Platinum-Induced Ototoxicity in Pediatric Cancer Patients: A Comprehensive Approach to Monitoring Strategies, Management Interventions, and Future Directions by Antonio Ruggiero, Alberto Romano, Palma Maurizi, Dario Talloa, Fernando Fuccillo, Stefano Mastrangelo, Giorgio Attinà

“…This approach addresses critical gaps in current practice while acknowledging resource limitations across diverse healthcare environments.…”
Get full text

Discovery of Genomic Targets and Therapeutic Candidates for Liver Cancer Using Single-Cell RNA Sequencing and Molecular Docking by Biplab Biswas, Masahiro Sugimoto, Md. Aminul Hoque

“…This study aims to uncover key genomic features, analyze their functional roles, and propose potential therapeutic drugs identified through molecular docking, utilizing single-cell RNA sequencing (scRNA-seq) data from liver cancer studies. …”
Get full text

Ethics of Sensor-Based Surveillance of People with Dementia in Clinical Practice by Jacob Lahr, Nicole Schulze, Larissa N. Wüst, Claus Beisbart, Lena C. Bruhin, Marcello Ienca, Tobias Nef, Manuel Trachsel, Stefan Klöppel

“…Sensor-based surveillance technology (SST) is increasingly employed in the care of people with dementia (PwD) in hospitals, nursing homes, and home care. With improved functionality and availability of SST, there will likely be a growing utilization in clinical settings. …”
Get full text

Performance of the National Tuberculosis Control Program in the post conflict Liberia. by Kassaye Tekie Desta, T E Masango, Zerish Zethu Nkosi

“…For the performance of tuberculosis laboratory testing, all the 107 functional tuberculosis microscopy centers in Liberia were included. …”
Get full text

Diagnosing skin neglected tropical diseases with the aid of digital health tools: A scoping review. by Ewelina Julia Barnowska, Anil Fastenau, Srilekha Penna, Ann-Kristin Bonkass, Sophie Stuetzle, Ricky Janssen

“…Recent developments in digital health have given rise to approaches that could increase access to diagnosis in resource-poor areas affected by skin NTDs. This scoping review provides an overview of current digital health approaches that aim to aid in the diagnosis of skin NTDs and provides an insight into the diverse functionalities of current digital health tools, their feasibility, usability, and the current gaps in research around these digital health approaches. …”
Get full text

Assessing the Impact of Covid19-Pandemic on the Household Income in Kamuganguzi Sub-County Kabale District. by Arinda, Redeemer Present

“…Additionally, the government should establish a physical and automated platform for coordination and resource mobilization to support poor students and the most vulnerable groups affected by COVID-19-related lockdowns.…”
Get full text

Exploring the Complexities of Seafood: From Benefits to Contaminants by Bettina Taylor, Kelvin Fynn Ofori, Ali Parsaeimehr, Gulsun Akdemir Evrendilek, Tahera Attarwala, Gulnihal Ozbay

“…Seafood plays a vital role in human diets worldwide, serving as an important source of high-quality protein, omega-3 fatty acids, and essential vitamins and minerals that promote health and prevent various chronic conditions. …”
Get full text

Targeting GJB4 to inhibit tumor growth and induce ferroptosis in pancreatic cancer by Xiangru Zheng, Wenjun Li, Xiaoli Li, Qianyi Yao, Luquan Zheng, Rongrong Fan, Ping Bie

“…Bioinformatics analysis was conducted to explore the function of GJB4 in PC cells. Changes in ferroptosis in PC cells following GJB4 downregulation were detected by immunofluorescence staining, transmission electron microscopy, and western blotting.ResultsGJB4 expression was found to be upregulated in PC tissues and positively correlated with patient survival. …”
Get full text

A Systematic Search for Candidate Supermassive Black Hole Binaries Using Periodic Mid-infrared Light Curves of Active Galactic Nuclei by Di Luo, Ning Jiang, Xin Liu

“…Analyzing a parent sample of 48,932 objects selected from about half a million AGNs, we have identified 28 candidate periodic AGNs with periods ranging from 1268 to 2437 days (in the observer frame), by fitting their WISE light curves with sinusoidal functions. However, our mock simulation of the parent sample indicates that stochastic variability can actually produce a similar number of periodic sources, underscoring the difficulty in robustly identifying real periodic signals with WISE light curves, given their current sampling. …”
Get full text

Human disturbance influences occupancy of red deer in Mongolia by Rhiannon R. Henderson, Brittany A. Mosher, Rebecca Watters, Tumursukh Jal, James D. Murdoch

