Optimizing Nav1.7‐Targeted Analgesics: Revealing Off‐Target Effects of Spider Venom‐Derived Peptide Toxins and Engineering Strategies for Improvement by Sen Luo, Xi Zhou, Meijing Wu, Gongxin Wang, Li Wang, Xujun Feng, Hang Wu, Ren Luo, Minjuan Lu, Junxian Ju, Wenxing Wang, Lei Yuan, Xiaoqing Luo, Dezheng Peng, Li Yang, Qingfeng Zhang, Minzhi Chen, Songping Liang, Xiuming Dong, Guoliang Hao, Yunxiao Zhang, Zhonghua Liu

“…Spider venom‐derived peptide toxins are recognized as significant sources of Nav1.7 inhibitors. However, their development has been impeded by limited selectivity. …”
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A Framework for Qualitative Analysis of Switching Techniques of Inductive Pulse Power Supply by Ayaz Ahmed, Zulkurnain Abdul-Malek, Hasmat Malik, Majed A. Alotaibi

“…This research examines the functionality, results, and constraints of the pulse transformer, Meatgrinder, and XRAM-based IPPS circuit topologies using different switching techniques, such as stretch Meatgrinder, ICCOS, SECT, CPFU, ACC, BCSC, and TWPT. …”
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Female Regency Rule in Western Pomerania Exemplified by Duchess Elizabeth, the Wife of Warcisław IV (1326–ca. 1350) by Patrycja Jędrzejewska-Michalak

“…An important aspect is also the presentation of how Elizabeth dealt with the problems she encountered during her rule, as well as the assessment of her actions. The source base consists mainly of selected documents that the duchess exhibited or co-exhibited with her sons.…”
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Between Astronomy and Revelation: Reassessing the Star of Bethlehem in Matthew 2:1–12 by Sugihyono, Nicolien Meggy Sumakul, Mangiring Sinaga, Natassa Sandriana, Norlina Rambu Jola Kalunga, Mulyani Susana

“…Employing a qualitative, literature-based method, the research critically examines various astronomical hypotheses—including planetary conjunctions, comets, and supernovae—alongside symbolic and theological readings grounded in biblical and patristic sources. The findings demonstrate that naturalistic explanations fail to fully account for the unique characteristics of the star, such as its guided movement, selective visibility, and stationary positioning above a specific location. …”
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Methodological approaches for research of local market of IT services in the information space of region by I. V. Antokhonova, O. A. Polukhina, L. N. Saibonova

“…Information analysis base is the system of statistics which sources can be an official statistics, analytics of Internet resources and data of selective inspections of demand in the local market.The technique of a research represents an analysis algorithm of all components of information space and the market of IT services. …”
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Genome-wide association study revealed candidate genes associated with leaf size in alfalfa (Medicago sativa L.) by Ming Xu, Yanchao Xu, Hao Liu, Qingsong Liu, Qingchuan Yang, Ruicai Long, Lin Chen, Fei He

“…Conclusion Our findings provide new molecular markers for marker-assisted selection in alfalfa breeding programs. Moreover, this study provides a solid foundation for subsequent functional verification and genetic improvement in alfalfa.…”
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On Euphemisms, Linguistic Creativity, and Humor by Craig Hamilton, Anne-Sophie Foltzer

“…Euphemisms are also a source of creativity, and studying their form and function uncovers an interesting interface where syntax and semantics meet. …”
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Nano selenium in broiler feeding: physiological roles and nutritional effects by Babak Hosseintabar-Ghasemabad, Olga Vilorievna Kvan, Elena Vladimirovna Sheida, Artem Vladimirovich Bykov, František Zigo, Alireza Seidavi, Mona Mohamed Mohamed Yasseen Elghandour, Moises Cipriano-Salazar, Maximilian Lackner, Abdelfattah Zeidan Mohamed Salem

“…Nutrition of permitted and optimal levels is very important in the consumption of nano selenium form and as it can have significant beneficial functional and health effects, in case of errors in the selected levels and doses, irreparable side effects and adverse results can occur. …”
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The whole set of constitutive promoters recognized by RNA polymerase RpoD holoenzyme of Escherichia coli. by Tomohiro Shimada, Yukiko Yamazaki, Kan Tanaka, Akira Ishihama

