Physiologically Based Pharmacokinetic Modeling of Antibiotics in Children: Perspectives on Model-Informed Precision Dosing by Ryota Tanaka, Kei Irie, Tomoyuki Mizuno

“…The appropriate use of antibiotics is crucial and involves selecting an optimal dosing regimen based on pharmacokinetic (PK) and pharmacodynamic (PD) indicators. …”
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Systematic identification and characterization of high efficiency Cas9 guide RNAs for therapeutic targeting of ADAR. by Benjamin G Gowen, Kory Melton, Weng In Leong, Prachi Khekare, Shannon McCawley, Jean Chan, Pierre Boivin, Vihasi Jani, Aaron J Cantor, Akshay Tambe, Mary Haak-Frendscho, Mary J Janatpour, Spencer C Wei

“…We determine that knockout of ADAR using these guide RNAs induces pharmacodynamic responses primarily consisting of immunological responses such as a type I interferon response, consistent with the known function of ADAR as a key regulator of dsRNA sensing. …”
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Advanced Monte Carlo for Acquisition Sampling in Bayesian Optimization by Javier Garcia-Barcos, Ruben Martinez-Cantin

“…Optimizing complex systems usually involves costly and time-consuming experiments, where selecting the experiments to perform is fundamental. …”
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Recent Advances and Challenges in the Production of Hydroxylated Natural Products Using Microorganisms by Chang Sun, Rumei Zeng, Tianpeng Chen, Yibing Yang, Yi Song, Qiang Li, Jie Cheng, Bingliang Liu

“…Hydroxylation reaction is a significant source of structural diversity in natural products (NPs), playing a crucial role in improving the bioactivity, solubility, and stability of natural product molecules. …”
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Nutritional value, antibacterial activity, ACE and DPP IV inhibitory of red pomegranate seeds protein and peptides by Zahra Akbarbaglu, Narges Mazloomi, Laleh Karimzadeh, Khashayar Sarabandi, Seid Mahdi Jafari, Mohammad Ali Hesarinejad

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High-Sensitivity Determination of K, Ca, Na, and Mg in Salt Mines Samples by Atomic Emission Spectrometry with a Miniaturized Liquid Cathode Glow Discharge by Jie Yu, Zhichao Zhang, Quanfang Lu, Duixiong Sun, Shuwen Zhu, Xiaomin Zhang, Xing Wang, Wu Yang

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Identification of miRnas with possible prognostic roles for HAM/TSP by Daniela Raguer Valadão de Souza, Rodrigo Pessôa, Youko Nukui, Juliana Pereira, Rosa Nascimento Marcusso, Augusto César Penalva de Oliveira, Jorge Casseb, Alberto José da Silva Duarte, Patricia Bianca Clissa, Sabri Saeed Sanabani

“…The seven most deregulated miRs target genes have been associated with a variety of biological processes and molecular functions. The reactome pathways relevant to our findings provide a rich source of data and offer the opportunity to better understand sRNA regulation and function in HTLV-1 pathophysiology. …”
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Plant Response to Environmental Gradient Mediated by Trait Through Ontogeny on Common Tree Species at Two Contrasting Habitats in Karst Forest of Southern Taiwan by Muhammad Abdullah, I Fang Sun

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Has stakeholder participation in health facility governing committees promoted social accountability? A qualitative study in Tanzania by Hussein Athuman Kapuya, Stephen Oswald Maluka, Anna-Karin Hurtig, Miguel San Sebastian

“…While previous studies have explored the functionality of the HFGCs, this study aimed to understand whether stakeholder participation in the HFGCs contributes to promoting social accountability in the health system. …”
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INDICATIVE PLANNING AS A TOOL OF ALTERATIONS PROCESSES MANAGEMENT by F. Pashchenko, V. Ivanyuk, N. Abdikeev

“…The indicative planning model implies selective intervention in the areas where there is an imbalance of positive and negative factors. …”
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Spatial and Temporal Dynamics of Bentho-Demersal Communities From Bottom Trawl Across the Moroccan Mediterranean Coast in Relation to Environmental Conditions: Implications for Fis... by Douaa Slimani, Souad Abdellaoui, Najib El Ouamari, Khaoula Kasmi, Rajae Mouedden, Imade Ouebdil, Nassir Kaddouri, Jamal Settih, Mostafa Layachi, Mohamed Fadili, Khalid Chaabane