Get full text

The biomarker potential of circPOLD1 and its binding protein YBX1 in cervical carcinogenesis by Lu Zhao, Xin Chen, Yanan Zhang, Yixuan Cen, Tingjia Zhu, Lingfang Wang, Lili Xia, Yang Li, Xiaodong Cheng, Xing Xie, Weiguo Lu, Junfen Xu

“…Mechanistically, circPOLD1 functioned as an oncogene by binding to and phosphorylating YBX1, activating the AKT/mTOR/HIF-1α pathway to enhance glycolysis-driven tumorigenesis. …”
Get full text

Bioactive matters based on natural product for cardiovascular diseases by Linfang Zhong, Xiaoying Tan, Wenhui Yang, Peishan Li, Lianbao Ye, Qi Luo, Honghao Hou

Get full text

Pyruvate formate lyase regulates fermentation metabolism and virulence of Streptococcus suis by Qingying Fan, Haikun Wang, Shuo Yuan, Yingying Quan, Rishun Li, Li Yi, Aiqing Jia, Yuxin Wang, Yang Wang

Get full text

Does tinnitus and emotional distress influence central auditory processing? A comparison of acute and chronic tinnitus in normal-hearing individuals. by Qian Zhou, Wenling Jiang, Haibin Sheng, Qinjie Zhang, Dian Jin, Haifeng Li, Meiping Huang, Lu Yang, Yan Ren, Zhiwu Huang

“…<h4>Design</h4>This study compared the auditory afferent and efferent functions of normal-hearing patients with acute tinnitus, chronic tinnitus, and control group using gap detection test, the Mandarin Hearing in Noise Test (MHINT), and contralateral suppression of transient evoked otoacoustic emissions (TEOAEs).…”
Get full text

Incorporating Non-Coding Annotations into Rare Variant Analysis. by Tom G Richardson, Colin Campbell, Nicholas J Timpson, Tom R Gaunt

“…<h4>Methods & results</h4>We conducted a candidate gene analysis using the UK10K sequence and lipids data, filtering according to functional annotations using the resource CADD (Combined Annotation-Dependent Depletion) and contrasting results with 'nonsynonymous' and 'loss of function' consequence analyses. …”
Get full text

Genome-Wide Ultrabithorax Binding Analysis Reveals Highly Targeted Genomic Loci at Developmental Regulators and a Potential Connection to Polycomb-Mediated Regulation. by Daria Shlyueva, Antonio C A Meireles-Filho, Michaela Pagani, Alexander Stark

“…Furthermore, Ubx binding was detected at known Polycomb response elements (PREs) and was associated with significant enrichments of Pc and Pho ChIP signals in contrast to binding sites of other developmental TFs. …”
Get full text

Origami-Inspired Biosensors: Exploring Diverse Applications and Techniques for Shape-Changing Sensor Platforms by Shikha Patil, Shariq Suleman, Nigar Anzar, Jagriti Narang, Roberto Pilloton, Suna Timur, Emine Guler Celik, Chandra S. Pundir, Sudheesh K. Shukla

“…Paper and biological substrates like DNA have been integrated with origami techniques to develop biosensors with enhanced functionality. The incorporation of aptamer origami into both paper and DNA biosensors further increases sensitivity and specificity for target detection. …”
Get full text

Melatonin: A Novel Indolamine in Oral Health and Disease by V. K. Chava, K. Sirisha

“…Recent studies, by Claustrat et al. (2005), detected few extrapineal sources of melatonin like retina, gastrointestinal tract, and salivary glands. …”
Get full text

Application of microscopic smartphone attachment for remote preoperative lab testing by Kefan Song, Kefan Song, Alexander T. Adams, Alexander T. Adams

“…This device is designed to assist both healthcare providers in resource-limited settings and patients by offering a low-cost, portable diagnostic tool that enables both in-clinic and at-home testing.MethodsThe system was tested for adaptability and compatibility by transitioning from its original Android platform to an iOS platform. …”
Get full text

Exploring the Medicinal Potential of <i>Taraxacum Kok-Saghyz</i> (<i>TKS</i>) Using Widely Targeted Metabolomics by Michele Tan, Jeffrey Shih-Chieh Chu, Daniel Robin Swiger

“…This study presents the first comprehensive metabolic profile of <i>TKS</i>, highlighting its potential value beyond rubber production. The detection of numerous therapeutic secondary metabolites supports its promise as a pharmaceutical and nutraceutical resource. …”
Get full text