Celastrol-loaded ginsenoside Rg3 liposomes boost immunotherapy by remodeling obesity-related immunosuppressive tumor microenvironment in melanoma by Hongyan Zhang, Jingyi Huang, Yujie Li, Wanyu Jin, Jiale Wei, Ninghui Ma, Limei Shen, Mancang Gu, Chaofeng Mu, Donghang Xu, Yang Xiong

“…Obesity usually exacerbates the immunosuppressive tumor microenvironment (ITME), hindering CD8+ T cell infiltration and function, which further represents a significant barrier to the efficacy of immunotherapy. …”
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Effect of Perfluorane on Electric Pulse-Modified Red Blood Cell Membranes by V. V. Moroz, Ye. K. Kozlova, M. S. Bogushevich, P. Yu. Alekseyeva, A. M. Chernysh

“…The induced calibrated electroporation of the membranes permitted the detection of the masked effects of perfluorane on blood cells. …”
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Quantification of glucagon and oxyntomodulin by protein precipitation-immunoaffinity enrichment-LC-MS/MS by Jessica O. Becker, Sara K. Shijo, Huu-Hien Huynh, Katrina L. Forrest, Michael J. MacCoss, Michelle A. Emrick, Elisha Goonatilleke, Andrew N. Hoofnagle

“…A glucagon calibration material was sourced commercially and characterized for purity and concentration by high-performance liquid chromatography-ultraviolet detection and amino acid analysis. …”
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Synergizing Multi-Temporal Remote Sensing and Systemic Resilience for Rainstorm–Flood Risk Zoning in the Northern Qinling Foothills: A Geospatial Modeling Approach by Dong Liu, Jiaqi Zhang, Xin Wang, Jianbing Peng, Rui Wang, Xiaoyan Huang, Denghui Li, Long Shao, Zixuan Hao

“…This framework quantitatively evaluates the nonlinear response mechanisms of town–village systems to flood disasters, emphasizing the synergistic effects of spatial scale, morphology, and functional organization. The proposed framework uniquely integrates three innovative modules: (1) a hybrid risk identification engine combining normalized difference vegetation index (NDVI) temporal anomaly detection and spatiotemporal hotspot analysis; (2) a morpho-functional resilience quantification model featuring a newly developed spatial morphological resilience index (SMRI) that synergizes landscape compactness, land-use diversity, and ecological connectivity through the entropy-weighted analytic hierarchy process (AHP); and (3) a dynamic scenario simulator embedding rainfall projections into a coupled hydrodynamic model. …”
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Digital Twin-Based Technical Research on Comprehensive Gear Fault Diagnosis and Structural Performance Evaluation by Qiang Zhang, Zhe Wu, Boshuo An, Ruitian Sun, Yanping Cui

“…However, the current gear operation is still faced with problems such as poor monitoring, a single detection index, and low data utilization, which lead to incomplete evaluation results. …”
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Unveiling smart contract vulnerabilities: Toward profiling smart contract vulnerabilities using enhanced genetic algorithm and generating benchmark dataset by Sepideh HajiHosseinKhani, Arash Habibi Lashkari, Ali Mizani Oskui

“…This dataset consists of 111,897 Solidity source code samples, ensuring the practical validation of the proposed approach. …”
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Impulse Shaping Method Based on Bayesian Deconvolution by JIA Tonghui, LIU Yi, WANG Ming, MA Yingjie, WANG Bo

“…The initial step of this method entailed expressing the measured pulse signal as the convolution of the current impulse pulse signal and the detection system response function. Then, the measured signal was expressed in the continuous time domain and decomposed into the form of an impulse signal and a double exponential kernel convolution by derivation. …”
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Genome-wide identification and expression pattern analysis of NAC family in Taxus yunnanensis and the TyuNAC30 role in paclitaxel production by Jiangtao Fan, Yong Wang, Mengke Dou, Qiuhong Hu, Qing Li, Shengmei Gan, Mingwei Jing, Gang Wang, Xiong Huang

“…Yeast one-hybrid and related assays revealed that TyuNAC30 functions as a negative regulator of TyuDBTNBT, a key enzyme gene in the paclitaxel biosynthetic pathway. …”
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NORDIC denoising on VASO data by Lasse Knudsen, Lasse Knudsen, Luca Vizioli, Federico De Martino, Lonike K. Faes, Daniel A. Handwerker, Steen Moeller, Peter A. Bandettini, Peter A. Bandettini, Laurentius Huber

“…However, VASO comes along with another reduction in detection sensitivity. NOise Reduction with DIstribution Corrected (NORDIC) PCA (principal component analysis) is a denoising technique specifically aimed at suppressing thermal noise, which has proven useful for increasing the SNR of high-resolution functional data. …”
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The Soviet Military Microbiologists’ Contribution to the Victory in the Great Patriotic War by A. S. Tumanov, I. V. Darmov, M. K. Bakulin, A. A. Leshchenko, D. A. Sharov, S. V. Bagin, I. V. Kosenkov

