, Ye. K. Kozlova, M. S. Bogushevich, P. Yu. Alekseyeva, A. M. Chernysh

“…The induced calibrated electroporation of the membranes permitted the detection of the masked effects of perfluorane on blood cells. …”
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Quantification of glucagon and oxyntomodulin by protein precipitation-immunoaffinity enrichment-LC-MS/MS by Jessica O. Becker, Sara K. Shijo, Huu-Hien Huynh, Katrina L. Forrest, Michael J. MacCoss, Michelle A. Emrick, Elisha Goonatilleke, Andrew N. Hoofnagle

“…A glucagon calibration material was sourced commercially and characterized for purity and concentration by high-performance liquid chromatography-ultraviolet detection and amino acid analysis. …”
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Synergizing Multi-Temporal Remote Sensing and Systemic Resilience for Rainstorm–Flood Risk Zoning in the Northern Qinling Foothills: A Geospatial Modeling Approach by Dong Liu, Jiaqi Zhang, Xin Wang, Jianbing Peng, Rui Wang, Xiaoyan Huang, Denghui Li, Long Shao, Zixuan Hao

“…This framework quantitatively evaluates the nonlinear response mechanisms of town–village systems to flood disasters, emphasizing the synergistic effects of spatial scale, morphology, and functional organization. The proposed framework uniquely integrates three innovative modules: (1) a hybrid risk identification engine combining normalized difference vegetation index (NDVI) temporal anomaly detection and spatiotemporal hotspot analysis; (2) a morpho-functional resilience quantification model featuring a newly developed spatial morphological resilience index (SMRI) that synergizes landscape compactness, land-use diversity, and ecological connectivity through the entropy-weighted analytic hierarchy process (AHP); and (3) a dynamic scenario simulator embedding rainfall projections into a coupled hydrodynamic model. …”
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Digital Twin-Based Technical Research on Comprehensive Gear Fault Diagnosis and Structural Performance Evaluation by Qiang Zhang, Zhe Wu, Boshuo An, Ruitian Sun, Yanping Cui

“…However, the current gear operation is still faced with problems such as poor monitoring, a single detection index, and low data utilization, which lead to incomplete evaluation results. …”
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Unveiling smart contract vulnerabilities: Toward profiling smart contract vulnerabilities using enhanced genetic algorithm and generating benchmark dataset by Sepideh HajiHosseinKhani, Arash Habibi Lashkari, Ali Mizani Oskui

“…This dataset consists of 111,897 Solidity source code samples, ensuring the practical validation of the proposed approach. …”
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Impulse Shaping Method Based on Bayesian Deconvolution by JIA Tonghui, LIU Yi, WANG Ming, MA Yingjie, WANG Bo

“…The initial step of this method entailed expressing the measured pulse signal as the convolution of the current impulse pulse signal and the detection system response function. Then, the measured signal was expressed in the continuous time domain and decomposed into the form of an impulse signal and a double exponential kernel convolution by derivation. …”
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Зелені дахи в сучасному благоустрої міст by Liliia Gnatiuk, Ivanna Nesteruk

“…In the world, the directions of future research are the study of all the beneficial functions of green roofs, as well as solutions for individual functional areas. …”
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Genome-wide identification and expression pattern analysis of NAC family in Taxus yunnanensis and the TyuNAC30 role in paclitaxel production by Jiangtao Fan, Yong Wang, Mengke Dou, Qiuhong Hu, Qing Li, Shengmei Gan, Mingwei Jing, Gang Wang, Xiong Huang

“…Yeast one-hybrid and related assays revealed that TyuNAC30 functions as a negative regulator of TyuDBTNBT, a key enzyme gene in the paclitaxel biosynthetic pathway. …”
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Biased thalamic innervation onto the distinct subregion where dopamine receptor 1 is dominantly expressed in the caudal striatum by Fuko Kadono, Jingqi Wang, Kenta Kobayashi, Fuyuki Karube, Fumino Fujiyama