“…The promoter selectivity of Escherichia coli RNA polymerase is determined by the sigma subunit with promoter recognition activity. …”
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Investigating the health systems of the word\'s armies and providing an appropriate model by Nader Markazi-Moghaddam, Sanaz Zargar Balaye Jame, Saeid Shahraki

“…Then, based on the collected information, a draft semi-structured interview was extracted within the framework of the functions and objectives of the proposed military health system. …”
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Biologically rapid synthesis of silver nanoparticles by Sphingobium sp. MAH-11T and their antibacterial activity and mechanisms investigation against drug-resistant pathogenic micr... by Shahina Akter, Md. Amdadul Huq

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Evidence of factors influencing delays in the diagnosis and treatment of bipolar disorder in adolescents and young adults. Protocol for a systematic scoping review. by Kamyar Keramatian, Emma Morton, Alexander Levit, John-Jose Nunez

“…Two independent reviewers will screen the references retrieved by the literature search and select relevant studies based on our inclusion criteria. …”
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QELPS Algorithm: A Novel Dynamic Optimization Technology for Quantum Circuits Scheduling Engineering Problems by Zuoqiang Du, Xingjie Li, Hui Li

“…Meanwhile, FJOSA employs a cross-layer optimization strategy that combines heuristic algorithms with cost functions to improve gate scheduling at a global level. …”
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Insight on the Planning and Construction of Shanghai City Railway Network by MAO Chen, LIU Chunjie

“…In terms of specific line schemes, it is necessary to combine needs, strengthen system functions, optimize railway standards, select key hub anchoring points and external connection points to create integrated demonstration stations, and further improve the level of interconnection; it is necessary to integrate into urban development internally, and strengthen cross-regional connections externally for the further optimization of planning network forms. …”
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Heat stress transcripts, differential expression, and profiling of heat stress tolerant gene TaHsp90 in Indian wheat (Triticum aestivum L.) cv C306. by Harinder Vishwakarma, Alim Junaid, Jayanand Manjhi, Gyanendra Pratap Singh, Kishor Gaikwad, Jasdeep Chatrath Padaria

“…To generate a genetic resource of heat stress responsive genes/ESTs, suppression subtractive hybridization (SSH) library was constructed in a heat and drought stress tolerant Indian bread wheat cultivar C306. …”
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Assessing the validity and reliability of the persian version of Self-concept and Identity Measure in an Iranian population by Saba Tutunchian, Ali Reza Shafiee-Kandjani, Ayyoub Malek, Behzad Shalchi

“…This study examines the validity and reliability of the Persian version of the Self-Concept and Identity Measure, designed to assess healthy and disrupted identity functions. Methods. This study utilized a methodological design and focused on students at Tabriz University of Medical Sciences for the 2023-2024 academic year. …”
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ANALYZING THE TECHNICAL EFFICIENCY OF FARMERS GROWING DIFFERENT CROPS IN DISTRICT MANSEHRA, PAKISTAN by Tayyba RIAZ, Arif ALAM, Adeel Jalal MALIK, FARIDULLAH

“…While, average technical efficiency of the selected crops i.e potato, onion and tomato was estimated79%, 74%, and 69%, respectively, indicating space for improvement in efficiency by 21%, 26%, and 31% by effective usage of available resources. …”
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Role of community health workers in type 2 diabetes mellitus self-management: A scoping review. by Bonaventure Amandi Egbujie, Peter Arthur Delobelle, Naomi Levitt, Thandi Puoane, David Sanders, Brian van Wyk

“…<h4>Results</h4>1008 studies were identified of which 54 full text articles were selected. Most (53) of the selected studies were in HIC and targeted mostly minority populations in low resource settings. …”
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Identification of Suitable Villages for Agritourism Development (A Case Study of Semirom County) by Narges Vazin, Ali Sadeghi, Zahra Barati

“…Agritourism can transform local resources into tourism products and services, as well as provide real opportunities for the development of rural communities. …”
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Developing soil quality indices to investigate degradation impacts of different land use types in Northern Ethiopia by Araya Kahsay, Mitiku Haile, Girmay Gebresamuel, Muktar Mohammed

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