“…The authors of this article have detected a sequence of events that led to relocation of a military scientific institution during the Great Patriotic War (the Sanitary engineering institution of the Red Army of Workers and Peasants) was relocated from Gorodomlya Island to Kirov. …”
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THE USE OF CRYOCONSERVATED PLACENTA FOR PREVENTION OF PATHOLOGIC SCAR FORMATION OF THE HEAD AND NECK AT THE INTRA- AND POSTOPERATIVE STAGE IN PLANNED SURGERY by O.A. Toropov, D.S. Avetikov, K.P. Lokes, D.V. Steblovskyi, V.M. Skrypnyk, R.A. Prykhidko

“…With the development of technology, it became possible to detect the phenotypic and functional heterogeneity of cell types. …”
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Retinal vein occlusion risk prediction without fundus examination using a no-code machine learning tool for tabular data: a nationwide cross-sectional study from South Korea by Na Hyeon Yu, Daeun Shin, Ik Hee Ryu, Tae Keun Yoo, Kyungmin Koh

“…An easy-to-use oversampling function was employed to address class imbalance, enhancing the usability of the workflow. …”
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Life cycle assessment of an entirely wood floor system designed for carbon negativity, future adaptability, and end-of-life de/re/construction by Muzan Williams Ijeoma, Sovanroth Ou, Amin Nabati, Hao Chen, Michael Stoner, Patricia Layton, Dustin Albright, Brandon Ross, Weichiang Pang, Michael Carbajales-Dale

“…Mass timber offers a promising alternative, with lower embodied carbon (EC) and the potential to function as a carbon sink when sustainably sourced. …”
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Oligosaccharide production using β-galactosidase from Lactobacillus bulgaricus and Kluyveromyces lactis in sweetened reconstituted nonfat dry milk by Giselle K.P. Guron, Arland T. Hotchkiss, Jr., Brittany H. Bodnar, Andrew Harron, John A. Renye, Jr., Michael J. McAnulty

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Effective disinfecting of negative pressure pipelines of DCUs reduces the risk of cross infection in dental care by Xuerong Lv, Ke Yan, Xiang Han, Feiyang Wang, Yuzhuo Ma, Shougang Zhang, Xiaoqian Wang

“…Objectives Microbial contamination of various accessory parts of the dental chair units (DCUs) is an essential source of cross infection, while the accessories of the crucial suction function are usually overlooked. …”
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Much More Than the Malady: The Promise of a Web-Based Digital Platform Incorporating Self-Report for Research and Clinical Care in Mild Cognitive Impairment by Andrew McGarry, MD, Oliver Roesler, PhD, Jackson Liscombe, PhD, Michael Neumann, PhD, Hardik Kothare, PhD, Abhishek Hosamath, MBM, Lakshmi Arbatti, MS, Anusha Badathala, MD, Stephen Ruhmel, BS, MPH, Bryan J. Hansen, PhD, Madeline Quall, BA, Sandrine Istas, MBio, Arthur Wallace, MD, PhD, David Suendermann-Oeft, PhD, Vikram Ramanarayanan, PhD, Ira Shoulson, MD

“…A complementary approach using digital biomarkers to surpass exam-based limitations for detecting physical change coupled with a direct report from participants on what their sources of suffering are could be a useful advance in reporting beneficial effects of interventions, particularly if changes track together. …”
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Differential involvement of neurotransmitter pathways in AD, bvFTD and MCI: Whole-brain MRI analysis by Ricardo Félix Morais, José Maria Sousa, Cemal Koba, Leon Andres, Tiago Jesus, Inês Baldeiras, Tiago Gil Oliveira, Isabel Santana

“…In MCI, early serotonergic dysregulation involving SERT occurs before detectable atrophy.…”
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Exploration of the interaction between antimicrobial peptides and gamma radiation for biosensor development. by Fabiane Modenese Garbim, Marcela Rabelo De Lima, Giulianna Santos Pereira, João Nilton Conceição Bandeira, Álvaro José Mendes-Boareto, Fernando Manuel Araújo-Moreira, N.F.G. Serrano

“…These findings indicate that, although AMPs demonstrate changes in activity as a function of dose and could be explored for biosensing, their functional stability is limited at higher radiation doses. …”
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Optimisation of bioaerosol sampling using an ultralight aircraft: A novel approach in determining the 3-D atmospheric biodiversity by Maria P. Plaza, Athanasios Charalampopoulos, Vivien Leier-Wirtz, Pia Viuf Ørby, Mathilde Kloster, Michael Dines Christiansen, Claudia Traidl-Hoffmann, Athanasios Damialis, Ulrich Gosewinkel

“…Moreover, biomonitoring campaigns often take place in urban environments, although sources can be located outside cities’ borders with ampler vegetation. …”
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TET3-facilitated differentiation of human umbilical cord mesenchymal stem cells into oligodendrocyte precursor cells for spinal cord injury recovery by Yubo Zhang, Zhibin Peng, Man Guo, Yangyang Wang, Jingsong Liu, Yishu Liu, Mi Li, Tianli Wei, Pengfei Li, Yingwei Zhao, Yansong Wang

“…Owing to the poor regenerative capabilities of endogenous oligodendrocyte precursor cells (OPCs) following SCI, there is a growing interest in alternative sources, such as human umbilical cord mesenchymal stem cells (HUCMSCs). …”
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