“…Retrograde tracer labeling identified potential sources of subcortical glutamatergic projections. …”
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The association between serum albumin–globulin ratio and overactive bladder in American adults: a cross-sectional study by Yuan-Zhuo Du, Jia-Hao Liu, Fu-Chun Zheng, Qiang Zhou, Ju Guo

“…However, despite its widely studied correlations in numerous health fields, the link between AGR and Overactive Bladder (OAB) is still not completely comprehended. Methods Data were sourced from the National Health and Nutrition Examination Survey (NHANES) database, selecting adult samples spanning from 2007 to 2018. …”
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GEANT4 Simulation of Proton Beam Properties from a Cyclotron Accelerator at King Chulalongkorn Memorial Hospital by Piyanud Thongjerm, Ekkachai Kongmon, Khwanjira Tangpong, Phalakorn Khwansungnoen, Sarinrat Wonglee, Weerawat Pornroongruengchok, Nantanat Chailanggar

“…For effective treatment, the linear energy transfer (LET) is a key parameter in ensuring the destruction of diseased cells, and both the dose and LET are typically represented as functions of depth. The distribution of dose and LET in the target depends on the beam properties, including beam energy, energy spread, beam size, and beam emittance. …”
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Alkaline-Potassium Ferrate Pretreatment Promoting Acid Production Through Co-Fermentation of Waste Activated Sludge and Corn Straw by Xintian YU, Wei ZENG

“…Microbial community analysis revealed a reduction in the Shannon index, with a notable enrichment of fermentation-related functional bacteria, including Firmicutes and Bacteroidota. …”
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NORDIC denoising on VASO data by Lasse Knudsen, Lasse Knudsen, Luca Vizioli, Federico De Martino, Lonike K. Faes, Daniel A. Handwerker, Steen Moeller, Peter A. Bandettini, Peter A. Bandettini, Laurentius Huber

“…However, VASO comes along with another reduction in detection sensitivity. NOise Reduction with DIstribution Corrected (NORDIC) PCA (principal component analysis) is a denoising technique specifically aimed at suppressing thermal noise, which has proven useful for increasing the SNR of high-resolution functional data. …”
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The Soviet Military Microbiologists’ Contribution to the Victory in the Great Patriotic War by A. S. Tumanov, I. V. Darmov, M. K. Bakulin, A. A. Leshchenko, D. A. Sharov, S. V. Bagin, I. V. Kosenkov

“…The authors of this article have detected a sequence of events that led to relocation of a military scientific institution during the Great Patriotic War (the Sanitary engineering institution of the Red Army of Workers and Peasants) was relocated from Gorodomlya Island to Kirov. …”
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THE USE OF CRYOCONSERVATED PLACENTA FOR PREVENTION OF PATHOLOGIC SCAR FORMATION OF THE HEAD AND NECK AT THE INTRA- AND POSTOPERATIVE STAGE IN PLANNED SURGERY by O.A. Toropov, D.S. Avetikov, K.P. Lokes, D.V. Steblovskyi, V.M. Skrypnyk, R.A. Prykhidko

“…With the development of technology, it became possible to detect the phenotypic and functional heterogeneity of cell types. …”
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Recreational Thematic Dominants in News TV Discourse by M. A. Gladko

“…The key tasks of the research are to identify the repertoire of thematic dominants of recreation, their functional characteristics, the specifics of participation in the construction of the news text, as well as a description of the recreation scale.Methodology and sources. …”
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A Systematic Review and Meta-analysis of Scrub Typhus and its Association with Liver Disease by Shalini Balamurugan, Reenaa Mohan, Jenifer Florence Mary, Kulkarni Sweta, Tresa Remya Athipozhi Thomas, Saranya Selvamurthy, Sanjay Pasupathy

“…The studies selected were all scrub typhus patients associated with liver diseases. …”
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