“…Understanding the temporal and spatial patterns, as well as habitat preferences, of marine communities is crucial for interpreting ecosystem functioning and effectively protecting marine organisms’ resources. …”
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Features of Designing a Web-Service of Didactic Materials by Yulya Khritonenko, Sergey Kozlov

“…The primary task is to identify the appropriate types of roles and their functional capabilities, which is necessary to identify the scheme of user interaction with the service. …”
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Capacitive deionisation for water desalination review: experimental and simulation by Rokhsareh Akbarzadeh, Mathias Ernst, Robert Meißner, Bodo Fiedler

“…Strategies such as hybrid CDI systems and electrode surface functionalization are discussed to mitigate these challenges. …”
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Exome analysis reveals species divergence in TYR and identifies species genetic markers in five endemic Macaca species on Sulawesi Island by Xiaochan Yan, Nami Arakawa, Kanthi Arum Widayati, Laurentia Henrieta Permita Sari Purba, Fahri Fahri, Bambang Suryobroto, Yohey Terai, Hiroo Imai

“…Additionally, it explores how these genetic differences influence biological functions, and identifies species-specific genetic markers for species identification and conservation. …”
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A system for generating chatbots to support learning in the field of exact sciences using generative artificial intelligence models by Oleksandr Prokhorov, Dmytro Shymko, Olena Kuzminska, Andrey Chukhray, Oleksii Shatalov, Oleksandr Kholodniak

“…The objectives include: analyzing the challenges and peculiarities of creating chatbots and preparing high-quality datasets; developing the structure and describing the functionality of the chatbot generation system; providing examples of creating various types of chatbots; conducting experiments to determine the effectiveness and cost of chatbot generation. …”
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Multi-directional deformation for coordinating isotropy and strength-ductility synergy in a CoCrNi alloy by Na Lin, Zhicheng Miao, Mingcan Li, Rumeng Huang, Kaiyuan Zheng, Zhaowen Huang, Donghui Wen, Cong Zhang, Anding Wang

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Comparison of Gut Microbiota in Overwintering Bees: <i>Apis cerana</i> vs. <i>Apis mellifera</i> by Heng Chen, Lijiao Gao, Jialin Liu, Conghui Ji, Xiaoqun Dang, Zeyang Zhou, Wenhua Luo

“…However, during the cold season, resources become limited, leading to significant losses in bee colonies. …”
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Characterize the Complete Mitogenome of Semiaquilegia guangxiensis and Assess the Efficiency of the Mitochondrial Genes in Ranunculales Phylogeny by Zheng‐Juan Zhu, Xin‐Mei Qin, Peng‐Wei Li, Yong‐Bin Lu, Xiao‐Yuan Mo, Yuan Fang, Qiang Zhang

“…Moreover, a large number of repetitive mitogenome sequences and chloroplast‐sourced sequences transferred to the mitogenome were detected. …”
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Research on Stacking Distribution of Steel Plates Input Based on Improved Multi-objective Particle Swarm Optimization by ZHONG Chuanjie, CHENG Wenming, DU Run, GAO Xuchao, ZHANG Lin

“…The inventory balance index was established based on the standard deviation of the number of steel plates allocated to each reservoir to fully mobilize and balance material storage resources during operation. These three indices were utilized to evaluate the degree of stack allocation and served as the objective function to establish a multi-objective decision optimization model for the stack allocation problem of steel plates. …”
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Genomics and integrative clinical data machine learning scoring model to ascertain likely Lynch syndrome patients by Ramadhani Chambuso, Takudzwa Nyasha Musarurwa, Alessandro Pietro Aldera, Armin Deffur, Hayli Geffen, Douglas Perkins, Raj Ramesar

“…Annovar, Intervar, Variant Effect Predictor (VEP), and OncoKB software tools were used to functionally annotate and interpret somatic variants detected. …”
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